PCP INDUCED SOCIAL BEHAVIOUR DEFICITS IN FEMALE RATS, IMPROVEMENT BY NOVEL BUT NOT CLASSICAL ANTIPSYCHOTICS, A POTENTIAL MODEL OF NEGATIVE SYMPTOMS

AbstractObjective: To assess the effects of relocation on the social behaviour and mental state of a group of 43 long stay psychiatric patients transferred from an old institution to a modern hospital. Method: Each patient was assessed using the MRC Social Behaviour Schedule and the Manchester Scale. Assessments were carried out prior to relocation and at six weeks and six months after transfer. Results: Some deterioration was apparent in the patients' social behaviour at six weeks following relocation but this trend was reversed to definite improvement at six months. There was an overall marked reduction in hostility and violence following relocation. Patients who showed most improvement in terms of social behaviour were the lower functioning group where greater emphasis was placed on promoting basic self care and social skills rather than on occupational therapy. Changes in mental state, following relocation, were minimal but a slight deterioration occurred especially in the area of negative symptoms. Conclusions: Relocations caused no serious adverse effects in the majority of these patients. The improvement observed in certain aspects of behaviour are attributable to the improved physical and psychological milieu of the receiving hospital.

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Role of early experience in social behaviour of laboratory-bred female rats

Behavioural Processes ◽

10.1016/0376-6357(77)90028-6 ◽

1977 ◽

Vol 2 (3) ◽

pp. 243-253 ◽

Cited By ~ 1

Author(s):

V. Nováková ◽

A. Babický

Keyword(s):

Social Behaviour ◽

Early Experience ◽

Female Rats

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Skill-based engagement with a rich landscape of affordances as an alternative to thinking through other minds

Behavioral and Brain Sciences ◽

10.1017/s0140525x1900284x ◽

2020 ◽

Vol 43 ◽

Author(s):

Julian Kiverstein ◽

Erik Rietveld

Keyword(s):

Social Behaviour ◽

Cultural Learning ◽

Other Minds ◽

Middle Way ◽

Internalist Account

Abstract Veissière and colleagues make a valiant attempt at reconciling an internalist account of implicit cultural learning with an externalist account that understands social behaviour in terms of its environment-involving dynamics. However, unfortunately the author's attempt to forge a middle way between internalism and externalism fails. We argue their failure stems from the overly individualistic understanding of the perception of cultural affordances they propose.

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Basal Lamina Formation in DMBA Induced Mammary Carcinoma

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100080109 ◽

1977 ◽

Vol 35 ◽

pp. 534-535

Author(s):

I. Russo ◽

J. Saby ◽

J. Russo

Keyword(s):

Mammary Carcinoma ◽

Virgin Female ◽

Mammary Glands ◽

Sesame Oil ◽

Female Rats ◽

Ultrastructural Changes ◽

Post Inoculation ◽

Intermediate Type ◽

Sprague Dawley ◽

Intercellular Spaces

It has been previously demonstrated that DMBA-induced rat mammary carcinoma originates in the terminal end bud (TEB) of the mammary gland by proliferation of intermediate type cells (1). The earliest lesion identified is the intraductal proliferation (IDP), which gives rise to intraductal carcinomas. These evolve to cribriform, papillary and comedo types (2). In the present work, we report the ultrastructural changes that take place in the IDP for the formation of a cribriform pattern.Fifty-five-day-old Sprague Dawley virgin female rats were inoculated intra- gastrically with 20 mg 7,12-dimethylbenz(a)anthracene (DMBA) in 1 ml sesame oil. Non-inoculated, age-matched females were used as controls. Mammary glands from both control and experimental rats were removed weekly from the time of inoculation until 86 days post-inoculation. The glands were fixed and processed for electron microscopy (2).The first change observed in IDP's was the widening of intercellular spaces and the secretion of an electron dense material into these spaces (Fig. 1).

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Morphological Changes in the Rat Granulosa Cell Surface During Differentiation Induced by Estradiol and Gonadotropins

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100079851 ◽

1977 ◽

Vol 35 ◽

pp. 484-485

Author(s):

P. Bagavandoss ◽

JoAnne S. Richards ◽

A. Rees Midgley

Keyword(s):

Cell Surface ◽

Granulosa Cell ◽

Morphological Changes ◽

Follicular Development ◽

Female Rats ◽

Functional Changes ◽

Group 4 ◽

Group 3 ◽

Group 5 ◽

Group 2

During follicular development in the mammalian ovary, several functional changes occur in the granulosa cells in response to steroid hormones and gonadotropins (1,2). In particular, marked changes in the content of membrane-associated receptors for the gonadotropins have been observed (1).We report here scanning electron microscope observations of morphological changes that occur on the granulosa cell surface in response to the administration of estradiol, human follicle stimulating hormone (hFSH), and human chorionic gonadotropin (hCG).Immature female rats that were hypophysectcmized on day 24 of age were treated in the following manner. Group 1: control groups were injected once a day with 0.1 ml phosphate buffered saline (PBS) for 3 days; group 2: estradiol (1.5 mg/0.2 ml propylene glycol) once a day for 3 days; group 3: estradiol for 3 days followed by 2 days of hFSH (1 μg/0.1 ml) twice daily, group 4: same as in group 3; group 5: same as in group 3 with a final injection of hCG (5 IU/0.1 ml) on the fifth day.

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The Fine Structure of Rat Granulosa Cell Cultures Correlated with Progestin Secretion

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100073209 ◽

1973 ◽

Vol 31 ◽

pp. 552-553

Author(s):

T. M. Crisp ◽

F.R. Denys

Keyword(s):

Fine Structure ◽

Granulosa Cell ◽

Cell Cultures ◽

Single Injection ◽

Surrounding Medium ◽

Petri Dish ◽

Female Rats ◽

Vaginal Smear ◽

Immature Female ◽

Serum Gonadotropin

The purpose of this paper is to present observations on the fine structure of rat granulosa cell cultures grown in the presence of an adenohypophyseal explant and to correlate the morphology of these cells with progestin secretion. Twenty-six day old immature female rats were given a single injection of 5 IU pregnant mares serum gonadotropin (PMS) in order to obtain ovaries with large vesicular follicles. At 66 hrs. post-PMS administration (estrus indicated by vaginal smear cytology), the ovaries were removed and placed in a petri dish containing medium 199 and 100 U penicillin/streptomycin (P/S)/ml. Under a 20X magnification dissecting microscope, some 5-8 vesicular follicles/ovary were punctured and the granulosa cells were expressed into the surrounding medium. The cells were transferred to centrifuge tubes and spun down at 1000 rpm for 5 mins.

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