Variation in resistance to haemonchosis: selection of female sheep resistant to Haemonchus contortus

1999 ◽  
Vol 73 (2) ◽  
pp. 137-142 ◽  
Author(s):  
V. Hooda ◽  
C.L. Yadav ◽  
S.S. Chaudhri ◽  
B.S. Rajpurohit
Keyword(s):  
Weight Loss ◽  
Haemonchus Contortus ◽  
Total Serum Protein ◽  
Total Serum ◽  
Serum Pepsinogen ◽  
Mean Values ◽  
Faecal Egg Counts ◽  
Female Sheep ◽  
Eosinophil Counts ◽  
Selection Of

Seventy female lambs (6–7 months old) which were exposed to natural infections of Haemonchus contortus were designated as responders or non-responders on the basis of 10 weekly cumulative faecal egg counts. Selected responder and non-responder lambs were treated with ivermectin, housed separately and 6 weeks post-housing, seven lambs from each group were given a trickle infection of Haemonchus contortus at 1000 L3 daily for 5 days per week up to 2 weeks and examined weekly for 10 weeks after first infection. Analysis of data revealed significantly lower mean faecal egg counts and non-significantly less weight loss in responder than non-responder lambs. Mean values of haemoglobin, packed cell volume, total serum protein and peripheral eosinophil counts were significantly higher in responders than non-responders. In contrast, serum pepsinogen concentration was significantly less in responders than in non-responders. At 10 weeks post-infection, there were fewer pathological lesions and significantly lower worm burdens in responders than in non-responders. These results demonstrate a distinct resistance in responders to Haemonchus contortus infection.

scholarly journals Genetic Selection for Resistance to Gastrointestinal Parasitism in Meat Goats and Hair Sheep through a Performance Test with Artificial Infection of Haemonchus contortus

Animals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1902
Author(s):  
Yoko Tsukahara ◽  
Terry A. Gipson ◽  
Steven P. Hart ◽  
Lionel Dawson ◽  
Zaisen Wang ◽  
...  
Keyword(s):  
Haemonchus Contortus ◽  
Performance Test ◽  
Genetic Selection ◽  
Total Serum ◽  
Parasite Resistance ◽  
Artificial Infection ◽  
Hair Sheep ◽  
Meat Goats ◽  
Selection For ◽  
Selection Of

Internal parasitism has been the leading cause of morbidity and mortality in small ruminants in many areas such as the southcentral USA. Among the different approaches and management practices to cope with internal parasitism, genetic selection for internal parasite resistance is recognized as one with considerable potential long-term impact. A central performance test with artificial infection of Haemonchus contortus for selection of growing meat goats and hair sheep for breeding to increase resistance to internal parasitism and on-farm selection of females was conducted for 3 years. The results varied considerably among breeds of goats and flocks of sheep. Spanish goats and St. Croix sheep maintained relatively low fecal egg count (FEC) each year, whereas for goats categorized as being of high resistance and Dorper sheep FEC decreased with advancing year. Packed call volume (PCV) and total serum immunoglobulin (Ig) levels were not strongly related to FEC. Genetic parameters varied between the two species, which might be related to previous selection pressure exerted for parasite resistance. Heritability of FEC was higher in goats than sheep. The genetic correlation between FEC and IgM and IgG was negative for both species, which suggests possible genetic association. Genetic and phenotypic correlations between ADG and FEC were nonsignificant for both species. In conclusion, different relationships of FEC and PCV between species require careful attention during selection and the lack of relationship between ADG and FEC suggests that selection of growing male meat goats and hair sheep for resistance to internal parasitism will not adversely affect growth performance.

The effect of different levels of crude protein on the pathophysiology of Haemonchus contortus infection in 2-year-old Boer dry does under confined conditions

2017 ◽  
Vol 57 (4) ◽  
pp. 719
Author(s):  
T. V. Can ◽  
M. A. Hohenhaus ◽  
P. J. Murray
Keyword(s):  
Serum Protein ◽  
Dietary Protein ◽  
Haemonchus Contortus ◽  
Haemoglobin Concentration ◽  
Basal Diet ◽  
Protein Supplementation ◽  
Total Serum Protein ◽  
Total Serum ◽  
Control Group ◽  
Cell Volumes

The effect of dietary protein supplementation on the pathophysiology of a single Haemonchus contortus infection in 2-year-old Boer dry does under confined conditions was examined. Twenty-four does were randomly confined in individual pens and allocated into three groups balanced by their liveweight. The goats in the Control group were offered a basal diet whereas goats in Treatments 1 and 2 were fed the basal diet plus 25% and 50% dietary protein increments, respectively. Each animal was orally administrated 100 H. contortus L3 larvae/kg liveweight on Day 0 of the experiment. The goat liveweights and FAMACHA scores were recorded at weekly intervals. Packed cell volumes, eosinophil percentage, haemoglobin concentration, total serum protein, globulin, and albumin concentrations were recorded on Days 0 and 14, and then at weekly intervals during the experiments. Faecal egg counts were measured on Days 0, 21, and then at weekly intervals thereafter. Antigen-specific IgA, IgG, and IgM titres were determined from Enzyme-linked immunosorbent assays tests on Days 0, 28, and at the termination of the experiment. The results of this study showed that a single H. contortus L3 infection did not cause pathogenic effects in 2-year-old Boer dry does. Dietary protein supplementation significantly lowered faecal egg count and significantly enhanced IgG titres (P < 0.05). However, the higher protein diets did not have any significant effects on liveweight, packed cell volumes, haemoglobin concentration, biological parameters (total serum protein, albumin, and globulin concentrations), and peripheral antibodies (IgA and IgM titres) between the treatments. Further investigations are required to clarify the role of protein supplementation to control H. contortus infection in goats.

scholarly journals Assessment of Some Biochemical Changes in Wistar Rats Following Administration of Three Polyherbal Preparations Repurposed for COVID-19

2020 ◽  
pp. 54-60
Author(s):  
Kennedy Iliya Amagon ◽  
Bukata Bayero Bukar ◽  
Jacob Adegboyega Kolawole ◽  
Kakjing Dadul Falang ◽  
Ukpe Ajima ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Specific Treatment ◽  
Laboratory Animals ◽  
Total Serum Protein ◽  
Total Serum ◽  
Creatinine Concentration ◽  
Mean Values ◽  
Significant Public Health ◽  
Liver And Kidney ◽  
The Mean

Background and Aims: The current pandemic known as Coronavirus Disease-19 (COVID-19) is a significant public health menace. Currently, there is no specific treatment for this disease, although some medicinal agents are under investigation. Some published articles have reported Severe Acute Respiratory Distress Syndrome Coronavirus-2 (SARS CoV-2) involvement in other organs, including the liver and kidneys, which can impair the metabolism and excretion of the medications taken to treat the disease. This study evaluated the effects of 3 herbal mixtures on some biochemical parameters of the liver and kidney of laboratory animals. Methods: Liver enzymes such as serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, albumin and total serum protein were quantified. Urea, creatinine and bilirubin (total and direct) were also evaluated. These parameters were determined for all three polyherbal combinations (CoV Pla-1, CoV Pla-2, CoV Pla-3). Results: The extracts did not produce any mortality up to 5000 mg/kg per oral. Results showed that the polyherbal extracts (CoV Pla-1, CoV Pla-2 CoV Pla-3) did not cause any significant changes in ALT, AST, ALP, compared to control. The mean values of urea showed an insignificant (P>0.05) decrease across all test doses in the three extracts, compared to the control. In the current   study, the mean creatinine concentration showed slight decrease across all three extracts. Total protein was observed to be lower in CoV Pla-1 and CoV Pla-2, and increased in CoV Pla-3,    though these changes were not statistically significant. Serum albumin decreased at the low   and intermediate doses for the three polyherbal extracts in an insignificant manner compared to control. Conclusion: The results obtained in this study indicate that the extracts did not cause  significant changes in biochemical parameters evaluated and support their use in the treatment of Covid-19.

scholarly journals The Physical Activity-Dependent Hematological and Biochemical Changes in School Horses in Comparison to Blood Profiles in Endurance and Race Horses

Animals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1128
Author(s):  
Małgorzata Maśko ◽  
Małgorzata Domino ◽  
Tomasz Jasiński ◽  
Olga Witkowska-Piłaszewicz
Keyword(s):  
Physical Activity ◽  
Blood Parameters ◽  
Total Serum Protein ◽  
Total Serum ◽  
Improve Performance ◽  
Blood Profile ◽  
Hematological And Biochemical Parameters ◽  
Activity Dependent ◽  
Race Horses ◽  
Blood Profiles

Blood testing is one of the most important ways to improve performance, facilitate recovery and monitor the training of endurance and race horses. However, little is known about the physical activity-dependent changes of blood parameters in horses used for pleasure and in riding schools. This study aimed to perform routine blood tests for training monitoring of sport horses in three different horse types of use. Then the values of blood indicators were compared between school, endurance and race horses to find similarities in the physical activity-dependent profile. The study was carried out on 15 endurance, 15 race and 15 school healthy horses who underwent the typical effort for their disciplines. The hemogram parameters, creatine phosphokinase (CPK), aspartate aminotransferase (AST), blood lactate (LAC), and total serum protein (TSP) concentrations were measured using the same protocol and equipment. Measurements of main hematological and biochemical physical activity-dependent parameters were conducted before, immediately after and 30 min after training. In school horses, the physical activity-dependent increase of WBC (40.9%) and CPK (76.4%) was similar to endurance horses, whereas an increase of RBC (19.1%), HGB (18.6%) and HCT (19.4%) were more similar to race horses. The moderate effort-dependent increase of LAC concentration (2775%) was lower than in race horses (7526%) and higher than in endurance horses (390%). Limiting the training or work monitoring assessment of school horses to only the endurance or racing blood profile may result in the omission of significant changes in hematological and biochemical parameters.

PARALLEL STUDIES OF COMPLEMENT AND COAGULATION IV. EFFECT OF CARBON TETRACHLORIDE

1951 ◽  
Vol 29 (2) ◽  
pp. 48-58
Author(s):  
Christine E. Rice ◽  
Paul Boulanger ◽  
P. J. G. Plummer
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Serum Protein ◽  
Guinea Pigs ◽  
Fatty Degeneration ◽  
Blood Groups ◽  
Total Serum Protein ◽  
Total Serum ◽  
Coagulation Time ◽  
Complement Activity

To determine whether liver injury would result in a parallel decline in the complement titer and coagulative properties of the blood, groups of guinea pigs were given series of injections of the liver poison, carbon tetrachloride. Marked fatty degeneration of the liver, a decline in total serum protein and albumin, a decrease in complement activity, and a prolongation of coagulation time was observed in the treated animals. A general relationship was noted between the albumin-globulin ratio and the complement titer of the serum and between the complement titer and the coagulation time of the plasma.

scholarly journals Prevalence of Ovine Haemonchosis in Wukro, Ethiopia

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Lidya Gebresilassie ◽  
Berihun Afera Tadele
Keyword(s):  
Body Condition ◽  
Haemonchus Contortus ◽  
Significant Variation ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Highly Pathogenic ◽  
Good Body Condition ◽  
Associated Risk Factors ◽  
Female Sheep ◽  
Important Disease

Background.Haemonchosiscaused byHaemonchus contortusis a predominant, highly pathogenic, and economically important disease of sheep and goats.Objective. Assessing the prevalence ofHaemonchusparasite and its associated risk factors in sheep slaughtered at different restaurants of Wukro.Methods. Cross-sectional study using random sampling from November 2013 to April 2014 in a total of 384 sheep was conducted and SPSS version 20 software using descriptive statistics was used for data analysis andP<0.05was considered significant.Result. The overall prevalence ofHaemonchus contortuswas 40.9% (n=157). The prevalence in medium body condition 27.3% (n=105) varies significantly from that of good body condition 13.5% (n=52) (P<0.05). Moreover, there was significant variation (P<0.05) in the prevalence in young and adult sheep with rates of 21.9% (n=84) and 19% (n=73), respectively. At the same time, there is significant variation (P<0.05) in male and female sheep with prevalence of 29.7% (n=114) and 11.2% (n=43), respectively. The prevalence of 25.3% (n=97) in sheep that originated from Negash compared to Wukro and Agulae showed no significant variation (P>0.05).Conclusion. The current finding revealed that significant numbers of sheep were affected by the parasites. Hence strategic deworming with good husbandry practice should be implemented.

Muscle Weight Relationship to Serum Proteins, Hemocytes, and Hepatopancreas in the Lobster, Homarus americanus

1967 ◽  
Vol 24 (11) ◽  
pp. 2339-2354 ◽  
Author(s):  
James E. Stewart ◽  
John W. Cornick ◽  
Diane M. Foley ◽  
M. F. Li ◽  
C. M. Bishop
Keyword(s):  
Serum Protein ◽  
Physiological Condition ◽  
Serum Proteins ◽  
Homarus Americanus ◽  
Total Serum Protein ◽  
Total Serum ◽  
Experimental Conditions ◽  
Muscle Weight ◽  
Beef Liver ◽  
The Relationship

Total serum protein values, hemocyte numbers, and muscle weights were determined for 216 intermolt lobsters immediately after their capture, and for 230 others held captive under a variety of dietary and environmental conditions. Average muscle values ranged from approximately 13% to the more normal 20–25% of the live animals' weight, depending upon experimental conditions. The total serum protein up to a level of 55 mg/ml was shown to be a reliable indicator of muscle weights, although the relationship was not identical for all lobster groups. It appeared to be modified chiefly by the areas from which the different groups were taken. Diet was more important than the temperatures (5 to 14 C) in affecting changes in muscle and serum protein values. Starvation caused a greater reduction (50 to 70%) in the size of the hepatopancreas than in the muscle. Histological examination of the hepatopancreatic tissue showed that the lipid content was markedly reduced upon starvation and that a degeneration of this organ was apparent for lobsters fed a beef liver and herring diet. Measurement of serum proteins would appear to be a useful technique in experiments on lobster nutrition and have value, within specified limits, for assessing the physiological condition of wild lobsters.

scholarly journals Studies on the toxicity of an aqueous extract of the leaves of Abrus precatorius in rats

2007 ◽  
Vol 74 (1) ◽  
Author(s):  
A.A. Adedapo ◽  
O.A. Omoloye ◽  
O.G. Ohore
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Aqueous Extract ◽  
Haemoglobin Concentration ◽  
Total Serum Protein ◽  
Total Serum ◽  
Blood Cell Count ◽  
Abrus Precatorius ◽  
White Rats ◽  
Histopathological Studies

The toxic effects of an aqueous extract of Abrus precatorius were studied in 20 male white rats over a period of 18 days. The rats were divided into four groups of five rats per group. Those in Group A served as controls while the rats in Groups B, C and D were dosed per os with 400 mg/kg, 800 mg/kg and 1 600 mg/kg of the extract, respectively. Blood samples were collected for haematological and biochemical analysis and specimens of the liver, kidney and testes were taken for histopathological studies. The study showed that the extract of A. precatorius caused decreased levels of packed cell volume, haemoglobin concentration, red blood cell count, white blood cell count, mean corpuscular volume and mean corpuscular haemoglobin. The extract also resulted in increased levels of total serum protein, albumin, alanine amino transaminase, aspartate amino transferase, alkaline phosphatase and total bilirubin. Histologically, testicular degeneration characterized by decreased numbers of lining cells of the epithelium as well as reduction in sperm cells with presence of scattered Sertoli cells were noted. The study thus showed that aqueous extract of Abrus precatorius is toxic and caution should be exercised in its use for medicinal purpose.

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