scholarly journals Effect of dietary fibre mixture on growth and intestinal iron absorption in rats recovering from iron-deficiency anaemia

2010 ◽  
Vol 104 (10) ◽  
pp. 1471-1476 ◽  
Author(s):  
Thabata Koester Weber ◽  
Karine de Cássia Freitas ◽  
Olga Maria Silvério Amancio ◽  
Mauro Batista de Morais

There is concern regarding the possible negative effects of ingestion of dietary fibre on growth and intestinal Fe absorption in infants. The aim of the present study was to compare the effect of a fibre mixture on the growth and the intestinal absorption of Fe in rats with Fe-deficiency anaemia with that of a diet without fibres. Faecal weight and caecal pH were also evaluated. According to the Hb depletion–repletion model, twenty-two male weaned Wistar rats were fed the AIN93-G diet without Fe until Fe-deficiency anaemia was induced with Hb < 70 g/l. The anaemic rats were divided into two groups: (1) fibre mixture group – fed 100 g of fibre mixture/kg of diet (soya polysaccharide, inulin, resistant starch, Arabic gum, fructo-oligossaccharide and cellulose) (n 11); (2) control group – fed without fibres (n 11). All diets had 157 mg of ferric citrate (30 mg of elemental Fe) added to lead to recovery from anaemia. Fe intestinal absorption was measured by Hb repletion efficiency (HRE) and apparent Fe intestinal absorption. The HRE was 44·8 (sd 9·5) % in the fibre mixture group and 43·0 (sd 9·5) % in the control group (P = 0·664). The apparent Fe absorption was 46·2 (sd 16·5) and 47·2 (sd 10·2) % (P = 0·861) in the fibre mixture and control groups, respectively. The faecal weight median was 6·17 g in the fibre mixture group and 2·11 g in the control group (P < 0·001). The caecal pH was in the same order: 6·11 (sd 0·59) and 7·07 (sd 0·34) (P < 0·001). Both the groups consumed similar quantities of diet, and growth was similar in both the groups. The fibre mixture had no influence either on growth or on Fe intestinal absorption in rats recovering from anaemia. This mixture favoured an increase in faecal weight and a decrease in caecal pH.

2011 ◽  
Vol 108 (6) ◽  
pp. 1008-1016 ◽  
Author(s):  
Karine de Cássia Freitas ◽  
Olga Maria Silvério Amancio ◽  
Mauro Batista de Morais

Considering the high frequency of anaemia due to Fe deficiency, it is important to evaluate the effects of prebiotics on the absorption of Fe. The aim of the present study was to evaluate the effects of high-performance (HP) inulin, oligofructose and synergy1 during recovery from anaemia in rats through the intestinal absorption of Fe, food intake, body growth, caecal pH and weight of the intestine. Wistar rats (n 47) were fed with rations of AIN93-G with no Fe to induce Fe deficiency anaemia. At 36 d of life, anaemic rats were divided into four groups: (1) the HP inulin group; (2) the synergy1 group; and (3) the oligofructose group, all with 100 g of the respective prebiotic per kg of ration; and (4) a control group, in which the prebiotic was replaced by maize starch. Then, 25 mg of elemental Fe/kg of ration was added to all rations to allow recovery from anaemia. The final values of Hb in the HP inulin, synergy1, oligofructose and control groups were, respectively: 98 (94–99); 83 (81–92); 100 (90–114); 77 (72–81) g/l, with a statistically significant difference (P ≤ 0·001) between the oligofructose and control groups and the HP inulin and control groups. The four groups had an increase in weight and body length and had similar consumption of rations. The intestinal weight and caecal pH were significantly different between the groups that consumed prebiotics and the control group. HP inulin and oligofructose increased the intestinal absorption of Fe in rats.


2020 ◽  
Vol 11 (2) ◽  
pp. 2288-2293
Author(s):  
Bhuvaneswari G.

WHO Global Database on Anaemia for 1993-2005, covering almost half of the world’s population, estimated the prevalence of anaemia worldwide at 25 per cent.The aim of the study is to determine the effectiveness of honey dates amla mix on biochemical markers among adolescent girls with Iron deficiency anaemia. Quantitative experimental and control group pre and post-test design was used in this study. The study was conducted among adolescent girls in two different residential homes. Total study population is 170 adolescent girls were selected by simple random sampling technique. 85 adolescents girls were assigned to the experimental group and 85 participants in control group. For experimental group honey dates amla mix was given for 3 months whereas in  the control group iron and folic acid supplementation were provided. The study results shows that pre and post-test intervention scores of control and experimental group were compared by Wilcoxon scores rank test. Comparison of pre-test and post-test scores of severity of anemia, clinical variables, and level of fatigue and level of satisfaction, bio chemical parameters (reticulocytes, MCV, haematocrite, serum iron, serum ferritin, TIBC) were assessed in both experimental and control group. Between the experimental and control group (unpaired‘t’ test) reticulocytes, mcv, heamatocrite, serum iron serum ferritin showed significant changes in the pre test and post-test but there is no changes in TIBC. The study concluded that alternative nutritional therapy was effective for enhancing the blood heamoglobin & biochemical paramteres level, decreased the clinical variables and fatigue level among the adolescent girls with iron deficiency anemia.


2021 ◽  
Vol 49 (1) ◽  
pp. 33-37
Author(s):  
Tahmina Akter ◽  
Qazi Shamima Akther ◽  
Saima Haque Lisa ◽  
Mst Ariza Sultana ◽  
Farhana Sultana ◽  
...  

Pregnancy is associated with several trace elements deficiency in developing countries. Supplementation of iron in iron deficiency anaemia (IDA) has several side effects including alterations of serum zinc level. Traditionally, amloki is used as a well known supplement in pregnancy, which is rich in trace elements.To determine the effects of iron and amloki on serum zinc level in IDA with pregnancy. The study was a non blind, non random sampling interventional type of clinical trial. This study was performed in the Department of Physiology, Dhaka Medical College, Dhaka on 43 pregnant women between 13th to 20th weeks of gestation with IDA from July 2016 to June 2017.  They were recruited from Outpatient Department of Obstetrics and Gynaecology of Dhaka Medical College Hospital. Anaemic pregnant women supplemented with oral iron and amloki were considered as study group (A) and control group (B) were with only iron supplementation for 45 days. Serum zinc level was estimated in the laboratory of the Department of Soil, Water and Environment, University of Dhaka, Bangladesh.  For statistical analysis, Paired Student’s‘t’ test and Unpaired Student’s‘t’ test were considered using SPSS 22.0 version. Significant decrease (p<0.001) of serum zinc level was observed after intervention of iron in both groups. In this study, there was no significant difference in serum zinc level in between study and control group. It can be concluded that oral iron supplementation causes decrease in serum zinc level in IDA with pregnancy. Amloki shows no significant role in preventing decrease of serum zinc level in this study.  Emblicaofficinalis (amloki) is traditionally used to treat iron deficiency anaemia. It can increase haemoglobin concentration and decrease side effects of iron supplementation. Bangladesh Med J. 2020 Jan; 49 (1): 33-37


2011 ◽  
Vol 108 (2) ◽  
pp. 357-362 ◽  
Author(s):  
Wei Xia ◽  
Xin Zhang ◽  
Jiajia Wang ◽  
Caihong Sun ◽  
Lijie Wu

In the present study, we investigated the prevalence of anaemia and Fe deficiency anaemia (IDA) and explored the relationship betweenHelicobacter pyloriinfection and IDA in adolescent girls. A total of 1037 adolescent girls from Suihua, China were enrolled. Hb, serum ferritin (SF), serum transferrin receptor (sTfR) and serum IgG antibodies toH. pyloriwere measured. Participants with IDA and co-existingH. pyloriinfection (n80) who had an intake of >25 mg/d of Fe were assigned randomly to the intervention and control groups. Patients in the intervention group were administered a 12-week course of oral EDTA–Na–Fe (60 mg Fe/dose, three times a week) and a 2-week course of colloidal bismuth subcitrate, amoxicillin and metronidazole. Subjects in the control group were administered EDTA–Na–Fe alone. Hb, SF and sTfR were reassessed 3 months after the 12-week regimen ended. Prevalence of anaemia, Fe deficiency (defined as SF < 12·0 μg/l), IDA andH. pyloriinfection in the population of 1037 was 19·5, 40·4, 17·1 and 31·2 %, respectively. The prevalence ofH. pyloriinfection in the IDA group was 46·9 %, while the non-anaemic group had 28·1 % prevalence. A significant increase in Hb and SF and a decrease in sTfR value were found in the intervention group and theH. pylori-negative group. Findings suggest that IDA is still one of the prominent problems in adolescent girls. There is an association betweenH. pyloriinfection and IDA. Treatment ofH. pyloriinfection is associated with a more rapid response to oral Fe therapy.


Author(s):  
Nurul Huda ◽  
Erwin Erwin ◽  
Eka Febriyanti

Cancer is a chronic disease with high morbidity and mortality rate in a year. One of therapy in curing cancer is chemotherapy. But unfortunately chemotherapy has some negative effects such as decreasing the level of hemoglobin (Hb). Mung bean that contain a lot of iron and Guava which is rich of vitamin C for iron absorption are useful in cancer patient with chemotherapy. Therefore, a mixture of both is believed in increasing hemoglobin level significantly. The purpose of this study was to determine the effectiveness of mixed juice mung bean and guava for increasing hemoglobin level in experiment and control group of cancer patient with chemotherapy.This research used Quasi Experiment design with pretest-posttest design control group approach. The total number of respondent was 30 chosen by purposive sampling method. Results of this study showed hemoglobin level in experiment group 14.07 and 10.42 in control group with p value (0,000) < α (0,05). It can be concluded that a mixture juice mung beans and guava effective for increasing hemoglobin level in cancer patient with chemotherapy. This research suggests that this mixture can be an option for nursing intervention in increasing hemoglobin level for cancer patient after receiving chemotherapy.


Author(s):  
Ahmat Pujianto ◽  
Titis Kurniawan ◽  
Helwiyah Ropi

One of the negative effects of the hospitalization process is low sleep quality. Low sleep quality in patients with ACS may increase stress, anxiety, and depression that potentially worsening patients’ chest pain. This study aimed to determine the effect of listening Surat Ar Rahman recital holy Qur’an on sleep quality in patients with ACS in the cardiac intensive unit. This study was quasi experiment with nonequivalent control group design. Thirty-six respondents were recruited purposively and divided into intervention (18 respondents) and control group (18 respondents) with matching in anxiety level. The intervention group received therapy listening Surat Ar Rahman recital holy Qur’an for 15 minutes before nocturnal sleep. Sleep quality measured using Richard Campbell Sleep Questionnaire (RCSQ) instrument. Collected data were analyzed using dependent and independent sample t test. The level of significance was set at p <0.05. Results showed significant different of sleep quality mean score, either before (61.38) and after intervention (66.06) (in the intervention group, p = 0.001) and the mean score of increasing sleep quality between intervention (5.76) and control group (0.68) (p = 0.001). Listening Surat Ar Rahman recital holy Qur’an can cause relaxing effect that can improve sleep quality. Intervention with listening of Surat Ar Rahman recital holy Qur’an significantly improves patients with ACS’s sleep quality. Therefore, it can be considered as one of the nursing interventions in improving sleep quality of patients with ACS. Keywords: sleep quality; Surat Ar Rahman recital holy Qur’an; ACS ABSTRAK Salah satu dampak negatif dari proses hospitalisasi pada pasien adalah kualitas tidur yang rendah. Kualitas tidur yang rendah pada pasien SKA dapat meningkatkan stress, kecemasan, dan depresi yang lebih lanjut bisa memperberat gejala nyeri dada yang dirasakan pasien. Melihat kondisi tersebut, perlu dilakukan penelitian lebih lanjut untuk menemukan upaya pemenuhan kebutuhan tidur pada pasien SKA yang lebih efektif. Penelitian ini bertujuan untuk melihat perbedaan kualitas tidur pada pasien SKA di ruang rawat intensif jantung setelah mendengarkan murattal Al-Qur’an Surat Ar Rahman. Penelitian ini merupakan penelitian quasi experiment dengan nonequivalent control group design. Sebanyak 36 responden diambil dengan purposive sampling yang kemudian dibagi menjadi kelompok intervensi dan kontrol masing-masing 18 responden. Kelompok intervensi diberikan intervensi mendengarkan murattal Al-Qur’an Surat Ar Rahman selama 15 menit menjelang tidur malam. Kualitas tidur diukur menggunakan instrumen Richard Campbell Sleep Questionnaire (RCSQ). Data dianalisis menggunakan independent dan dependent sample t test. Tingkat signifikansi yang digunakan p < 0.05. Hasil menunjukkan adanya perbedaan yang bermakna rerata skor kualitas tidur pada kelompok intervensi antara sebelum (61,38) dan setelah pemberian intervensi (66,06) (p = 0,001), maupun pada rerata peningkatan kualitas tidur antara kelompok intervensi (5,76) dan kontrol (0,68) (p = 0,001). Intervensi mendengarkan murattal Al Qur’an Surat Ar Rahman dapat menimbulkan efek relaksasi sehingga dapat meningkatkan kualitas tidur. Intervensi mendengarkan murattal Al-Qur’an Surat Ar Rahman berpengaruh secara signifikan terhadap peningkatan kualitas tidur pasien dengan SKA, sehingga dapat dipertimbangkan sebagai salah satu intervensi keperawatan dalam usaha meningkatkan kualitas tidur pada pasien SKA. Kata kunci: kualitas tidur; murattal Surat Ar Rahman; SKA


2021 ◽  
Vol 9 (2) ◽  
pp. 110
Author(s):  
Frisca Angreni ◽  
DESWATY FURQONITA ◽  
AHMAD JUSUF

Ibu hamil yang terpapar bising akan memengaruhi janin yang dikandungnya bahkan memiliki efek negatif terhadap neurogenesis. Suara dari gelombang ritmis (musik) dapat meningkatkan neurogenesis yang berpengaruh langsung terhadap fungsi memori. Penelitian ini bertujuan untuk mengetahui efek positif gelombang ritmis untuk meredam atau menjadi terapi bagi bagian otak yang sebelumnya mendapat efek negatif gelombang monoton, dilihat dari peningkatan ekspresi densitas optik protein postsynapticdensity-95 dan waktu uji labirin T. Penelitian eksperimental ini dilakukan di laboratorium Developmental Biologi dan Patologi Anatomik Fakultas Kedokteran Universitas Indonesia pada bulan September 2018. Penelitian menggunakan 24 telur ayam yang difertilisasi dan dibagi empat kelompok: kelompok suara ritmis, monoton, gabungan (kombinasi suara monoton dan ritmis), dan kontrol. Telur yang sudah difertilisasi diinkubasi selama 21 hari dan dimiringkan secara otomatis tiap 4 jam. Dilakukan proses candling hari ke-3, ke-5, ke-10 dan ke-15 untuk menilai perkembangan embrio ayam. Hasil penelitian ini, terdapat perbedaan bermakna densitas optik protein postsynapticdensity 95 dan waktu uji labirin T antara kelompok gabungan dengan kelompok ritmis dan monoton, namun tidak terjadi perbedaan bermakna dengan kelompok kontrol. Gelombang ritmis dapat mengurangi efek buruk gelombang monoton dan mengembalikannya menjadi sama dengan normal (kelompok kontrol). Kata kunci: ritmis, monoton, kombinasi suara, memori, postsynapticdensity-95.   Effect of Auditory Exposure combination of Monotonous and Rhythmic Waves on Postsynapticdensity-95 Expression on Neonatal Hippocampus Abstract Pregnant women who are exposed to noise will affect the fetus they contain and even have a negative effect on neurogenesis. Sound from rhythmic waves (music) can increase neurogenesis which directly affects memory function. This study aims to determine the positive effect of rhythmic waves to dampen or become therapy for parts of the brain that previously received the negative effects of monotonous waves, seen from the increase in the expression of the optical density of the postsynapticdensity-95 protein and the labyrint T test time. This experimental study was conducted in the Developmental Biology laboratory and Anatomic Pathology, Faculty of Medicine, University of Indonesia in September 2018. The study used 24 fertilized chicken eggs and divided into four groups: rhythmic, monotonous, combined (a combination of monotonous and rhythmic sounds), and control. Fertilized eggs are incubated for 21 days and automatically tilted every 4 hours. The candling process was carried out on the 3rd, 5th, 10th and 15th days to assess the development of chicken embryos. The results of this study, there was a significant difference in the optical density of the postsynaptic density protein 95 and the time of the T labyrint test between the combined group and the rhythmic and monotonous group, but there was no significant difference with the control group. Rhythmic waves can reduce the bad effects of monotonous waves and return them to normal (control group). Keywords: rhythmic, monotone, sound combination, memory, postsynaptic density-95.


2017 ◽  
Vol 6 (1) ◽  
Author(s):  
Omer Awad ◽  
Abdel Malek ◽  
Julius Ogeng’o

Iron deficiency anaemia causes adverse pregnancy outcome. Studies reveal its generalized effects on histomorphometry of the placenta, without details on specific zones nor effect of gestational age. These data are important for planning  intervention. This study was, therefore, designed to describe the histomorphometric changes associated with iron deficiency anaemia on placenta of albino rat. Fourty nine (49) Sprague – Dawely albino rats were randomly separated into experimental and control groups. The  experimental group was rendered anaemic by removing 1.5 ml of blood per bleed on five alternate days. Placentas were collected on gestational days 17, 19 and 21. Five cubic milimetre segments were fixed in 10 % buffered formaldehyde solution; dehydrated in ethanol and embedded in paraffin wax. Five micron thick sections were cut, deparaffinized and stained with Hematoxylin and Eosin. Micrographs were taken using Leica ICC 50 digital photomicrographic camera attached to a computer at magnification x40 and the thickness of the labyrinth and junctional zones measured. Student t- test was used to compare values for the   experimental and control groups. The labyrinth in the chronic anaemia group was thinner than in the control group at gestational days 17, 19 and 21. The junctional zone, on the other hand, was consistently thicker in anaemic than in the control animals. The difference in thickness of junctional zone varied with  gestational age. At gestational day 17, the zone was significantly thicker in the anaemic group (628.9 μ) than in the control (381 μ). On day 19 and 21, however, the difference was not statistically  significant. In conclusion, the effects of chronic iron deficiency anaemia on the labyrinth differ from those on the junctional zone of the placenta. This differential effect appears to depend on the function and gestational age. The decrease in thickness of the  labyrinth may be designed to maintain placental diffusion capacity while increased thickness of the junctional zone constitutes a compensatory physical and nutritional adaptation to hypoxia.Key words: placenta, labyrinthine, junctional zones, thickness, anaemia.


1994 ◽  
Vol 59 (1) ◽  
pp. 131-139 ◽  
Author(s):  
M. J. C. Hessing ◽  
M. J. M. Tielen

AbstractTwo similar style experiments were carried out in a climate-controlled pig house to determine the effects of adverse climatic conditions and relocating and mixing on the health status and productivity of pigs. In both experiments, 120 pigs were used. The climate-controlled pig house consisted of two fully separated but identical rooms (experimental and control) with five pens each (12 pigs per pen). Pigs exposed to draught and low environmental temperature had lower daily gain (experiment 1: 45 g/day; experiment 2: 25 g/day) and higher food conversion (food: gain ratio) than pigs housed under optimal climatic conditions (control). Moreover, clinical disease signs (i.e. diarrhoea, coughing, sneezing and haemorrhagic ear lesions) were more pronounced in the experimental than in the control group. In experiment 1, pigs were relocated and mixed at 10 weeks of age either within or between the experimental and control room. Data showed clear negative effects on daily gain and clinical disease signs especially among pigs that were relocated to suboptimal climatic conditions. In experiment 2, pigs were either relocated and mixed between both rooms or they remained in their own pens. Data on daily gain and clinical disease signs revealed that the health of the pigs was strongly affected by mixing. Therefore, the present work emphasizes the importance of climatic environment and social factors in intensive pig production.


The advent of filmmaking provided a means for affective communication, whereby what was real and what was filmed became conflated, helping to create tourism imaginaries that, in turn, drove tourism. However, increased tourism created negative impacts, especially for charismatic subjects like whales that elicit strong emotional responses of connectedness in viewers. In the whale watching industry, getting too close to whales to satisfy visitor expectations has a major detrimental impact. Here, we test whether the very characteristics of film that have helped create the problem, might be used to fix the problem by re-creating tourism imaginaries and changing visitor expectations. We produced a video about sustainable whale watching using a formula designed specifically to enhance its affective and emotional qualities. Survey respondents were randomly assigned to Test and Control Groups, and shown the video either before or after recording their likelihood of going whale watching in the future. Those in both groups that were “Likely” or “Very Likely” to go whale watching, identified affective qualities of the video nearly identically. Elements of the video associated with affective communication (imagery of whales in their natural environment and authentic reactions of tourists seeing whales) were most liked equally by Test and Control Group subjects. However, significantly less of the Test Group found the imagery of close encounters between whales and humans to be their favorite aspect of the video, while significantly more of them noted that the clarity of the message or the way it was told (editing) were their most liked aspects. In sum, the affective features of filmmaking that influence tourism imaginaries, also offer the potential to thwart the negative effects of tourism by invoking changes in attitudinal and behavioral intentions that should lead to more sustainable tourism practices.


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