scholarly journals Pathophysiology of COVID-19 and its potential therapeutics

2021 ◽  
Vol 10 (2) ◽  
pp. 201
Author(s):  
Sarfaraz Alam Khan ◽  
Nazeem Ishrat Siddiqui
Keyword(s):  
Virus Disease ◽  
Respiratory Illness ◽  
Viral Disease ◽  
Significant Morbidity ◽  
Respiratory Illnesses ◽  
Corona Virus ◽  
Global Pandemic ◽  
The World ◽  
Approved Drugs ◽  
Potential Therapeutics

A series of acute and atypical serious respiratory illnesses were reported in December 2019 from Wuhan, a city of China. It spread to other places and became a global pandemic involving more than 200 countries of the world. Soon, it was discovered that this atypical respiratory illness was caused by a novel corona virus. It was named as the severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) and the disease caused by it as corona virus disease-19 (COVID-19). Since COVID-19 is a new viral disease, world is still struggling to find out a permanent remedy to control this serious health problem. It seems prudent to study or have a look on the pathophysiology of SARS CoV-2 in the light of available research. Further, a review on pathophysiology may give an insight on the potential therapeutic options. Being a new virus and having potential to cause significant morbidity and mortality in short span of time various approved drugs are being repurposed for the treatment of COVID-19.

UPDATE ON CARDIOVASCULAR IMPLICATIONS OF COVID 19

2021 ◽  
pp. 238-242
Author(s):  
Pradeep Kumar Radhakrishnan ◽  
Gayathri Ananyajyothi Ambat ◽  
Roshini Ambat ◽  
Syed Ilas Basha ◽  
Hema Prakash ◽  
...  
Keyword(s):  
Virus Disease ◽  
Systemic Vasculitis ◽  
Myocardial Damage ◽  
Viral Disease ◽  
Cardiac Damage ◽  
Corona Virus ◽  
Global Pandemic ◽  
Acute Myocardial Injury ◽  
Exercise Induced

On March 11 2020 WHO declares corona viral disease as a global pandemic .COVID 19 pandemic has taken the world by storm and many countries like India is now experiencing a second surge due to mutant strains. Global health emergency has been precipitated by this corona virus disease caused by SARS CoV2.Acute and intermediate effects on cardiovascular system are becoming obvious with progression of time. SARS-CoV-2-related endothelial dysfunction results in an augmented risk for venous thromboembolism, systemic vasculitis, endothelial cell apoptosis, and inammation in various organs. Acute infections have troponin elevation more due to indirect cardiac damage though denite patterns of direct damage do exist. Intermediate evaluation in patients with resolved infections shows increased incidence of exercise induced arrhythmias and residual cardiovascular symptoms. The virus with its zoonotic origin based upon its genomic identity to bat derived SARS corona virus has a human to human transmission mode.ACE 2 receptors facilitate cellular entry and has been implicated in direct and indirect myocardial damage. Myocarditis, acute myocardial injury, arrhythmias and thromboembolism dominates the clinical picture. Role of imaging must be dened in relation to relevant clinical ndings. With arrival of vaccine and widespread vaccination global programs, we can look forward to understanding and managing long term complications of this disease. Prognostic implications of a resolved disease need to be evaluated by future studies.

scholarly journals The Effect of COVID-19 on Hospitalized Cancer Patients and Their Healthcare

2021 ◽  
pp. 699-703
Author(s):  
Jahnvi Garg ◽  
Ranjit S. Ambad ◽  
Nandkishor Bankar
Keyword(s):  
Cancer Patients ◽  
Virus Disease ◽  
Rt Pcr ◽  
Vulnerable Group ◽  
Healthcare Facilities ◽  
Corona Virus ◽  
Global Pandemic ◽  
The World ◽  
Utmost Care ◽  
Staying At Home

Introduction: This article includes the effect of Corona virus disease on cancer patients and their healthcare facilities. The global pandemic mentioned around the world has impacted the most vulnerable group of patients- cancer. With the assistance of RT PCR tests and HRCT, oncologists and doctors have tried to provide treatment to Covid-19 patients. Cancer patients are more susceptible to Covid-19 than non-cancer or non-survivor patients, according to reports. To avoid the prevalence and infection of cancer victims, WHO has suggested staying at home and continuing their treatment through telemedicine unless the situation is critical for which they might require therapy and/or surgery. Covid-19 is here to stay so we should practice with utmost care and precaution.

scholarly journals Obstetrics and gynaecology in the era of COVID-19

2020 ◽  
Vol 9 (11) ◽  
pp. 4777
Author(s):  
Angela Mary George ◽  
Daniel Manoj ◽  
Sowmya Ramani ◽  
Lalropuii . ◽  
Murugan Timiri Palani ◽  
...  
Keyword(s):  
Women’S Health ◽  
Women's Health ◽  
Psychosocial Support ◽  
Viral Disease ◽  
World Health ◽  
Significant Morbidity ◽  
Obstetrics And Gynaecology ◽  
Global Pandemic ◽  
The World ◽  
Health Organization

The World Health Organization has declared the outbreak of COVID-19 as a global pandemic. The alarming levels of spread and severity of the viral disease has resulted in significant morbidity and mortality. Women often face the highest risk of suffering devastating losses from the pandemic. Historically, women’s health has always been inadequately represented in responses to global outbreaks. Resources are often funnelled away from women’s health services towards targets perceived to be more important. Pregnant women with suspected, probable or confirmed COVID-19, should have access to obstetric and foetal medicine, neonatal care as well as mental health and psychosocial support, at facilities ready to tackle maternal and neonatal complications. In this article, we attempt to look at the challenges faced by gynaecologists because of this pandemic, and provide an overview on the current protocols in antenatal care, foetal care, childbirth, and oncological care.

scholarly journals Loss of Smell and Taste: Potential of Using Them as Markers for Early Detection of Covid-19

2020 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Early Detection ◽  
Severe Acute Respiratory Syndrome ◽  
Virus Disease ◽  
Age Groups ◽  
Viral Disease ◽  
Human Race ◽  
Health Crisis ◽  
Corona Virus ◽  
The World

The world is currently witnessing a severe health crisis of its time. Everyone is juggling and struggling to fight a viral disease named Covid-19 (Corona virus disease 2019) caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2). The genome of newly identified virus is less than 30,000 letters long where pathogenesis involve from being asymptomatic to deadly in all age groups. Almost everybody is at a grave risk in such an unpredictable scenario where range of symptoms are so variable from people to people making this pandemic a threat to human race.

scholarly journals COVID-19: A Global Pandemic of 21st Century

2020 ◽  
Vol 10 (3-s) ◽  
pp. 311-321
Author(s):  
Prabhakar Budholiya ◽  
Abdul Wajid Ali ◽  
Deepshikha Gunwan ◽  
Sana Sahil ◽  
C.K. Tyagi ◽  
...  
Keyword(s):  
Virus Disease ◽  
Respiratory Illness ◽  
World Health ◽  
Severe Illness ◽  
Director General ◽  
Corona Virus ◽  
The World ◽  
Control And Prevention ◽  
Health Organization ◽  
Corona Viruses

In last of 2019, the Centers for Disease Control and Prevention started monitoring the outbreak of a new corona virus, SARS-CoV-2, which causes the respiratory illness now known as COVID-19. Authorities first identified the virus in Wuhan, China. More than 82542 case of Corona virus in China at 31 March 2020. Health authorities have identified many other people with COVID-19 around the world. On 31 March 2020, the virus spread more than 750890 People in the World. The World Health Organization (WHO) has declared a public health emergency relating to COVID-19. Since then, this strain has been diagnosed in several residents of world. The CDC have advised that it is likely to spread to more people. COVID-19 has affected at least 213 countries or territories or areas. The first people with COVID-19 had links to an animal and seafood market. This fact suggested that animals initially transmitted the virus to humans. However, people with a more recent diagnosis had no connections with or exposure to the market, confirming that humans can pass the virus to each other. Corona viruses will infect most people at some time during their lifetime. Corona viruses can mutate effectively, which makes them so contagious. Information on the virus is scarce at present. In the past, respiratory conditions that develop from corona viruses, such as SARS and MERS, have spread through close contacts. On 17 February 2020, the Director-General of the WHO presented at a media briefing the following updates on how often the symptoms of COVID-19.However, while some viruses are highly contagious, it is less clear how rapidly corona viruses will spread. Symptoms vary from person-to-person with COVID-19. It may produce few or no symptoms. However, it can also lead to severe illness and may be fatal. On 11 March 2020, WHO declared Novel Corona virus Disease (COVID-19) outbreak as a Pandemic. Keywords: WHO, ICMR, SARS-CoV-2, Bats, Wuhan City, Pneumonia, Respiratory Infection, Pandemic

scholarly journals Pregnancy and Childbirth in COVID-19 Positive/Probable and Suspected Patients: A Comprehensive Review

2020 ◽  
pp. 91-108
Author(s):  
Mosammat Rashida Begum ◽  
Nazia Ehsan ◽  
Mariya Ehsan ◽  
Azaz Bin Sharif
Keyword(s):  
Virus Disease ◽  
Treatment Options ◽  
Specific Treatment ◽  
International Health ◽  
Respiratory Illness ◽  
Viral Disease ◽  
Gravid Uterus ◽  
Published Data ◽  
Pregnancy And Childbirth ◽  
Corona Virus

Corona virus disease 2019 (COVID-19) is a global pandemic disease caused by novel corona virus called SARS-CoV-2. Over 213 countries as of July 15, 2020, 13.1 million people are affected by this deadly virus. More than 100 million women are pregnant worldwide and potentially all are at risk of exposure to SARS-CoV-2 infection. Coronaviruses cause illness ranging in severity from common cold and severe respiratory illness to death. Frequent manifestations of COVID-19 include fever, cough, myalgia, headache, and diarrhoea. Abnormal test result shows abnormalities on chest radiographic imaging, lymphopenia, leukopenia, and thrombocytopenia. Physiological changes during pregnancy like altered immunity, reduced functional residual volume, pressure on diaphragm by advanced gravid uterus may lead to adverse respiratory outcome in any viral disease. Maternal mortality was very high in other corona viruses like Severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). No evidence of in utero transmission was seen in SARS or MERS. Coronavirus disease 2019 might increase the risk of vertical transmission and pregnancy complications. So, meticulous management is necessary for safe maternal and foetal outcome. Early isolation, aggressive infection control procedures, oxygen therapy are the key component of COVID-19 management. In pregnancy multidisciplinary approach should be taken for general and obstetrical management. At present there is no specific treatment for COVID-19. Based on results from observational studies empiric antibacterial and antiviral drugs are used. Very recently a few controlled trials were published that suggest few treatment options. On the basis of published data and recommendations of international health organizations, the aim of this review is to explore effective treatment and care of the pregnant women throughout pregnancy, during childbirth and afterwards in this novel SARS-CoV-2 crisis. J Bangladesh Coll Phys Surg 2020; 38(0): 91-108

Covid-19, SARS -CoV-2, Origin, transmission and treatment aspects, a brief review

2020 ◽  
Vol 20 ◽  
Author(s):  
Shahid Nawaz
Keyword(s):  
Mortality Rate ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Manifestation ◽  
Virus Disease ◽  
The Novel ◽  
Research Activities ◽  
Corona Virus ◽  
Global Pandemic ◽  
The World

: The emergence of severe acute respiratory syndrome (SARS) in Wuhan (china) named as corona virus disease 19(covid-19) caused by the novel corona virus SARS-CoV-2 has caused hundreds of thousands of mortalities across the world ,while the mortality rate is in millions, leading it to be declared as a global pandemic. Numerous research activities are undergoing to reveal the disease and etiological features of covid-19. In this review, some of the interesting aspects of covid-19 are discussed, that includes, the origin of the SARS-CoV-2, clinical manifestation, treatment and future aspects of the disease.

scholarly journals A Study on Novel Corona Virus Disease (COVID-19)

2021 ◽  
Vol 10 (1) ◽  
pp. 29-37
Author(s):  
Harsimran Singh ◽  
Santosh Kumar ◽  
Rakesh Kumar
Keyword(s):  
Preventive Measures ◽  
Virus Disease ◽  
Human Life ◽  
Wuhan City ◽  
Zoonotic Virus ◽  
Infectious Bronchitis ◽  
Corona Virus ◽  
Global Pandemic ◽  
The World ◽  
Life Threatening

COVID-19 is a global pandemic and life threatening virus that mainly influences the respiratory tract of mammals, consisting humans being. It was 1st isolated in 1937 from an infectious bronchitis virus in birds. Many years ago, scientists have investigated that corona virus can infect mice, horses, dogs, pigs, rats, cats, cattle and turkeys. This zoonotic virus was first identified from Wuhan City, China and presently increasing very rapidly. The world has confirmed 141,057,106 cases, which includes 3,015,043 deaths and 793,484,083 vaccine doses administered as per the WHO till 20th April, 2021. Hence the aim of this paper is to provide a detailed review of COVID-19 including their history, origin, characteristics, symptoms and impacts along with preventive measures to be taken to restrict the outbreak of this evil virus of on human life.

Hospitalitas Kristen Yang Hampir Hilang Pada Kasus Kematian Salah Satu Anggota Masyarakat Di Dusun Beringin, Luwu Utara, Sulawesi Selatan Akibat Covid-19

2021 ◽  
Author(s):  
desna rura sarapang
Keyword(s):  
Virus Disease ◽  
Social Distancing ◽  
Indonesian Government ◽  
Risk Of Death ◽  
The Earth ◽  
Corona Virus ◽  
The World ◽  
Global World ◽  
The Impact ◽  
Christian Hospitality

The emergence of a new virus in the global world at the end of 2019, namely Corona Virus Disease 2019, brought tremendous excitement to all inhabitants of the earth. The emergence of this virus brings tremendous concern and fear to the world because the spread of this virus is quite fast, even the most frightening is that the risk of death of people exposed to this virus is very large. Indonesia itself, cannot avoid the impact of this Covid-19 case. As a form of efforts to prevent and minimize transmission of the virus, the Indonesian government has issued a social distancing / physical distancing recommendation. This situation also causes the interaction between communities to be very limited. This situation seems to be able to eliminate hospitality among the community. This paper aims to emphasize the importance of maintaining the value of Christian hospitality in society amid the Covid-19 pandemic.

Coronavirus and Fingerprint Technology

2021 ◽  
Vol 13 (4) ◽  
pp. 1-16
Author(s):  
Gabriel B. Iwasokun
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Viral Infection ◽  
Virus Disease ◽  
High Rate ◽  
Corona Virus ◽  
The World ◽  
Almost All

The corona virus disease, otherwise known as COVID-19, is an extremely communicable and pathogenic viral infection caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), which emerged in Wuhan, China in December 2019 and has spread to almost all the countries in the world. The transmission of the virus is through touching of the nose, eyes, or mouth by a finger that has been contaminated through droplets on a surface when a carrier sneezes or coughs. Since the existing fingerprint devices are predominantly contact based, it implies that they can aid in the transmission of the virus. This paper discusses the application of fingerprint devices in notable places with high rate of COVID-19 infection as well as the threats to fingerprint technologies and the countermeasures. The need to change focus and orientation towards contactless biometric technologies as sure solution to the fear and animosity expressed towards contact-based fingerprint technology is also expatiated.

Sign in / Sign up

Export Citation Format

Share Document