Merkel Tactile Cells of the Human Embryo Nail

1971 ◽  
Vol 29 ◽  
pp. 546-547
Author(s):  
K. Hashimoto
Keyword(s):  
Synaptic Vesicles ◽  
Direct Contact ◽  
Basal Layer ◽  
The Body ◽  
Human Embryos ◽  
Perivascular Spaces ◽  
Merkel Cells ◽  
Merkel Cell ◽  
Present Survey ◽  
Nail Matrix

The Merkel tactile cell of the human skin has mainly been described in association with the Haarscheibe (hair disc) in the part of the body where lanugo hairs are present. In the present survey a number of Merkel cells were found in the nail matrix of 15-18 weeks old human embryos (figs. 1,2). Dorsal matrix contained more cells than the ventral half. It was also found in the perivascular spaces of the finger of the same embryos (fig. 3). In both locations nerve endings rich in mitochondria and synaptic vesicles were in direct contact with the Merkel cell (figs. 1-3). In the nail matrix the Merkel cell was most commonly found within or just above the basal layer. Less frequently, they were present in the upper dermis. Such dermal Merkel cells were completely covered with basal lamina suggesting that they were projecting downward from the basal layer. Occasionally, two cells with centrioles were seen side by side suggesting that one of them was produced from the other by mitosis (fig. 1).

scholarly journals Markel Cell Carcinoma

2010 ◽  
Vol 49 (178) ◽  
Author(s):  
S Wallis ◽  
A Durham-hall ◽  
N Tondon ◽  
TM Brotherstone ◽  
BM Shrestha
Keyword(s):  
Cell Carcinoma ◽  
Neuroendocrine Tumour ◽  
Basal Layer ◽  
Metastatic Potential ◽  
Hair Follicles ◽  
High Rate ◽  
Merkel Cells ◽  
Merkel Cell ◽  
Review Of The Literature ◽  
Poor Outcomes

Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine tumour of the skin with high rate of local recurrence and distant metastatic potential leading to poor outcomes. Merkel cells are normally found as innervated clusters of cells around hair follicles in the basal layer of the epidermis and are thought to function as touch receptors. Here, we describe a case of MCC in a 71-year-old female and provide an up-to-date review of the literature pertinent to the management of MCC. KEYWORDS: merkell cell carcinoma, diagnosis, imunohistochemistry, management.

Localization of Merkel cells at hairless and hairy human skin sites using keratin 18

1995 ◽  
Vol 73 (9-10) ◽  
pp. 635-639 ◽  
Author(s):  
Julie Fradette ◽  
Marie-Josée Godbout ◽  
Martine Michel ◽  
Lucie Germain
Keyword(s):  
Human Skin ◽  
Basal Layer ◽  
Sensory Nerve ◽  
Neurosecretory Cells ◽  
Nerve Fibers ◽  
Hair Follicles ◽  
Merkel Cells ◽  
Merkel Cell ◽  
Skin Receptor ◽  
And Function

Merkel cells are neurosecretory cells of the skin with epithelial features such as desmosomes and expression of keratins 8, 18, 19, and 20. Merkel cells are scarcely distributed in adult human skin. Although they are present in hair follicles, their density is higher at hairless anatomic sites such as palms and soles. These cells are often innervated by sensory nerve fibers and are thought to be specialized mechanosensory skin receptor cells. However, their precise origin and function are not clearly established. The aim of this study was to localize Merkel cells in human hairless and hairy skin by immunohistochemistry with antibodies Ks18.174 and Ks19.1 directed against keratins 18 and 19, respectively. In glabrous skin of palm and sole, Merkel cells have been localized at the bottom of the rete ridges, in the epidermal basal layer. To study Merkel cell distribution at hairy anatomic sites, we have chosen breast skin, a tissue containing small hair follicles typical of those covering most of the body's surface. Merkel cells were present in the interfollicular epidermis. In hair follicles, they have been identified in the isthmus region.Key words: skin, human, Merkel cell, keratin, hair follicle.

Fine structure of the kinetochores in six species of the Coleoptera

Genome ◽  
1997 ◽  
Vol 40 (3) ◽  
pp. 379-385
Author(s):  
Klaus Werner Wolf
Keyword(s):  
Direct Contact ◽  
Karyotype Evolution ◽  
Coccinella Septempunctata ◽  
Cell Types ◽  
Male Meiosis ◽  
Serial Sections ◽  
Cell Type ◽  
Present Survey ◽  
Transmission Electron ◽  
Size Variability

Kinetochore structure was examined in a total of 6 species from 5 different families of the Coleoptera using transmission electron microscopy of ultrathin serial sections. Metaphase spermatogonia and primary and secondary spermatocytes were studied in Tenebrio molitor (Tenebrionidae) to determine whether kinetochore structure varies depending on the cell type. In all three cell types, the kinetochore microtubules (MTs) were in direct contact with the chromosomal surface, and kinetochore plates were not detectable. In the other species, only metaphase I spermatocytes were examined. As in T. molitor, distinct kinetochore plates were also absent in Adelocera murina (Elateridae), Agapanthia villosoviridescens (Cerambycidae), and Coccinella septempunctata (Coccinellidae). However, bivalents in male meiosis of two representatives of the Chrysomelidae, Agelastica alni and Chrysolina graminis, showed roughly spherical kinetochores at their poleward surfaces. Microtubules were in contact with this material. Thus, although the present survey covers only a small number of species, it is clear that at least two kinetochore types occur in the Coleoptera. The cytological findings are discussed in the context of chromosome number and genome size variability in the Coleopteran families studied. It is suggested that properties of the kinetochores could play a role in karyotype evolution in the Coleoptera.Key words: bivalent, microtubule, meiosis, metaphase, spermatocyte.

scholarly journals Homo- and heterotypic cell-cell contacts in Merkel cells and Merkel cell carcinomas: heterogeneity and indications for cadherin switching

2011 ◽  
Vol 58 (2) ◽  
pp. 286-303 ◽  
Author(s):  
Anna M Werling ◽  
Yvette Doerflinger ◽  
Johanna M Brandner ◽  
Franca Fuchs ◽  
Jürgen C Becker ◽  
...  
Keyword(s):  
Merkel Cells ◽  
Merkel Cell ◽  
Cell Contacts ◽  
Cell Cell

Lice

1995 ◽  
Vol 16 (9) ◽  
pp. 336-337
Author(s):  
Howard C. Sonnenblick
Keyword(s):  
Direct Contact ◽  
Common Type ◽  
The Body ◽  
School Age Children ◽  
School Age ◽  
Sexually Active ◽  
Head Lice ◽  
Pediculosis Capitis ◽  
Small Children ◽  
Pediculosis Pubis

Three forms of pediculosis affect the human host, each with a predilection for certain parts of the body. Pediculosis capitis. or head lice, is the most common type and is seen primarily in preschool and school-age children, especially girls. Transmission occurs by coming into direct contact with lice or by sharing infested brushes, combs, and hats. Adult lice and their eggs (nits) are found principally in the occipital region and behind the ears. Symptoms include severe itching, often resulting in excoriation and secondary bacterial infection. Pediculosis pubis is seen most commonly in sexually active adolescents and young adults, although occasionally it may be found on the eyelashes of small children who come in contact with infected individuals.

Metastasis of cancer from Merkel cells to the thyroid gland

2021 ◽  
Vol 19 (1) ◽  
pp. 86-88
Author(s):  
Piotr Przyczyna ◽  
◽  
Elżbieta Trojnar ◽  
Dorota Bartusik-Aebisher ◽  
David Aebisher ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Thyroid Cancer ◽  
Thyroid Gland ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Uterine Fibroids ◽  
Degenerative Changes ◽  
Merkel Cells ◽  
Merkel Cell ◽  
Left Buttock

Introduction. Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer. Aim. Herein described is a case of hypertensive patient, after removal of Merkel cancer of the left gluteus skin (2011), after pulmonary embolism (2013), with degenerative changes of the spine and uterine myoma, chronically treated with Warfarin, because of suspected thyroid cancer. Description of the case. A 70-year-old woman case after removing Merkel cancer of the left buttock skin (2011), after pulmonary embolism (2013), with degenerative changes of the spine and uterine fibroids treated chronically with Warfarin because of suspected thyroid cancer is described. Conclusion. Increasing evidence of Merkel cell carcinoma with immunodeficiency and neoplasia, and the management and outcome of these patients requires study.

scholarly journals Mark of the Spirit: Body Marks as Icons of Spirituality among the Dangme in Ghana

2020 ◽  
pp. 25-35
Author(s):  
Alice Korkor Ebeheakey ◽  
Steve Kquofi ◽  
Eric Appau Asante ◽  
Charlotte Buerkie Nubuor
Keyword(s):  
Driving Force ◽  
Direct Contact ◽  
Cultural Practices ◽  
Relevant Information ◽  
Qualitative Approach ◽  
The Body ◽  
Traditional Religion ◽  
Beliefs And Practices ◽  
Higher Power ◽  
The Will

In African traditional religion, priding oneself in the beliefs and practices of one’s culture is intensely essential. The driving force for this is mainly the need to satisfy the will of a higher power. Cultural practices, being a channel between the living, the dead and the spirits is one of the ways in which a group of people satisfy the will of these higher beings. Body marking, among the Dangme, forms a great deal of aspects of cultural practices which connotes spirituality. This study discusses the concept of spirituality as enshrined in the body marks of the Dangme people of Ghana. To obtain the relevant information needed, the qualitative approach to research has been adopted using interviews and observation as the main data collection tools. These give a rich and in-depth understanding of the body marks that are practiced for spiritual purposes among the Dangme. This paper is a collation of findings from studies conducted between February, 2012 and February, 2019. It is evident from the research that, marks for spiritual purposes seemed to be practiced irrespective of the clan individuals hail from. These marks are seen as methods (or modes) of maintaining direct contact and proving allegiance to the spirits that protect them as a people.

scholarly journals Solidification of the Sense of Eminency by Distraction of Light and Shadow at Sheikh Lotfollah Mosque

2015 ◽  
Vol 10 (Special-Issue1) ◽  
pp. 208-214
Author(s):  
Moeid Farsa ◽  
Mahdiye Jahri ◽  
Mehdi Alirezai
Keyword(s):  
The Body ◽  
The Other ◽  
Moral Sense ◽  
Natural Light ◽  
Present Survey ◽  
Traditional Architecture ◽  
Physical Presence ◽  
The Mind ◽  
Light And Shadow

Architecture and light are to that extent dependent on each other which body and spirits are.One for living and the other for physical presence in this world needs the other and while light is flown on the body of the space both two perceptible worlds become “ existed “.Since long ago, bright and shimmering materials which remind something living in the mind of individual were respectable and adorable. Being aware of the process of exploitation of sunlight is of importance as much as the process of materials formation or different fundamental forms of construction in order to design. Almost in all religions, light is the symbol of Devine wisdom and the Essene of all beneficence and purities and mobility from darkness to light, was considered as the main objective. Islamic Mosques which are ornamented with light are perfectly able to transmit this divine and moral sense. In such spaces which are lighten up with a shimmering light and by observance of the imprecise shadows of substances and masses, individual starts to complete the pictures in his mind and by such an activity gets in to an ecstasy and as a result a feeling of getting close to the source of existence and reality wakens up inner inside him. The present survey by depending on descriptive-analytic methods, studies light in Islamic and traditional architecture. This paper by case study of Sheikh Lotfollah Mosque, aims to find out whether the presence of light and specifically natural light in architecture might have further meaning rather than brightness, and whether accessing an accurate pattern of application of light is possible or there is basically no compulsion in it ?

scholarly journals CRITICAL STUDY OF TVAK IN THE VIEW OF MODERN SCIENCE: A REVIEW ARTICLE

2021 ◽  
Vol 9 (8) ◽  
pp. 1795-1799
Author(s):  
Ishan Malhotra ◽  
Sakshi Sakshi ◽  
Subhash Upadhyay
Keyword(s):  
Direct Contact ◽  
External Surface ◽  
Modern Science ◽  
Review Article ◽  
The Body ◽  
Critical Study ◽  
Entire Body ◽  
Internal Structures ◽  
Normal Colour ◽  
Modern Era

In Ayurveda, the term Tvak, Twacha and Charma are frequently used to denote the skin. Tvak is described as the organ which covers the external surface of the entire body. Tvak and its related diseases have great importance because these are easily noticeable. It is the first part of the body that is in direct contact with any harmful sub- stances or infective microorganisms. It protects the internal structures of the body from injury or infections and regulates the temperature of the body. Skin is also the beauty of a human being. Therefore, it should be protected from any abnormal conditions. Ayurveda Acharyas have described Tvak many years ago. They explained each layer of Tvak in meaningful sequences, its related diseases and measurement of each layer. They also explained that it maintains the normal colour of individuals and conveys the sensation of touch. Some topics of Ayurveda are easy to understand, and some topics become easy if we study along with modern science. So, for a proper un- derstanding of the concept of Tvak, it is very essential to correlate it with modern science and elaborate according to the modern era. Keywords: Tvak, Sparshanendriya, Sharirsthan, Santanika, Vrihi, Skin, Dermis, Epidermis

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