The efficacy of the probiotic feed additive Calsporin® (Bacillus subtilis C-3102) in weaned piglets: combined analysis of four different studies

Author(s):  
T. Marubashi ◽  
M. I. Gracia ◽  
B. Vilà ◽  
V. Bontempo ◽  
S. K. Kritas ◽  
...  

SummaryThe efficacy of the probiotic feed product, Calsporin® (Bacillus subtilis C-3102) in weaned piglets was evaluated by statistical analysis of the combined results from four different experiments. The body weight, average daily gain, feed intake, feed conversion ratio and mortality data from these four experiments were tested for homogeneity before being pooled and analysed as a whole, with experiment being included as a blocking factor. Piglets fed diets supplemented with Calsporin® were significantly heavier (3.4%) at 43 days (P < 0.05), their feed intakes decreased by 2.1% and feed efficiency (FCR) improved by 3.2% between 15 and 43 days, although these latter differences were not significant. Over the entire study period (day 1 to 43), significant improvements in daily gain (4.8%) and feed efficiency (6.2%) were observed with Calsporin® supplementation (P < 0.05). The results demonstrated that Calsporin® at 30 mg/kg inclusion in commercial-type diets can improve zootechnical performance in weaned piglets.

2012 ◽  
Vol 1 ◽  
Author(s):  
T. Marubashi ◽  
M. I. Gracia ◽  
E. Esteve-Garcia ◽  
M. Piskoríková

SummaryThe efficacy of the probiotic feed additive, Calsporin® (CAL; Bacillus subtilis C-3102), included in broiler diets at 50 mg/kg was evaluated using statistical meta-analysis of data from four different studies conducted using broilers from day-old to market weight at 42 days of age. The body weight, average daily gain, feed intake, feed to gain ratio, mortality and European Production Efficiency Factor (EPEF) data from each experiment were tested for homogeneity between trials before being pooled and analysed in combination to determine whether benefits were consistent independent of trial site and conditions. CAL supplementation significantly improved weight gain (P = 0.0037) between 1 and 21 days of age (3.3%) and feed conversion ratio (P = 0.0492) between 22 and 42 days of age (3.0%). Over the entire experimental period (day 1 to day 42 of age), broilers fed the CAL diets had significantly better (P = 0.0142) feed conversion (2.6%) and higher (P = 0.0062) EPEF (4.6%) compared to the controls. Birds fed diets supplemented with CAL were 1.6% heavier than controls at 42 days of age, a near-significant trend (P = 0.0558). The results demonstrated that CAL in broiler diets, added at an inclusion rate of 50 mg/kg, can be beneficial in terms of broiler performance.


2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 472-472
Author(s):  
Benjamin Bass ◽  
Stacie Crowder ◽  
Murali Raghavendra Rao

Abstract Ambitine Feed Additive (AMB), a proprietary blend of phytogenics and acidifiers (PMI, Arden Hills, MN), is formulated to help mitigate late finishing stress in pigs. Several studies using AMB in the late finishing period resulted in improved pig performance. A meta-analytic method used 13 studies (3 studies with ractopamine and 10 studies without) to determine the overall impact of AMB on average daily gain, average daily feed intake, and feed conversion. The combined data were considered a randomized complete block design. Analysis of variance was completed using the GLIMMIX procedure of SAS (9.4; Cary, NC) and least squares means were compared using Fisher’s least significant difference (P &lt; 0.05). In the analysis of 10 studies with no added ractopamine (73 pens/treatment of 5 to 10 pigs/pen and 48 pens/treatment of 17 to 20 pigs/pen), pigs provided AMB had higher average daily gain (0.90 vs 0.86 kg/d; P &lt; 0.05), increased average daily feed intake (2.99 vs 2.94 kg/d; P &lt; 0.05), and improved feed efficiency (0.30 vs 0.29 kg gain/kg feed intake; P &lt; 0.05) compared to pigs fed control diets. Additionally, when pigs were provided AMB in addition to ractopamine (3 studies; 33 pens/treatment of 18 to 22 pigs/pen), average daily gain was increased 4.7% (1.206 vs 1.152 kg/d; P &lt; 0.05) and feed efficiency was improved 5.3% (0.40 vs 0.38 kg gain/kg feed intake; P &lt; 0.05) compared to pigs provided only ractopamine, with no difference in feed intake. Pigs provided AMB in addition to ractopamine had increased hot carcass weight and dressing percentage (P &lt; 0.05) compared to those provided ractopamine alone. In conclusion, providing AMB to pigs in late finishing improved ADG and feed efficiency and the improvement was maintained when ractopamine was included in the diets.


2021 ◽  
Vol 9 (3) ◽  
pp. 572
Author(s):  
Sandrine Dufourny ◽  
Nadine Antoine ◽  
Elena Pitchugina ◽  
Véronique Delcenserie ◽  
Stéphane Godbout ◽  
...  

Apple pomace (AP) is known to be rich in biomolecules beneficial for health and it may advantageously be used to overcome the critical step of piglets’ weaning. The study aimed to determine the effect of two levels of incorporation of AP on the performance, intestinal morphology, and microbiota of weaned piglets and investigate this feed ingredient as a weaning strategy. An experiment was performed with 42 piglets from weaning (28 days old) over a five-week period, including three iso-energetic and iso-nitrogenous diets (0%, 2%, and 4% dried AP diets) with seven pen-repetitions per diet (two pigs per pen). AP diets were beneficial for the average daily gain calculated on week 3 (p = 0.038) and some parameters of the intestinal architecture on the 35 post-weaning day. The 4% AP diet was beneficial for the feed conversion ratio (p = 0.002) and the energetic feed efficiency (p = 0.004) on the 35 post-weaning day. AP tended to influence the consistency of feces (softer to liquid, p = 0.096) and increased the counts of excreted pathogens (p = 0.072). Four percent AP influenced the richness of the microbiota and the bacteria profile as observed for the phylum Bacteroidetes or the class Clostridia. The 4% AP diet appeared as an interesting weaning strategy that should be evaluated in a large cohort.


2016 ◽  
Vol 37 (2) ◽  
pp. 977
Author(s):  
João Vinícius Barbosa Roberto ◽  
Bonifácio Benicio de Souza ◽  
Gabriel Jorge Carneiro de Oliveira  ◽  
Jaime Miguel de Araujo Filho ◽  
Thaiz Lamy Alves Ribeiro ◽  
...  

This study evaluated food intake and productive performance of crossbred (½ Santa Inês x ½ dorper) lambs supplemented with different levels of faveleira (Cnidoscolus quercifolius Pohl) fodder salt. Thirty male sheep fed tifton grass hay, water, and faveleira fodder salt were randomly allocated into five treatments with six replicates each. The treatments consisted of diets with different inclusion levels of faveleira hay in the fodder salt composition: Treatment 1 (1% mineral salt + 99% faveleira hay), Treatment 2 (3% mineral salt + 97% faveleira hay), Treatment 3 (5% mineral salt + 95% faveleira hay), Treatment 4 (7% mineral salt + 93% faveleira hay), and Treatment 5 (Control - 100% mineral salt). Intake of dry matter, tifton hay and water, average daily gain, feed conversion, and feed efficiency were not affected by fodder salt supplementation (P > 0.05). There was a significant difference (P < 0.05) in fodder salt intake between Treatments 4 and 5, and daily intake was higher in animals submitted to Treatment 4 (61.0 g day-1). Mineral salt intake increased significantly with increasing mineral salt levels in the diet. However, no significant difference was observed in average daily gain across treatments, indicating that faveleira hay, even in small quantities, and tifton hay were able to meet the nutritional requirements of animals to support a good average daily gain. The inclusion of up to 99% faveleira hay in fodder salt formulations did not affect voluntary intake of forage, water and dry matter, average daily gain, feed conversion, and feed efficiency. Lambs supplemented with faveleira fodder salt had average daily gains within the optimal range for slaughter and high feed conversion and feed efficiency values. Faveleira was shown to be an effective supplementary feed alternative in sheep.


2000 ◽  
Vol 80 (3) ◽  
pp. 529-531 ◽  
Author(s):  
P. J. Munro ◽  
A. Lirette ◽  
D. M. Anderson ◽  
H. Y. Ju

Two-hundred and nine purebred Yorkshire newly weaned piglets were used to determine the effect of the sweetener Stevia (Stevia rebaudiana) at 83.3, 167 or 334 mg kg−1 diet on feed consumption (FC), average daily gain (ADG) and feed to gain ratio (F/G) compared with treatments with 5% sucrose and no sweetener (control; C). The Stevia-containing diets did not appear to have detrimental effects on the FC and F/G ratios of the piglets when compared with C. The results indicated only a limited potential for Stevia as feed additive for piglets. Key words: Sweetener, palatability, Stevia, weaned pigs


2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 175-176
Author(s):  
Benjamin Bass ◽  
Stacie Crowder ◽  
Terry Weeden ◽  
Murali Raghavendra Rao ◽  
Brenda de Rodas ◽  
...  

Abstract OutPace® Feed Additive (OP), contains a carefully researched blend of activated medium chain fatty acids (MCFAs; PMI, Arden Hills, MN), formulated to help mitigate the effects of stress in nursery pigs. Several studies using OP in both late and full nursery periods resulted in improved pig performance. A meta-analysis using 9 studies (4 studies during late nursery [15 to 26.8 kg BW] and 5 studies during the full nursery [5.9 to 25.4 kg]) was done to determine the impact of OP (included at 0.25% Phase 1 and 2; 0.125% Phase 3) on average daily gain, average daily feed intake, and feed conversion. The combined data was considered a randomized complete block design. Analysis of variance was completed with mixed models using the GLIMMIX procedure of SAS (SAS 9.4, SAS Institute Inc., Cary, NC) and least squares means were compared using Fisher’s least significant difference (P &lt; 0.05). In the analysis of 5 studies conducted in late nursery (45 pens/treatment of 6 to 20 pigs/pen), pigs provided OP had higher average daily gain (0.67 vs 0.63 kg/d; P &lt; 0.05), increased average daily feed intake (0.99 vs 0.97 kg/d; P &lt; 0.05), and improved feed efficiency (0.67 vs 0.65 kg gain/kg feed intake; P &lt; 0.05) compared to pigs fed control diets. Additionally, when pigs were provided OP throughout the nursery period (20 pens/treatment of 7 to 20 pigs/pen), average daily gain was increased 6.1% (0.48 vs 0.45 kg/d; P &lt; 0.05), average daily feed intake tended to be increased 2.2% (0.62 vs 0.61 kg/d; P &lt; 0.1), and feed efficiency was improved 2.7% (0.76 vs 0.74 kg gain/kg feed intake; P &lt; 0.05) compared to pigs provided control diets. In conclusion, providing OP to pigs during the nursery period improved ADG and feed efficiency.


Animals ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2839
Author(s):  
Anthony Pokoo-Aikins ◽  
Jennifer Rumsey Timmons ◽  
Byungrok Rok Min ◽  
William Robert Lee ◽  
Samuel Njoroge Mwangi ◽  
...  

This study was designed to evaluate the effects of dietary supplemental DL-methionine (MET) on live performance and meat yield for broilers raised to a common weight. A total of 1552 one-day old Ross 708, sexed broilers were randomly distributed to 32 pens resulting in eight treatments (TRT) of four replicates with 44 male or 53 female/pen. A randomized complete block with a 2 × 4 (sex × 4 MET levels 0, 0.5, 1, and 2 g/kg) factorial arrangement of TRT was used. A common weight of 2400 g was approached by day 46 (1 and 2 g MET/kg feed) and day 48 (0 and 0.5 g MET/kg feed). Supplementation of MET at 1, and 2 g/kg had a lower (p < 0.01) feed conversion ratio (FCR) at day 46/48 than broilers fed 0.5 g MET/kg. Broilers without supplemental MET had the worst (p < 0.01) feed conversion and average daily gain (ADG) at day 46/48. Birds fed 0 g MET/kg of feed had lower (p < 0.05) whole eviscerated carcass without giblets (WOG), yield than birds fed 2 g MET/kg of feed. Additionally, birds fed 0 g MET/kg of feed had lower (p < 0.05) breast fillet and tender percent yields than birds fed supplemental MET. Elimination of MET from organic broiler diets resulted in reduced ADG, breast fillet yield and feed efficiency of meat yield of broilers raised to day 46/48. Reduction in MET supplementation below current levels reduced the efficiency of meat production of organic broilers raised to day 46/48.


2021 ◽  
Vol 273 ◽  
pp. 02011
Author(s):  
Galina Molyanova ◽  
Maxim Nogotkov ◽  
Nelly Chigina

The effect of Bisolbi drug based on Bacillus subtilis on the physiological, biochemical and productive parameters of calves was studied. The research and production experiment was carried out in a dairy farm “Kupinskoe” of Samara Region on 30 calves of the Holstein-Frisian breed. The drug increases the intensity of the anabolic processes in animals: the amount of total protein in blood serum of calves of the experimental group at 120 days of age was higher by 8.9% (p≤0.05), albumin 9.2% (p≤0.01), compared with control animals. The purpose of Bisolbi contributed to the increase in the intensity of carbohydrate-lipid metabolism: cholesterol was higher by 23% (p≤0.01), glucose 0.4 mmol/l (p≤0.05) in blood 120-day calves of the experimental group, relative to the data of the control group. It was found that the body weight of calves in the control group at 100 days of age was 105.23±2.11 kg, in the experimental group -108.6±2.19 kg. The average daily gain in the experimental group was significantly higher by 0.075 kg (p≤0.01). At 120 days of age, the body weight of the experimental calves was higher by 4.19 kg (p≤0.05), the average daily increase by 0.080 kg (p≤0.05), relative to the control animals.


2003 ◽  
Vol 54 (1) ◽  
pp. 11 ◽  
Author(s):  
I. McCauley ◽  
M. Watt ◽  
D. Suster ◽  
D. J. Kerton ◽  
W. T. Oliver ◽  
...  

The use of a vaccine (Improvac) directed against gonadotrophin-releasing factor (GnRF), to prevent boar taint in male pigs, is also associated with an increase in feed consumption, growth, and higher deposition of subcutaneous fat. Daily administration of porcine somatotropin (pST) consistently increases average daily gain, and feed conversion efficiency, and reduces subcutaneous fat, particularly in gilts. The objective of this study was to examine the effect of combining these treatments in boars and gilts. Forty-eight pigs (Large White × Landrace), housed individually, were used in a 2 × 2 × 2 factorial experiment with the respective factors being vaccination with GnRF vaccine (at 14 and 18 weeks of age), daily injection with pST (from 18 weeks to slaughter at 22 weeks), and sex (boars and gilts). Performance was measured over the period of pST administration. Over the entire 28 days of the study, daily gain was lower for gilts than for boars (1216 v. 1410 g/day, P < 0.001), was increased by pST (1219 v. 1407 g/day, P < 0.001), but not significantly altered by vaccination against GnRF (1284 v. 1342 g/day, P = 0.15). However, GnRF vaccination increased daily gain in the second 2 weeks of the study, and overall, there were interactions such that the vaccine increased gain in all groups except boars not receiving pST. Feed intake over the study period was less for gilts than for boars (3139 v. 3407 g/day, P < 0.001), was decreased by pST (3537 v. 3009 g/day, P < 0.001), and increased by vaccination against GnRF (3139 v. 3407 g/day, P < 0.001). When averaged over the entire study, feed conversion ratio (FCR) was higher for gilts than for boars (2.76 v. 2.51, P = 0.013), was decreased by pST (3.05 v. 2.22, P < 0.001), but unchanged by vaccination against GnRF (2.62 v. 2.65, P = 0.70). Fat deposition was lower in gilts than in boars (335 v. 378 g/day, P = 0.037), was decreased by pST treatment ((442 v. 271 g/day, P < 0.001), and increased by vaccination against GnRF (333 v. 379 g/day, P = 0.026). In boars, fat androstenone was reduced by vaccination against GnRF (0.10 v. 2.47 μg/g, P < 0.001) and tended to be reduced by pST (1.71 v. 2.44, P = 0.10), but only vaccination against GnRF reduced skatole (0.174 v. 0.050 μg/g, P < 0.001). The combination of the treatments in all cases was at least additive, and in some cases synergistic. The concomitant vaccination against GnRF and treatment with pST affords an opportunity to increase growth rate and feed intake above control levels and above those of pigs treated with either treatment alone.


2020 ◽  
Author(s):  
Linghong Sun ◽  
Anam Khalid ◽  
Fatima Khalid ◽  
Zaigui Wang

Abstract Background:The effects of Bacillus subtilis protease on the silkworm (Bombyxmori L) production performance and feed efficiency were investigated. 2250 silkworms were randomly divided into two groups, the test group and the control group, each group had three replicates. A certain concentration of protease was sprayed to the mulberry leaves of the test group, while equal volume of deionized water was sprayed to the control group. Test diets were fed in three phases: 3rd instar, 4th instar and 5th instar larval stage.Results: The results demonstrated that: (i) final weight (FW), average daily gain (ADG), average daily feed intake(ADFI), and feed conversion ratio (FCR) in 4th and 5th larval instar, (ii) midgut protease activity, crude protein digestibility (CPD), crude fiber digestibility (CFD) and cocoon shell conversion rate (CSCR) (iii) the total number of bad cocoons,coarse cocoon, average pupa weight (APW), average cocoon shell weight (ACSW) and average cocoon weight (ACW) were extremely significantly higher (P<0.01) in test group as compared to control group. While, (i) the digestibility of crude lipid (EED) and (ii) the fly larvae cocoons in test group were higher significantly (P<0.05) than that of the control group. Conclusion:These results indicated that the B. subtilis protease could enhance the silkworm growth performance, feed efficiency and the cocoon quality of silkworm.


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