scholarly journals Seroprevalence ofChlamydia PneumoniaeAntibodies in Stroke in Young

2009 ◽  
Vol 36 (6) ◽  
pp. 725-730 ◽  
Author(s):  
V. C. S. Srinivasarao Bandaru ◽  
D. Babu Boddu ◽  
V. Laxmi ◽  
M. Neeraja ◽  
S. Kaul
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Magnetic Resonance ◽  
Acute Ischemic Stroke ◽  
Tertiary Care ◽  
Control Group ◽  
Care Hospital ◽  
Igg Antibodies ◽  
Stroke Patients ◽  
Stroke In Young

Background:Younger patients, aged below 45 years, usually lack the conventional risk factors of stroke whereas infections, especially in developing countries, may play a role. There have been many reports in the last decade about the association ofChlamydia pneumoniae(C.pneumoniae) and atherosclerosis involving cerebral vessels.Objective:To investigate the seroprevalence ofC.pneumoniaeIgG and IgA antibodies in patients aged below 45 years with acute ischemic stroke.Methods:This study was done at a tertiary care hospital in South India between January 2004 and December 2006 where we recruited consecutive patients aged less than 45years with acute ischemic stroke. Age and sex matched controls were recruited from the outpatient department with non stroke diagnosis. All stroke patients underwent CT (Computerized Tomography), MRI (Magnetic Resonance Image), MRA (Magnetic Resonance Angiography), Transthoracic Echocardiography and Carotid Doppler for stroke sub group diagnosis. We measuredC.pneumoniaeantibodies IgG and IgA by microimmunofluorescence technique in all patients and controls.Results:A total of 120 patients and 120 controls were studied over a period of two years. We foundC.pneumoniaeantibodies in 29.1% (35/120) stroke patients and in 12.5% (15/120) control subjects (p=0.002).C.pneumoniaeIgG antibodies were found in 27.5 % (33/120) of stroke patients and 12.5% (15/120) of controls (p=0.006). IgAantibodies were observed in 5 % (6/120) of strokes and none in control group (p=0.03). After adjustment of all risk factorsC.pneumoniaeIgG seropositivity showed odds ratio of 2.6; 95% Confidence Interval 1.2-5.6.Conclusions:C.pneumoniaeIgG antibodies were found to be associated with ischemic stroke in young.

scholarly journals An observational study from a new tertiary care hospital in North Odisha: clinical and etiological profile of acute ischemic stroke patients

2019 ◽  
Vol 6 (5) ◽  
pp. 1605
Author(s):  
Bibhu P. Behera ◽  
Partha S. Mohanty
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Observational Study ◽  
Acute Ischemic Stroke ◽  
Hemorrhagic Stroke ◽  
Tertiary Care ◽  
Care Hospital ◽  
Stroke Patients ◽  
Middle Income ◽  
Stroke Subtypes

Background: Worldwide, cerebrovascular accidents (stroke) are the second leading cause of death and the third leading cause of disability. According to WHO estimation, by 2050 nearly 80% of stroke cases may occur in low and middle-income countries like China and India. It is critical that we understand the etiology causing the stroke so that appropriate treatment can be initiated in a timely fashion. Furthermore, understanding the risk factors associated with stroke is important before primary and secondary preventive measures can be prescribed to the patient.Methods: This observational study was carried out amongst 481 acute ischemic stroke patients that fulfils the inclusion and exclusion criteria and admitted in medicine ward of Pandit Raghunath Murmu Medical College and Hospital, Baripada, Dist. Mayurbhanj, Odisha, India from June 2018 to January 2019. Results: In our study, 481(60.43%) patients had ischemic stroke and 315 (39.57%) patients had hemorrhagic stroke. The incidence of stroke is maximum in 51-70 years of age group which comprises of 59.46% of total patients. The average age + SD were 61.4±13.1 in our study. The most common risk factor was hypertension with 69.85% followed by dyslipidemia 51.77%. Most common clinical presentation was hemiplegia (72.35%) followed by speech involvement (59.46%). Most common site of infarct was parietal (22.25%), followed by periventricular (12.68%).Conclusions: Most of the patients had ischemic stroke as compared to hemorrhagic stroke. It was more common in males. The study contributes to understanding of demographic characteristics, risk factors, and stroke subtypes in acute ischemic stroke. The importance of various risk factors among ischemic stroke subtypes should be stressed for prompt preventive strategies and treatment.

scholarly journals Ischemic stroke: Observations and analysis of stroke patients admitted in a tertiary hospital of Kathmandu

2019 ◽  
Vol 8 (2) ◽  
pp. 66-71
Author(s):  
Dipesh Shakya ◽  
Rabindra Shrestha ◽  
Krishna Dhungana ◽  
Raisha Kafle ◽  
Sabnam Bhatta
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Carotid Artery ◽  
Public Awareness ◽  
Tertiary Care ◽  
Care Hospital ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Carotid Artery Atherosclerosis ◽  
Common Risk Factors

Background: Stroke is a disabling condition that has physical and mental impact on a patient’s life. Stroke is an important morbidity for low and middle income countries like Nepal. Hypertension, diabetes, smoking, and dyslipidemia are common risk factors in this regard and are inadequately controlled; mainly because of poor public awareness, inadequate infrastructure, lack of service and qualified manpower.Objectives: This study aims to provide insight into the epidemiology and risk factors in ischemic stroke patients.Methodology: A descriptive cross sectional study was conducted in 92 ischemic stroke patients at a tertiary care hospital Kathmandu Medical College and Teaching Hospital (KMCTH), Sinamangal, Nepal from December 2017 to June 2018. Consecutive sampling technique was used and data was collected from ischemic stroke patients above 14 years of age who were admitted in the Department of Neurology. Information regarding pre-morbid and morbid conditions, imaging findings as well as results was obtained from biochemical analysis of blood after taking consent from the patient or patient’s relative. Statistical Package for the Social Sciences Version 20 was used as a tool for statistical analysis.Results: Their mean age was 63.25 years with standard deviation of 16.45. Dyslipidemia was the most commonly found risk factor which was present in 77.2% of the subjects, followed by smoking (59.8%), presence of carotid artery atherosclerosis (59.8%), hypertension (50%), atrial fibrillation (26.1%) and diabetes mellitus(15.2%). Smoking was significant in males and heart disease was mostly seen in females.Conclusion: Dyslipidemia and smoking were the most common risk factors followed by carotid artery atherosclerosis. Patients with hypertension and dyslipidemia had higher incidence of stroke in both young and elderly group.

scholarly journals Study On Stroke In Young Patient Due To Cardiac Disease in Tertiary Care Hospital in Dhaka City

2016 ◽  
Vol 17 (2) ◽  
pp. 95-99
Author(s):  
Sanjoy Kumar Saha ◽  
Prodip Kumar Biswas ◽  
Meherunessa Mukta ◽  
Mohammed Shahadat Hossain ◽  
Mimal Kumar Basu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Ischemic Stroke ◽  
Cardiac Disease ◽  
Heart Diseases ◽  
Tertiary Care ◽  
Care Hospital ◽  
Stroke Patients ◽  
Female Ratio ◽  
Valvular Heart Diseases

Objectives: Study of the risk factors associated with stoke due to cardiac disease in age group between 18 to 45 years of age,evaluate the risk factor of hospitalized stroke patients & to search for cardiac disease associated with stroke also appropriate preventive measure applicable for our country.Materials & Methods: Non randomized prospective observational study was carried out in the department of Neurology, Medicine & Cardiology unit of Dhaka Medical College Hospital between the periods of July 2009 to December 2009. Fifty (50) consecutive indoor patients more than 18 years of both sex admitted with suspicion of stroke. Diagnosis of stroke will be made from details clinical history clinical examination and confirmed by CT scan or MRI.Result: Fifty patients were randomly chosen for this study, of which 26 (52%) patients were male, 24 (48%) patients were female & male: female ratio was 1.08:1. Highest incidence of stroke was in between 3rd & 4th decade. The incidence of ischemic stroke 46 (92%) & hemorrhagic stroke 4(8%).Cardio embolism is the major (92%) risk factor for ischemic stroke. Among the cardiac risk factors, valvular disease (64%), MI (16%), &IHD (10%), Atrial fibrillation 8%, Patent foramen ovale 2%.Among the patients 33.33% of women with cerebral infarction were using OCP. Majority of the patients in this study were sedentary worker (45%). Among the stroke patients 8% & 10% had previous H/O stroke & TIA respectively.Conclusion: In this study a number of modifiable risk factors were identified, of which valvular heart disease & HTN are important risk factor next are DM & IHD smoking. Most of the valvular heart diseases are rheumatic in origin, which can be prevented through primary & secondary prevention of rheumatic fever.J MEDICINE July 2016; 17 (2) : 95-99

Risk Factors, Etiology, and Clinical Outcome of Ischemic Stroke in Young Adults Admitted in a Tertiary Care Hospital in India

2019 ◽  
Vol 2 (1) ◽  
pp. 32-39
Author(s):  
Madhavi Karri ◽  
Balakrishnan Ramasamy
Keyword(s):  
Risk Factors ◽  
Young Adults ◽  
Ischemic Stroke ◽  
Clinical Outcome ◽  
Tertiary Care ◽  
Care Hospital ◽  
Diagnostic Challenge ◽  
Stroke Treatment ◽  
Stroke In Young Adults ◽  
Stroke In Young

Background: Ischemic stroke in young adults is becoming a rising concern with the increase in vulnerability to traditional risk factors and changing lifestyles. Aim: An overview of risk factors, classification, and clinical outcome of ischemic stroke in young adults (19 to 45 years) has been presented. Methods: Data fulfilling the study criteria from the stroke registry between June 2014 and June 2017 were collected, and a detailed proforma was taken that included history, clinical examination, and routine investigations. Selective investigations such as prothrombotic workup and 24-hour Holter monitoring were performed. Stroke was subclassified using the Trial of Org 10172 in Acute Stroke Treatment criteria. National Institute of Health Stroke Scale (NIHSS) scores at baseline and the modified Rankin score (mRS) scoring after 3 months of patients’ admission were calculated. Results: Out of 223 identified cases of ischemic stroke in young adults, 186 (83.4%) were taken for analysis, constituting 7.3% of the total stroke population of 3,059. Among the cases taken for analysis, 137 were males and 49 were females. A total of 150 patients were among the age group of 36 to 45 years. Dyslipidemia, smoking, and alcohol consumption were prevalent in the study group. Atherosclerotic strokes were predominant in the study population. NIHSS scores at admission had a significant impact on mRS scores after 3 months. In this study, only 4% reported the recurrence of stroke, whereas mortality was about 0.02%. Conclusions: Workup required for ischemic stroke in young adults has always been a diagnostic challenge for physicians who treat the stroke patients, and this must be optimized in all health care centers. Despite extensive workup, 23.66% participants were found to be cryptogenic in this study. The clinical outcome was good in this study with less mortality observed.

scholarly journals Association of Mean Platelet Volume with Risk Factors and Functional Outcome in Acute Ischemic Stroke

2021 ◽  
Author(s):  
Sreejith OT ◽  
Lubna Zafar ◽  
Mujahid Beg ◽  
Obaid Ahmed Siddiqui
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Mean Platelet Volume ◽  
Tertiary Care ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Care Hospital ◽  
Platelet Volume ◽  
Vessel Occlusion

Abstract Background Stroke is the second leading cause of death in the world and a major cause of disability, with ischemic stroke contributing to 87% of all strokes. Platelets are central in the formation of thrombus, and in the process, they enlarge in size, become active, and secrete prothrombotic factors. This is supported by the presence of large platelets in ischemic stroke, where they may be implicated in the pathogenesis of vessel occlusion, leading to stroke. The mean platelet volume (MPV) is an important laboratory marker of platelet function and activation. Materials and Methods The present study was conducted to assess the role of MPV in the pathogenesis, severity, and outcome of ischemic stroke. It was an observational study in 100 acute ischemic stroke (AIS) patients (excluding cardioembolic stroke) admitted to the Medicine wards, Department of Medicine, Jawaharlal Nehru Medical College, a tertiary care hospital at Aligarh. The MPV was correlated with the conventional risk factors of ischemic stroke and outcome (using modified Rankin scale [mRS]). The study revealed statistically significant correlation between MPV and hypertension, type 2 diabetes mellitus, and carotid intima media thickness (CIMT). Also, the MPV at presentation positively correlated with mRS (correlation coefficient 0.818); thus, high MPV was associated with more severe disability. Conclusion The MPV at the time of presentation of ischemic stroke may be useful in predicting the severity of stroke and neurological recovery. However, a larger study including diverse population is required to endorse its predictive value in AIS.

scholarly journals Impact of hyponatremia on outcome of acute ischemic stroke in a tertiary care hospital.

2019 ◽  
Vol 26 (10) ◽  
pp. 1789-1793
Author(s):  
Aneela Altaf Kidwai ◽  
Jamal Ara ◽  
Shumaila Abdul Rasheed ◽  
Najeebullah ◽  
Saleemullah Paracha
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Serum Sodium ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Stroke Patients ◽  
Cerebral Salt Wasting ◽  
Cross Sectional ◽  
Salt Wasting

Objectives: To determine the frequency and impact of hyponatermia on outcome in patients of acute ischemic stroke admitted to a Tertiary Care Hospital, Karachi. Study Design: Prospective, cross-sectional, observational study. Setting: Department of Medicine, Abbasi Shaheed Hospital, Karachi. Period: January 2015 to May 2018. Material and Methods: A total of 110 patients of both gender presented with acute ischemic stroke and hyponatermia (2 consecutive serum sodium levels (< 135 mEq/L). Diagnosis of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and cerebral salt wasting (CSW) was based on predefined criteria. Mortality was considered in terms of modified Rankin Scale with score of 6 within four weeks of admission. Data was analyzed by using SPSS Version 20. Result: Out of 110 acute ischemic stroke patients, 66 (60%) were male and 44 (40%) were female. The mean age was 61.45 ± 11.8 years. Mean serum sodium level was 128.4 ± 6.07. Older ages are associated with high mortality rate of 20%. Moderate (29%) and severe (11%) hyponatremia was associated with 21% and 33% mortality respectively. Overall mortality in patients with hyponatremia was 14.5%. Conclusion: Mortality rates are higher in acute ischemic stroke patients presented with moderate to severe hyponatremia.

scholarly journals A Prospective Observational Study on Risk Factors and Prescribing Patterns of Drugs used in Stroke Patients at a Tertiary Care Teaching Hospital.

2020 ◽  
Vol 10 (5-s) ◽  
pp. 71-75
Author(s):  
Syed Areefulla Hussainy ◽  
Madiha Habeeb ◽  
Ayesha Jeelani ◽  
Sumaiya Sultana ◽  
Mohammed Mohiuddin Meeran
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Observational Study ◽  
Hemorrhagic Stroke ◽  
Tertiary Care ◽  
Prescribing Patterns ◽  
Care Hospital ◽  
Stroke Patients ◽  
Optimal Care ◽  
Early Management

Objectives: The main aim of the study is to identify the different risk factors, prescribing patterns of medication and rationality of the prescription by observing the management of stroke patients carefully. Methodology: A prospective and observational study was carried out for a period of 6 months in an in-patient department of a tertiary care hospital. Patients above 18 years of age, patients of either sex and patients who previously had stroke were included. Children below 18 years, pregnant women, AIDS patients, patients unable to respond to verbal questions with no caretakers and patients with head injury were excluded. Results: A total of 100 prescriptions were analyzed during the 6 months study period. This was found to be higher in males (79) and females (21). The higher risk with notable occurrence in the age group of 60-79 years (43%). Out of these study populations, (68%) experienced Ischemic stroke and (32%) experienced Hemorrhagic stroke. The major risk factors were Hypertension (62%), alcoholics (41%). Smoking (33%) and Diabetes (24%). Among the 100 prescriptions, Atorvastatin was highly prescribed (96) followed by Pantoprazole (92), Mannitol (64). Out of 100 prescriptions, (67) were rational and (33%) were irrational. Conclusion: The prescribing patterns of drug should be based on specificity and severity of stroke in order to facilitate rational use of drugs providing optimal care. Early management of hypertension and diabetes may reduce risk of stroke. Cessation of smoking and alcohol place a key role in prevention of stroke. Keywords: Ischemic stroke, hemorrhagic stroke, hypertension, diabetes.

scholarly journals Socio-demographic characteristics of ischemic stroke patients in a tertiary care hospital of Nepal

2020 ◽  
Vol 1 (1) ◽  
pp. 16-19
Author(s):  
Ritesh Luitel ◽  
Sujan Dhital ◽  
Subodh Sharma Paudel ◽  
Suman Bhattarai
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Ischemic Stroke ◽  
Alcohol Consumption ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Demographic Characteristics ◽  
Care Hospital ◽  
Stroke Patients ◽  
History Of

Introduction: Incidence of stroke patients is increasing in low income countries like Nepal where management of these patients is challenging due to poor healthcare resources. Ischemic stroke is related to risk factors like age, male population, hypertension, diabetes mellitus, smoking and alcohol. Identification of these risk factors in the vulnerable population is important for prevention of ischemic stroke. The purpose of this study is to find out the social and demographic characteristics of patients with acute ischemic stroke treated at Upendra Devkota Memorial National Institute of Neurological and Allied Sciences, a tertiary care hospital of Nepal. Methods: Data was collected from all acute ischemic stroke patients presenting to the hospital over a period of one year. The age, sex, medical history of hypertension and diabetes and history of smoking and alcohol consumption were recorded. Statistical analysis of data was performed using Microsoft EXCEL 2019. Result: Total 310 patients were studied, out of which two-thirds were male. The highest number of patients were within the age group of 60-80 years with the mean age being 60 years. Hypertension and diabetes were present in 67.42% and 28.53% of patients respectively. 43.93% of the patients smoked while 33.87% of the patients consumed alcohol. Conclusion: Identification of association between risk factors like age, sex, hypertension, diabetes mellitus, smoking and alcohol consumption must be the emphasis for targeted preventive action to decrease the increasing burden of ischemic stroke among developing countries.

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