On Some Experiments in the Graduation of Mortality Statistics

1932 ◽  
Vol 63 (1) ◽  
pp. 12-57 ◽  
Author(s):  
Wilfred Perks

In these days of continuous change in mortality, with the necessity of forecasting in many of our operations, a paper concerned with the graduation of mortality statistics may appear to be academic, the more so if attention is restricted to the fitting of mathematical curves, with or without any attempt to advance that elusive and, as some think, delusive conception, the law of mortality. Nevertheless, it is felt that if progress is to be made in any branch of science, theoretical research and experiment are essential, as also is the publication of the results, unless the work is completely abortive. It has become the fashion to speak of graduation as though its function were restricted to the provision of a practical instrument for monetary calculations; as Todhunter is reputed to have said, the tabulated values of lx are merely successive terms in a commutation column. Notwithstanding this, most of us retain, consciously or unconsciously, a feeling that, underlying all the roughnesses in our data referable to errors of observation and an ever-changing environment, there may be an inherent mathematical system of law and order, which if it could but be discovered would give such insight into the meaning of the unadjusted figures that a considerable advance would be made in the practical application of our science.

CounterText ◽  
2016 ◽  
Vol 2 (2) ◽  
pp. 217-235
Author(s):  
Gordon Calleja

This paper gives an insight into the design process of a game adaptation of Joy Division's Love Will Tear Us Apart (1980). It outlines the challenges faced in attempting to reconcile the diverging qualities of lyrical poetry and digital games. In so doing, the paper examines the design decisions made in every segment of the game with a particular focus on the tension between the core concerns of the lyrical work being adapted and established tenets of game design.


2009 ◽  
Vol 2009 ◽  
pp. 1-12 ◽  
Author(s):  
Rolf K. Eckhoff

Right from the early days of the process industries, continuous efforts have been made to develop and improve measures for prevention and mitigation of dust explosions in these industries. Nevertheless this hazard continues to threaten industries that manufacture, use and/or handle powders and dusts of a wide range of combustible materials. To improve methods for predicting explosion development in real industrial plant has been one major challenge. Hence, during the last years comprehensive numerical simulation codes, for addressing this problem, have been developed. Progress has also been made in other areas, for example, ignition source prevention. The importance of adopting inherently safer process design, by building on firm knowledge in powder science and technology, and of systematic education/training of personnel, is also emphasized.


2013 ◽  
Vol 394 (1) ◽  
pp. 89-95 ◽  
Author(s):  
Mamta Jaiswal ◽  
Eyad Kalawy Fansa ◽  
Radovan Dvorsky ◽  
Mohammad Reza Ahmadian

Abstract Major advances have been made in understanding the structure, function and regulation of the small GTP-binding proteins of the Rho family and their involvement in multiple cellular process and disorders. However, intrinsic nucleotide exchange and hydrolysis reactions, which are known to be fundamental to Rho family proteins, have been partially investigated in the case of RhoA, Rac1 and Cdc42, but for others not at all. Here we present a comprehensive and quantitative analysis of the molecular switch functions of 15 members of the Rho family that enabled us to propose an active GTP-bound state for the rather uncharacterized isoforms RhoD and Rif under equilibrium and quiescent conditions.


1995 ◽  
Vol 347 (1319) ◽  
pp. 21-25 ◽  

Over the past three or four years, great strides have been made in our understanding of the proteins involved in recombination and the mechanisms by which recombinant molecules are formed. This review summarizes our current understanding of the process by focusing on recent studies of proteins involved in the later steps of recombination in bacteria. In particular, biochemical investigation of the in vitro properties of the E. coli RuvA, RuvB and RuvC proteins have provided our first insight into the novel molecular mechanisms by which Holliday junctions are moved along DNA and then resolved by endonucleolytic cleavage.


The freeze-etching technique must be improved if structures at the molecular size level are to be seen. The limitations of the technique are discussed here together with the progress made in alleviating them. The vitrification of living specimens is limited by the fact that very high freezing rates are needed. The critical freezing rate can be lowered on the one hand by the introduction of antifreeze agents, on the other hand by the application of high hydrostatic pressure. The fracture process may cause structural distortions in the fracture face of the frozen specimen. The ‘double-replica’ method allows one to evaluate such artefacts and provides an insight into the way that membranes split. During etching there exists the danger of contaminating the fracture faces with condensable gases. Because of specimen temperatures below —110 °C, special care has to be taken in eliminating water vapour from the high vacuum. An improvement in coating freeze-etched specimens has resulted from the application of electron guns for evaporation of the highest melting-point metals. If heat transfer from gun to specimen is reduced to a minimum, Pt, Ir, Ta, W and C can be used for shadow casting. Best results are obtained with Pt-C and Ta-W . With the help of decoration effects Pt-C shadow castings give the most information about the fine structural details of the specimen.


2012 ◽  
Vol 94 (888) ◽  
pp. 1455-1479 ◽  
Author(s):  
Olivier Dubois ◽  
Katharine Marshall ◽  
Siobhan Sparkes McNamara

AbstractThe field of humanitarian action is far from static, and the ICRC has worked over the years to evolve and respond to changing needs and changing circumstances. The past several decades have seen a proliferation of humanitarian actors, protracted, complex conflicts, and the rapid rise of new technologies that have significantly impacted how humanitarian work is done. The ICRC has been continually challenged to adapt in this changing environment, and its core work of supporting separated families – through restoration of family links and through support to the families of the missing – provides insight into ways that it has met this challenge and areas in which it may still seek to improve.


2018 ◽  
Vol 39 (2) ◽  
pp. 151-158 ◽  
Author(s):  
Kali S. Thomas ◽  
Emily A. Gadbois ◽  
Renee R. Shield ◽  
Ucheoma Akobundu ◽  
Andrea M. Morris ◽  
...  

Background and Objectives: Meals on Wheels (MOW) programs provide home-delivered meals to over 1.5 million older adults; yet, very little is known about the drivers who make meal deliveries possible. Specifically, we do not have clear insight into their interaction with clients or the benefits that they may receive through their service. The objective of this article is to describe the characteristics of MOW drivers, the interactions among drivers and clients, and the benefits of the program to both. Research Design and Method: This qualitative research study reports on interviews with 84 MOW staff (leadership, case managers/client assessors, volunteer coordinators) and drivers at six geographically and operationally distinct programs across the United States. Results: Qualitative analysis of the interviews with MOW staff and drivers revealed the following key themes: (a) clients have multiple vulnerabilities; (b) clients appear to derive social, as well as nutritional benefit from receiving meals; (c) drivers report they provide additional support to their clients beyond delivering the meal; (d) social bonds between drivers and clients were reported to strengthen over time; (e) drivers claim that they, too, derive validation and personal benefit through their meal delivery. Discussion and Implications: This research highlights the significant contributions that meal delivery drivers made in the lives of MOW clients beyond the actual meal itself. This research also spotlights the perceived benefits experienced by the drivers and points to the importance of conducting further research to determine the effects of meal delivery on client and drivers’ outcomes, more broadly.


2020 ◽  
Vol 17 (1) ◽  
pp. 38-52
Author(s):  
Aníbal Areia ◽  
Francisco Esteves ◽  
João Rocha Santos ◽  
Pedro Anunciação

AbstractResearch purpose. To get a validation of the structure, pillars and components that seem to be central, and under which, business management and managers need to develop abilities and competences to ensure the sustainability of their organizations according to the ‘DPOBE Model for Organizational Sustainability’ structure.Design/Methodology/Approach. For the validation of the structure, pillars and components and it’s practical application to measure the organization’s sustainability level with the referred model, despite the focus group exercise made in an early stage, it’s also important to get a solid opinion about it among managers and also in academia, specifically among teachers and investigators on management, business administration and economics as well near master and doctorate students in this field. In this paper, we analyse the results obtained in an exploratory study, based on a survey made among students from four different master’s degree in several specific areas of business management from the School of Business Administration from the Polytechnic Institute of Setúbal (Portugal).Findings. Main results obtained with this exploratory study let the authors be granted with the developments made so far in the model and its structure, pillars and components. However, only with a major collection of opinions (answer to the survey) from the referred groups, it’s possible to define and adjust the final structure and components of the DPOBE Model.Originality/Value/Practical implications. Being an investigation with several years of development, with several articles, chapters of books, master’s degree thesis, congress presentations and papers made so far, only with a solid and validated structure, pillars and components of the DPOBE Model for Organizational Sustainability, it’s possible to go to its aim, the use of it as a quantitative tool to measure the effective organizations sustainability in a way different from other existing sustainability tools and indexes.


2020 ◽  
Vol 240 ◽  
pp. 07011
Author(s):  
Kushagra Shrivastava ◽  
Keith Wen Kai Chia ◽  
Kang Jun Wong ◽  
Alfred Yong Liang Tan ◽  
Hwee Tiang Ning

Solar activity research provides insight into the Sun’s past, future (Science Daily, 2018). The solar activity includes observations of large numbers of intense sunspots, flares, and other phenomena; and demands a wide range of techniques and measurements on the observations. This research needs long term data collection before critical analyses can occur, to generate meaningful learning and knowledge. In this project, we will use solar imaging to make observations of solar activity, and take our baby steps to make contributions in citizen science. Observations will be made in 3 wavelengths to gain a more thorough analysis by looking at different perspectives of the Sun, namely H-Alpha, Calcium-K, and white light.


2021 ◽  
Vol 11 (22) ◽  
pp. 305-315
Author(s):  
Krisztina Scheffer ◽  
Enikő Szvák ◽  
Hedvig Győry

The HNM Semmelweis Museum of Medical History's exhibition „Diseases for the Ages, What the Deceased Tell Us”, is displaying the anthropological collection of the Museum which never was presented earlier, and the mummy-research made in the framework of the Nephthys Project, with some additional material from the Hungarian Natural History Museum and the Hopp Ferenc Asian Art Museum. Visitors can learn about the appearance of known and little-known diseases visible on archaeological human remains and gain insight into the know-how and the results of the mummy research. The exhibition is accompanied by a museum educational program and a series of lectures.


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