scholarly journals Problematic internet use: an exploration of associations between cognition and COMT rs4818, rs4680 haplotypes

CNS Spectrums ◽  
2019 ◽  
Vol 25 (3) ◽  
pp. 409-418
Author(s):  
Konstantinos Ioannidis ◽  
Sarah A. Redden ◽  
Stephanie Valle ◽  
Samuel R. Chamberlain ◽  
Jon E. Grant

ObjectiveProblematic internet users suffer from impairment in a variety of cognitive domains. Research suggests that COMT haplotypes exert differential effects on cognition. We sought to investigate differences in the genetic profiles of problematic internet users and whether those could shed light on potential cognitive differences.MethodsWe recruited 206 non-treatment seeking participants with heightened impulsive traits and obtained cross-sectional demographic, clinical, and cognitive data as well as the genetic haplotypes of COMT rs4680 and rs4818. We identified 24 participants who presented with problematic internet use (PIU) and compared PIU and non-PIU participants using one-way analysis of variance (ANOVA) and chi square as appropriate.ResultsPIU was associated with worse performance on decision making, rapid visual processing, and spatial working memory tasks. Genetic variants were associated with altered cognitive performance, but rates of PIU did not statistically differ for particular haplotypes of COMT.ConclusionThis study indicates that PIU is characterized by deficits in decision making and working memory domains; it also provides evidence for elevated impulsive responses and impaired target detection on a sustained attention task, which is a novel area worth exploring further in future work. The effects observed in the genetic influences on cognition of PIU subjects imply that the genetic heritable components of PIU may not lie within the genetic loci influencing COMT function and cognitive performance; or that the genetic component in PIU involves many genetic polymorphisms each conferring only a small effect.

2020 ◽  
Vol 46 ◽  
Author(s):  
Claudia Venuleo ◽  
Lucrezia Ferrante ◽  
Simone Rollo

Scholars have highlighted the role of negative affect as key correlates of Problematic Internet Use (PIU). According to the assumption that Internet-related behaviours can be seen as mechanisms to cope with everyday life (Kardefelt-Winther, 2017), the present study aims to explore the relation between PIU and psychosocial malaise, expecting that adolescents with high levels of social anxiety, negative emotions, and loneliness are more likely to be associated to the problem group of Internet users. Measures of PIU (GPIUS–2), social anxiety (IAS), negative affectivity (PANAS), and loneliness (ILS) were detected in a sample of 766 students attending Year 9–11 (13–19 years old; 47% females) of public high schools in the territory of Lecce (Apulia–Italy). A sub-group of problematic Internet users was identified (n = 185) and a control group was selected (n = 187). A logistic regression was applied to estimate the effect of psychosocial variables on the differentiation between problematic and control Internet users. Results of the present cross-sectional study show that a higher level of social anxiety, negative emotions, and loneliness increases the probability of belonging to the group of problematic Internet users. No significant differences between males and females were found in GPIU levels. The findings show that, for a better understanding of PIU onset and maintenance among adolescents, it is important, to take into account the life problems which may lead young people to overindulge in Internet use.RésuméLes scientifiques ont mis en lumière le rôle de l’affect négatif comme corrélat significatif de la dépendance. Partant de l’hypothèse que les comportements dans Internet peuvent être vus comme des mécanismes d’adaptation à la vie quotidienne (Kardefelt-Winther, 2017), notre étude visait à explorer la relation entre la cyberdépendance et le malaise psychosocial. On s’attendait à ce que les adolescents affichant un degré élevé d’anxiété sociale, d’émotions négatives et de solitude fassent partie du groupe d’internautes à problème. Des indicateurs de la cyberdépendance (GPIUS-2), de l’anxiété sociale (IAS), de l’affect négatif (PANAS) et de la solitude (ILS) ont été relevés dans un échantillon de 766 élèves de la 9e à la 11e année (13 à 19 ans; 47 % de filles) choisi dans des écoles secondaires publiques du territoire de Lecce (Apulia, Italie). Un sous-groupe d’internautes cyberdépendants a été défini (n=185) et un groupe contrôle sélectionné (n=187). Un modèle de régression logistique a été appliqué en vue d’estimer l’effet des variables psychosociales sur la différenciation entre joueurs cyberdépendants et joueurs du groupe contrôle. Les résultats de l’étude transversale montrent qu’un degré plus élevé d’anxiété sociale, d’émotions négatives et de solitude augmentait la probabilité d’appartenir au groupe d’internautes cyberdépendants. Aucune différence notable n’a été constatée entre les hommes et les femmes quant au degré de cyberdépendance. Les résultats indiquent qu’une compréhension plus fine du développement de la cyberdépendance et de sa persistance chez les adolescents devra tenir compte des problèmes vécus dans leur vie personnelle qui les inciteraient à un usage excessif d’Internet.


Author(s):  
Silke M. Müller ◽  
Johannes Schiebener ◽  
Matthias Brand ◽  
Magnus Liebherr

AbstractIn several studies, individuals who reported to frequently multitask with different media displayed reduced cognitive performance, for example in fluid intelligence and executive functioning. These cognitive functions are relevant for making advantageous decisions under both objective risk (requiring reflection and strategical planning) and ambiguous risk (requiring learning from feedback). Thus, compared to low media multitaskers (LMMs), high media multitaskers (HMMs) may perform worse in both types of decision situations. The current study investigated HMMs and LMMs in a laboratory setting with the Game of Dice Task (GDT; objective risk), the Iowa Gambling Task (IGT; ambiguous risk), various tests quantifying cognitive functions (logical reasoning, working memory, information processing, general executive functions), and self-report measures of impulsivity, media multitasking expectancies, and problematic Internet use. From 182 participants, 25 HMMs and 19 LMMs were identified using the Media Multitasking Index. Results show that HMMs compared to LMMs performed weaker on the IGT but not on the GDT. Furthermore, HMMs had slightly decreased performance in tests of logical reasoning and working memory capacity. HMMs tended to increased information processing speed but this difference was not significant. Furthermore, HMMs have more positive expectancies regarding media multitasking and reported higher tendencies toward problematic Internet use. HMMs and LMMs did not differ significantly with respect to impulsivity and executive functions. The results give a first hint that HMMs may have difficulties in decision-making under ambiguous but not under objective risk. HMMs may be more prone to errors in tasks that require feedback processing. However, HMMs appear not to be impaired in aspects of long-term strategic decision-making.


2019 ◽  
Author(s):  
Francesco Brigo ◽  
Simona Lattanzi ◽  
Giorgia Giussani ◽  
Laura Tassi ◽  
Nicola Pietrafusa ◽  
...  

BACKGROUND The Internet has become one of the most important sources of health information, accessed daily by an ever-growing number of both patients and physicians, seeking medical advice and clinical guidance. A deeper insight into the current use of the Web as source of information on epilepsy would help in clarifying the individual attitude towards this medium by Internet users. OBJECTIVE We investigated views towards the Internet in a sample of Italian healthcare specialists involved in epilepsy field, to explore factors which explained the influence of information found on the internet. METHODS This study was a self-administered survey conducted in a group of members of the Italian Chapter of the International League Against Epilepsy (ILAE) in January 2018. RESULTS 184 questionnaires were analyzed. 97.8% of responders reported to seek online information on epilepsy. The Internet was most frequently searched to obtain new information (69.9%) or to confirm a diagnostic or therapeutic decision (37.3%). The influence of consulting the Internet on clinical practice was associated with registration to social network(s) (OR: 2.94; 95%CI: 1.28-6.76; p=0.011), higher frequency of Internet use (OR: 3.66; 95%CI: 1.56-9.21; p=0.006) and higher confidence in reliability of online information (OR: 2.61; 95%CI: 1.09-6.26; p=0.031). No association was found with age, sex, years in epilepsy practice or easiness to find online information. CONCLUSIONS Internet is frequently used among healthcare professionals involved in the epilepsy to obtain information about this disease. The attitude of being influenced by the Internet for diagnostic and/or therapeutic decisions in epilepsy is independent on age and years of experience in epilepsy, and probably reflects an individual approach towards the Web.


2021 ◽  
pp. 089443932199865
Author(s):  
José-María Romero-Rodríguez ◽  
José-Antonio Marín-Marín ◽  
Francisco-Javier Hinojo-Lucena ◽  
Gerardo Gómez-García

The problematic Internet use (PIU) has become a topic of special relevance since it is a problem that affects the whole world. It has been detected that the population at greatest risk is university students along with adolescents. At the same time, Spain is one of the countries with the highest PIU rate. The purposes of this article were to analyze the presence and degree of Internet addiction among university students and to check the sociodemographic factors that influence the PIU. To this end, 13 hypotheses were put forward and contrasted using a structural equation model. The study adopted a cross-sectional approach by applying the Internet addiction test to a sample of undergraduate students in southern Spain ( n = 1,013). The results indicated a prevalence of PIU among students of almost 12.5% and with a moderate degree of addiction. In turn, the following hypotheses that had a significant effect on the PIU were supported: gender; field of knowledge; living in the parents’ home; Internet daily use for leisure; Internet daily use for academic purposes; number of social networks; sexual orientation; marital status. Finally, the main findings of the study were reviewed, and the main recommendations and implications for mitigating the negative effects of technology and enhancing the positive ones were established.


1998 ◽  
Vol 353 (1377) ◽  
pp. 1819-1828 ◽  
Author(s):  
◽  
S. M. Courtney ◽  
L. Petit ◽  
J. V. Haxby ◽  
L. G. Ungerleider

Working memory enables us to hold in our ‘mind's eye’ the contents of our conscious awareness, even in the absence of sensory input, by maintaining an active representation of information for a brief period of time. In this review we consider the functional organization of the prefrontal cortex and its role in this cognitive process. First, we present evidence from brain–imaging studies that prefrontal cortex shows sustained activity during the delay period of visual working memory tasks, indicating that this cortex maintains on–line representations of stimuli after they are removed from view. We then present evidence for domain specificity within frontal cortex based on the type of information, with object working memory mediated by more ventral frontal regions and spatial working memory mediated by more dorsal frontal regions. We also propose that a second dimension for domain specificity within prefrontal cortex might exist for object working memory on the basis of the type of representation, with analytic representations maintained preferentially in the left hemisphere and image–based representations maintained preferentially in the right hemisphere. Furthermore, we discuss the possibility that there are prefrontal areas brought into play during the monitoring and manipulation of information in working memory in addition to those engaged during the maintenance of this information. Finally, we consider the relationship of prefrontal areas important for working memory, both to posterior visual processing areas and to prefrontal areas associated with long–term memory.


Author(s):  
Neha Priya ◽  
Samreen Khan ◽  
Sachin Lal

Background: Internet is a boon and has certainly helped to bring the world closer. It has been a great medium for students to communicate and get information by transforming the academic landscape. However the excessive and undisciplined use of internet by individuals especially in the last decade, has led to the emergence of the concept of internet addiction. Therefore, a cross sectional study has been conducted to investigate the use of internet facility among undergraduate students from Teerthankar Mahaveer University using a validated questionnaire. There were about 42 million active internet users in urban India in 2008 when compared to 5 million in 2000. India now has the world’s third-largest national digital population, with approximately, 159 million Internet users in 2014, which is projected to reach 314 million by 2017 (IMRB 2014). The aim was to study prevalence and pattern of internet usage among undergraduate students in Moradabad. Methods: A cross sectional study was conducted among medical students (n=382) belonging to all the professionals of medical college, to assess the pattern of internet usage. A semi-structured proforma along with Young’s internet addiction scale was used. Results: Of the 382 adolescents who took part in the study, 150 (39.27%) were female and 232 (60.73%) were males. Their mean age was 16.20 years. Using Young’s original criteria, 22 (5.76%) were found to be addicts, 230 (60.21%) were moderately addicted, 45 (11.78%) were average users while in 85 (22.25%) of student’s internet use was less than average. Most of internet use was for social networking 183(47.9%), downloading media files 125 (32.7%), online gaming 45 (11.8%), academic purposes 10 (2.6%) and others 19 (5%). About 275 (72%) of the students were using smart phones to access the internet. Conclusions: Most of the internet usage was for the purpose of social networking (Facebook, Whats App, Mails, etc). Availability of high speed free wi-fi internet on mobile phones as well as more reliance on virtual friendship than real may be the reason for spending more time on social network websites. 


Author(s):  
Laura Widyanto ◽  
Mark Griffiths

Previous research has alluded to the existence of a relationship between self-esteem and problematic Internet use. The main aim of the study was to examine the relationship between problematic Internet use and a number of distinct demographic, behavioural, and psychosocial variables. Using an online survey, a self-selected sample comprising 1,467 Internet users participated in the study. The survey comprised 50 questions including validated scales for both self-esteem (Rosenberg’s Self-Esteem Scale) and problematic Internet use (Internet Related Problem Scale; IPRS) in addition to demographic information. Based on previous literature, it was hypothesized that problematic Internet users were more likely than non-problematic Internet users to post low self-esteem scores. Results showed that self-esteem was strongly and negatively associated with IRPS. Also, for those with high IRPS scores, participation in online forums was the primary online activity followed by online gaming and chatting. Although the study comprised a self-selecting sample and utilized self-report, the results appear to provide robust evidence of an association between self-esteem and problematic Internet use mirroring prior research in the area.


2019 ◽  
Vol 130 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Marianne Myhre ◽  
Henrik Børsting Jacobsen ◽  
Stein Andersson ◽  
Audun Stubhaug

Abstract EDITOR’S PERSPECTIVE What We Already Know about This Topic Perioperative administration of pregabalin has been associated with decreased postoperative pain and opioid requirements What This Article Tells Us That Is New This secondary analysis of data demonstrating that perioperative administration of pregabalin was associated with a reduction in opioid requirements and incisional hyperalgesia suggests that these benefits may be compromised by an increased risk of developing impaired postoperative cognitive performance Background Pregabalin has shown opioid sparing and analgesic effects in the early postoperative period; however, perioperative effects on cognition have not been studied. A randomized, parallel group, placebo-controlled investigation in 80 donor nephrectomy patients was previously performed that evaluated the analgesic, opioid-sparing, and antihyperalgesic effects of pregabalin. This article describes a secondary exploratory analysis that tested the hypothesis that pregabalin would impair cognitive function compared to placebo. Methods Eighty patients scheduled for donor nephrectomy participated in this randomized, placebo-controlled study. Pregabalin (150 mg twice daily, n = 40) or placebo (n = 40) was administered on the day of surgery and the first postoperative day, in addition to a pain regimen consisting of opioids, steroids, local anesthetics, and acetaminophen. Specific cognitive tests measuring inhibition, sustained attention, psychomotor speed, visual memory, and strategy were performed at baseline, 24 h, and 3 to 5 days after surgery, using tests from the Cambridge Neuropsychological Test Automated Battery. Results In the spatial working memory within errors test, the number of errors increased with pregabalin compared to placebo 24 h after surgery; median (25th, 75th percentile) values were 1 (0, 6) versus 0 (0, 1; rate ratio [95% CI], 3.20 [1.55 to 6.62]; P = 0.002). Furthermore, pregabalin significantly increased the number of errors in the stop-signal task stop-go test compared with placebo; median (25th, 75th percentile) values were 3 (1, 6) versus 1 (0, 2; rate ratio, 2.14 [1.13 to 4.07]; P = 0.020). There were no significant differences between groups in the paired associated learning, reaction time, rapid visual processing, or spatial working memory strategy tests. Conclusions Perioperative pregabalin significantly negatively affected subdomains of executive functioning, including inhibition, and working memory compared to placebo, whereas psychomotor speed was not changed.


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