scholarly journals Prospective study of diarrhoeal disease in a cohort of rural Mexican children: incidence and isolated pathogens during the first two years of life

1988 ◽  
Vol 101 (1) ◽  
pp. 123-134 ◽  
Author(s):  
Alejandro Cravioto ◽  
Rosa E. Reyes ◽  
Roberto Ortega ◽  
Guadalupe Fernández ◽  
Raymundo Hernández ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Prospective Study ◽  
Diarrhoeal Disease ◽  
First Year ◽  
Colonization Factor ◽  
Mexican Children ◽  
Heat Stable ◽  
Colonization Factors ◽  
Second Year ◽  
First Year Of Life

SUMMARYColonization of the intestine by putative pathogens was followed longitudinally in a cohort of 56 infants born during one calendar year in a rural Mexican village with faecal cultures taken every fortnight and every time a child had diarrhoea. The frequency of isolation of pathogens during episodes of diarrhoea was compared with that of matched controls from the same cohort. Incidence of diarrhoea during the first year of life was 98%, diminishing to 93% during the second year. The incidence curves for each year were not significantly different (P> 0·1). Isolation of enteropathogenicEscherichia coli, enterotoxigenicEscherichia coliproducing heat-stable (ST) and/or heat-labile (LT) enterotoxins and rotaviruses was significantly higher in infants with diarrhoea during the first 2 years of life. In the case of shigella, although no significant differences were found by semester of life, 13 of 16 children in which these strains were found had diarrhoea. Isolation ofSalmonellaspp.,Campylobacterspp. and protozoa were not significantly different in the two groups during the period studied. Strains showing localized adherence to HEp-2 cells or the presence of colonization factor antigens I or E8775 were found with significantly higher frequency in children with diarrhoea. Eighty-two percent of ST+or LT+ETEC strains isolated produced one of the three known colonization factors.

scholarly journals Prospective study to assess maternal knowledge, attitude and practices regarding childhood diarrhoea

2018 ◽  
Vol 5 (3) ◽  
pp. 804 ◽  
Author(s):  
Naresh Kumar ◽  
Supriya Malik
Keyword(s):  
Prospective Study ◽  
Low Income ◽  
Diarrhoeal Disease ◽  
First Year ◽  
Maternal Knowledge ◽  
Highly Educated ◽  
Vernacular Language ◽  
A Prospective Study ◽  
First Year Of Life ◽  
Children Under 5

Background: Diarrhoea is one of the major and most frequently encounter problem by the paediatrician. Diarrhoeal disease is the second leading cause of death n children under 5 yrs and is responsible for killing around 5,25,000 children every year. In low income counties, children under three years old, experience on an average three episodes of diarrhoea every year. Each episode deprives the child of the nutrition necessary for growth. Current study was conducted to assess maternal knowledge, attitude over practice regarding diarrhoeal disease.Methods: The present study is a prospective study, carried out at department of paediatrics, at Sri Guru Ram Das University of Medical Sciences and Research Amritsar from Jan 2016—Jan 2018 over period of 2 years. Total 25-0 mothers were intervened to assess their knowledge, attitude and practices during episodes of diarrhoea on basis of educational qualification of mothers, data were divided into three categories: Illiterate, moderately educated including mothers having qualification up to graduation, highly educated-mothers who did post-graduation or some professional education.Results: Total 250 mothers were included in the study with prior informed consent and question were asked as per preformed questionnaire and vernacular language and English too. In present study, it was observed that maximum number of diarrhoea causes 77.76% were seen in first year of life and there was higher incidence (74.4%) among male children. Incidence of diarrhoea was 67.6% among children of illiterate mother in contrast to 12% among a mother of having higher qualification.Conclusions: Finding of present study indicated low proportion of maternal knowledge and practice about etiologies and management of diarrhoeal disease among children under 5 years of age. Programme should focus on provided awareness to patients and education of mother should focus on symptoms of dehydration, knowledge on ORS, hoe to prepare an ORS, prevention on danger sign and diseases. rural population.

Prevalence of Toxin Types and Colonization Factors in Enterotoxigenic Escherichia coli Isolated during a 2-Year Period from Diarrheal Patients in Bangladesh

2000 ◽  
Vol 38 (1) ◽  
pp. 27-31
Author(s):  
Firdausi Qadri ◽  
Swadesh Kumar Das ◽  
A. S. G. Faruque ◽  
George J. Fuchs ◽  
M. John Albert ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Severe Disease ◽  
Surface Antigens ◽  
Enterotoxigenic Escherichia Coli ◽  
Colonization Factor ◽  
Heat Stable ◽  
Routine Surveillance ◽  
Stool Samples ◽  
Colonization Factors ◽  
Severity Of The Disease

ABSTRACT The prevalence of toxin types and colonization factors (CFs) of enterotoxigenic Escherichia coli (ETEC) was prospectively studied with fresh samples ( n = 4,662) obtained from a 2% routine surveillance of diarrheal stool samples over 2 years, from September 1996 to August 1998. Stool samples were tested by enzyme-linked immunoassay techniques and with specific monoclonal antibodies for the toxins and CFs. The prevalence of ETEC was 14% ( n = 662), with over 70% of the strains isolated from children 0 to 5 years of age, of whom 93% were in the 0- to 3-year-old age range. Of the total ETEC isolates, 49.4% were positive for the heat-stable toxin (ST), 25.4% were positive for the heat-labile toxin (LT) only, and 25.2% were positive for both LT and ST. The rate of ETEC isolation peaked in the hot summer months of May to September and decreased in winter. About 56% of the samples were positive for 1 or more of the 12 CFs that were screened for. The coli surface antigens CS4, CS5, and/or CS6 of the colonization factor antigen (CFA)/IV complex were most prevalent (incidence, 31%), followed by CFA/I (23.5%) and coli surface antigens CS1, CS2, and CS3 of CFA/II (21%). In addition, other CFs detected in decreasing order were CS7 (8%), CS14 (PCFO166) (7%), CS12 (PCFO159) (4%), CS17 (3%), and CS8 (CFA/III) (2.7%). The ST- or LT- and ST-positive ETEC isolates expressed the CFs known to be the most prevalent (i.e., CFA/I, CFA/II, and CFA/IV), while the strains positive for LT only did not. Among children who were infected with ETEC as the single pathogen, a trend of relatively more severe disease in children infected with ST-positive ( P < 0.001) or LT- and ST-positive ( P < 0.001) ETEC isolates compared to the severity of the disease in children infected with LT only-positive ETEC isolates was seen. This study supports the fact that ETEC is still a major cause of childhood diarrhea in Bangladesh, especially in children up to 3 years of age, and that measures to prevent such infections are needed in developing countries.

An inevitable crisis? From first to second year in counsellor training

2020 ◽  
Vol 5 (1) ◽  
pp. 74-89
Author(s):  
Hugh Crago
Keyword(s):  
Right Hemisphere ◽  
Training Programme ◽  
First Year ◽  
Training Experience ◽  
Counsellor Training ◽  
Student Dropout ◽  
Second Year ◽  
Neurological Research ◽  
First Year Of Life ◽  
And Control

In a seminal 1973 paper, Robert Clark described the very different “cultures” of the first and second year students in a four year clinical psychology PhD programme. The author applies Clark’s template to his own experiences as trainee or trainer in five different counsellor education programmes, one in the US and four in Australia. Each of the programmes, to varying degrees, demonstrates key features of the pattern identified by Clark, where the first year is “therapeutic” and other-oriented, the second is “professional” and self-focused. The author concludes that all the surveyed programmes exhibited some level of “second year crisis”, in which a significant number of students felt abandoned, dissatisfied, or rebellious. The author extends and refines Clark’s developmental analogy (first year = childhood; second year = adolescence) to reflect recent neurological research, in particular, the shift from a right hemisphere-dominant first year of life, prioritising affiliative needs, to a left hemisphere-dominant second year, prioritising autonomy and control. This shift is paralleled later by a more gradual move from a protective, supportive childhood to necessary, but sometimes conflictual, individuation in adolescence. The first two years of a counsellor training programme broadly echo this process, a process exacerbated by the second year internship/placement, in which students must “leave home” and adjust to unfamiliar, potentially less nurturing, authority figures. Finally, the author suggests introducing more rigorous “academic holding” into the first year, and greater attention to “therapeutic holding” of dissident students in the second, hopefully decreasing student dropout, and achieving a better balanced training experience.

scholarly journals Influence of increasing doses of nitrogen on feed productivity of perennial grasses

2019 ◽  
pp. 19-24
Author(s):  
Svetlana Vasil'evna Ivanova ◽  
Olga Vasil'evna Kurdakova ◽  
Aminat Msostovna Konova ◽  
Anna Yurievna Gavrilova
Keyword(s):  
Dry Matter ◽  
The State ◽  
Perennial Grasses ◽  
Nitrogen Fertilizers ◽  
First Year ◽  
Yield Increase ◽  
Green Mass ◽  
State Register ◽  
Second Year ◽  
First Year Of Life

In the course of the experiment, the effect of increasing doses of nitrogen fertilizers on the yield of clover of the meadow variety Nadezhny, entered in the State Register of Breeding Achievements in 2012, was analyzed. A comparison is also made of this influence with the timothy of the meadow variety Leningradskaya 204. It was established that the pre-sowing introduction of mineral nitrogen for clover and timothy has influenced the productivity of these crops, but the nature of this effect varies depending on the type of grass. The introduction of N20 against the background of P30K90, which provided an increase in control of 51.2% for green mass and 33.6% for air-dry matter, was optimal for meadow clover of the first year of life. For grassland clover second year of life, the best option was N0P30K90, which gave an increase of 56.6% to the control on green mass and 50.6% on air-dry matter. A further increase in the dose of nitrogen on the options caused a decrease in yield increase. Timothy meadow for two years of life was traced responsiveness to the provision of nitrogen. The most productive in all respects was the option N120P30K90.    

scholarly journals ANÁLISIS DEL CRECIMIENTO Y LA MORTALIDAD DE ANISOTREMUS INTERRUPTUS (GILL) (PERCIFORMES: HAEMULIDAE) EN LA COSTA DE COLIMA, MÉXICO

2016 ◽  
Vol 33 ◽  
Author(s):  
Elaine Espino Barr ◽  
Manuel Gallardo Cabello ◽  
Fernando González Orozco ◽  
Arturo Garcia Boa
Keyword(s):  
Mortality Rate ◽  
Growth Parameters ◽  
Total Mortality ◽  
Condition Index ◽  
First Year ◽  
The Third ◽  
Second Year ◽  
First Year Of Life ◽  
Mortality Analysis

This paper deals with the growth and mortality analysis of the burrito grunt A n i s o t remus interru p t u s on the coast of Colima, México. The estimated growth parameters are: L¥ = 50.59 cm; W¥ = 5,051.04 g; k = 0.147 years- 1; to = -0.916 years; A0 . 9 5 = 19.46 years. Most of the growth occurred during the first year of life, when the grunt grows 12.52 cm, the second year it grows 4.95 cm and the third, 4.60 cm. The highest value of the condition index took place between February and September. The total mortality rate (Z) was calculated as 0.53 years- 1. These values are basic for the plan of administration of the fishery of this species.

scholarly journals Prescription Writing Skills of Pre-Clinical Medical and Dental Undergraduate Students

2008 ◽  
Vol 47 (172) ◽  
Author(s):  
GP Rauniyar ◽  
RK Roy ◽  
BP Das ◽  
G Bhandari ◽  
SK Bhattacharya
Keyword(s):  
Prospective Study ◽  
Undergraduate Students ◽  
Writing Skills ◽  
First Year ◽  
Limited Extent ◽  
Dental Examination ◽  
Preclinical Phase ◽  
Rational Prescribing ◽  
Second Year ◽  
Prescription Writing

Objective of this prospective study was to assess the acquisition of prescribing skill of preclinicalmedical and dental undergraduate students. Prescription writing skills of 258 students of both firstand second year of MBBS and BDS students were analyzed through an objective structured practicalexamination. MBBS student of second year scored 85.01% and 92.82% respectively in physician anddrug related component whereas first year MBBS students scored 89.9% and 83.4%. BDS studentof first year scored 91.96% and 86.33% in physician and drug related components which is betterthan second year that scored 83.33% and 77.94% respectively. This study revealed that the studentsof both courses acquire prescribing skills to a limited extent during preclinical phase. Prescribingerrors were found both in physician and drug related components. To minimize the different form ofprescribing errors vigorous training in the internship period will help to minimize prescribing errorsand improve rational prescribing too.Key words: dental, examination, medical, objective, prescription, student

scholarly journals Variation in the Protein Composition of Human Milk during Extended Lactation: A Narrative Review

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1124 ◽  
Author(s):  
Sergio Verd ◽  
Gemma Ginovart ◽  
Javier Calvo ◽  
Jaume Ponce-Taylor ◽  
Antoni Gaya
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Protein Content ◽  
Milk Protein ◽  
Mammalian Species ◽  
Protein Composition ◽  
Developed Countries ◽  
First Year ◽  
Second Year ◽  
First Year Of Life

The aim of this review is to evaluate changes in protein parameters in the second year postpartum. There is considerable agreement among authors about the declining trend of human milk protein concentrations, but most research on protein content in breast milk focuses on the first year of life and comes from developed countries. Whereas this is the case for exclusive breastfeeding or for breastfeeding into the first year of life, the opposite applies to weaning or extended breastfeeding. This review is predominantly based on observational epidemiological evidence and on comparative research linking breast milk composition with cutting down on breastfeeding. Studies dating back several decades have shown an increase in the proportion of immunoglobulins, lactoferrin, and serum albumin during weaning. According to the limited data available, it seems likely that the regulation of milk protein composition during involution can be ascribed to alterations in tight junctions. In studies on humans and other mammalian species, offspring suckle more from mothers that produce more dilute milk and the increase in milk protein concentration is positively correlated to a decrease in suckling frequency during weaning. High milk protein contents were first reported in nonindustrial communities where breastfeeding is sustained the longest, but recent papers from urbanized communities have taken credit for rediscovering the increase in protein content of human milk that becomes evident with prolonged breastfeeding. This review presents an overview of the changes in breast milk protein parameters in the second year postpartum to enable milk banks’ practitioners to make informed nutritional decisions on preterm infants.

Diarrhea in Breast-Fed and Non-Breast-Fed Infants

PEDIATRICS ◽  
1982 ◽  
Vol 70 (6) ◽  
pp. 921-925
Author(s):  
Alice H. Cushing ◽  
Linda Anderson
Keyword(s):  
Breast Milk ◽  
First Year ◽  
Milk Samples ◽  
Colonization Factor ◽  
Fecal Carriage ◽  
Heat Labile ◽  
Insignificant Difference ◽  
First Year Of Life ◽  
Breast Fed

During the first year of life a group of babies was prospectively observed for diarrhea and for fecal carriage of heat-labile toxigenic bacteria, with or without colonization factor, and rotavirus. Approximately half of the babies were breast-fed for the first six months of life. There was no difference between groups (breast-fed vs non-breast-fed) in number of babies who had diarrhea during any two-month period. Nor was there any difference between groups in the number of babies who had diarrhea while carrying toxigenic bacteria, with or without colonization factor. Secretory antibody to toxin was found in 37% of colostrum and milk samples. There was a small but insignificant difference in the number of babies who had diarrhea when they carried toxigenic bacteria depending on the presence of antibody in the breast milk they received.

EPIDEMIC DIARRHEA AMONG INFANTS ASSOCIATED WITH THE ISOLATION OF A NEW SEROTYPE OF ESCHERICHIA COLI: E. COLI 0127:B8

PEDIATRICS ◽  
1955 ◽  
Vol 16 (2) ◽  
pp. 215-227
Author(s):  
Merlin L. Cooper ◽  
Edward W. Walters ◽  
Helen M. Keller ◽  
James M. Sutherland ◽  
Hollis J. Wiseman
Keyword(s):  
Escherichia Coli ◽  
Rectal Swab ◽  
Specific Treatment ◽  
First Year ◽  
Average Dose ◽  
Clinical Value ◽  
E Coli ◽  
Severe Diarrhea ◽  
First Year Of Life

During an outbreak of epidemic diarrhea a new serotype of Escherichia coli: E. coli 0127:B8, was isolated from 44 of 145 infants and from 1 nurse among 82 adult personnel in attendance. Among the 44 infants whose rectal swab cultures were positive, 20 were in the first month of life, 16 were 2 to 6 months of age, and 6 were 7 to 12 months of age, a total of 42 being in the first year of life. Severe epidemic diarrhea associated with the presence of E. coli 0127:B8 was characterized by the sudden development of extreme abdominal distention among some of the infants; explosive onset of diarrhea and the presence of a pungent, musty, objectionable odor not noticed around other patients with diarrhea. E. coli 0127: B8 was isolated more frequently while the patients were having diarrhea. Neomycin® was used orally for the specific treatment of patients with diarrhea. The early dosage was small due to our caution in using a new antibiotic. Over the 4 months period of this study the dosage was gradually increased. The average dose was 40 mg./kg./day for the patients with positive cultures and 46 mg./kg./day for those with negative cultures. Of 22 patients with positive cultures, 12 who were treated with Neomycin® alone or in addition to other antibiotics continued to show the presence of E. coli 0127:B8 after Neomycin® therapy had been terminated; however, only 2 of these patients had recurrence of diarrhea, both having had negative cultures while receiving Neomycin®. The administration of Neomycin® to every infant on the 2 wards, regardless of clinical condition, was followed by a decreasing incidence of diarrhea and decreasing detection of E. coli 0127:B8. The dose of Neomycin® was 40 to 50 mg./kg./day. It is our feeling that Neomycin® administered orally was of definite clinical value therapeutically and prophylactically but in the dosage used was inadequate bacteriologically. Four deaths occurred among the 44 infants whose rectal swab cultures were positive for E. coli 0127:B8 and necropsy studies were made on each. A hemorrhagic enteritis was present in 3 infants and in the fourth infant the cause of death was a congenital heart condition. Death of 1 patient with negative rectal swab cultures may very likely be attributed to severe diarrhea. Sera from patients and personnel failed to show the presence of agglutinins for E. coli 0127:B8. in vitro sensitivity tests showed that the order of decreasing bactericidal effectiveness of 5 antibiotics for E. coli 027:B8 was polymyxin, Neomycin®, chloramphenicol, Achromycin®, and Terramycin®. All strains were resistant to dihydrostreptomycin and sodium sulfadiazine. Only the last strains isolated from 2 patients showed increased resistance to Neomycin®, four-and sixteenfold when compared with the first strains isolated from the same patients.

TRENDS

PEDIATRICS ◽  
1952 ◽  
Vol 9 (5) ◽  
pp. 648-650
Author(s):  
C. COLLINS-WILLIAMS
Keyword(s):  
Child Care ◽  
Preventive Medicine ◽  
Educational Program ◽  
Causes Of Death ◽  
Medical Profession ◽  
First Year ◽  
Concerted Effort ◽  
Third Place ◽  
Second Year ◽  
First Year Of Life

ACCIDENTS, at the present time, are one of the principal causes of death, particularly among children. In Canada approximately 1,500 children die each year as the result of accidents, a mortality greater than that due to the 10 acute infectious diseases of childhood combined. During the five year period 1942-46 inclusive, in Canada, accidents stood in eighth place as a cause of death during the first year of life, in third place during the second year, and in first place during each year after infancy up to the fifteenth birthday. During the same period, 21% of the deaths between the first and fifteenth birthdays were due to accidents. In this age of preventive medicine when our chief purpose as physicians is the prevention of morbidity and mortality, we, as pediatricians, cannot neglect this extremely important phase of child care. In any campaign to reduce the number of accidents, there are three ways in which the physician can play an important part. Firstly, the general public must be made aware of the seriousness of the situation and must be educated in the ways in which they, as citizens and parents, can help to reduce accidents. Secondly, the medical profession, working through its associations and publications, must stimulate all physicians to a concerted effort to reduce the number of accidents. Finally, and most important, the physician must concentrate on an educational program for his own private patients. A few words from the physician who looks after the child will do more to impress parents than will reams of propaganda published by someone unknown to them.

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