New Approach to Low-Cost FMS for Wide Range of Manufacturing Applications

As the 3DIC market matures, more is understood about the technical and cost challenges [1]. At the 2013 Semicon-West gathering, a panel of global experts identified these technical challenges to represent some of the most significant barriers to the industry's efforts to maintain progress with Moore's Law [2]. Searching and achieving high value manufacturing of 3DIC devices requires wrestling with several technologies and processes, all which may assert a different value for the manufacturer [3]. Current technologies for thin wafer support use a wide range of adhesives applied to the device wafer, bonded to a carrier, backside processed, and de-bonded by an array of methods. Daetec has been investigating temporary bonding for nearly 15yrs, is producing a range of products for semiconductor (e.g. WaferBondTM (Brewer-Science, Inc.)) [4], and for the display market using a low-cost tunable adhesion-force material that is peeled by simple means [5]. Daetec has developed a new technology, DaeBond 3DTM, allowing de-bonding to occur in a batch process while thinned wafers are affixed to film frames. This new approach provides a shift in conventional practice. Our paper presents several temporary bonding options with DaeBond 3DTM in an effort to define value-added approaches for thin wafer handling.

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The Field Guide to 3D Printing in Microscopy

10.20944/preprints202105.0352.v1 ◽

2021 ◽

Author(s):

Mario Del Rosario ◽

Hannah S. Heil ◽

Afonso Mendes ◽

Vittorio Saggiomo ◽

Ricardo Henriques

Keyword(s):

Additive Manufacturing ◽

Open Access ◽

3D Printing ◽

Low Cost ◽

Maker Movement ◽

New Approach ◽

Starting Point ◽

Manufacturing Applications ◽

Model Structures ◽

The Maker Movement

The maker movement has reached the optics labs, empowering researchers to actively create and modify microscope designs and imaging accessories. 3D printing has especially had a disruptive impact on the field, as it entails an accessible new approach in fabrication technologies, namely additive manufacturing, making prototyping in the lab available at low cost. Examples of this trend are taking advantage of the easy availability of 3D printing technology. For example, inexpensive microscopes for education have been designed, such as the FlyPi. Also, the highly complex robotic microscope OpenFlexure represents a clear desire for the democratisation of this technology. 3D printing facilitates new and powerful approaches to science and promotes collaboration between researchers, as 3D designs are easily shared. This holds the unique possibility to extend the open-access concept from knowledge to technology, allowing researchers from everywhere to use and extend model structures. Here we present a review of additive manufacturing applications in microscopy, guiding the user through this new and exciting technology and providing a starting point to anyone willing to employ this versatile and powerful new tool.

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Factors Affecting Molecular Self-Assembly and Its Mechanism

Scientific Research Journal ◽

10.24191/srj.v9i1.5385 ◽

2012 ◽

Vol 9 (1) ◽

pp. 43 ◽

Cited By ~ 1

Author(s):

Hueyling Tan

Keyword(s):

Self Assembly ◽

Building Blocks ◽

Molecular Engineering ◽

Molecular Structures ◽

Polymer Science ◽

New Approach ◽

Factors Affecting ◽

Dna Structures ◽

Self Assembling ◽

Wide Range

Molecular self-assembly is ubiquitous in nature and has emerged as a new approach to produce new materials in chemistry, engineering, nanotechnology, polymer science and materials. Molecular self-assembly has been attracting increasing interest from the scientific community in recent years due to its importance in understanding biology and a variety of diseases at the molecular level. In the last few years, considerable advances have been made in the use ofpeptides as building blocks to produce biological materials for wide range of applications, including fabricating novel supra-molecular structures and scaffolding for tissue repair. The study ofbiological self-assembly systems represents a significant advancement in molecular engineering and is a rapidly growing scientific and engineering field that crosses the boundaries ofexisting disciplines. Many self-assembling systems are rangefrom bi- andtri-block copolymers to DNA structures as well as simple and complex proteins andpeptides. The ultimate goal is to harness molecular self-assembly such that design andcontrol ofbottom-up processes is achieved thereby enabling exploitation of structures developed at the meso- and macro-scopic scale for the purposes oflife and non-life science applications. Such aspirations can be achievedthrough understanding thefundamental principles behind the selforganisation and self-synthesis processes exhibited by biological systems.

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Janus – A New Approach to Air Combat Pilot Training

Transactions on Aerospace Research ◽

10.2478/tar-2019-0019 ◽

2019 ◽

Vol 2019 (4) ◽

pp. 7-22

Author(s):

Georges Bridel ◽

Zdobyslaw Goraj ◽

Lukasz Kiszkowiak ◽

Jean-Georges Brévot ◽

Jean-Pierre Devaux ◽

...

Keyword(s):

Low Cost ◽

Cost Effective ◽

High Energy ◽

Training System ◽

Embedded Sensors ◽

Pilot Training ◽

New Approach ◽

Combat Aircraft ◽

Air Combat ◽

The Cost

Abstract Advanced jet training still relies on old concepts and solutions that are no longer efficient when considering the current and forthcoming changes in air combat. The cost of those old solutions to develop and maintain combat pilot skills are important, adding even more constraints to the training limitations. The requirement of having a trainer aircraft able to perform also light combat aircraft operational mission is adding unnecessary complexity and cost without any real operational advantages to air combat mission training. Thanks to emerging technologies, the JANUS project will study the feasibility of a brand-new concept of agile manoeuvrable training aircraft and an integrated training system, able to provide a live, virtual and constructive environment. The JANUS concept is based on a lightweight, low-cost, high energy aircraft associated to a ground based Integrated Training System providing simulated and emulated signals, simulated and real opponents, combined with real-time feedback on pilot’s physiological characteristics: traditionally embedded sensors are replaced with emulated signals, simulated opponents are proposed to the pilot, enabling out of sight engagement. JANUS is also providing new cost effective and more realistic solutions for “Red air aircraft” missions, organised in so-called “Aggressor Squadrons”.

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Extraction of DNA from a Wide Range of Objects by Treatment with Ammonium Salts

Biotekhnologiya ◽

10.21519/0234-2758-2020-36-6-98-106 ◽

2020 ◽

Vol 36 (6) ◽

pp. 98-106

Author(s):

E.I. Levitin ◽

B.V. Sviridov ◽

O.V. Piksasova ◽

T.E. Shustikova

Keyword(s):

Dna Extraction ◽

Dna Isolation ◽

Tissue Samples ◽

New Approach ◽

Cell Wall Disruption ◽

Wide Range ◽

Low Salt ◽

Mammalian Blood ◽

Plasmid Extraction ◽

Two Hybrid

Currently, simple, rapid, and efficient techniques for DNA isolation from a wide range of organisms are in demand in biotechnology and bioinformatics. A key (and often limiting) step is the cell wall disruption and subsequent DNA extraction from the disintegrated cells. We have developed a new approach to DNA isolation from organisms with robust cell walls. The protocol includes the following steps: treatment of cells or tissue samples with ammonium acetate followed by cell lysis in low-salt buffer with the addition of SDS. Further DNA extraction is carried out according to standard methods. This approach is efficient for high-molecular native DNA isolation from bacteria, ascomycetes, yeast, and mammalian blood; it is also useful for express analysis of environmental microbial isolates and for plasmid extraction for two-hybrid library screening. express method for DNA isolation; ammonium salt treatment (в русских ключевых такой порядок), osmotic breakage of cells This study was financially supported by the NRC "Kurchatov Institute"-GOSNIIGENETIKA Kurchatov Genomic Center.

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Information and information resources in COVID-19: Awareness, control, and prevention

Journal of Librarianship and Information Science ◽

10.1177/09610006211016519 ◽

2021 ◽

pp. 096100062110165

Author(s):

Mohammadhiwa Abdekhoda ◽

Fatemeh Ranjbaran ◽

Asghar Sattari

Keyword(s):

Low Cost ◽

Information Resources ◽

Age And Gender ◽

Use Of Resources ◽

Strategic Approach ◽

Wide Range ◽

Data Collection Instrument ◽

Control And Prevention ◽

And Gender ◽

And Control

This study was conducted with the aim of evaluating the role of information and information resources in the awareness, control, and prevention of COVID-19. This study was a descriptive-analytical survey in which 450 participants were selected for the study. The data collection instrument was a researcher-made questionnaire. Descriptive and inferential statistics were used to analyze the data through SPSS. The findings show that a wide range of mass media has become well known as information resources for COVID-19. Other findings indicate a significant statistical difference in the rate of using information resources during COVID-19 based on age and gender; however, this difference is not significant regarding the reliability of information resources with regard to age and gender. Health information has an undisputable role in the prevention and control of pandemic diseases such as COVID-19. Providing accurate, reliable, and evidence-based information in a timely manner for the use of resources and information channels related to COVID-19 can be a fast and low-cost strategic approach in confronting this disease.

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Advanced mycelium materials as potential self-growing biomedical scaffolds

Scientific Reports ◽

10.1038/s41598-021-91572-x ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Maria Elena Antinori ◽

Marco Contardi ◽

Giulia Suarato ◽

Andrea Armirotti ◽

Rosalia Bertorelli ◽

...

Keyword(s):

Tissue Engineering ◽

Low Cost ◽

Direct Interaction ◽

Dermal Fibroblasts ◽

Engineering Systems ◽

Edible Fungi ◽

Avant Garde ◽

Fibrous Network ◽

Body Tissues ◽

Wide Range

AbstractMycelia, the vegetative part of fungi, are emerging as the avant-garde generation of natural, sustainable, and biodegradable materials for a wide range of applications. They are constituted of a self-growing and interconnected fibrous network of elongated cells, and their chemical and physical properties can be adjusted depending on the conditions of growth and the substrate they are fed upon. So far, only extracts and derivatives from mycelia have been evaluated and tested for biomedical applications. In this study, the entire fibrous structures of mycelia of the edible fungi Pleurotus ostreatus and Ganoderma lucidum are presented as self-growing bio-composites that mimic the extracellular matrix of human body tissues, ideal as tissue engineering bio-scaffolds. To this purpose, the two mycelial strains are inactivated by autoclaving after growth, and their morphology, cell wall chemical composition, and hydrodynamical and mechanical features are studied. Finally, their biocompatibility and direct interaction with primary human dermal fibroblasts are investigated. The findings demonstrate the potentiality of mycelia as all-natural and low-cost bio-scaffolds, alternative to the tissue engineering systems currently in place.

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Rheology and Water Absorption Properties of Alginate–Soy Protein Composites

Polymers ◽

10.3390/polym13111807 ◽

2021 ◽

Vol 13 (11) ◽

pp. 1807

Author(s):

Estefanía Álvarez-Castillo ◽

José Manuel Aguilar ◽

Carlos Bengoechea ◽

María Luisa López-Castejón ◽

Antonio Guerrero

Keyword(s):

Soy Protein ◽

Water Solubility ◽

Divalent Cations ◽

Low Cost ◽

Soy Protein Isolate ◽

Protein Isolate ◽

Guluronic Acid ◽

Wide Range ◽

Anionic Polysaccharides ◽

Porous Matrices

Composite materials based on proteins and carbohydrates normally offer improved water solubility, biodegradability, and biocompatibility, which make them attractive for a wide range of applications. Soy protein isolate (SPI) has shown superabsorbent properties that are useful in fields such as agriculture. Alginate salts (ALG) are linear anionic polysaccharides obtained at a low cost from brown algae, displaying a good enough biocompatibility to be considered for medical applications. As alginates are quite hydrophilic, the exchange of ions from guluronic acid present in its molecular structure with divalent cations, particularly Ca2+, may induce its gelation, which would inhibit its solubilization in water. Both biopolymers SPI and ALG were used to produce composites through injection moulding using glycerol (Gly) as a plasticizer. Different biopolymer/plasticizer ratios were employed, and the SPI/ALG ratio within the biopolymer fraction was also varied. Furthermore, composites were immersed in different CaCl2 solutions to inhibit the amount of soluble matter loss and to enhance the mechanical properties of the resulting porous matrices. The main goal of the present work was the development and characterization of green porous matrices with inhibited solubility thanks to the gelation of alginate.

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Optically transparent and very thin structure against electromagnetic pulse (EMP) using metal mesh and saltwater for shielding windows

Scientific Reports ◽

10.1038/s41598-021-80969-3 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Duy Tung Phan ◽

Chang Won Jung

Keyword(s):

Electromagnetic Pulse ◽

Low Cost ◽

High Energy ◽

Metal Plate ◽

Optical Transparency ◽

Shielding Effectiveness ◽

Concrete Wall ◽

Metal Mesh ◽

Wide Range ◽

Optically Transparent

AbstractAn electromagnetic pulse (EMP) with high energy can damage electronic equipment instantly within a wide range of thousands of kilometers. Generally, a metal plate placed inside a thick concrete wall is used against an EMP, but it is not suitable for an EMP shielding window, which requires not only strong shielding effectiveness (SE) but also optical transparency (OT). In this paper, we propose a very thin and optically transparent structure with excellent SE for EMP shielding window application. The proposed structure consists of a saltwater layer held between two glass substrates and two metal mesh layers on the outside of the glass, with a total thickness of less than 1.5 cm. The SE and OT of the structure are above 80 dB and 45%, respectively, which not only meet the requirement of EMP shielding for military purposes but also retain the procedure of good observation. Moreover, the OT of the structure can be significantly improved using only one metal mesh film (MMF) layer, while the SE is still maintained high to satisfy the required SE for home applicants. With the major advantages of low cost, optical transparency, strong SE, and flexible performance, the proposed structure can be considered a good solution for transparent EMP shielding windows.

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Photocatalytic three-component asymmetric sulfonylation via direct C(sp3)-H functionalization

Nature Communications ◽

10.1038/s41467-021-22690-3 ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Shi Cao ◽

Wei Hong ◽

Ziqi Ye ◽

Lei Gong

Keyword(s):

Asymmetric Catalysis ◽

Organic Synthesis ◽

Photochemical Reaction ◽

Low Cost ◽

Bioactive Molecules ◽

Atom Economy ◽

Mild Conditions ◽

Wide Range ◽

Unsaturated Carbonyl Compound ◽

Direct Functionalization

AbstractThe direct and selective C(sp3)-H functionalization of cycloalkanes and alkanes is a highly useful process in organic synthesis owing to the low-cost starting materials, the high step and atom economy. Its application to asymmetric catalysis, however, has been scarcely explored. Herein, we disclose our effort toward this goal by incorporation of dual asymmetric photocatalysis by a chiral nickel catalyst and a commercially available organophotocatalyst with a radical relay strategy through sulfur dioxide insertion. Such design leads to the development of three-component asymmetric sulfonylation involving direct functionalization of cycloalkanes, alkanes, toluene derivatives or ethers. The photochemical reaction of a C(sp3)-H precursor, a SO2 surrogate and a common α,β-unsaturated carbonyl compound proceeds smoothly under mild conditions, delivering a wide range of biologically interesting α-C chiral sulfones with high regio- and enantioselectivity (>50 examples, up to >50:1 rr and 95% ee). This method is applicable to late-stage functionalization of bioactive molecules, and provides an appealing access to enantioenriched compounds starting from the abundant hydrocarbon compounds.

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