scholarly journals Folate deficiency is associated with nutritional anaemia in Lebanese women of childbearing age

2006 ◽  
Vol 9 (7) ◽  
pp. 921-927 ◽  
Author(s):  
Lynn Al Khatib ◽  
Omar Obeid ◽  
Abla-Mehio Sibai ◽  
Malek Batal ◽  
Nada Adra ◽  
...  

AbstractObjectiveThe objective of this study was to identify the determinants of anaemia in Lebanese women of childbearing age attending health centres in Lebanon.DesignCross-sectional study carried out between May and December 2003. Anthropometric measurements as well as sociodemographic, health and dietary intake data were collected using a questionnaire. Haemoglobin (Hb), plasma ferritin, plasma folate and vitamin B12were assessed using standard laboratory methods.SettingGovernmental health centres in Lebanon.SubjectsFour hundred and seventy non-pregnant Lebanese women aged 15–45 years.ResultsAnaemia (Hb <12 g dl−1) and iron deficiency (ferritin <15 μg l−1) were prevalent in 16.0 and 27.2% of the study sample, respectively. Of the total sample, 7.7% had iron-deficiency anaemia. The percentage of women with either Hb or ferritin deficiency or both was 35.6%. Plasma folate and vitamin B12deficiency was reported in 25.1 and 39.4%, respectively, and 12.6% of the women had both folate and vitamin B12deficiencies. Of the anaemic group, 48.0% of the women had iron deficiency. The intake of iron was lower in iron-deficient than in non-deficient women and a positive relationship was shown between folate intake and its corresponding serum levels. Regression analysis showed that ferritin, plasma folate and family history of anaemia were significant determinants of the anaemia in the sample of women.ConclusionsAnaemia not related to iron deficiency was partly explained by plasma folate deficiency. Measures to control folate and iron deficiency should be considered.




2009 ◽  
Vol 5 (2) ◽  
pp. 104-116 ◽  
Author(s):  
Yaling Zhao ◽  
Ling Hao ◽  
Le Zhang ◽  
Yihua Tian ◽  
Yiwu Cao ◽  
...  


Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 3265-3265
Author(s):  
Mohamed Akkad ◽  
Mohammed Shaik ◽  
Anas Al-Janadi

Abstract Introduction: Iron deficiency (ID) is the most common nutritional deficiency in the world and remains relatively common in at-risk groups in the United States. The development of (ID) is dependent upon the individual's iron stores which is a balance between iron absorption and loss. Commonly associated with (ID) is iron deficiency anemia (IDA) which has a well known association with fatigue. Fatigue is a common complaint in general, with a prevalence in population-based surveys in Great Britain and the United States of 6.0 and 7.5 % respectively. However it is not uncommon to have (ID) without subsequent anemia in females childbearing age group. Our study aims to evaluate the prevalence of ID in non anemic females of childbearing age and its association with fatigue. Methods: Data was obtained from continuous NHANES database, a nationally representative health survey conducted from 2005-2010. The data including age, race, complete blood count (CBC), ferritin and fatigue was obtianed from laboratory and questionnaire datasets, respectively. Subjects were further divided based on ferritin levels into two groups, Group A; ferritin ≤20 ng/mL and Group B; ferritin >20 ng/mL. The question regarding fatigue- "feeling tired or having little energy for past two weeks" was obtained from PHQ-9 scale. Univariate analysis was done comparing Group A and Group B using chi-square test and t-test for categorical and numerical variables, respectively. The effect of iron deficiency on fatigue was obtained using logistic regression to calculate odds ratio (OR) after adjusting for age and race. Results: Of 3230 female subjects( age 18yrs -49yrs), there were 809 with ID with no anemia. The weighted prevalence of iron deficiency in non-anemic women of childbearing age was 22.5% (95% CI 20.76-24.22). The weighted prevalence of fatigue in Group A and Group B was 61.8% (95% CI 56.4-67.2) and 59.7 % (95%CI 57-62.4) respectively (p=0.45)(table 1). In multivariate analysis, after adjusting for age and race, the odds ratio (OR) for fatigue with iron deficiency was 1.1 ( 95% CI 0.8-1.4). Conclusion: The prevalence of ID in non anemic females of childbearing age in the United States was 22.5 % .The percentage of subjects who reported fatigue was significantly high in both iron deficient and non-iron deficient subjects in this age group. There was no statistical difference in self-reported fatigue in both iron deficient and non-iron deficient women of childbearing age. Further studies are needed to validate our findings. Table 1. Comparision of GpA and GpB Variables Ferritin≤ 20 ng/mL (GpA) Ferritin > 20 ng/mL Fatigue - Yes 512 1452 Fatigue - No 297 986 Total 809 2421 Disclosures No relevant conflicts of interest to declare.



2020 ◽  
pp. 201010582095872
Author(s):  
Roghieh Bayrami ◽  
Alireza Didarloo ◽  
Afsaneh Asadinejad

Purpose: Although preconception care (PCC) has been integrated into women’s care programmes in the country for more than a decade, it has not yet been welcomed by Iranian women, and the rate of PCC uptake is very low. Therefore, this study aims to determine predictors of uptake of PCC based on the Beliefs, Attitudes, Subjective Norms and Enabling Factors (BASNEF) model among women of reproductive age referred to health centres in Urmia, Northwest Iran, in 2019. Methods: This cross-sectional study was carried out on 230 women of childbearing age at Urmia health centres during 2019. Subjects were selected using a multistage sampling method. A valid reliable researcher-made questionnaire, including demographic information, items related to the BASNEF model constructs regarding PCC and items related to PCC behaviour, was used to collect data. Data were analysed using descriptive and inferential statistics (frequencies, means and standard deviations, independent t-test, chi-square test, logistic and linear regression). Results: The findings showed that the rate of receiving PCC was 19.6%. Overall, the BASNEF model predicted 42% of the intention to receive health care. Among the model constructs, enabling factors (β=0.32, p<0.001) and attitude (β=0.41, p<0.001) significantly explained women’s behavioural intention towards receiving PCC. In the logistic regression model, intention (β=0.15, p<0.001) and enabling factors (β=0.12, p=0.034) had a significant role in predicting PCC. Conclusion: The low uptake of PCC by women of childbearing age in Urmia suggests the need to design and implement interventions based on women’s attitudes, intentions and enabling factors in order to stimulate and maintain women’s health-promoting behaviours during childbearing age.



2017 ◽  
Vol 147 (6) ◽  
pp. 1183-1193 ◽  
Author(s):  
Jorge Rosenthal ◽  
Natalia Largaespada ◽  
Lynn B Bailey ◽  
Michael Cannon ◽  
CJ Alverson ◽  
...  


2020 ◽  
Vol 16 (4) ◽  
pp. 543-553
Author(s):  
Luciana Y. Tomita ◽  
Andréia C. da Costa ◽  
Solange Andreoni ◽  
Luiza K.M. Oyafuso ◽  
Vânia D’Almeida ◽  
...  

Background: Folic acid fortification program has been established to prevent tube defects. However, concern has been raised among patients using anti-folate drug, i.e. psoriatic patients, a common, chronic, autoimmune inflammatory skin disease associated with obesity and smoking. Objective: To investigate dietary and circulating folate, vitamin B12 (B12) and homocysteine (hcy) in psoriatic subjects exposed to the national mandatory folic acid fortification program. Methods: Cross-sectional study using the Food Frequency Questionnaire, plasma folate, B12, hcy and psoriasis severity using the Psoriasis Area and Severity Index score. Median, interquartile ranges (IQRs) and linear regression models were conducted to investigate factors associated with plasma folate, B12 and hcy. Results: 82 (73%) mild psoriasis, 18 (16%) moderate and 12 (11%) severe psoriasis. 58% female, 61% non-white, 31% former smokers, and 20% current smokers. Median (IQRs) were 51 (40, 60) years. Only 32% reached the Estimated Average Requirement of folate intake. Folate and B12 deficiencies were observed in 9% and 6% of the blood sample respectively, but hyperhomocysteinaemia in 21%. Severity of psoriasis was negatively correlated with folate and B12 concentrations. In a multiple linear regression model, folate intake contributed positively to 14% of serum folate, and negative predictors were psoriasis severity, smoking habits and saturated fatty acid explaining 29% of circulating folate. Conclusion: Only one third reached dietary intake of folate, but deficiencies of folate and B12 were low. Psoriasis severity was negatively correlated with circulating folate and B12. Stopping smoking and a folate rich diet may be important targets for managing psoriasis.



Author(s):  
Fatma Ben Cherifa ◽  
Jalila El Ati ◽  
Radhouene Doggui ◽  
Myriam El Ati-Hellal ◽  
Pierre Traissac

The protective role of high high-density lipoprotein cholesterol (HDL-C) against cardiovascular risk has been questioned recently. Due to the increasing trend of cardiovascular diseases (CVD) in Tunisia, this study aimed to determine the prevalence of high HDL-C and its associated factors in Tunisian women of childbearing age. A cross-sectional survey was conducted among a subsample of 1689 women, aged 20 to 49 years, in the Great Tunis region. Data on socio-demographic and lifestyle factors were collected by a questionnaire. Overall adiposity was assessed by body mass index (BMI). All biological variables were assayed in blood samples coated with anticoagulant ethylene diamine tetra acetic acid (EDTA) by enzymatic methods. Stata software (2015) was used for data management and statistical analysis. High HDL-C values were recorded in 26.6% of selected women. After adjustment for all socio-demographic and lifestyle factors, age, hypertension, and smoking were negatively associated with high HDL-C levels, while family history of cancer was positively associated with high HDL-C in women. An additional investigation on the relationship between high HDL-C and cancer risk should be performed due to controversial results.



Author(s):  
Yulia Ivanovna Кorshikova

The article presents clinical observations proving the importance of constitutional menorrhagia in the iron-deficiency anaemia genesis and a decrease in nonspecific resistance in women of childbearing age, as well as relevant use of phytotherapy method as a therapeutic and prophylactic agent.



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