Longitudinal imaging studies in schizophrenia: the relationship between brain morphology and outcome measures

2010 ◽  
Vol 19 (3) ◽  
pp. 207-210 ◽  
Author(s):  
Marcella Bellani ◽  
Nicola Dusi ◽  
Paolo Brambilla
Keyword(s):  
Longitudinal Studies ◽  
Outcome Measures ◽  
Brain Morphology ◽  
Imaging Studies ◽  
Longitudinal Imaging ◽  
The Relationship ◽  
Worse Prognosis

AbstractImaging studies have tried to identify morphological outcome measures of schizophrenia in the last two decades. In particular, longitudinal studies have reported a correlation between larger ventricles, decreased prefrontal volumes and worse outcome. This would potentially allow to isolate subtypes of schizophrenia patients with a worse prognosis and more evident biological impairments, ultimately helping in designing specific rehabilitation interventions.

scholarly journals Using longitudinal imaging to map the ‘relapse signature’ of schizophrenia and other psychoses

2014 ◽  
Vol 23 (3) ◽  
pp. 219-225 ◽  
Author(s):  
V. L. Cropley ◽  
C. Pantelis
Keyword(s):  
Longitudinal Studies ◽  
Clinical Picture ◽  
Detailed Examination ◽  
Multiple Time ◽  
Imaging Studies ◽  
Cross Sectional ◽  
Time Points ◽  
Effect Of Treatment ◽  
Longitudinal Imaging ◽  
Multiple Time Points

Brain imaging studies in schizophrenia have typically involved single assessment and cross-sectional designs, while longitudinal studies rarely incorporate more than two time points. While informative, these studies do not adequately capture potential trajectories of neurobiological change, particularly in the context of a changing clinical picture. We propose that the analysis of brain trajectories using multiple time points may inform our understanding of the illness and the effect of treatment. This paper makes the case for frequent serial neuroimaging across the course of schizophrenia psychoses and its application to active illness epsiodes to provide a detailed examination of psychosis relapse and remission.

scholarly journals Participant followup rate can bias structural imaging measures in longitudinal studies

2021 ◽  
Author(s):  
Richard Beare ◽  
Gareth Ball ◽  
Joseph Yuan-Mou Yang ◽  
Chris Moran ◽  
Velandai Srikanth ◽  
...  
Keyword(s):  
Longitudinal Studies ◽  
Brain Volume ◽  
Great Difficulty ◽  
Group Differences ◽  
Structural Imaging ◽  
Imaging Studies ◽  
Software Pipeline ◽  
Longitudinal Imaging ◽  
The Individual ◽  
Statistical Results

AbstractLoss of participants to followup (dropout) in longitudinal studies is inevitable and leads to great difficulty in interpretation of statistical results if dropout is correlated with a study outcome or exposure. In this article we test whether there is an additional problem that must be considered in longitudinal imaging studies, namely whether dropout has an impact on the function of FreeSurfer, a popular software pipeline used to estimate important structural brain metrics. We find that the number of acquisitions per individual does have an impact on the function of the FreeSurfer longitudinal pipelinei, and can induce group differences in brain metrics.HighlightsThis study found that group differences in the number of acquisitions involved in construction of the individual templates used in the FreeSurfer longitudinal pipeline can cause group differences in estimated cortical thickness and brain volume.

scholarly journals Emotional Regulation and Overeating Behaviors in Children and Adolescents: A Systematic Review

2021 ◽  
Vol 11 (1) ◽  
pp. 11
Author(s):  
Francesca Favieri ◽  
Andrea Marini ◽  
Maria Casagrande
Keyword(s):  
Systematic Review ◽  
Emotional Intelligence ◽  
Emotion Regulation ◽  
Children And Adolescents ◽  
Longitudinal Studies ◽  
Emotional Regulation ◽  
Inadequate Response ◽  
Cross Sectional ◽  
The Relationship

The worldwide prevalence of obesity has dramatically increased, mostly in children and adolescents. The Emotional Eating theoretical model has proposed that the failure in emotional regulation could represent a risk factor for establishing maladaptive overeating behavior that represents an inadequate response to negative emotions and allows increasing body-weight. This systematic review investigates the relationship between overeating and both emotional regulation and emotional intelligence in childhood and adolescence, considering both cross-sectional and longitudinal studies. Moreover, another goal of the review is evaluating whether emotional regulation and emotional intelligence can cause overeating behaviors. The systematic search was conducted according to the PRISMA-statement in the databases Medline, PsychArtcles, PsychInfo, PubMed, Scopus, and Web of Sciences, and allows 484 records to be extracted. Twenty-six studies were selected according to inclusion (e.g., studies focused on children and adolescents without clinical conditions; groups of participants overweight or with obesity) and exclusion (e.g., studies that adopted qualitative assessment or cognitive-affective tasks to measure emotional variables; reviews, commentary, or brief reports) criteria detailed in the methods. Cross-sectional studies showed a negative association between emotional regulation and overeating behavior that was confirmed by longitudinal studies. These findings highlighted the role of maladaptive emotion regulation on overeating and being overweight. The relationship between these constructs in children and adolescents was consistent. The results indicated the complexity of this association, which would be influenced by many physiological, psychological, and social factors. These findings underline the need for further studies focused on emotion regulation in the development of overeating. They should analyze the mediation role of other variables (e.g., attachment style, peer pressure) and identify interventions to prevent and reduce worldwide overweight prevalence.

scholarly journals Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes

2018 ◽  
Vol 132 (23) ◽  
pp. 2509-2518 ◽  
Author(s):  
Gargi Mahapatra ◽  
S. Carrie Smith ◽  
Timothy M. Hughes ◽  
Benjamin Wagner ◽  
Joseph A. Maldjian ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
White Matter ◽  
African Americans ◽  
Mitochondrial Function ◽  
Brain Morphology ◽  
Intracranial Volume ◽  
Peripheral Blood Mononuclear ◽  
Relationship Of ◽  
The Relationship

Blood-based bioenergetic profiling has promising applications as a minimally invasive biomarker of systemic bioenergetic capacity. In the present study, we examined peripheral blood mononuclear cell (PBMC) mitochondrial function and brain morphology in a cohort of African Americans with long-standing Type 2 diabetes. Key parameters of PBMC respiration were correlated with white matter, gray matter, and total intracranial volumes. Our analyses indicate that these relationships are primarily driven by the relationship of systemic bioenergetic capacity with total intracranial volume, suggesting that systemic differences in mitochondrial function may play a role in overall brain morphology.

Cardiorespiratory Responses During Underwater and Land Treadmill Exercise in College Athletes

2011 ◽  
Vol 20 (3) ◽  
pp. 345-354 ◽  
Author(s):  
Peter Brubaker ◽  
Cemal Ozemek ◽  
Alimer Gonzalez ◽  
Stephen Wiley ◽  
Gregory Collins
Keyword(s):  
Athletic Training ◽  
Outcome Measures ◽  
Sports Medicine ◽  
Perceived Exertion ◽  
College Athletes ◽  
Random Order ◽  
Original Research ◽  
Cardiorespiratory Responses ◽  
Significant Difference ◽  
The Relationship

Context:Underwater treadmill (UTM) exercise is being used with increased frequency for rehabilitation of injured athletes, yet there has been little research conducted on this modality.Objective:To determine the cardiorespiratory responses of UTM vs land treadmill (LTM) exercise, particularly with respect to the relationship between heart rate (HR) and oxygen consumption (VO2).Design and Setting:This quantitative original research took place in sports medicine and athletic training facilities at Wake Forest University.Participants:11 Wake Forest University student athletes (20.8 ± 0.6 y, 6 women and 5 men).Intervention:All participants completed the UTM and LTM exercise-testing protocols in random order. After 5 min of standing rest, both UTM and LTM protocols had 4 stages of increasing belt speed (2.3, 4.9, 7.3, and 9.6 km/h) followed by 3 exercise stages at 9.6 km/h with increasing water-jet resistance (30%, 40%, and 50% of jet capacity) or inclines (1%, 2%, and 4% grade).Main Outcome Measures:A Cosmed K4b2 device with Polar monitor was used to collect HR, ventilation (Ve), tidal volume (TV), breathing frequency (Bf), and VO2 every minute. Ratings of perceived exertion (RPE) were also obtained each minute.Results:There was no significant difference between UTM and LTM for VO2 at rest or during any stage of exercise except stage 3. Furthermore, there were no significant differences between UTM and LTM for HR, Ve, Bf, and RPE on any exercise stage. Linear regression of HR vs VO2, across all stages of exercise, indicates a similar relationship in these variables during UTM (r = .94, y = .269x − 10.86) and LTM (r = .95, y = .291x − 12.98).Conclusions:These data indicate that UTM and LTM exercise elicits similar cardiorespiratory responses and that HR can be used to guide appropriate exercise intensity for college athletes during UTM.

scholarly journals COVID-19 and Mental Health: Predicted Mental Health Status is Associated with Clinical Symptoms and Pandemic-Related Psychological and Behavioral Responses

2021 ◽  
Author(s):  
Joyce Y Chung ◽  
Alison Gibbons ◽  
Lauren Atlas ◽  
Elizabeth Ballard ◽  
Monique Ernst ◽  
...  
Keyword(s):  
Mental Health ◽  
Health Status ◽  
Outcome Measures ◽  
Social Life ◽  
Clinical Symptoms ◽  
Behavioral Responses ◽  
Mental Health Status ◽  
Convenience Sample ◽  
Social Distancing ◽  
The Relationship

Abstract Background: The COVID 19 pandemic led to dramatic threats to health and social life. Study objectives are to develop a prediction model leveraging subsample of known Patient/Controls and evaluate the relationship of predicted mental health status to clinical outcome measures and pandemic-related psychological and behavioral responses during lockdown (spring/summer 2020). Methods: Online cohort study conducted by National Institute of Mental Health Intramural Research Program. Convenience sample of English speaking adults (enrolled 4/4 to 5/16/20; n=1,992). Enrollment measures: demographics, clinical history, functional status, psychiatric and family history, alcohol/drug use. Outcome measures (enrollment and q2 weeks/6 months): distress, loneliness, mental health symptoms, and COVID 19 survey. NIMH IRP Patient/Controls survey responses informed assignment of Patient Probability Scores (PPS) for all participants. Regression models analyzed the relationship between PPS and outcome measures. Outcomes: Mean age 46.0, female (82.4%), white (88.9 %). PPS correlated with distress, loneliness, depression, and mental health factors. PPS associated with negative psychological responses to COVID 19. Worry about mental health (OR 1.46) exceeded worry about physical health (OR 1.13). PPS not associated with adherence to social distancing guidelines but was with stress related to social distancing and worries about infection of self/others. Interpretation: Mental health status (PPS) was associated with concurrent clinical ratings and COVID 19 specific negative responses. A focus on mental health during the pandemic is warranted, especially among those with mental health vulnerabilities. We will include PPS when conducting longitudinal analyses of mental health trajectories and risk and resilience factors that may account for differing clinical outcomes. Funding: NIMH (ZIAMH002922); NCCIH (ZIAAT000030)

scholarly journals Assessment of Subacromial Space and Its Relationship With Scapular Upward Rotation in College Baseball Players

2013 ◽  
Vol 22 (3) ◽  
pp. 216-223 ◽  
Author(s):  
Stephen John Thomas ◽  
Charles Buz Swanik ◽  
Thomas W. Kaminski ◽  
Jill S. Higginson ◽  
Kathleen A. Swanik ◽  
...  
Keyword(s):  
Outcome Measures ◽  
Laboratory Setting ◽  
Subacromial Space ◽  
Baseball Players ◽  
Type Design ◽  
Dependent Variables ◽  
Injured Population ◽  
College Baseball ◽  
Acromiohumeral Distance ◽  
The Relationship

Context:Subacromial impingement is a common injury in baseball players and has been linked to a reduction in the subacromial space. In addition, it has been suggested that decreases in scapular upward rotation will lead to decreases in the subacromial space and ultimately impingement syndrome.Objective:The objective of this study was to evaluate the relationship between acromiohumeral distance and scapular upward rotation in healthy college baseball players.Design:Posttest-only study design.Setting:Controlled laboratory setting.Participants:24 healthy college baseball players.Intervention:Participants were measured for all dependent variables at preseason.Main Outcome Measures:Acromiohumeral distance at rest and 90° of abduction was measured with a diagnostic ultrasound unit. Scapular upward rotation at rest and 90° of abduction was measured with a digital inclinometer.Results:Dominant-arm acromiohumeral distance at rest and 90° of abduction (P = .694, P = .840) was not significantly different than in the nondominant arm. In addition, there was not a significant correlation between acromiohumeral distance and scapular upward rotation at rest and 90° of abduction for either the dominant or the nondominant arm.Conclusions:These results indicate that the acromiohumeral distance is not adapting in the dominant arm in healthy throwing athletes. In addition, a relationship was not identified between acromiohumeral distance and scapular upward rotation, which was previously suggested. These results may suggest that changes that are typically seen in an injured population may be occurring due to the injury and are not preexisting. In addition, scapular upward rotation may not be the only contributing factor to acromiohumeral distance.

Sarcopenia and Frailty in PD: Impact on Mortality, Malnutrition, and Inflammation

2018 ◽  
Vol 38 (6) ◽  
pp. 447-454 ◽  
Author(s):  
Yuka Kamijo ◽  
Eiichiro Kanda ◽  
Yoshitaka Ishibashi ◽  
Masayuki Yoshida
Keyword(s):  
Muscle Mass ◽  
Secondary Outcome ◽  
Related Factors ◽  
Clinical Frailty Scale ◽  
Risk Of Mortality ◽  
All Cause Mortality ◽  
Comorbidity Index ◽  
The Relationship ◽  
Worse Prognosis

Background It is known that sarcopenia is related to malnutrition-inflammation-atherosclerosis (MIA) syndrome and is an important problem in dialysis patients. The notion of frailty includes various physical, psychological, and social aspects. Although it has been reported that sarcopenia is associated with poor prognosis in patients with hemodialysis, reports on peritoneal dialysis (PD) patients are rare. In this study, we examined the morbidity and mortality of sarcopenia and frailty in PD patients. We also investigated the MIA-related factors. Methods We evaluated 119 patients cross-sectionally and longitudinally. The Asian Working Group for Sarcopenia criteria and the Clinical Frailty Scale (CFS) were used to diagnose sarcopenia and frailty. The primary outcome is all-cause mortality with sarcopenia and frailty. The secondary outcome is the relationship between various MIA-related factors. Results Morbidity of sarcopenia and frailty in PD patients was 8.4% and 10.9%, respectively. Old age, high values of Barthel Index, Charlson Comorbidity Index, CFS, and low values of body mass index (BMI), muscle strength, muscle mass, and slow walking were associated with sarcopenia. Interleukin-6, albumin, and prealbumin were significantly correlated with muscle mass. During follow-up, the presence of sarcopenia or frailty was associated with the risk of mortality. In multivariate analysis, CFS was related to the mortality rate of PD patients. Conclusions The presence of sarcopenia or frailty was associated with a worse prognosis.

Guidance for Custom Alarm Design: You Don’t Have to “Crank it up to 11”

2019 ◽  
Vol 8 (1) ◽  
pp. 142-145
Author(s):  
Morgan E. Reynolds ◽  
Michael F. Rayo ◽  
Morgan Fitzgerald ◽  
Mahmoud Abdel - Rasoul ◽  
Susan D. Moffatt - Bruce
Keyword(s):  
Longitudinal Studies ◽  
First Impressions ◽  
Change Over Time ◽  
Daily Exposure ◽  
Real Work ◽  
Two Measures ◽  
The Relationship ◽  
Over Time

Changes in alarm perception and response after prolonged daily exposure is not well studied due to the difficulties in setting up rigorous longitudinal studies in real work domains. A prime example of this is the absence of research studying how conveyed urgency and identifiability of auditory alarms change over time. We conducted a three-year study to understand how alarm performance with respect to these two measures changed over time, ostensibly due to prolonged nurse exposure. Gaining a better understanding of the relationship between these two aspects of a sound’s sensory dimension could be extremely valuable to acoustical alarm designers, as it allows them to anticipate changes in the sounds’ sensory performance over time, and not be overly sensitive to first impressions of the auditory alarm set.

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