Zinc deficiency in patients with recurrent aphthous stomatitis: a pilot study

2014 ◽  
Vol 128 (6) ◽  
pp. 531-533 ◽  
Author(s):  
G S Özler
Keyword(s):  
Zinc Deficiency ◽  
Systemic Disease ◽  
Serum Zinc ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Controlled Study ◽  
Control Group ◽  
Common Disease ◽  
Dental Surgery ◽  
Zinc Levels

AbstractObjective:Recurrent aphthous stomatitis is a common disease of the oral mucosa, affecting 20 per cent of the general population.1 However, the aetiology of this disease is unknown. This is the first controlled study to compare zinc levels in recurrent aphthous stomatitis patients with those of a well-matched, healthy, control population.Methods:Twenty-five patients with a history of recurrent aphthous stomatitis and 25 healthy people (control group) took part in the study. Patients aged between 20 and 40 years with recurrent oral aphthous ulcers less than 1 cm in diameter were included. Exclusion criteria were pregnancy and lactation, systemic disease (ulcerative colitis, Crohn's disease, Behçet's disease), any current medication (topical or systemic), dental surgery during the previous month and deficiencies in iron, folic acid or vitamin B1, B2, B6 or B12. Serum zinc levels were compared between patient and control groups.Results:Zinc deficiency was detected in 28 per cent of recurrent aphthous stomatitis patients and in 4 per cent of controls. The mean serum zinc level in the patient group was significantly lower than in the control group.Conclusion:These results suggest an association between zinc deficiency and recurrent aphthous stomatitis.

scholarly journals Evaluation of Salivary Interferon-Gamma Level in Patients with Recurrent Aphthous Stomatitis

2020 ◽  
Author(s):  
Marieh Honarmand ◽  
Ramin Saravani ◽  
Hossein Ansari ◽  
Iman Teimoori
Keyword(s):  
Interferon Gamma ◽  
Systemic Disease ◽  
Recovery Period ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Control Group ◽  
Healthy Individuals ◽  
Salivary Level ◽  
The Mean ◽  
Control Study

Introduction: Recurrent aphthous stomatitis (RAS) is defined by recurring ulcers restricted to oral mucosa in the patients with no other signs of systemic disease. The purpose of this study was to evaluate the salivary level of interferon gamma in patients with RAS. Methods: In this case-control study, 30 patients with RAS (in Recurrence and recovery period) in the experimental and 25 healthy people as the control group were compared. Salivary interferon gamma level was evaluated by the use of ELISA method. Data were analyzed via SPSS version 16 software with Mann-U-Whitney test and Wilcoxon. P <0.05 was considered significant. Results: The mean salivary interferon gamma levels were 45.01±31.02 pg/ml and 32.04±19.02 pg/ml in the patients with RAS and healthy individuals, respectively. (P>0.001). In addition, interferon gamma level was 45.01± 31.02 pg/ml and 58.03± 52.04 pg/ml in the recurrence and recovery periods, respectively. (P=0.67). Conclusion: Salivary interferon gamma levels were higher in the patients with RAS than healthy individuals.

Association between serum zinc levels and recurrent aphthous stomatitis: a meta-analysis with trial sequential analysis

2021 ◽  
Vol 25 (2) ◽  
pp. 407-415
Author(s):  
Sadeq A. Al-Maweri ◽  
Esam Halboub ◽  
Hesham Mohammed Al-Sharani ◽  
Anas Shamala ◽  
Ahlam Al-Kamel ◽  
...  
Keyword(s):  
Sequential Analysis ◽  
Meta Analysis ◽  
Serum Zinc ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Trial Sequential Analysis ◽  
Zinc Levels ◽  
Serum Zinc Levels

Zinc deficiency is an independent risk factor for prehypertension in healthy subjects

2019 ◽  
pp. 1-6 ◽  
Author(s):  
Sara C. Nevárez-López ◽  
Luis E. Simental-Mendía ◽  
Fernando Guerrero-Romero ◽  
Jorge A. Burciaga-Nava
Keyword(s):  
Blood Pressure ◽  
Zinc Deficiency ◽  
Healthy Subjects ◽  
Serum Zinc ◽  
Control Group ◽  
Case Group ◽  
Zinc Levels ◽  
And Control ◽  
Control Study ◽  
Apparently Healthy

Abstract. Objective: To assess whether zinc deficiency is associated with prehypertension (preHTN) in apparently healthy subjects. Design: Apparently healthy women and men, aged 20 to 60 years were enrolled into a case-control study. Individuals with and without preHTN were allocated into the case and control groups, respectively. Hypertension, liver disease, renal disease, smoking, pregnancy, diabetes, malignancy, hypernatremia, hypomagnesemia, medical treatment, and use of supplements containing zinc were exclusion criteria. PreHTN was defined by systolic blood pressure (SBP) and/or diastolic blood pressure (DBP) of 120–139 mmHg and/or of 80–89 mmHg, respectively, and the zinc deficiency by serum zinc levels < 74 μg/dL in men and < 70 μg/dL in women. Results: In total, 142 subjects (90 women and 52 men) were enrolled and allocated in the case (n = 71) and control (n = 71) groups. In the overall population, the frequency of zinc deficiency was 11.1%; individuals in the case group showed significant higher frequency of zinc deficiency as compared with the control group (16.9% vs 5.5%, p = 0.04). The logistic regression analysis showed a significant association between zinc deficiency and preHTN (OR = 4.61; 95% CI: 1.24–17.12, p = 0.02). Conclusion: Our results suggest that zinc deficiency is associated with the presence of preHTN in apparently healthy subjects.

scholarly journals Evaluation of serum zinc levels in patients with recurrent aphthous stomatitis (RAS)

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Zuzanna Ślebioda ◽  
Ewa Krawiecka ◽  
Elżbieta Szponar ◽  
Barbara Dorocka-Bobkowska
Keyword(s):  
Serum Zinc ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Zinc Levels ◽  
Serum Zinc Levels

scholarly journals Calcium And Zinc Deficiency In Preeclamptic Women

1970 ◽  
Vol 6 (2) ◽  
pp. 94-99 ◽  
Author(s):  
Selina Akhtar ◽  
Shelina Begum ◽  
Sultana Ferdousi
Keyword(s):  
Pregnant Women ◽  
Zinc Deficiency ◽  
Serum Calcium ◽  
Colorimetric Method ◽  
Serum Zinc ◽  
Control Group ◽  
Medical Complication ◽  
Study Group ◽  
Gestational Period ◽  
Zinc Levels

Background: Pre-eclampsia is the most common medical complication of pregnancy associated with increased maternal and infant mortality and morbidity. Reduced serum calcium and zinc levels are found associated with elevated blood pressure in preeclampsia. Objective: To observe serum calcium and zinc levels in preeclamptic women. Methods: This cross sectional study was carried out in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka between July 2009 to June 2010. In this study, 60 pregnant women of preeclampsia, aged 18-39 years with gestational period more than 20th weeks were included as the study (group B). For comparison age and gestational period matched 30 normotensive pregnant women control (group A) were also studied. All the subjects were selected from Obstetric and Gynae In and Out patient Department of BSMMU and Dhaka Medical College Hospital. Serum calcium was measured by Colorimetric method and serum zinc was measured by Spectrophotometric method. Data were analysed by independent sample t test and Pearson’s correlation coefficient test. Results: Mean serum calcium and zinc levels were significantly (p<0.001) lower in study group than those of control group. Again, serum calcium and zinc showed significant negative correlation with SBP and DBP in preeclamptic women. Conclusion: This study concludes that serum calcium and zinc deficiency may be one of the risk factor of preeclampsia. Therefore, early detection and supplementation to treat this deficiency may reduce the incidence of preeclampsia. DOI: http://dx.doi.org/10.3329/jbsp.v6i2.9758 JBSP 2011 6(2): 94-99

scholarly journals Correlation of the Protein Expression of Salivary Cortisol, Serum Vitamin B12 and Interleukin 1 Beta in Patients with Recurrent Aphthous Stomatitis

2021 ◽  
pp. 189-193
Author(s):  
R. Deepa Viswasini ◽  
Pratibha Ramani ◽  
J. Selvaraj
Keyword(s):  
Salivary Cortisol ◽  
Interleukin 1 ◽  
Serum Vitamin ◽  
Integrated Approach ◽  
Mean Value ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Controlled Study ◽  
Control Group ◽  
Salivary Cortisol Level

This study will help in determining which molecules participate in the ulceration with an integrated approach combining external and internal factors. Recurrent aphthous stomatitis (RAS) is a common condition affecting the oral mucosa. Clinically it is manifested through recurrent painful lesions. A total of 28 subjects were recruited for this systematic case-controlled study (14 Control and 14). Whole unstimulated saliva was used for measuring Cortisol and IL-1 b levels. Patients with RAS lesions exhibited an elevated salivary cortisol level as against their healthy counterparts. The mean value for salivary cortisol among RAS patients was determined to be 16.2 nM/dL as against the control group which had a mean salivary cortisol of 12 nM/dL. Overall, this study helps provide insights into the correlation of the different biomarkers and RAS patients which can eventually lead to better therapeutic options and prevent recurrence in patients.

scholarly journals The Rapeutic Effect of Proaftol in Treatment of Recurrent Aphthous Stomatitis

PRILOZI ◽  
2014 ◽  
Vol 35 (3) ◽  
pp. 195-202
Author(s):  
Aneta Atanasovska Stojanovska ◽  
Mirjana Popovska ◽  
Ilijana Muratovska ◽  
Kristina Mitic ◽  
Emilija Stefanovska ◽  
...  
Keyword(s):  
Lesion Size ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Controlled Study ◽  
Unknown Etiology ◽  
Control Group ◽  
Subjective Feeling ◽  
Double Blind ◽  
Two Parameters ◽  
The Impact

AbstractRecurrent aphthous stomatitis (RAS) is a quite frequent, painful, ulcerative disease that affects the lining of the oral cavity and has an unknown etiology. The aim of this article is to examine the impact of the medication proaftol on epithelization speed and severity of pain in patients with RAS. In this randomized, double-blind, placebo-controlled study respondents were divided into two groups where one group was treated with proaftol spray and the other with a placebo. Aphthae considered for treatment had a diameter of 5-6 mm. The participants were given instruction on the use of the spray, two sprayings on the place of the aphtae 3-4 times a day. We examined two parameters in the symptomatology of RAS-lesion size (mm) and pain intensity (noted on four subjective levels: 0-no pain, 1-discomfort, 2-moderate pain, 3-severe pain). These parameters were noted on the baseline, the third, the fifth and the eighth days of examination.Results: A significant faster reduction of the dimension of aphthous ulcers in patients treated with proaftol 3rd day p < 0.001, 5th day p < 0.0006, 8th day full epithelization in the control group. The magnitude of pain in the experimental compared with the control group on 3rd, 5th and 8th day was also significantly reduced: p < 0.0001, p < 0.007, p < 0.007 respectively.Conclusion: The use of proaftol positively influences the rate of epithelization and reduction of subjective feeling of pain in patients with RAS. The action of propolis should be the goal of studies with a larger number of subjects.

scholarly journals Evaluation of serum zinc level and IL-18 mRNA expression in children with pneumonia

2021 ◽  
Vol 67 (3) ◽  
pp. 168-171
Author(s):  
Shixiong Yang ◽  
Jin Shi
Keyword(s):  
Mrna Expression ◽  
Zinc Deficiency ◽  
Internal Control ◽  
Serum Zinc ◽  
Rna Isolation ◽  
Zinc Level ◽  
Control Group ◽  
Healthy Children ◽  
Serum Zinc Level ◽  
Zinc Levels

Pneumonia is currently one of the leading causes of death in children. Increased susceptibility to pneumonia may be due to their decreased immunity. One of the reasons for the decrease in immunity is zinc deficiency. In children with pneumonia, on the other hand, some cytokines are secreted, resulting in inflammation that spreads, persists, and makes treatment difficult for specialists. In this study, we investigated the serum zinc level in children with pneumonia and healthy children. Also, we tried to find its relationship with IL-18 mRNA expression as an inflammatory cytokine. For this purpose, serum zinc levels and IL-18 mRNA expression were evaluated in 120 children aged 3-60 months with pneumonia and 120 healthy children. After taking 2ml of blood from children and measuring serum zinc level, the level of the IL-18 mRNA was measured by real-time PCR. Total RNA was extracted by bioZOL™-G RNA Isolation Reagent kit. The primary cDNA was amplified by the extracted RNA, and in the next step, 2µl of cDNA were amplified by specific primers to measure IL-18 mRNA. The Beta-actin gene was also used as internal control and housekeeping gene. Results showed that the level of zinc in the patient group was 412.625±28.87?M and in the control group was 514.40±49.67?M. This difference was statistically significant (P=0.0053). Also, the expression of the IL-18 gene was increased in children with pneumonia, significantly (P=0.0015). Therefore, from the results, it can be deduced that children with zinc deficiency were at higher risk for a lung infection. Inflammatory cytokines such as IL-18 also were increased in these children. Hence, it can be concluded that zinc levels can reduce the expression of IL-18 mRNA and play an important role in the prevention and treatment of children with pneumonia.

scholarly journals The Effect of Biscuits Made From Pumpkin Seeds Flour on Serum Zinc Levels and Weight in Malnutrition Wistar Rats

2020 ◽  
Vol 8 (A) ◽  
pp. 428-433
Author(s):  
Aminuddin Syam ◽  
Fitrah Khaerani Burhan ◽  
Veni Hadju ◽  
C. Citrakesumasari ◽  
Andi Muhammad Akhmar
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Serum Zinc ◽  
Zinc Content ◽  
Control Group ◽  
Test Results ◽  
Pumpkin Seed ◽  
Seed Flour ◽  
Zinc Levels ◽  
Serum Zinc Levels

BACKGROUND: Serum zinc levels are found to be low in children of protein energy malnutrition globally. Pumpkin seed flour has a high zinc content of 6.88 mg/100 g, has been formulated biscuits made from pumpkin seed flour with a zinc content of 1.52 mg/100 g. AIM: This study aims to determine the effect of giving biscuits made from pumpkin seed flour to serum zinc levels and body weight in malnutrition Wistar rats. METHODS: This research is a true experiment with pre-post-test with control group design. Subjects were 28 male Wistar strain rats induced by fasting malnutrition for 3 days and then given biscuits with a zinc dose of 0.027 mg; 0.054 mg; and 0.081 mg/BW/day and in the control group without biscuits for 2 weeks. Serum zinc levels were examined using the atomic absorption spectrophotometry method. Data were analyzed using paired t-test and one-way ANOVA test. RESULTS: Paired t-test results on serum zinc levels obtained p > 0.05 and on body weight obtained p < 0.05. One-way ANOVA test results on serum zinc levels after the intervention obtained p > 0.05 and at body weight obtained p < 0.05 followed by post hoc least significant difference test found that there were significant differences between the control group and the P1 group, a dose of 0.027 mg (p = 0.015) and P2 groups, doses of 0.054 mg (p = 0.012). Greater weight gain was found in the P1 group with an increase of 38.85%. CONCLUSION: The provision of biscuits made from pumpkin seed flour has an effect on increasing body weight of malnutrition Wistar rats and has no effect on serum zinc levels, so further research is expected to use different doses.

scholarly journals Oral Microbiota Composition and Antimicrobial Antibody Response in Patients with Recurrent Aphthous Stomatitis

2019 ◽  
Vol 7 (12) ◽  
pp. 636 ◽  
Author(s):  
Zuzana Stehlikova ◽  
Vojtech Tlaskal ◽  
Natalie Galanova ◽  
Radka Roubalova ◽  
Jakub Kreisinger ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Serum Levels ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Common Disease ◽  
Oral Microbiota ◽  
Healthy Controls ◽  
Alpha And Beta Diversity ◽  
Oral Site ◽  
Bacteria And Fungi

Recurrent aphthous stomatitis (RAS) is the most common disease of the oral mucosa, and it has been recently associated with bacterial and fungal dysbiosis. To study this link further, we investigated microbial shifts during RAS manifestation at an ulcer site, in its surroundings, and at an unaffected site, compared with healed mucosa in RAS patients and healthy controls. We sampled microbes from five distinct sites in the oral cavity. The one site with the most pronounced differences in microbial alpha and beta diversity between RAS patients and healthy controls was the lower labial mucosa. Detailed analysis of this particular oral site revealed strict association of the genus Selenomonas with healed mucosa of RAS patients, whereas the class Clostridia and genera Lachnoanaerobaculum, Cardiobacterium, Leptotrichia, and Fusobacterium were associated with the presence of an active ulcer. Furthermore, active ulcers were dominated by Malassezia, which were negatively correlated with Streptococcus and Haemophilus and positively correlated with Porphyromonas species. In addition, RAS patients showed increased serum levels of IgG against Mogibacterium timidum compared with healthy controls. Our study demonstrates that the composition of bacteria and fungi colonizing healthy oral mucosa is changed in active RAS ulcers, and that this alteration persists to some extent even after the ulcer is healed.

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