scholarly journals The Effect of Aerobic Exercise on Concussion Recovery: A Pilot Clinical Trial

2021 ◽  
Vol 27 (8) ◽  
pp. 790-804 ◽  
Author(s):  
Aliyah R. Snyder ◽  
Sarah M. Greif ◽  
James R. Clugston ◽  
David B. FitzGerald ◽  
Joshua F. Yarrow ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Aerobic Exercise ◽  
Mixed Model ◽  
Exercise Intervention ◽  
Reference Group ◽  
Exercise Program ◽  
Neurocognitive Performance ◽  
Post Injury ◽  
Post Intervention ◽  
Severity Scores

AbstractObjective:The purpose of this study was to pilot safety and tolerability of a 1-week aerobic exercise program during the post-acute phase of concussion (14–25 days post-injury) by examining adherence, symptom response, and key functional outcomes (e.g., cognition, mood, sleep, postural stability, and neurocognitive performance) in young adults.Method:A randomized, non-blinded pilot clinical trial was performed to compare the effects of aerobic versus non-aerobic exercise (placebo) in concussion patients. The study enrolled three groups: 1) patients with concussion/mild traumatic brain injury (mTBI) randomized to an aerobic exercise intervention performed daily for 1-week, 2) patients with concussion/mTBI randomized to a non-aerobic (stretching and calisthenics) exercise program performed daily for 1-week, and 3) non-injured, no intervention reference group.Results:Mixed-model analysis of variance results indicated a significant decrease in symptom severity scores from pre- to post-intervention (mean difference = −7.44, 95% CI [−12.37, −2.20]) for both concussion groups. However, the pre- to post-change was not different between groups. Secondary outcomes all showed improvements by post-intervention, but no differences in trajectory between the groups. By three months post-injury, all outcomes in the concussion groups were within ranges of the non-injured reference group.Conclusions:Results from this study indicate that the feasibility and tolerability of administering aerobic exercise via stationary cycling in the post-acute time frame following post-concussion (14–25 days) period are tentatively favorable. Aerobic exercise does not appear to negatively impact recovery trajectories of neurobehavioral outcomes; however, tolerability may be poorer for patients with high symptom burden.

Randomized clinical trial on the effect of a supervised exercise program on quality of life, fatigue, and fitness following esophageal cancer treatment (PERFECT study).

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 12055-12055
Author(s):  
Anne Maria May ◽  
Jonna van Vulpen ◽  
Anouk E Hiensch ◽  
Jelle P. Ruurda ◽  
Grard Nieuwenhuijzen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Esophageal Cancer ◽  
Cardiorespiratory Fitness ◽  
Exercise Intervention ◽  
Exercise Program ◽  
Post Intervention ◽  
Supervised Exercise ◽  
Supervised Exercise Program

12055 Background: Patients with potentially curable esophageal cancer are often treated with chemoradiotherapy followed by surgery. This treatment might have a negative impact on physical fitness, fatigue and quality of life (QoL). In patients with other types of cancer, evidence suggests that physical exercise reduces treatment related side effects. We investigated whether a supervised exercise program also beneficially affects QoL, fatigue and cardiorespiratory fitness (CRF) in patients after treatment for esophageal cancer. Methods: The multicenter PERFECT study randomly assigned patients in the first year after esophagectomy to an exercise intervention (EX) or usual care (UC) group. EX patients participated in a 12-week moderate to high intensity aerobic and resistance exercise program supervised by a physiotherapist. UC patients were advised to maintain their physical activity levels. Attendance and compliance with the exercise intervention protocol were retrieved from exercise logs. QoL (primary outcome, EORTC-QLQ-30, range 0-100), fatigue (MFI-20, range 4-20) and CRF (cardiopulmonary exercise testing) were assessed at baseline and after 12 weeks (post-intervention). The outcomes were analyzed as between-group differences using either linear mixed effects models or ANCOVA adjusted for baseline and stratification factors (i.e. sex, time since surgery, center), according to the intention-to-treat principle. Results: A total of 120 patients (age 64±8) were included and randomized to EX (n = 61) or UC (n = 59). Patients in the EX group participated in 96% (IQR:92-100%) of the supervised exercise sessions and compliance with all parts of the exercise program was high ( > 90%). Post-intervention, global QoL was not statistically different between groups, but significant (p < 0.05) beneficial EX effects were found for QoL-Summary scores (between-group difference 3.5, 95% CI 0.2;6.8) and QoL-role functioning (9.4, 1.3;17.5). Physical fatigue wat non-significantly lower in the EX group (-1.2; -2.6;0.1, p = 0.08). CRF was significantly higher (VO2peak (1.8 mL/min/kg, 0.6;3.0) following the EX intervention. Conclusions: Patients were well capable to complete an intensive supervised exercise program after esophageal cancer treatment, which led to small but significant improvements in several aspects of QoL and cardiorespiratory fitness. Our results suggest that supervised exercise is a beneficial addition to routine care of patients with esophageal cancer. Clinical trial information: NTR5045 .

scholarly journals AEROBIC EXERCISE VOLUME, NOT PRESCRIPTION, INFLUENCES POST-CONCUSSION SYMPTOMS: A RANDOMIZED CLINICAL TRIAL

2021 ◽  
Vol 9 (7_suppl3) ◽  
pp. 2325967121S0014
Author(s):  
David R. Howell ◽  
Danielle Hunt ◽  
Stacey E. Aaron ◽  
William P. Meehan ◽  
Can Ozan Tan
Keyword(s):  
Clinical Trial ◽  
Aerobic Exercise ◽  
Symptom Severity ◽  
Exercise Prescription ◽  
Standard Of Care ◽  
Care Group ◽  
Initial Symptom ◽  
Initial Visit ◽  
Severity Scores ◽  
Text Figure

Background: Current recommendations for sport-related concussion uniformly emphasize the importance of physical activity. However, specifics of this recommendation remain vague and do not account for an exercise dosage or compliance. Purposes: First, we examined if an 8-week individualized sub-symptom threshold aerobic exercise prescription, initiated within the first two weeks of concussion, alleviates symptom severity or affects the amount of exercise performed during the study. Second, we examined whether prescription adherence, rather than randomized group assignment, reflects the actual impact of aerobic exercise in post-concussion recovery. Methods: For this single-site prospective randomized clinical trial, participants completed an aerobic exercise test within 14 days of injury, and were randomized to an individualized aerobic exercise program or standard-of-care, and returned for assessments 1 month and 2 months after the initial visit (Table 1). The aerobic exercise group was instructed to exercise 5 days/week, 20 minutes/day, at a target heart rate based on an exercise test at the initial visit. Participants reported their symptom exercise volume each week over the 8-week study period, and reported symptoms at each study visit (initial, 1 month, 2 month). Results: Initial symptom severity was not different between randomized groups (Figure 1A), and no significant differences in symptom severity were found at the 4-week (Figure 1B) or 8-week (Figure 1C) assessment. In addition, there was no significant differences between groups for average weekly exercise volume during the first four weeks (Figure 2A) or second four weeks (Figure 2B) of the study. During the first four weeks of the study, 65% (n=11/17) of the exercise intervention participants were compliant with their exercise recommendation (≥100 min/week), compared to 45% (n=9/20) of the standard-of-care group (p=0.33). During the second four weeks of the study, 71% (n=12/17) of the exercise prescription group exercised ≥100 min/week, compared to 55% (n=11/20) of the standard-of-care group (p=0.50). When grouped by exercise volume, the group who exercised ≥100 minutes/week during the first month of the study reported significantly lower symptom severity scores than those who exercised <100 minutes/week (Figure 3B), despite similar initial symptom severity scores (Figure 3A). Conclusion: Participant randomization within 14 days of concussion did not lead to a significant reduction in symptoms, or greater exercise volume. Given that greater exercise volume was associated with lower symptoms after one month of the study, researchers and clinicians should pay particular attention to adherence to aerobic exercise programs for the treatment of concussion. [Table: see text][Figure: see text][Figure: see text][Figure: see text]

Effect of exercise on sleep and bi-directional associations with accelerometer-assessed physical activity in men with obesity

2020 ◽  
Author(s):  
Tatiana Plekhanova ◽  
Alex V. Rowlands ◽  
Melanie Davies ◽  
Charlotte L. Edwardson ◽  
Andrew Hall ◽  
...  
Keyword(s):  
Physical Activity ◽  
Sleep Quality ◽  
Aerobic Exercise ◽  
Sleep Duration ◽  
Exercise Intervention ◽  
Vigorous Physical Activity ◽  
Sleep Onset ◽  
Onset Time ◽  
Post Intervention

This study examined the effect of exercise training on sleep duration and quality and bidirectional day-to-day relationships between physical activity (PA) and sleep. Fourteen inactive men with obesity (49.2±7.9 years, BMI 34.9±2.8 kg/m²) completed a baseline visit, eight-week aerobic exercise intervention, and one-month post-intervention follow-up. PA and sleep were assessed continuously throughout the study duration using wrist-worn accelerometry. Generalised estimating equations (GEE) were used to examine associations between PA and sleep. Sleep duration increased from 5.2h at baseline to 6.6h during the intervention period and 6.5h at one-month post-intervention follow-up (p<0.001). Bi-directional associations showed that higher overall activity volume and moderate-to-vigorous physical activity (MVPA) were associated with earlier sleep onset time (p<0.05). Later timing of sleep onset was associated with lower overall volume of activity, most active continuous 30 minutes (M30CONT), and MVPA (p<0.05). Higher overall activity volume, M30CONT, and MVPA predicted more wake after sleep onset (WASO) (p<0.001), whereas greater WASO was associated with higher overall volume of activity, M30CONT, and MVPA (p<0.001). An aerobic exercise intervention increased usual sleep duration. Day-to-day, more PA predicted earlier sleep onset, but worse sleep quality and vice versa. Novelty: • Greater levels of physical activity in the day were associated with an earlier sleep onset time that night, whereas a later timing of sleep onset was associated with lower physical activity the next day in men with obesity • Higher physical activity levels were associated with worse sleep quality, and vice versa

scholarly journals Can Active Aerobic Exercise Reduce the Risk of Cardiovascular Disease in Prehypertensive Elderly Women by Improving HDL Cholesterol and Inflammatory Markers?

2020 ◽  
Vol 17 (16) ◽  
pp. 5910
Author(s):  
Nayoung Ahn ◽  
Kijin Kim
Keyword(s):  
Blood Pressure ◽  
Physical Fitness ◽  
Aerobic Exercise ◽  
Inflammatory Markers ◽  
Elderly Women ◽  
Exercise Program ◽  
Cvd Risk ◽  
Post Intervention ◽  
Fitness Level ◽  
Tnf Α

This study aims to verify the efficacy of exercise programs designed to prevent and treat hypertension-induced cardiovascular disease (CVD) by analyzing the effects of a 6-month active aerobic exercise program, administered to prehypertensive elderly women, on reducing the risk of developing CVD by enhancing their physical fitness level and improving the detailed markers of high-density lipoprotein cholesterol (HDL-C) and inflammatory markers. We assigned the elderly women (≥65 years) recruited into normal blood pressure (120–129/80–84; NBP, n = 18) and high-normal blood pressure (130–139/85–89; HNBP, n = 12) groups according to the European guidelines for the management of arterial hypertension. The exercise program was made up of combined workouts of elastic band resistance exercise and aerobics with dance music. The program took place three times a week for six months, with each session lasting 60 min. We measured pre- and post-intervention body composition, blood pressure, physical fitness level, blood lipids profile, HDL-C, SAA, TNF-α, IL-6, IL-4, IL-15, CRP, and HSP70 and calculated the Framingham risk scores for comparison. A significant post-intervention reduction in the mean systolic blood pressure (SBP) was observed in the HNBP group (p < 0.001), with significant increase in HDL-C (p < 0.01) and significant decrease in serum amyloid A (SAA) concentration (p < 0.01). A significant improvement in physical fitness factors such as physical efficiency index (PEI) was also observed in the HNBP group (p < 0.05). The post-intervention TNF-α, IL-6, and SAA concentrations were more significantly lower in the HNBP than in the NBP group (p < 0.05). Compared to the baseline values, a significant decrease in SAA concentration (p < 0.01) and significant increase in HSP70 concentration (p < 0.001) were observed in the HNBP group. The HNBP group’s 10-year CVD risk was also significantly reduced (p < 0.05). The pre–post differences in SBP and DBP were significantly correlated with those in the anti-inflammatory markers IL-4 and IL-15 (p < 0.01). In conclusion, the 6-month active aerobic exercise program of moderate intensity administered to prehypertensive elderly women (≥65 years) had the effect of reducing the 10-year CVD risk through a substantial reduction in SBP, overall physical fitness improvement, increase in HDL-C, decrease in SAA concentration, and substantial decrease in inflammatory biomarkers. It was also confirmed that an increase in anti-inflammatory markers, which showed a small range of increase with respect to the decrease in blood pressure, may have a major effect.

Resistance exercise versus aerobic exercise combined with metformin therapy in the treatment of type 2 diabetes: a 12-week comparative clinical study

2020 ◽  
Vol 20 ◽  
Author(s):  
Walid Kamal Abdelbasset
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Resistance Exercise ◽  
Aerobic Exercise ◽  
Exercise Intervention ◽  
Fasting Blood Glucose ◽  
Exercise Program ◽  
Model Assessment ◽  
Study Program

Backgrounds: Both exercise and metformin are used to control blood glucose levels in patients with type 2 diabetes mellitus (T2DM) while no previous studies have investigated the effect of resistance exercise combined with metformin versus aerobic exercise with metformin in T2DM patients. Objectives: This study was conducted to compare the effects of resistance exercise combined with metformin versus aerobic exercise with metformin in T2DM patients Methods: Fifty-seven T2DM patients with a mean age of 46.2±8.3 years were randomized to three study groups, each group included nineteen patients. The first group conducted a resistance exercise program (REP, 50-60% of 1RM, for 40-50 min) combined with metformin, the second group conducted an aerobic exercise program (AEP, 50-70% maxHR, for 40-50 min) combined with metformin, and the third group received only metformin without exercise intervention (Met group). The study program was conducted trice weekly for executive twelve weeks. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), homeostatic model assessment of insulin resistance (HOMAIR), and maximal oxygen uptake (VO2max) were evaluated before and after study intervention. Results: Significant differences were reported after the 12-week intervention inter-groups in the outcome variables (p˂0.05). FBG, HbA1c, HOMA-IR, and VO2max improved significantly in REP group (p˂0.001) and also in the AEP group (p=0.016, p=0.036, p=0.024, and p=0.019 respectively) while the Met group showed only significant reduction in FBG (p=0.049), and non-significant changes in HbA1c, HOMA-IR, and VO2max (p˃0.05). REP group achieved greater improvements than AEP group (FBG, p=0.034; HbA1c%, p=0.002; HOMA-IR, p˂0.001; and VO2max, p=0.024). Conclusions: Both resistance and aerobic exercise programs combined with metformin are effective in controlling T2DM. Resistance exercise combined with metformin is more effective than aerobic exercise combined with metformin in the treatment of T2DM.

A randomized controlled pilot of home-based exercise (HBEX) versus standard care (SC) among breast (BC) and prostate cancer (PC) patients receiving radiation therapy (RTH)

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 8504-8504 ◽  
Author(s):  
K. M. Mustian ◽  
G. R. Morrow ◽  
J. Yates ◽  
L. Gillies ◽  
C. Boles
Keyword(s):  
Aerobic Exercise ◽  
Aerobic Capacity ◽  
Exercise Intervention ◽  
Treatment Compliance ◽  
Positive Influence ◽  
Phase Iii ◽  
Post Intervention ◽  
Change Scores ◽  
Randomized Controlled ◽  
Home Based

8504 Background: Cancer-related fatigue (CRF) is reported in up to 97% of cancer patients during RTH. 60% rate it as moderate to severe. Fatigue can significantly reduce functional capacity (FC), treatment compliance, and QOL. Although there is no standard treatment for CRF, aerobic exercise has demonstrated a positive influence on CRF and FC during RTH, but the influence of combined resistance and aerobic exercise is not clear. We explored the efficacy of a low to moderate home-based exercise intervention, including resistance and aerobic training, to SC on CRF and domains of FC (aerobic capacity and strength), in a sample of BC and PC patients during RTH. Methods: BC and PC patients (N=38; ξ age=56; 71% BC), beginning at least 28 sessions of RTH were randomized to a 4wk HBEX (7 days/wk) or SC condition, with CRF (FACT subscale), aerobic capacity (6-min. walk), and strength (handgrip dynamometry) assessments pre and post-intervention. Results: Change scores indicated improvements in the HBEX group (N=19) in CRF (ξ=3.6, SE=2.1) and aerobic capacity (ξ=43.6, SE=52.3), while the SC group declined in CRF (ξ=-1.1, SE=1.1) and aerobic capacity (ξ=-28.5 SE=71.6). Change scores revealed declines in strength among both groups, however the HBEX group showed smaller declines in strength (ξ=-.05, SE=0.7) compared to the SC group (ξ=-.80, SE=.91). T-tests using intent-to-treat indicated statistically significant between group differences on changes in CRF (ES=.63; p=.05) from pre to post-intervention, as well as significantly higher aerobic capacity (ES=1.3; p<.001) with a statistical trend toward lower CRF (ES=.51; p=.09) between groups post-intervention. Conclusions: HBEX improved CRF and aerobic capacity, while SC resulted in declines. HBEX reduced declines in strength compared to SC. Future phase III randomized controlled trials are needed with larger samples to fully investigate the influence of this HBEX intervention on CRF, aerobic capacity and strength. Funded by NCI grant 1R25CA102618. No significant financial relationships to disclose.

Decrease in musculoskeletal pain after 4 and 12 months of an aerobic exercise intervention: a worksite RCT among cleaners

2017 ◽  
Vol 46 (8) ◽  
pp. 846-853 ◽  
Author(s):  
Mette Korshøj ◽  
Marie Birk Jørgensen ◽  
Mark Lidegaard ◽  
Ole Steen Mortensen ◽  
Peter Krustrup ◽  
...  
Keyword(s):  
Aerobic Exercise ◽  
Musculoskeletal Pain ◽  
Exercise Intervention ◽  
Reference Group ◽  
Random Effect ◽  
Exercise Group ◽  
Physical Work ◽  
Exercise Interventions ◽  
Body Regions

Background: Prevalence of musculoskeletal pain is high in jobs with high physical work demands. An aerobic exercise intervention targeting cardiovascular health was evaluated for its long term side effects on musculoskeletal pain. Objective: The objective was to investigate if aerobic exercise affects level of musculoskeletal pain from baseline to 4- and 12-months follow-up. Methods: One-hundred-and-sixteen cleaners aged 18–65 years were cluster-randomized. The aerobic exercise group ( n = 57) received worksite aerobic exercise (30 min twice a week) and the reference group ( n = 59) lectures in health promotion. Strata were formed according to closest manager (total 11 strata); clusters were set within strata (total 40 clusters, 20 in each group). Musculoskeletal pain data from eight body regions was collected at baseline and after 4- and 12-months follow-up. The participants stated highest pain in the last month on a scale from 0, stating no pain, up to 10, stating worst possible pain. A repeated-measure 2 × 2 multi-adjusted mixed-models design was applied to compare the between-groups differences in an intention to treat analysis. Participants were entered as a random effect nested in clusters to account for the cluster-based randomization. Results: Clinically significant reductions (>30%, f 2 > 0.25) in the aerobic exercise group, compared to the reference group, in pain intensity in neck, shoulders, arms/wrists were found at 12-months follow-up, and a tendency ( p = 0.07, f 2 = 0.18) to an increase for the knees. At 4-months follow-up the only significant between-group change was an increase in hip pain. Conclusions: This study indicates that aerobic exercise reduces musculoskeletal pain in the upper extremities, but as an unintended side effect may increase pain in the lower extremities. Aerobic exercise interventions among workers standing or walking in the majority of the working hours should tailor exercise to only maintain the positive effect on musculoskeletal pain.

scholarly journals The Effects of Exercise on the Psycho-cognitive Function of Brain-Derived Neurotrophic Factor (BDNF) in the Young Adults

2021 ◽  
Vol 7 (1) ◽  
pp. 33-56
Author(s):  
Nur Izzati Umar Zaman ◽  
Mohd Zaki Salleh ◽  
Najihah Hanisah Marmaya ◽  
Haliza Hasan ◽  
Mokhtar Muhammad ◽  
...  
Keyword(s):  
Young Adults ◽  
Resistance Training ◽  
Aerobic Exercise ◽  
Neurotrophic Factor ◽  
Exercise Intervention ◽  
Meta Analysis ◽  
Exercise Program ◽  
Brain Derived Neurotrophic Factor ◽  
Beneficial Effects ◽  
Single Bout

The benefit of exercise in inducing brain-derived neurotrophic factor (BDNF) functions in relation to cognition had been reported. Nevertheless, the ambiguity remains with regards to the types of exercise and the duration of exercise required for one to have beneficial effects. In this study, we aimed to analyse the effects of varying modes of exercises and the duration required to improve BDNF functions, specifically in the young adults. The types of exercises evaluated in the meta-analysis include (1) single bout of acute aerobic exercise, (2) repeated and frequent sessions of aerobic exercise (program exercise) over a course of several weeks, and (3) resistance training. Only a single bout of acute aerobic exercise (z=4.92, p=0.00001) is sufficient to cause an increase in BDNF following exercise intervention, while program exercise (z=1.02, p=0.31) and resistance training (z=0.92, p=0.36) demonstrated inconsistencies, some exhibited significant increase in BDNF levels while others exhibited similar results with the control groups.

Feasibility and Perception of the Impact From Aerobic Exercise in Older Adults With Alzheimer’s Disease

2012 ◽  
Vol 27 (6) ◽  
pp. 397-405 ◽  
Author(s):  
Fang Yu ◽  
Ruth M. Swartwood
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Aerobic Exercise ◽  
Family Caregivers ◽  
Subjective Experience ◽  
Exercise Intervention ◽  
Exercise Program ◽  
Moderate Intensity ◽  
The Impact

Background: The subjective experience of participating in aerobic exercise is unknown in Alzheimer’s disease (AD). Objective: The purpose of this study was to understand the subjective perceptions of the feasibility and impact of a 6-month, moderate-intensity aerobic exercise intervention by older adults with AD and their family caregivers. Methods: Ten older adults with AD who completed the intervention and their family caregivers participated in four focus group interviews. Results: Four converging themes were identified: “There was no perceived positive change in cognitive symptoms,” “The 6-month exercise program was socially rewarding,” “The 6-month exercise program increased physical strength,” and “Participation in aerobic exercise was a positive experience.” Family caregivers further identified two additional themes: “The exercise program led to improved attitude in older adults with AD” and “The exercise program reduced caregiver stress.” Discussion: Aerobic exercise is a feasible and well-perceived intervention for older adults with AD and their family caregivers.

scholarly journals Effects of Rehabilitation Exercise on Cardiovascular Risk Factors and Muscle Cross-Sectional Area in Overweight Patients with Low Back Pain

Healthcare ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 809
Author(s):  
Won-Moon Kim ◽  
Su-Ah Lee ◽  
Yun-Jin Park ◽  
Yong-Gon Seo
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Exercise Intervention ◽  
Exercise Program ◽  
Normal Weight ◽  
Post Intervention ◽  
Cross Sectional ◽  
Lumbar Muscle ◽  
Rehabilitation Exercise

Limited studies exist on the effects of exercise therapy on obese and normal-weight patients. Herein, we investigated the effect of a 12-week rehabilitation exercise program on cardiovascular risk factors, Oswestry Disability Index (ODI), and change in the cross-sectional area (CSA) of lumbar muscles in patients with obesity and normal-weight low back pain (LBP). LBP patients were allocated to the overweight LBP group (OLG; n = 15) and normal-weight LBP group (NLG; n = 15). They performed a rehabilitation exercise program three times per week for 12 weeks. Cardiovascular risk factors, ODI score, and lumbar muscle CSA were assessed pre- and post-intervention. Body composition, body weight (p < 0.001), and body mass index (p < 0.001) significantly improved after the exercise intervention in OLG. Body fat percentage significantly decreased in both groups, but OLG (p < 0.001) showed slightly greater improvement than NLG (p = 0.034). Total cholesterol (p = 0.013) and low-density lipoprotein (p = 0.002) significantly improved in OLG. ODI score improved significantly in both groups (p = 0.000). Lumbar muscle CSA showed a significant difference in the context of the time result (p = 0.008). OLG showed a significant improvement post-intervention (p = 0.003). The rehabilitation exercise program was more beneficial on cardiovascular risk factors and change in lumbar muscle CSA in OLG, suggesting an intensive exercise intervention needed for overweight patients with LBP.

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