The effect of dietary addition of a polysaccharide from Atractylodes macrophala Koidz on growth performance, immunoglobulin concentration and IL-1β expression in weaned piglets

2009 ◽  
Vol 147 (5) ◽  
pp. 625-631 ◽  
Author(s):  
L. L. LI ◽  
X. WU ◽  
H. Z. PENG ◽  
M. Z. FAN ◽  
Z. P. HOU ◽  
...  

SUMMARYThe present study was conducted to determine the effects of a polysaccharide of Atractylodes macrophala Koidz (PAM) as a dietary additive on growth performance, immunoglobulin concentration and IL-1β expression in weaned piglets. One hundred and twenty Landrace×Yorkshire piglets weaned at 28 days old (body weight 7·5±0·07 kg) were assigned to five treatment groups (three pens/group, eight piglets/pen) fed maize/soybean-based diets supplemented with 0, 3, 6 or 9 g of PAM/kg diet or antibiotics (0·4 g flavomycin/kg+0·13 g olaquindox/kg). The experimental period was 28 days. With increasing PAM supplementation levels, average daily gain was greater (quadratic, P<0·05) and the ratio of amount fed to live weight (LW) gain (feed/gain) improved (quadratic, P<0·05) during days 14–28 and overall, and diarrhoea incidence decreased (linear, P<0·05) during days 14–28. Supplementation of PAM also increased (quadratic, P<0·05) serum concentrations of interleukin (IL)-2 and IL-6 on day 14, and increased (quadratic, P<0·05) IL-1β expression in jejunal mucosa and lymph nodes. Concentrations of PAM between 6 and 9 g/kg presented the strongest bioactivity compared to the control group or antibiotic-fed group. These findings indicate that PAM is effective in improving growth performance and cytokine response, which suggests that PAM can be used as a diet additive for weanling piglets.

2020 ◽  
Vol 33 (5) ◽  
pp. 802-811 ◽  
Author(s):  
Wenwei Zhang ◽  
Holden He ◽  
Limin Gong ◽  
Wenqing Lai ◽  
Bing Dong ◽  
...  

Objective: Two experiments were conducted to investigate the effects of dietary sucralose on diet preference and growth performance of weaned piglets, and a third experiment was a 28-d safety study to examine if high-dose sucralose could affect the health state of weaned piglets.Methods: In experiment one, 48 piglets had free access to a corn-soybean based diet and the same diet supplemented with 150 mg/kg sucralose for 15 d. In experiment two, 180 piglets were blocked into 5 treatments with 6 replications. They were fed basal diets supplemented with 0, 75, 150, 225, and 300 mg/kg sucralose for 28 days. In experiment three, 108 piglets were randomly assigned to 3 treatments and fed diets supplemented with 0, 150 (suitable level), and 1,500 (ten-fold suitable level) mg/kg sucralose for 28 d.Results: The experiment 1 showed that piglets preferred (p<0.05) diets containing sucralose during experimental period. In experiment 2, piglets fed a diet supplemented with 150 mg/kg sucralose had a higher average daily gain (ADG) and average daily feed intake (ADFI) than pigs in the control group and other treatment groups during the experiment period. The concentrations of sucralose over 150 mg/kg may decrease feed intake. However, no difference in feed conversion ratio was observed. In experiment 3, piglets fed diet supplemented with 150 mg/kg sucralose had a higher ADG and ADFI than that of pigs in the control group and 1,500 mg/kg treatment groups during the experiment period. Clinical blood metabolites, organ index and histological morphology were not significantly different between sucralose treatments.Conclusion: Sucralose can promote feed intake and thereby improve growth performance of weaned piglets. Moreover, inclusion of 1,500 mg/kg sucralose was demonstrated to have no observed adverse effects. Supplementing 150 mg/kg sucralose for weaned piglets is recommended in this study.


2022 ◽  
Vol 18 (1) ◽  
Author(s):  
Min-Jin Kwak ◽  
Sun-Woo Choi ◽  
Yong-Soon Choi ◽  
Hanbae Lee ◽  
Kwang-Youn Whang

Abstract Background In animals, weaning stress is the first and most critical stress. Weaning can negatively affect the growth performance of animals physically, psychologically, and pathologically. Our previous studies on the HT-29 cell line and early-weaned rats demonstrated that adequate sophorolipid (SPL) supplementation in feed could enhance the mucin-producing and wound healing capacities of the gut defense system by modulating gut microbiota. Methods We conducted an experiment with one hundred forty 21-day-old early weaned piglets (L x Y x D). They were allocated into 4 treatment and 7 replications (4 pigs per pen) according to their initial body weight. Body weight and feed intake were measured biweekly during experimental period. After 6 weeks, 28 pigs were randomly selected and sacrificed to collect plasma, jejunum, and cecal content samples. Results Dietary SPL supplementation at 5 and 10 mg/kg quadratically increased the average daily gain during the experimental period in the treatment groups when compared with the control group. The albumin levels of piglets fed with the SPL supplemented diet were downregulated to the normal range. Moreover, in feed, SPL supplementation at 5 and 10 mg/kg improved jejunal histological indices and gene expression levels related to mucin secretion and local inflammation markers. Consistent with these results, adequate SPL supplementation (5 and 10 mg/kg) increased the population of Prevotella, a beneficial bacterium, and its short-chain fatty acid production in the ceca of piglets. Conclusions The occurrence of diarrhea after weaning in piglets could be reduced by feeding a 10 ppm of SPL supplemented diet which improves the gut defense system by improving the microbial population and enhancing mucin layer integrity.


Animals ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1284
Author(s):  
Angela M. Craig ◽  
Melanie L. Graham

This experiment was conducted to investigate the effects of common commercially available dietary supplementation in the peri-weaning period on feed intake, growth, and survival in C57Bl/6J mouse pups and lactating dams. A total of 96 pups and their dams were randomized to the control group or one of three nutritional supplement treatment groups: (i) control group without supplementation, or (ii) weanling-targeted Clear H2O gel (Gel), (iii) transgenic-targeted Bio-Serv dough (Dough), or (iv) dam diet as a mash (Chow), in the peri-weaning period (from 11 to 28 days). Stool was observed daily for a dye marker indicating supplement consumption. Pups were weaned at 21 days and followed for a total of 42 days. No pup morbidity or mortality was observed. There was a higher proportion of pups consuming dough and gel earlier than chow (p = 0.0091). The majority of treated pups (>95%) were consuming the supplement by day 23 (range 15–23), suggesting interplay between organoleptic properties of the supplement and pup maturity. All groups gained weight, with typical sexual dimorphism observed in the growth curves. Dough treatment led to significantly higher average daily gain in male pups (0.64 ± 0.03 g/d) as compared with controls (0.58 ± 0.03 g/d). The highest average daily gain in all groups was observed pre-weaning between days 21 and 28. Compared with controls, the weight gain slope was significantly higher in the Dough and Chow treatment groups and lower in Gel treatment groups, with a more pronounced effect in males. In this study, the composition of nutritional supplementation was the dominant factor in increasing the growth trend as opposed to energy density. Peri-weaning supplementation with Dough and Chow treatments improved pre- and post-growth performance in a comparable way and was more effective than Gel treatment during adaptation to solid feeding. Proper application of supplements to support weanlings can directly improve welfare and limit unintended experimental variability.


2011 ◽  
Vol 51 (No. 10) ◽  
pp. 444-448 ◽  
Author(s):  
Zou XT ◽  
Zheng GH ◽  
Fang XJ ◽  
Jiang JF

An experiment was conducted to investigate the effects of glutamine on growth performance of weanling piglets. Sixty piglets weaned at 21 days of age were randomly assigned to two groups (10 piglets per pen, 3 pens per group). The control group received a maize-soybean meal-based diet. The treatment group received a maize-soybean meal-based diet supplemented with 1.0% free l-glutamine. Piglets were fed the diets for 20 days. Results showed that piglets fed the glutamine diet had lower diarrhoea ratio and shorter diarrhoea duration than those fed the control diet during 20 days after weaning. During the first ten days after weaning, pigs supplemented with glutamine had a 12.05% lower feed:gain ratio than those fed the control diet (P &lt; 0.05). During the second ten days after weaning, they had a 27.75% higher average daily gain than those fed the control diet (P &lt; 0.05); there were no differences in the feed:gain ratio and average daily feed intake. During the first ten days after weaning, the serum urea nitrogen of pigs supplemented with glutamine was reduced by 17.36% (P &gt; 0.05) compared to the control. During the second ten days after weaning, serum urea nitrogen was reduced by 4.27% and serum concentrations of total protein increased by 18.70% in pigs supplemented with glutamine compared to the control (P &gt; 0.05). There were no differences in albumin, T<sub>3,</sub> T<sub>4</sub> and growth hormone. &nbsp;


Animals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 2030
Author(s):  
Anna Szuba-Trznadel ◽  
Anna Rząsa ◽  
Tomasz Hikawczuk ◽  
Bogusław Fuchs

The aim of this study was to evaluate the effect of zinc (Zn) supplementation in different commercial forms on the growth performance, health status, and Zn balance of weaners in field conditions. The animals were fed pre-starter (from the 28th to 47th day of life) and starter (from the 48th to 74th day of life) mixtures differing in Zn form and concentration. Group I was given ZnSO4 at 150 mg kg−1; Group II received pre-starter zinc oxide (ZnO) at 3000 mg kg−1 and starter at 150 mg kg−1; and Group III was given 150 mg kg−1 of zinc oxide nanoparticles (nZnO). We found that the average daily gain in Group I was significantly lower, compared to Groups II and III. A commonly accepted level of Zn (150 mg kg−1) as nZnO can be recommended, instead of therapeutic doses of Zn preparations with the same efficiency. Moreover, a lower level of Zn in the diet can prevent the excessive accumulation of this element in waste and, thus, reduce environmental damage.


Author(s):  
L. A. Nikanova ◽  

The influence of feed additive "Ormik" consisting of organic acids (formic acid, lactic acid, orthophosphoric acid, acetic acid), as a filler of diatomite crumb, introduced into concentrated fodders, on the biochemical parameters of blood serum of pigs and on productivity is considered in the article. The studied feed additive was added to the feed daily in the form of loose powder, mixing thoroughly. The initial dosage of the feed additive in the 1st week was 1 g/kg of feed, 2nd week and the following – 3 g/kg of feed. The average daily gain in the live weight of pigs in the experimental group was 11,0% higher than the control group. The animals of the experimental group were less sick and the safety of this group was 100%, in the control group it was 90%.


2020 ◽  
Vol 23 (1) ◽  
pp. 44-54
Author(s):  
Nadezhda Palova ◽  
Jivko Nakev ◽  
Teodora Popova ◽  
Maya Ignatova

Abstract(An experiment with two groups of East Balkan pigs – castrated males (n=10) and females (n=10), was carried out to study the growth performance and fattening abilities of the animals from the weaning until slaughter. The pigs were included in the trial at 60 day age. The average live weight of the castrated males was 8. 65±1.08 kg and for the females, 8.5±0.62 kg.The pigs were reared using traditional technology, grazing on natural pastures in the Strandzha mountain, Bulgaria. In autumn, acorns were naturally present in their diet. According to the category, the animals additionally received ground organic feed (50% barley and 50% wheat). The trial lasted 304 days (from February to November, 2019). During this period the final live weight of the male castrated pigs reached 88.00 kg while that of the females was 84.4 kg. The difference, however, was not significant. Furthermore, no significant differences in the growth performance characteristics that could be attributed to the sex of the animals were observed. The average daily gain of both sexes tended to be lower in summer and higher in autumn. The feed conversion ratio was higher in summer. The animals showed high average daily weight gain at pasture when their live weight was over 50 kg.


Author(s):  
M. Sychov ◽  
H. Pryumak

The effect of using different levels guanidinoacetic acid in compound feeds on the growth of young quails meat direction of productivity. It is proved that adding to the basic diet of different levels guanidinoacetic acid (0.06, 0.12, 0.18 %) increases live weight of quails on 3.9 – 13.5 g and improves the absolute, average daily and relative gains compared to a bird in the control group, which were fed the main diet. The data show that at the age of 42 days of live weight was the highest in the diet of quail which was administered 0.12% GAA and dominant control of 13.5 g However, in 21 days live weight of quail fed 0.06 and 0.12 % guanidinoacetic acid was greater than control respectively 9.2 and 7.6 grams (P < 0.01). In absolute increments quail, fed GAA prevailed bird control group. The largest absolute increase was in birds that consumed the main diet of GAA level of 0.12% and prevailed controls 6.5 g (P < 0.001). A similar situation was of average daily gain. Young animals that received feed containing 0.12% guanidinoacetic acid had the highest average growth, which exceeded 0.9 g (15.5%) bird control group. As for the relative performance increases here were different. The lowest relative growth observed in birds which were administered GAA 0.06%, it lagged behind the controls 0.1 g in the same period quail treated with 0.12 and 0, 18% guanidinoacetic acid superior control respectively 2 and 1.1 g.


2011 ◽  
Vol 106 (5) ◽  
pp. 688-699 ◽  
Author(s):  
S. G. Leonard ◽  
T. Sweeney ◽  
B. Bahar ◽  
B. P. Lynch ◽  
J. V. O'Doherty

The present study investigated the effects of dietary supplementation of a seaweed extract (SWE) to sows and weaned pigs on post-weaning growth performance, intestinal morphology, intestinal microflora, volatile fatty acid concentrations and immune status of pigs at days 11 and 117 post-weaning. Gestating sows (n20) were supplemented with a SWE (0v.10·0 g/d) from day 107 of gestation until weaning (day 26). At weaning, pigs (four pigs per sow) were divided into two groups based on sow diet during lactation and supplemented with a SWE (0v.2·8 g/kg diet), resulting in four treatment groups: (1) BB (basal sows–basal pigs); (2) BS (basal sows–treated pigs); (3) SB (treated sows–basal pigs); (4) SS (treated sows–treated pigs). Pigs weaned from SWE-supplemented sows had a higher average daily gain (ADG) between days 0 and 21 (P < 0·05) post-weaning compared with pigs weaned from non-SWE-supplemented sows. Pigs offered post-weaning diets (PW) containing SWE had decreased colonicEscherichia colipopulations on day 11 (P < 0·01) and decreased colonic Enterobacteriaceae numbers on day 117 (P < 0·05). Pigs offered PW containing SWE had a greater mRNA abundance ofMUC2in the colon at day 11 post-weaning (P < 0·05) compared with pigs offered unsupplemented diets. In conclusion, these results demonstrate that SWE supplementation post-weaning provides a dietary means to improve gut health and to enhance growth performance in starter pigs. Dietary SWE supplementation increased ADG during the grower–finisher (GF) phases. However, there was no growth response to SWE inclusion in GF diets when pigs were weaned from SWE-supplemented sows.


Author(s):  
Ramesh Kumar ◽  
Sanjay Kumar ◽  
Jyoti Palod ◽  
Himani Tewari ◽  
Balwan Singh

The aim of the present study was to determine the effect of chedu and mattha on growth performance of Murrah buffalo calves. To assess the effect of chedu and mattha on growth rate, 20 growing buffalo calves of around 1 year of age and approximately of same weights were selected and were divided into 4 treatment groups having 5 animals in each group. The animals had access to ad libitum berseem hay as the basal roughage T0 (Control), T1 (Administration of mattha @ 2% of body weight with salt @ 0.5% of mattha), T2 (Application of chedu on their body @ 150 g per animal), T3 (Administration of mattha and application of chedu). Body weight of all buffalo calves was recorded at 15 days interval during the experimental period. From 75th day of experiment, significant effect (P<0.05) was observed in body weight, heart girth and height at withers of treatment groups as compared to control group whereas, body length and paunch girth showed significant effect (P<0.05) on 90th day of experiment. The results further indicated that use of chedu and mattha improved the health status of the calves and helped to attain a comparatively higher body weight and an early puberty. It can be concluded on the basis of findings of present research work that the use of chedu and mattha may be recommended for supplementation of calves’ diet, as it improves the health status of the calves and helps in the attainment of higher body weight and an early onset of puberty in the calves.


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