Routine Limulus amoebocyte lysate (LAL) test for endotoxin determination in milk using a Toxinometer ET-201

1993 ◽  
Vol 60 (2) ◽  
pp. 223-228 ◽  
Author(s):  
Jozef Mottar ◽  
Jan De Block ◽  
Martine Merchiers ◽  
Kristien Vantomme ◽  
Renaat Moermans
Keyword(s):  
Raw Materials ◽  
Raw Material ◽  
Plate Count ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Uht Milk ◽  
Limulus Amoebocyte Lysate ◽  
Endotoxin Content ◽  
Initial Transmission

SummaryA rapid method of performing the Limulus amoebocyte lysate (LAL) test in milk is proposed using the Toxinometer ET-201. This instrument measured the increase in turbidity due to the interaction between the endotoxins of the Gram-negative bacteria and the LAL reagent, monitored the ratio Rt of the sequential to the initial transmission at 12 s intervais and quantified endotoxins by determination of the reaction time Tr required to obtain a 5% decrease in Rt. There was a good correlation between the toxinometrically determined endotoxin concentrations and the number of Gram-negative bacteria (SD, 0·18 log(plate count units)), and the repeatability (CV, 6·10%) was high. The assay may be useful for screening raw materials for UHT milk production, as the endotoxin content of the raw material is related to the rest proteinase activity in the UHT milk.

Liquid Chromatographic Determination of Amiodarone Hydrochloride and Related Compounds in Raw Materials and Tablets

1994 ◽  
Vol 77 (6) ◽  
pp. 1447-1453 ◽  
Author(s):  
Pauline M Lacrok ◽  
Norman M Curran ◽  
Wing-Wah Sy ◽  
Dennis K J Goreck ◽  
Pierre Thibault ◽  
...  
Keyword(s):  
Raw Materials ◽  
Chromatographic Determination ◽  
Raw Material ◽  
Liquid Chromatographic Method ◽  
Limit Of Quantitation ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic ◽  
Amiodarone Hydrochloride ◽  
Related Compounds

Abstract A liquid chromatographic method for the determination of amiodarone hydrochloride and 10 related compounds in drug raw material and for assay of drug in tablets was developed. The method specifies a 3 jxm Hypersil nitrile column (150 × 4.6 mm), a mobile phase of 1 + 1 acetonitrile–ammonium acetate buffer (0.1 M adjusted to pH 6.0 with 0.1 M acetic acid), a flow rate of 1 mL/min, and detection at 240 nm. The lower limit of quantitation of the related compounds is 0.02% or less. Drug contents in 2 raw material samples were 100.1 and 99.9% and ranged from 98.2 to 99.4% in 3 tablet formulations. Impurity levels in 2 samples of raw material from different manufacturers were ca 0.4%. The presence of 3 of the known related compounds in these samples was confirmed by liquid chromatographymass spectrometry. The method applied to raw materials was evaluated by a second laboratory and found to be satisfactory.

scholarly journals Penerapan metode fuzzy sugeno untuk prediksi persediaan bahan baku

2019 ◽  
Vol 9 (2) ◽  
pp. 12-20
Author(s):  
Julio Warmansyah ◽  
Dida Hilpiah
Keyword(s):  
Fuzzy Logic ◽  
Raw Materials ◽  
Mean Absolute Percentage Error ◽  
Raw Material ◽  
Percentage Error ◽  
Human Power ◽  
Absolute Percentage Error ◽  
Input Variables ◽  
A Company

 PT. Cahaya Boxindo Prasetya is a company engaged in the manufacture of carton boxes or boxes. The company's activities also include cutting and printing services using machinery and human power. The problem faced in this company is the difficulty of predicting the amount of inventory of raw materials that will be  included in the production. The remaining raw materials for production will be used as the final stock to get the minimum, the goal is to reduce excess stock Overcoming this problem, fuzzy logic is used to predict raw material inventories by focusing on the final stock. In this study using Fuzzy Sugeno, with three input variables, namely: initial inventory, purchase, production, while the output is the final stock. Determination of prediction results using defuzzification using the average concept of MAPE (Mean Absolute Percentage Error). The results obtained, using the Fuzzy Sugeno method can predict the inventory of raw materials with a MAPE value of 38%. 

scholarly journals PERENCANAAN BAHAN BAKU DAN HASIL PRODUKSI MENGGUNAKAN METODE LINIER PROGRAMMING SIMPLEK

2017 ◽  
Vol 12 (2) ◽  
Author(s):  
Monika Handayani ◽  
Eka Kusuma Dewi
Keyword(s):  
Linear Programming ◽  
Production Planning ◽  
Simplex Method ◽  
Raw Materials ◽  
Raw Material ◽  
Planning System ◽  
Testing System ◽  
Basic Solution ◽  
Linear Programming Method

<p>CV. Baja Utama Landasan Ulin is a business entity that manufactures various products using the basic ingredients of iron. In the management of raw materials for the production of common regulatory process raw materials into sections for further processing. This setting is often done manually without doing careful planning, so that at the end of each production process there are many remaining pieces of the raw materials that should be used in production. In addition to the determination of the production is necessary to reference how the product should be made for each type of existing products. This is often an important factor that pushed for the optimization of production planning in determining the number of products for each type of product and raw material consumption.Linear Programming is one of the methods used in production planning to regulate the use of raw materials is limited. Simplex method is part of the linear programming method that can be used in the production planning system implementation. Simplex method identifies an initial basic solution and then move systematically to other basic solution that has the potential to improve the value of the objective function.The calculation result of production planning using the simplex method can be used as a reference in the decision making production planning. By building an application using the simplex method can assist in the calculation of production peencanaan more efficiently and effectively. Accuracy testing system constructed show significant results with great value reached 94% level of accuracy.<br />Keywords: simplex, production planning, the maximum gain, linear programming</p>

The issue of "oil shrinkage" during the compounding of oils in the processes of production, collection, preparation and transportation of hydrocarbon raw materials

2021 ◽  
pp. 104-113
Author(s):  
O. P. Deryugina ◽  
E. A. Trapeznikov
Keyword(s):  
Raw Materials ◽  
Raw Material ◽  
Colloidal System ◽  
Main Pipelines ◽  
Different Types ◽  
Preliminary Study ◽  
The Stability ◽  
Mixed Oil

The article discusses the issue of industrial compounding, which improves the quality of the raw materials supplied to the main pipelines. Compounding from "to compound" (English) - to mix. When mixing different types of oil obtained, "incompatibility" is possible, which is expressed in the precipitation of a solid sediment and violation of the stability of the colloidal system and due to the differing properties of oils. Attention to this problem is due to the tightening of requirements for the quality of raw materials that must comply with modern standards. The article discusses the causes of the problem of "incompatibility" of oil during compounding and effective ways of solving it, substantiates the need for a preliminary study of the properties of mixed oil in order to identify possible incompatibility of various types of oil. The standard tests for determination of incompatibility indices characterizing the ability of raw materials to mix are considered. The article substantiates the need to develop methods for diagnosing the incompatibility of oils as the most important task of modern chemical science, the solution of which will improve the quality of the raw material obtained and solve many technological problems in the compounding process.

Determination of carbapenemase genes in clinical isolates using Cepheid Xpert Carba-R

2021 ◽  
pp. 16-19
Author(s):  
N. I. Gabrielyan ◽  
V. G. Kormilitsyna ◽  
V. K. Zaletaeva ◽  
A. V. Krotevich ◽  
I. A. Miloserdov ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Infection Control ◽  
Resistance Genes ◽  
Carbapenem Resistance ◽  
Critical Issue ◽  
Sensitivity Study ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Carbapenem Resistant

Detection of carbapenem resistance genes is a critical issue for hospitals due to possible recommendations for infection control and targeted therapy. The Cepheid Xpert instrument, a Carba-R test for the detection and differentiation of five common carbapenemase genes, was tested from September 2020 to February 2021. As part of the approbation, 20 tests were provided. This review presents the results of the approbation of a relatively regular sensitivity study on Siemens WalkAway‑96 plus. Cepheid Xpert Carba-R analysis has been shown to be an accurate and fast tool for detecting colonization by carbapenem-resistant gram-negative bacteria, which can help limit the spread of these organisms in hospitals.

scholarly journals Nilai Tambah Produk Olahan Jahe Merah pada UD. VisionBali Herbal Indonesia, Denpasar

2017 ◽  
Author(s):  
ARIEF SETIAWAN ROSO ◽  
I KETUT SUAMBA ◽  
NI WAYAN PUTU ARTINI
Keyword(s):  
Production Process ◽  
Raw Materials ◽  
Production Costs ◽  
Raw Material ◽  
Added Value ◽  
Chemical Components ◽  
Red Ginger ◽  
The Cost ◽  
Product Output

The Added Value of Processed Red Ginger Product at UD. VisionBali Herbal Indonesia, DenpasarThis research aimed to determine the added value of red ginger as an herbal drink in one production process and to determine the level of profits earned by the company in the red ginger processing in one production process. Determination of the study area was done purposively and the analytical methods used was the method of added value calculation, i.e. the product value is deducted by the value of raw materials and other supporting materials.It can be concluded from the result of the research that the added value of the red ginger processing business obtained in one production process is Rp. 84.600,00/kg. The added value is obtained from the deduction of the value of the product/output of Rp. 175.000,00/kg with the cost of raw material (input prices) Rp. 25.000,00/kg and the contribution of the cost of other inputs of Rp. 65.400,00/kg. It was also found that the profits gained by the manufacturer from the processed red ginger into herbal drink in one production process was Rp. 200.954,06. The suggestion that can be given to the company is to put more attention in the details of its production costs so as not to result in a low ratio of added value and further to improve the marketing of the products, so that people are interested in re-use of herbal medicine that is free of chemical components.

scholarly journals Low-Frequency Magnetic Scanning Device and Algorithm for Determining the Magnetic and Non-Magnetic Fractions of Moving Metallurgical Raw Materials

2019 ◽  
Vol 9 (10) ◽  
pp. 2001
Author(s):  
Vladimir Kochemirovsky ◽  
Svetlanav Kochemirovskaia ◽  
Michael Malygin ◽  
Alexey Kuzmin ◽  
Maxim Novomlinsky ◽  
...  
Keyword(s):  
Mass Fraction ◽  
Raw Materials ◽  
Low Frequency ◽  
Raw Material ◽  
Magnetic Characteristics ◽  
Magnetic Fraction ◽  
Measuring Device ◽  
Mathematical Algorithm ◽  
Macroscopic Objects

The development of an algorithm to automate the process of measuring the magnetic properties of macroscopic objects in motion is an important problem in various industries, especially in ferrous metallurgy and at factories where ferrous scrap is a strategic raw material. The parameter that requires work control is the hidden mass fraction of a non-magnetic substance that is present in the ferromagnetic raw material. The solution to this problem has no prototypes. In our work, a simple measuring device and a mathematical algorithm for calculating the mass fraction of the non-magnetic fraction in a strongly magnetic matrix were developed. The device is an inductance coil, in which the angle of the electromagnet losses is related to the mass of the magnetic material moving the coil. The magnitude of the instantaneous values of the lost angle integral was compared with the result of weighing the object on scales. This allowed us to calculate the proportion of the magnetic and non-magnetic fractions. The use of this prototype is herein illustrated. The experimental results of the determination of the magnetic-fractional composition depending on the mass of scrap metal and its bulk and the magnetic characteristics are presented.

scholarly journals TLS and SfM Approach for Bulk Density Determination of Excavated Heterogeneous Raw Materials

Minerals ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 174 ◽  
Author(s):  
Peter Blistan ◽  
Stanislav Jacko ◽  
Ľudovít Kovanič ◽  
Julián Kondela ◽  
Katarína Pukanská ◽  
...  
Keyword(s):  
Bulk Density ◽  
Laser Scanning ◽  
Large Scale ◽  
Raw Materials ◽  
Terrestrial Laser Scanning ◽  
Mineral Resources ◽  
Point Clouds ◽  
Raw Material

A frequently recurring problem in the extraction of mineral resources (especially heterogeneous mineral resources) is the rapid operative determination of the extracted quantity of raw material in a surface quarry. This paper deals with testing and analyzing the possibility of using unconventional methods such as digital close-range photogrammetry and terrestrial laser scanning in the process of determining the bulk density of raw material under in situ conditions. A model example of a heterogeneous deposit is the perlite deposit Lehôtka pod Brehmi (Slovakia). Classical laboratory methods for determining bulk density were used to verify the results of the in situ method of bulk density determination. Two large-scale samples (probes) with an approximate volume of 7 m3 and 9 m3 were realized in situ. 6 point samples (LITH) were taken for laboratory determination. By terrestrial laser scanning (TLS) measurement from 2 scanning stations, point clouds with approximately 163,000/143,000 points were obtained for each probe. For Structure-from-Motion (SfM) photogrammetry, 49/55 images were acquired for both probes, with final point clouds containing approximately 155,000/141,000 points. Subsequently, the bulk densities of the bulk samples were determined by the calculation from in situ measurements by TLS and SfM photogrammetry. Comparison of results of the field in situ measurements (1841 kg∙m−3) and laboratory measurements (1756 kg∙m−3) showed only a 4.5% difference in results between the two methods for determining the density of heterogeneous raw materials, confirming the accuracy of the used in situ methods. For the determination of the loosening coefficient, the material from both large-scale samples was transferred on a horizontal surface. Their volumes were determined by TLS. The loosening coefficient for the raw material of 1.38 was calculated from the resulting values.

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