scholarly journals Cognitive and Electrophysiological Correlates of Working Memory Impairments in Neurofibromatosis Type 1

2021 ◽  
Author(s):  
Gorana Pobric ◽  
Jason R. Taylor ◽  
Hemavathy M. Ramalingam ◽  
Emily Pye ◽  
Louise Robinson ◽  
...  
Keyword(s):  
Working Memory ◽  
Single Gene ◽  
Neurofibromatosis Type ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
Group Differences ◽  
Control Group ◽  
P300 Latency ◽  
Memory Impairments

AbstractNeurofibromatosis 1 (NF1) is a single gene disorder associated with working Memory (WM) impairments. The aim of this study was to investigate P300 event-related potential (ERP) associated with WM in NF1. Sixteen adolescents with NF1 were compared with controls on measures of WM and EEG was recorded during a WM nback task. The NF1 group showed poorer performance on measures of WM as compared to the control group. No group differences were observed in P300 amplitude at Pz, but P300 latency was shorter in the NF1 group. Topographic analyses of P300 amplitude showed group differences indicating neural processing differences in the NF1 group relative to controls, which possibly contribute to the cognitive deficits seen in this population.

scholarly journals Generalization of Context-Specific Training in Individuals with Mild Cognitive Impairment: An Event-Related Potential Study

2016 ◽  
Vol 6 (3) ◽  
pp. 568-579 ◽  
Author(s):  
Sam C.C. Chan ◽  
Tommy L.H. Lam ◽  
Kenneth N.K. Fong ◽  
Marco Y.C. Pang ◽  
Chetwyn C.H. Chan
Keyword(s):  
Working Memory ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Event Related Potential ◽  
Future Research ◽  
Control Group ◽  
P300 Latency ◽  
Experimental Conditions ◽  
Memory Functions ◽  
Context Specific

Background: This study examined the neural processes associated with the generalization of the effect of context-specific (CS) training to noncontextual situations among individuals with mild cognitive impairment (MCI). Methods: Fourteen and 16 participants with MCI were randomly allocated to a Chinese calligraphy writing (CW) training or a control group, respectively. The CW participants learned how to write Chinese strokes in a semicursive style to construct characters, tapping on working memory functions. The control group, on the other hand, learned how to use a tablet computer without emphasis on working memory functions. They then performed two 2-back tasks with CS semicursive strokes and non-context-specific (NCS) digits. Event-related electroencephalogram signals were concurrently recorded. Results: The CW participants had a significantly shorter reaction time in the CS than in the NCS task (p < 0.05). They showed significantly longer latency in working memory updating (N200; t<Sub>11</Sub> = 4.70, p = 0.05) and shorter latency in the evaluation of visual representation (P300; t<Sub>12</Sub> = 4.67; p = 0.05) than the control group when performing the 2-back CS task. Shorter P300 latency was also revealed in the 2-back NCS task (t<Sub>12</Sub> = 5.15, p = 0.041), suggesting a possible generalization of the training effect among the CW participants. Conclusion: The results suggest that CS working memory is likely to be generalized to NCS domains among individuals with MCI. Future research should extend the scope of the generalization and apply it beyond experimental conditions.

Social and nonsocial cognitive functions in patients with schizophrenia: A comparative neuropsychological and neurophysiological study

2017 ◽  
Vol 41 (S1) ◽  
pp. s817-s817
Author(s):  
M.A. Khalil ◽  
A.A. Saleh ◽  
N.M. El-Fayoumy ◽  
S.M. Gohar
Keyword(s):  
Social Cognition ◽  
Psychiatric Disorders ◽  
Cognitive Deficits ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
Psychotic Symptoms ◽  
Control Group ◽  
P300 Latency ◽  
Symptom Scale ◽  
The Mind

BackgroundPatients with schizophrenia suffer from cognitive deficits in seven domains in addition to social cognition. P300 latency and amplitude have been linked in these patients to the basic cognitive deficits.ObjectivesComparing patients suffering from schizophrenia with matched healthy subjects as regards auditory event related potential tests as measured by P300.Subjects and methodsFifty-two subjects were divided into 2 groups: group (A): 27 patients with schizophrenia according to the diagnostic and statistical manual of mental disorders-text revised (DSM-IV TR). Those with current substance use, psychiatric disorders or organic disorders were excluded. Group (B): 25 healthy control subjects with negative history of substance and psychiatric disorders. Patients were assessed using Positive and Negative Symptom Scale (PANSS) for severity of psychotic symptoms, Addenbrook's Cognitive Examination Revised (ACE-R) for basic cognitive, reading the mind in the eye test for social cognition, P300 and electro-encephalography (EEG)ResultsThe two groups were different significantly in ACE total and its subtests measuring attention-orientation, memory, language, visuospatial and reading the mind in the eye test for social cognition scores with patients showing lower scores (P = 0.000, 0.012, 0.000, 0.038, 0.041 and 0.001 respectively). Control group had higher amplitude of P300 and shorter latency than patients (P = 0.003 and 0.005 respectively). P300 amplitude correlated positively with visuospatial memory (P = 0.015). PANSS general pathology scale correlated positively with duration of untreated psychosis (P = 0.029) and with fluency (P = 0.047).ConclusionPatients with schizophrenia differ from controls in P300.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Response-Specific Scalp Distributions in Deception Detection and ERP Correlates of Psychopathic Personality Traits

2004 ◽  
Vol 18 (1) ◽  
pp. 13-26 ◽  
Author(s):  
Antoinette R. Miller ◽  
J. Peter Rosenfeld
Keyword(s):  
Deception Detection ◽  
Event Related Potential ◽  
Psychopathic Personality ◽  
P300 Amplitude ◽  
Group Differences ◽  
Post Hoc Analysis ◽  
P300 Component ◽  
Psychopathic Personality Inventory ◽  
Post Hoc ◽  
First Time

Abstract University students were screened using items from the Psychopathic Personality Inventory and divided into high (n = 13) and low (n = 11) Psychopathic Personality Trait (PPT) groups. The P300 component of the event-related potential (ERP) was recorded as each group completed a two-block autobiographical oddball task, responding honestly during the first (Phone) block, in which oddball items were participants' home phone numbers, and then feigning amnesia in response to approximately 50% of items in the second (Birthday) block in which oddball items were participants' birthdates. Bootstrapping of peak-to-peak amplitudes correctly identified 100% of low PPT and 92% of high PPT participants as having intact recognition. Both groups demonstrated malingering-related P300 amplitude reduction. For the first time, P300 amplitude and topography differences were observed between honest and deceptive responses to Birthday items. No main between-group P300 effects resulted. Post-hoc analysis revealed between-group differences in a frontally located post-P300 component. Honest responses were associated with late frontal amplitudes larger than deceptive responses at frontal sites in the low PPT group only.

scholarly journals Effects of multi-domain cognitive training on working memory retrieval in older adults: behavioral and ERP evidence from a Chinese community study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiangfei Hong ◽  
You Chen ◽  
Jijun Wang ◽  
Yuan Shen ◽  
Qingwei Li ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Training Program ◽  
Cognitive Training ◽  
Local Community ◽  
Training Group ◽  
Event Related Potential ◽  
Control Group ◽  
Baseline Session

AbstractWorking memory (WM) is a fundamental cognitive function that typically declines with age. Previous studies have shown that targeted WM training has the potential to improve WM performance in older adults. In the present study, we investigated whether a multi-domain cognitive training program that was not designed to specifically target WM could improve the behavioral performance and affect the neural activity during WM retrieval in healthy older adults. We assigned healthy older participants (70–78 years old) from a local community into a training group who completed a 3-month multi-domain cognitive training and a control group who only attended health education lectures during the same period. Behavioral and electroencephalography (EEG) data were recorded from participants while performing an untrained delayed match or non-match to category task and a control task at a pre-training baseline session and a post-training follow-up session. Behaviorally, we found that participants in the training group showed a trend toward greater WM performance gains than participants in the control group. Event-related potential (ERP) results suggest that the task-related modulation of P3 during WM retrieval was significantly enhanced at the follow-up session compared with the baseline session, and importantly, this enhancement of P3 modulation was only significant in the training group. Furthermore, no training-related effects were observed for the P2 or N2 component during WM retrieval. These results suggest that the multi-domain cognitive training program that was not designed to specifically target WM is a promising approach to improve WM performance in older adults, and that training-related gains in performance are likely mediated by an enhanced modulation of P3 which might reflect the process of WM updating.

scholarly journals Lower fasting blood glucose in neurofibromatosis type 1

2016 ◽  
Vol 5 (1) ◽  
pp. 28-33 ◽  
Author(s):  
Aline Stangherlin Martins ◽  
Ann Kristine Jansen ◽  
Luiz Oswaldo Carneiro Rodrigues ◽  
Camila Maria Matos ◽  
Marcio Leandro Ribeiro Souza ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Neurofibromatosis Type 1 ◽  
Fasting Blood Glucose ◽  
Neurofibromatosis Type ◽  
Control Group ◽  
Adult Health ◽  
Main Criterion ◽  
Clinical Records ◽  
Age Range

Studies indicate a lower occurrence of diabetes mellitus (DM) in patients with neurofibromatosis type 1 (NF1). Fasting blood glucose (FBG) level is the main criterion used to diagnose DM and glucose intolerance. Therefore, this study compared FBG level between adults with NF1 and non-NF1 controls. We selected clinical records of 57 out of 701 individuals attending the Neurofibromatosis Outpatient Reference Center of the Clinics Hospital of the Federal University of Minas Gerais in Brazil. The selected patients with NF1 were matched to non-NF1 controls selected from the Brazilian Longitudinal Study of Adult Health according to sex, age (range, 35–74 years) and BMI at a ratio of 1:3. In both groups, individuals with DM were excluded. Median FBG level in the NF1 group (86 mg/dl (range, 56–127 mg/dl)) was lower than that in the non-NF1 control group (102 mg/dl (range, 85–146 mg/dl)) (P<0.001). Prevalence of FBG level ≥100 mg/dl in the NF1 group (16%) was lower than that in the non-NF1 control group (63%) (P<0.05). The chance of a high FBG level was 89% lower in the NF1 group (odds ratio, 0.112; 95% CI, 0.067–0.188) (P<0.05). In conclusion, adults with NF1 showed a lower FBG level and a lower prevalence of high FBG level compared with non-NF1 controls.

scholarly journals Lung parenchima changes in neurofibromatosis type 1

2016 ◽  
Vol 73 (2) ◽  
pp. 202-204
Author(s):  
Aleksandra Ilic ◽  
Snezana Raljevic ◽  
Tatjana Adzic ◽  
Vesna Skodric-Trifunovic ◽  
Jelena Stanimirovic
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Case Report ◽  
Neurofibromatosis Type 1 ◽  
Single Gene ◽  
Neurofibromatosis Type ◽  
Nerve Sheath Tumor ◽  
X Rays ◽  
Neurogenic Tumors

Introduction. Neurofibromatosis type 1 (NF1), also known as von Recklinghausen disease, is one of the most common single-gene disorders (mutation on chromosome 17q) and usually associated with cutaneous, musculoskeletal and neurological disorders in humans. NF1 is generally complicated with one or more neurobehavioral disorders or tumors located in the peripheral nervous system such as neurofibromas, peripheral nerve sheath tumor, pheochromocytoma, etc. In the available medical literature, the thoracic manifestations of NF1 have been rarely described in these patients. There are few reports about intrathoracic neurogenic tumors, kyphoscoliosis, pneumonitis and pulmonary fibrosis in patients with NF1. Case report. A 65-year-old female was admitted to the Intensive Care Unit at the Lung Clinic of Belgrade University Clinical Center of Serbia. The patient?s general condition was poor with shortness of breath and present cyanosis. At the same time, the skin changes similar to NF1 were noticed, which were additionally documented by her medical history and diagnosed as NF1. After the application of noninvasive mechanical ventilation and other emergency respiratory medicine measures, the patient soon felt better. The parenchymal changes were viewed by subsequent X-rays and CT scanning of the thorax. Conclusion. This is a case report presenting the NF1 associated with the abnormality of lung parenchyma established during diagnostic procedures at the Intensive Care Unit, Clinic of Pulmonology.

scholarly journals Emotional Substrates in Neuroticism: The Reactions to Arousal-evoking Stimuli of Various Strengths

2020 ◽  
Vol 19 (2) ◽  
pp. 262-267
Author(s):  
Nasir Yusoff ◽  
Faruque Reza ◽  
Nik NurAzhani Anuar ◽  
Roslee Ahmad
Keyword(s):  
Significant Interaction ◽  
Medical Condition ◽  
Medical Science ◽  
Visual Stimuli ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Significant Interaction Effect ◽  
Mean Values ◽  
Emotional Pictures

Objective: Neuroticism is a medical condition associated with negative affect and is considered to predispose one to mental disorders. This study examined the effectsof arousal-evoking stimuli of various strengths on the severity of neuroticism. Materials and Methods: In the Event Related Potential (ERP)/electroencephalograph (EEG) recording session that was held at the Clinical Neuroscience Laboratory at a local hospital, Electroencephalogram was recorded in 58 participants (N=29 for moderate neuroticism and 29 for mild neuroticism) after they were screened for the severity of the neurotic trait. Universal emotional pictures were chosen randomly from the International Affective Picture System (IAPS) and were used as visual stimuli in the experiment. Visual stimuli weredivided into three categories (high, moderate, low) based on the IAPS normative mean values of arousal. Results: The significant interaction effect of P300 latency between neuroticism and arousal strength was found in the mid-frontal region. Meanwhile, independent of neuroticism, the main effects of arousal strength of the P300 (amplitude and latency) and N200 (latency) were observed in the mid-central region. Conclusion: There is a significant interaction between the severity of neuroticism and the emotional arousal strength, thus, points to the implication of the emotion process in the brain rewards system especially among individuals with neuroticism. Bangladesh Journal of Medical Science Vol.19(2) 2020 p.262-267

scholarly journals Neural Processing of Other-Race Faces as a Function of Racial Familiarity: A P300 Study

2018 ◽  
Vol 7 (3.22) ◽  
pp. 21
Author(s):  
Tai Yan Shan ◽  
Faruque Reza ◽  
Tahamina Begum ◽  
Nasir Yusoff
Keyword(s):  
Repeated Measures ◽  
Event Related Potential ◽  
The Other ◽  
P300 Amplitude ◽  
Control Group ◽  
Neural Processing ◽  
Oddball Task ◽  
The Social ◽  
Independent Variable ◽  
Cognition Model

Background: The other-race categorisation advantage (ORCA) is a well-established phenomenon, whereby other-race faces are categorised faster than own race faces. Objectives: This study investigated whether extraverts would demonstrate an ORCA-like effect toward unfamiliar other-race faces and familiar other-race faces in a modified oddball and choice reaction paradigm.  Methods: This event-related potential (ERP) study employed a repeated measures experimental design with one independent variable (racial familiarity) and three levels (familiar other-race/Malay faces, unfamiliar other-race/African faces, control group/furniture photos). In the oddball task, African faces and Malay faces were the target stimuli and furniture photos were the standard stimuli. Electroencephalography data (EEG) was collected during the oddball task, from which ERP components were derived. Results: The reaction time (RT) for African and Malay faces were not significantly different.  Significant effect of racial familiarity on P300 latencies at all electrode sites was not observed.  However, there was a significant effect of racial familiarity on P300 amplitudes at midline electrodes (Cz).  It was also observed that the P300 amplitude was larger for African faces than Malay faces at midline electrodes (Cz). Conclusion: An ORCA-like effect was not found in categorisation tasks involving faces from a familiar and an unfamiliar other-race, but a larger P300 amplitude was evoked by African faces. This dissociation between RT and P300 amplitude provided important theoretical implications with regard to models associated with ORCA. Specifically, the current findings lent support to the social cognition model and the Categorisation-Individuation Model (CIM).

P300 event-related potential and serotonin-1A activity in depression

1999 ◽  
Vol 14 (3) ◽  
pp. 143-147 ◽  
Author(s):  
M Hansenne ◽  
M Ansseau
Keyword(s):  
Critical Role ◽  
Brain Structures ◽  
Significant Negative Correlation ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Endocrine Response ◽  
Major Depressive ◽  
Serotonergic Activity ◽  
The Brain

SummaryThe identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of P300 could lead to important clinical implications. Since serotonin disturbances seem to play a critical role in depression, the aim of the study was to assess the possible relationships between the P300 event-related brain potential and serotonergic activity in depression. The study was conducted among 45 major depressive inpatients, and serotonergic activity was assessed by prolactin (PRL) response to flesinoxan (a 5-HT1A agonist). Results showed a significant negative correlation between P300 amplitude and PRL response to flesinoxan (r = –0.40, P = 0.007 at Cz; r = –0.47, P = 0.001 at Pz). In contrast, both P300 latency and reaction time were not related to endocrine response. This study supports a role for serotonin-1A in the neurobiological modulation of P300 amplitude.

The Effect of Apolipoprotein E ɛ4 (APOE E4) on Visuospatial Working Memory in Healthy Elders and Amnestic Mild Cognitive Impairment Patients: An Event-related Potentials Study

2017 ◽  
Vol 41 (S1) ◽  
pp. S171-S172 ◽  
Author(s):  
L. Gu
Keyword(s):  
Working Memory ◽  
Apolipoprotein E ◽  
Event Related Potentials ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
Parahippocampal Gyrus ◽  
Time Range ◽  
Visuospatial Working Memory ◽  
Related Potentials ◽  
Competing Interest

IntroductionPrevious studies provided inconsistent evidences for the effect of apolipoprotein E ɛ4 (APOE ɛ4) status on the visuospatial working memory (VSWM). Our study was the first investigation with event-related potential (ERP) to explore the effect of APOE ɛ4 on VSWM in healthy elders and aMCI patients.ObjectiveThe aim was to investigate the effect of APOE ɛ4 on VSWM with event-related potential (ERP) study in healthy elders and aMCI patients.MethodsThirty-nine aMCI patients (27 APOE ɛ4 non-carriers and 12 APOE ɛ4 carriers) and 43 their matched control (25 APOE ɛ4 non-carriers and 18 APOE ɛ4 carriers) performed an N-back task, a VSWM paradigm that manipulated the number of items to be stored in memory.ResultsOur study detected reduced accuracy and delayed mean correct response time in aMCI patients than healthy elders. P300 was elicited by VSWM and its amplitude was lower in aMCI patients at the central-parietal and parietal electrodes than healthy controls. In healthy elders, P300 amplitude declined prior to task performance change in APOE ɛ4 carriers than non-carriers. Regarding aMCI patients, P300 amplitude result revealed exacerbated VSWM deficits in APOE ɛ4 carriers than APOE ɛ4 non-carriers. Additionally, standardized low-resolution brain electromagnetic tomography analysis (s-LORETA) result showed enhanced brain activation in right parahippocampal gyrus during P300 time range in APOE ɛ4 carriers than non-carriers in aMCI patients (Fig. 1, Tables 1 and 2).ConclusionsIt demonstrated that P300 amplitude might serve as a biomarker for recognizing aMCI patients and contribute to early detection of worse VSWM in APOE ɛ4 carriers than non-carriers.Disclosure of interestThe author has not supplied his/her declaration of competing interest.

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