scholarly journals P140 TeCC (TeleMedicine, Cystic Fibrosis, Corona-Virus) study in a previous telemedicine-naive centre: clinical challenges, outcomes, and user experience in the first six months of a global pandemic

2021 ◽  
Vol 20 ◽  
pp. S81-S82
Author(s):  
D. Morrissy ◽  
T. Vagg ◽  
M. McCarthy ◽  
J. Dorgan ◽  
C. Fleming ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
User Experience ◽  
Corona Virus ◽  
Global Pandemic

Unique nCoV-2019 (COVID 19) spike glycoprotein processing by host protease: Analysis and Implication on infection

2020 ◽  
Vol 17 ◽  
Author(s):  
Ajoy Basak ◽  
Sarmistha Basak
Keyword(s):  
World Health ◽  
Spike Glycoprotein ◽  
Binding Domains ◽  
Corona Virus ◽  
Global Pandemic ◽  
High Infection ◽  
Crucial Information ◽  
Glycoprotein Processing ◽  
Health Organization ◽  
Host Reservoir

: The current global pandemic outbreak of a novel type of corona virus termed by World Health Organization as COVID-19 became an grave concern and worry to human health and world economy. Intense research efforts are now underway worldwide to combat and prevent the spread of this deadly disease. This zoonotic virus, a native to bat population is most likely transmitted to human via a host reservoir. Due to its close similarity to previously known SARS CoV (Severe Acute Respiratory Syndrome Corona Virus) of 2002 and related MERS CoV (Middle East Respiratory Syndrome Corona Virus) of 2012, it is also known as SARS CoV2. But unlike them it is far too infectious, virulent and lethal. Among its various proteins, the surface spike glycoprotein “S” has drawn significant attention because of its implication in viral recognition and host-virus fusion process. A detail comparative analysis of “S” proteins of SARS CoV (now called SARS CoV1), SARS CoV2 (COVID-19) and MERS CoV based on structure, sequence alignment, host cleavage sites, receptor binding domains, potential glycosylation and Cys-disulphide bridge locations has been performed. It revealed some key features and variations that may elucidate the high infection and virulence character of COVID-19. Moreover this crucial information may become useful in our quest for COVID-19 therapeutics and vaccines.

P214 Virtual cystic fibrosis doctor: design, development, and user experience pilot study

2021 ◽  
Vol 20 ◽  
pp. S104
Author(s):  
D. Morrissy ◽  
A. Curran ◽  
T. Vagg ◽  
J. Dorgan ◽  
C. Fleming ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pilot Study ◽  
User Experience ◽  
Design Development

UPDATE ON CARDIOVASCULAR IMPLICATIONS OF COVID 19

2021 ◽  
pp. 238-242
Author(s):  
Pradeep Kumar Radhakrishnan ◽  
Gayathri Ananyajyothi Ambat ◽  
Roshini Ambat ◽  
Syed Ilas Basha ◽  
Hema Prakash ◽  
...  
Keyword(s):  
Virus Disease ◽  
Systemic Vasculitis ◽  
Myocardial Damage ◽  
Viral Disease ◽  
Cardiac Damage ◽  
Corona Virus ◽  
Global Pandemic ◽  
Acute Myocardial Injury ◽  
Exercise Induced

On March 11 2020 WHO declares corona viral disease as a global pandemic .COVID 19 pandemic has taken the world by storm and many countries like India is now experiencing a second surge due to mutant strains. Global health emergency has been precipitated by this corona virus disease caused by SARS CoV2.Acute and intermediate effects on cardiovascular system are becoming obvious with progression of time. SARS-CoV-2-related endothelial dysfunction results in an augmented risk for venous thromboembolism, systemic vasculitis, endothelial cell apoptosis, and inammation in various organs. Acute infections have troponin elevation more due to indirect cardiac damage though denite patterns of direct damage do exist. Intermediate evaluation in patients with resolved infections shows increased incidence of exercise induced arrhythmias and residual cardiovascular symptoms. The virus with its zoonotic origin based upon its genomic identity to bat derived SARS corona virus has a human to human transmission mode.ACE 2 receptors facilitate cellular entry and has been implicated in direct and indirect myocardial damage. Myocarditis, acute myocardial injury, arrhythmias and thromboembolism dominates the clinical picture. Role of imaging must be dened in relation to relevant clinical ndings. With arrival of vaccine and widespread vaccination global programs, we can look forward to understanding and managing long term complications of this disease. Prognostic implications of a resolved disease need to be evaluated by future studies.

scholarly journals The Effect of COVID-19 on Hospitalized Cancer Patients and Their Healthcare

2021 ◽  
pp. 699-703
Author(s):  
Jahnvi Garg ◽  
Ranjit S. Ambad ◽  
Nandkishor Bankar
Keyword(s):  
Cancer Patients ◽  
Virus Disease ◽  
Rt Pcr ◽  
Vulnerable Group ◽  
Healthcare Facilities ◽  
Corona Virus ◽  
Global Pandemic ◽  
The World ◽  
Utmost Care ◽  
Staying At Home

Introduction: This article includes the effect of Corona virus disease on cancer patients and their healthcare facilities. The global pandemic mentioned around the world has impacted the most vulnerable group of patients- cancer. With the assistance of RT PCR tests and HRCT, oncologists and doctors have tried to provide treatment to Covid-19 patients. Cancer patients are more susceptible to Covid-19 than non-cancer or non-survivor patients, according to reports. To avoid the prevalence and infection of cancer victims, WHO has suggested staying at home and continuing their treatment through telemedicine unless the situation is critical for which they might require therapy and/or surgery. Covid-19 is here to stay so we should practice with utmost care and precaution.

scholarly journals Patients’ case scenario as well as approaches and strategies adopted to manage COVID-19 pandemic at Aligarh Muslim University, Aligarh, India

2020 ◽  
Author(s):  
Syed Ziaur Rahman ◽  
Saif Khan
Keyword(s):  
Health Care Professionals ◽  
Disease Transmission ◽  
Recovery Rate ◽  
Tertiary Care ◽  
Medical Science ◽  
Transmission Curve ◽  
Corona Virus ◽  
Global Pandemic ◽  
Severe Acute Respiratory Infection ◽  
The University

Corona virus Disease 2019 (COVID-19) is a severe acute respiratory infection caused by corona virus-2 (SARS-CoV-2). It originated from Wuhan city of China in December 2019 and spread like a wild fire to the entire globe and was declared as global pandemic by WHO on March 11, 2020. With no available cure and vaccine, this disease has taken a mammoth toll on the human life; therefore, SMS (‘Social Distancing’, use of ‘Mask’ and regular hand washing with ‘Soap’) has emerged as a sole tool to prevent its spread. The Indian government declared the first lockdown from March 25th 2020 with subsequent second, third and fourth lockdowns up to 31st March 2020 to decrease the disease transmission and flatten the disease transmission curve. Aligarh Muslim University is one of the prestigious central and residential universities in India. It is located in Aligarh district adjoining national capital region. The university has an attached tertiary care ‘Jawaharlal Nehru Medical College Hospital’. This narrative review discusses the various steps and procedures taken up by the university and hospital administration, other functionaries, faculty members and doctors in tackling the serious pandemic until 22nd June 2020. The proactive role of administration, dedication and hard work of health care professionals and innovation of some academicians has given a new vista of opportunities to tackle this global health pandemic. The recovery rate of coronavirus patients at AMU hospital is recorded as 71.9%, which is much higher than national average recovery rate (56%). Thus, AMU model gives some positive insights to fight the current global pandemic. Bangladesh Journal of Medical Science Vol.19(0) 2020 p. S 28-S 35

scholarly journals COVID-19 di ERA 4.0, Disrubsi dalam Disrubsi: Bertahan di Tengah Pandemi Antara Gangguan dan Inovasi

2021 ◽  
Vol 2 (1) ◽  
pp. 43-60
Author(s):  
Mohamad Arif Majid
Keyword(s):  
Industrial Revolution ◽  
Complex Problem ◽  
Islamic Education ◽  
Main Character ◽  
Corona Virus ◽  
Global Pandemic ◽  
The World ◽  
Biological World ◽  
Fierce Competition

The world has started the industrial revolution era or 4.0 era since 1995 in which the industrial world integrated cyber and automatic technology. This resulted in massive changes through technology which later reduce boundaries among physical, digital, and biological world. The main character of 4.0 era is disruption on which out-of-date companies, products, or models are disrupted by the fierce competition. The disruption impacts on many fields, including Islamic education world. The world problems are exacerbated with the coming of Corona virus in China at the end of 2019 and then it spreads to many countries and becomes global pandemic. Thus, it is a disruption within disruptions when a new complex problem comes before previous problems have not been overcome. This paper discusses about this issue and comprehensive solutions to this hard situation will be explained further

scholarly journals Genomic variation and epidemiology of SARS-CoV-2 importation and early circulation in Israel

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0243265
Author(s):  
Neta S. Zuckerman ◽  
Efrat Bucris ◽  
Yaron Drori ◽  
Oran Erster ◽  
Danit Sofer ◽  
...  
Keyword(s):  
Public Health ◽  
Decision Making ◽  
Respiratory Disease ◽  
Virus Disease ◽  
Genomic Variation ◽  
Health Issues ◽  
Acute Respiratory Disease ◽  
Corona Virus ◽  
Global Pandemic ◽  
Whole Genomes

Severe acute respiratory disease coronavirus 2 (SARS-CoV-2) which causes corona virus disease (COVID-19) was first identified in Wuhan, China in December 2019 and has since led to a global pandemic. Importations of SARS-CoV-2 to Israel in late February from multiple countries initiated a rapid outbreak across the country. In this study, SARS-CoV-2 whole genomes were sequenced from 59 imported samples with a recorded country of importation and 101 early circulating samples in February to mid-March 2020 and analyzed to infer clades and mutational patterns with additional sequences identified Israel available in public databases. Recorded importations in February to mid-March, mostly from Europe, led to multiple transmissions in all districts in Israel. Although all SARS-CoV-2 defined clades were imported, clade 20C became the dominating clade in the circulating samples. Identification of novel, frequently altered mutated positions correlating with clade-defining positions provide data for surveillance of this evolving pandemic and spread of specific clades of this virus. SARS-CoV-2 continues to spread and mutate in Israel and across the globe. With economy and travel resuming, surveillance of clades and accumulating mutations is crucial for understanding its evolution and spread patterns and may aid in decision making concerning public health issues.

scholarly journals Socio-Economic Implications of Novel Corona Virus Pandemic (COVID-19): The Indian Scenario

2020 ◽  
Vol 2 (12, 20) ◽  
Author(s):  
Pankaj Thakur ◽  
Keyword(s):  
World Health Organisation ◽  
World Health ◽  
Economic Implications ◽  
Transportation Services ◽  
Medical Supplies ◽  
Corona Virus ◽  
Global Pandemic ◽  
The People ◽  
Novel Virus ◽  
Indian Scenario

The global pandemic Covid-19 and its ill effects has created a fear all over the world. This novel virus has affected 216 countries across the globe. The number of confirmed cases and death are on the hype as per the daily reports by world health organisation and it has sparked an economic crisis. Due to self-isolation, social-distancing, restrictions on transportation services have put every sector of economy on downturn. The people in unorganised sectors are losing their jobs. The demand for manufactured goods and other commodities has been decreased. The demand for medical supplies and essential food items are on an increase. In this article, the socio-economic implications of Covid-19 on India has been summarized. Key Words: Corona Virus (Covid-19), Pandemic, Socio- Economic Implications & Indian Scenario

scholarly journals Pathophysiology of COVID-19 and its potential therapeutics

2021 ◽  
Vol 10 (2) ◽  
pp. 201
Author(s):  
Sarfaraz Alam Khan ◽  
Nazeem Ishrat Siddiqui
Keyword(s):  
Virus Disease ◽  
Respiratory Illness ◽  
Viral Disease ◽  
Significant Morbidity ◽  
Respiratory Illnesses ◽  
Corona Virus ◽  
Global Pandemic ◽  
The World ◽  
Approved Drugs ◽  
Potential Therapeutics

A series of acute and atypical serious respiratory illnesses were reported in December 2019 from Wuhan, a city of China. It spread to other places and became a global pandemic involving more than 200 countries of the world. Soon, it was discovered that this atypical respiratory illness was caused by a novel corona virus. It was named as the severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) and the disease caused by it as corona virus disease-19 (COVID-19). Since COVID-19 is a new viral disease, world is still struggling to find out a permanent remedy to control this serious health problem. It seems prudent to study or have a look on the pathophysiology of SARS CoV-2 in the light of available research. Further, a review on pathophysiology may give an insight on the potential therapeutic options. Being a new virus and having potential to cause significant morbidity and mortality in short span of time various approved drugs are being repurposed for the treatment of COVID-19.

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