B-vitamins and metabolic syndrome in Mesoamerican children and their adult parents

Abstract Objective: To examine the associations between vitamins of the methionine-homocysteine (Hcys) cycle (B6, B12 and folate) and Hcys with metabolic syndrome (MetS) among Mesoamerican children and their adult parents. Design: We conducted a cross-sectional study. Exposures were plasma vitamins B6 and B12 concentrations, erythrocyte folate and plasma Hcys. In children, the outcome was a continuous metabolic risk score calculated through sex- and age standardisation of waist circumference, the homoeostatic model assessment for insulin resistance, mean arterial pressure (MAP), serum HDL-cholesterol and serum TAG. In parents, the outcome was the prevalence of MetS according to the Adult Treatment Panel III Criteria. We estimated mean differences in the metabolic risk score and prevalence ratios of MetS between quartiles of the exposures using multivariable-adjusted linear and Poisson regression models, respectively. Setting: Capital cities of Belize, Guatemala, El Salvador, the Dominican Republic, Honduras, Nicaragua, Panama, Costa Rica and Chiapas State in Mexico. Participants: In total, 237 school-aged children and 524 parents. Results: Among children, vitamin B12 was inversely associated with the metabolic risk score (quartiles 4–1 adjusted difference = –0·13; 95 % CI: –0·21, –0·04; Ptrend = 0·008) through MAP, HDL-cholesterol and TAG. In contrast, folate was positively associated with the metabolic risk score (quartiles 4–1 adjusted difference = 0·11; 95 % CI: 0·01, 0·20; Ptrend = 0·02). In adults, vitamin B6 was inversely associated with MetS prevalence, whereas vitamin B12 and folate were positively related to this outcome. Conclusions: Vitamins of the methionine-Hcys cycle are associated with MetS in different directions. The associations differ between children and adults.

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Association of Alcohol Drinking Patterns with Metabolic Syndrome and Its Components in Korean Adults: The Korea National Health and Nutrition Examination Survey 2016–2018

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18126433 ◽

2021 ◽

Vol 18 (12) ◽

pp. 6433

Author(s):

Seung Won Lee ◽

Sung-In Jang

Keyword(s):

Metabolic Syndrome ◽

Binge Drinking ◽

Alcohol Drinking ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Drinking Patterns ◽

Cross Sectional ◽

Korean Adults ◽

Alcohol Drinking Patterns ◽

Drinking Frequency

This study examined the association of alcohol drinking patterns with metabolic syndrome (MetS) and its components in a nationally representative sample of South Korean adults. The cross-sectional study included 12,830 current drinkers (6438 men and 6392 women) who were at least 20 years old. Measures of alcohol drinking patterns included average drinking frequency, usual quantity, and binge drinking frequency over the past year. Multivariate logistic regression was performed to estimate odds ratios and 95% confidence intervals for MetS and its components according to alcohol drinking patterns, and also to examine linear trends in these relationships. The prevalence of MetS was 1822 (26.2%) in men and 1313 (17.5%) in women. After adjusting for potential confounding factors, drinking quantity and binge drinking frequency were positively associated with MetS in both sexes. Regarding components of MetS, while the risk of low HDL cholesterol decreased as drinking frequency increased, other MetS components (abdominal obesity, high blood pressure, and impaired fasting glucose) worsened. Our results suggest that separate management of each component of MetS will be required to protect cardio-metabolic health, and a healthy drinking culture that refrains from binge drinking should be established in the context of public health.

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Insulin resistance in PLHIV on HAART and HAART naïve PLHIV: A Cross-sectional Study

10.36106/ijar/3506686 ◽

2020 ◽

pp. 1-3

Author(s):

Prabir Kumar Ganguly ◽

Niladri Das

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Antiretroviral Therapy ◽

Cross Sectional Study ◽

Metabolic Effects ◽

People Living With Hiv ◽

Model Assessment ◽

Sectional Study ◽

Cross Sectional ◽

Group I

ABSTRACT HAART (Highly active antiretroviral therapy) has transformed a fatal disease to a chronic, manageable disease. But long term toxicities are emerging after prolonged exposure to antiretroviral therapy(ART). Adverse metabolic effects like dyslipidemia, increased blood pressure, and insulin resistance(IR) have been attributed to HAART. Therefore, the use of HAART raises concerns regarding metabolic disorders and cardiovascular risk in HIV(Human immunodeficiency virus) infected patients. Objective: To determine the prevalence of insulin resistance in a cohort of HIV infected patients on HAART as compared to HAART naïve PLHIV(People living with HIV) Methods: A cross sectional study includes 53 subjects, out of which 26 were PLHIV on ART –Group I, 27 were ART naïve PLHIV-Group II was conducted. Insulin resistance was determined by homeostasis model assessment (HOMA-IR) mathematical model. Statistical analysis was performed to assess the association between demographic, clinical characteristics, laboratory results and insulin resistance. Results: 69.5 % PLHIV on HAART showed IR, as compared to 37 % of ART naïve PLHIV (p= 0.01). MetS(Metabolic Syndrome) was found in 53.8% among PLHIV on ART , compared to 11.1% among ART naïve PLHIV(p= 0.001) .In the multivariate analysis, presence of metabolic syndrome was found to be directly associated with insulin resistance.

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Comparing the validity of continuous metabolic syndrome risk scores for predicting pediatric metabolic syndrome: the CASPIAN-V study

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2018-0384 ◽

2019 ◽

Vol 32 (4) ◽

pp. 383-389 ◽

Cited By ~ 1

Author(s):

Mehri Khoshhali ◽

Ramin Heshmat ◽

Mohammad Esmaeil Motlagh ◽

Hasan Ziaodini ◽

Mahdi Hadian ◽

...

Keyword(s):

Metabolic Syndrome ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Principal Component ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Risk Scores ◽

Cross Sectional ◽

Z Scores ◽

Iranian Children

Abstract Background The aim of this study was to compare the validity of various approaches to pediatric continuous metabolic syndrome (cMetS) scores including siMS scores (2 waist/height + fasting blood glucose [FBG]/5.6 + triglycerides [TG]/1.7 + systolic blood pressure [BP]/130 + high-density lipoprotein [HDL]/1.02), Z-scores, principal component analysis (PCA) and confirmatory factor analysis (CFA) for predicting metabolic syndrome (MetS). Methods This nationwide cross-sectional study was conducted on 4200 Iranian children and adolescents aged 7–18 years. The cMetS was computed using data on HDL, cholesterol, TGs, FBG, mean arterial pressure (MAP) and waist circumference (WC). The areas under the receiver operating characteristic curves (AUCs) were used to compare the performances of different cMetS scores. Results Data of 3843 participants (52.4% boys) were available for the current study. The mean (standard deviation [SD]) age was 12.6 (3) and 12.3 (3.1) years for boys and girls, respectively. The differences in AUC values of cMetS scores were significant based on the Delong method. The AUCs (95% confidence interval [CI]) were for Z-scores, 0.94 (0.93, 0.95); first PCA, 0.91 (0.89, 0.93); sum PCA, 0.90 (0.88, 0.92), CFA, 0.79 (0.76, 0.3) and also for siMS scores 1 to 3 as 0.93 (0.91, 0.94), 0.92 (0.90, 0.93), and 0.91 (0.90, 0.93), respectively. Conclusions The results of our study indicated that the validity of all approaches for cMetS scores for predicting MetS was high. Given that the siMS scores are simple and practical, it might be used in clinical and research practice.

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Association between proinsulin, insulin, proinsulin/insulin ratio, and insulin resistance status with the metabolic syndrome

Arquivos Brasileiros de Endocrinologia & Metabologia ◽

10.1590/s0004-27302007000700016 ◽

2007 ◽

Vol 51 (7) ◽

pp. 1128-1133 ◽

Cited By ~ 9

Author(s):

Ivana Pivatto ◽

Patricia Bustos ◽

Hugo Amigo ◽

Ana Maria Acosta ◽

Antonio Arteaga

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Risk Factor ◽

Resistance Index ◽

Cross Sectional Study ◽

Blood Levels ◽

Model Assessment ◽

Cross Sectional ◽

Predictive Values ◽

The Metabolic Syndrome

The Metabolic Syndrome (MS) constitutes an independent risk factor of cardiovascular disease. There is evidence that proinsulin blood levels and the proinsulin/insulin ratio are associated to the MS. The purpose of this study was to compare proinsulin and insulin, insulin resistance index, and the proinsulin/insulin ratio as predictors of MS. This is a cross-sectional study involving 440 men and 556 women with a mean age of 24 years. Diagnosis of MS was made according to the National Cholesterol Education Program Adult Treatment Panel III. Blood levels of insulin and proinsulin were measured, and the insulin resistance status was estimated using the homeostatic model assessment (HOMA-IR). The prevalence of MS was 10.1%. HOMA-IR was the best MS risk factor for both women and men (OR = 2.04; 95% CI: 1.68-2.48 and 1.09; 95% CI: 1.05-1.13, respectively). HOMA-IR presented the best positive predictive value for MS: 22% and 36% for men and women, respectively, and was the best MS indicator. The proinsulin/insulin ratio did not show significant association with MS. HOMA-IR, proinsulin, and insulin presented good negative predictive values for both genders that could be used to identify an at-risk population.

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Association between Total Sugar Intake and Metabolic Syndrome in Middle-Aged Korean Men and Women

Nutrients ◽

10.3390/nu11092042 ◽

2019 ◽

Vol 11 (9) ◽

pp. 2042 ◽

Cited By ~ 5

Author(s):

Eun Ha Seo ◽

Hyesook Kim ◽

Oran Kwon

Keyword(s):

Metabolic Syndrome ◽

Energy Intake ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Total Sugar ◽

Middle Aged ◽

Cross Sectional ◽

Men And Women ◽

Sugar Intake ◽

Increased Risk

There is increasing evidence emerging that suggests high sugar intake may adversely increase the incidence of chronic diseases. However, there are only a few related studies in Korea. Based on the current Dietary Reference Intakes for Koreans, this study examined whether total sugar intake above 20% of the total energy was a risk factor for metabolic syndrome in middle-aged Korean adults. This cross-sectional study involved 7005 adults (3751 men and 3254 women) aged 40–69 years, who participated in the Korean Genome and Epidemiology Study (KoGES), a large community-based cohort study. Daily total sugar intake was estimated using a validated food frequency questionnaire. About 9% and 16% of the men and women, respectively, derived >20% of energy intake from total sugar. The males in this category had a significantly higher odds of obesity defined as having a BMI ≥ 25 (OR = 1.491, 95% CI = 1.162–1.914), low HDL-cholesterol (OR = 1.313, 95% CI = 1.038–1.660), and metabolic syndrome (OR = 1.332, 95% CI = 1.038–1.709) than those who received a lower proportion of energy intake from total sugar. These results suggest that high (>20%) energy intake from total sugar may be associated with an increased risk of metabolic syndrome in middle-aged Korean men.

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Demographic and Biochemical Parameters of Community Survey Participants with Metabolic Syndrome from Terai Region of Nepal

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/50730.15577 ◽

2021 ◽

Author(s):

Birendra Kumar Jha ◽

Mingma Lhamu Sherpa ◽

Binod Kumar Dahal ◽

Jitendra Kumar Singh ◽

Chamma Gupta

Keyword(s):

Metabolic Syndrome ◽

Glucose Tolerance ◽

Biochemical Parameters ◽

Central Obesity ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Atherogenic Dyslipidemia ◽

Sectional Study ◽

Cross Sectional ◽

The Mean

Introduction: The Metabolic Syndrome (MS) is a multifactorial disease associated with central obesity, hypertension, atherogenic dyslipidemia and impaired glucose tolerance. Low grade inflammatory and a prothrombotic state are also involved in MS. Aim: To explore the demographic and biochemical parameters of participants with MS in Terai region of Nepal using community based cross-sectional study. Materials and Methods: A cross-sectional study was carried out during September 2019-December 2019 in adult participants with central obesity (n=378) selected from three districts of Terai region of Nepal. International Diabetes Federation (IDF) criteria were used to define MS. The C-reactive protein-ultra sensitive, fibrinogen, and apolipoprotein-B were estimated as inflammatory, prothrombotic, and atherogenic dyslipidemia markers, respectively. Results: The MS was present in 283 participants with central obesity. The mean (±SD) age, height, weight, and BMI of the participants with MS were 46.36±12.52 years, 5.56±0.11 feet, 66.54±13.45 kg and 27.28±4.98 kg/m2, respectively. The mean (±SD) of biochemical factors were significantly different than their respective normal ranges: decreased serum High Density Lipoprotein (HDL) cholesterol in mg/dL (male: 34.50±9.93, p<0.001, female: 36.77±7.28, p<0.001), raised serum triglycerides level- 184.96±85.72 mg/dL (p<0.001), and impaired fasting serum glucose level 108.14±48.27 mg/dL (p=0.002). Significant increase in inflammatory (CRP-US: 1.12±2.17 mg/L, p<0.001), prothrombotic (fibrinogen: 3.42±1.04 gm/L, p<0.001) and atherogenic dyslipidemia marker (Apo-B: 149.35±59.13 mg/dL, p=0.003) from normal values were observed in subjects with MS. Conclusion: Lowered serum HDL cholesterol, increased triglycerides followed with impaired fasting glucose tolerance were observed as the major abnormal biochemical parameters and increased inflammatory and prothrombotic activities were present among participants with MS.

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The Association of Vitamin D with Metabolic Syndrome in Adults with Prediabetes

Bangladesh Journal of Medicine ◽

10.3329/bjm.v32i2.53805 ◽

2021 ◽

Vol 32 (2) ◽

pp. 170-174

Author(s):

Md Shahed Morshed ◽

Tahniyah Haq ◽

Shahjada Selim ◽

Habibul Ghani ◽

Ibrahim Faisal ◽

...

Keyword(s):

Metabolic Syndrome ◽

Vitamin D ◽

High Performance ◽

Fasting Blood Glucose ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Glycerol Phosphate ◽

Chromatography Method ◽

Cross Sectional ◽

Liquid Chromatography Method

Background: Vitamin D may play important role in the pathogenesis of several components of metabolic syndrome (MS). The aim of this study was to observe the association of vitamin D with MS and its components in Bangladeshi adults with prediabetes. Methods: This cross-sectional study was done among 117 newly detected nonpregnant adults with prediabetes [age (years): 36.30±9.99; BMI (kg/ m2): 28.89±4.35, mean±SD; M/F: 23/94] based on American Diabetes Association 2018 criteria. Metabolic syndrome was diagnosed by any three of five criteria: central obesity; elevated blood pressure, fasting blood glucose & triglyceride (TG) and lower HDL cholesterol. Glucose was measured by glucose oxidase, lipid by glycerol phosphate dehydrogenase-peroxidase and vitamin D by high performance liquid chromatography method. Vitamin D <20 ng/ml was considered as deficiency (VDD). Results: Among all the variables only TG was significantly higher in patients with VDD than those without VDD (³20 ng/ml) [163.0 (135.50, 224.50) vs. 143.50 (101.25, 190.0), median (IQR), p=0.048]. There were no significant correlations [p=NS for all] and associations of vitamin D with MS or its components in linear and logistic regression [p=NS for all]. Conclusions: Except TG vitamin D has no associations with MS or its components in Bangladeshi adults with prediabetes. Bangladesh J Medicine July 2021; 32(2) : 170-174

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Correlation of Uric Acid Levels and Parameters of Metabolic Syndrome

Physiological Research ◽

10.33549/physiolres.933410 ◽

2017 ◽

pp. 481-487 ◽

Cited By ~ 15

Author(s):

L. CIBIČKOVÁ ◽

K. LANGOVÁ ◽

H. VAVERKOVÁ ◽

V. KUBÍČKOVÁ ◽

D. KARÁSEK

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Uric Acid ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Anthropometric Parameters ◽

Cross Sectional ◽

Hypertriglyceridemic Waist ◽

Low Hdl ◽

Hypertriglyceridemic Waist Phenotype

Hyperuricemia has been described as associated with the risk of development metabolic syndrome; however the relationship between the uric acid level and particular parameters of metabolic syndrome remained unclear. We performed a cross-sectional study on a cohort of 833 dyslipidemic patients and correlated their levels of uric acid with parameters of insulin resistance, lipid metabolism, C-reactive protein, anthropometric parameters. We also defined patients with hypertriglyceridemic waist phenotype and compered their uric acid levels with those without this phenotype. We found that levels of uric acid are associated with parameters of metabolic syndrome. Specifically, dyslipidemia characteristic for metabolic syndrome (low HDL cholesterol and high triglycerides) correlates better with uric acid levels than parameters of insulin resistance. Also waist circumference correlates better with uric acid levels than body mass index. Patients with hypertriglyceridemic waist phenotype had higher levels of uric acid when compared with patients without this phenotype. Serum uric acid levels are even in low levels linearly correlated with parameters of metabolic syndrome (better with typical lipid characteristics than with parameters of insulin resistance) and could be associated with higher cardiovascular risk.

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Psychosocial job conditions and biomarkers of cardiovascular disease: A cross-sectional study in the Swedish CArdioPulmonary bioImage Study (SCAPIS)

Scandinavian Journal of Public Health ◽

10.1177/14034948211064097 ◽

2022 ◽

pp. 140349482110640

Author(s):

Mia Söderberg ◽

Helena Eriksson ◽

Kjell Torén ◽

Göran Bergström ◽

Eva Andersson ◽

...

Keyword(s):

Metabolic Syndrome ◽

Ldl Cholesterol ◽

High Strain ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Cross Sectional ◽

Diastolic Hypertension ◽

Low Hdl ◽

Job Conditions

Aims: The aim of this study was to investigate associations between psychosocial work exposure and the presence of biological and imaging biomarkers of cardiovascular disease. Methods: This cross-sectional study was conducted in a sub-cohort of the Swedish CArdioPulmonary bioImage Study (SCAPIS). Psychosocial exposure was evaluated with the job demand–control model, and analysed according to the standard categorization: high strain, active, passive and low strain (reference). Biomarkers (blood pressure, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, coronary artery calcification (CAC) and metabolic syndrome) were measured, or derived through measurements, from clinical examinations. Gender-specific prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated with regression models and adjusted for age, education, smoking, physical activity, general life stress and body mass index (BMI). Results: The analyses included 3882 participants (52.5% women). High strain (high demands–low control) was linked to increased PR for low HDL cholesterol in women, adjusted for all covariates (PR 1.76; 95% CI 1.25–2.48). High strain was also related to moderately increased PR for metabolic syndrome in men, after adjustments for all covariates except BMI (PR 1.25; 95% CI 1.02–1.52). In addition, passive work (low demands–low control) was associated with diastolic hypertension in women (fully adjusted: PR 1.29; 95% CI 1.05–1.59). All relationships between psychosocial factors and LDL cholesterol or CAC (both genders), or hypertension (men), were non-significant. Conclusions: Poor psychosocial job conditions was associated with the presence of low HDL cholesterol and diastolic hypertension in women, and metabolic syndrome in men. These findings contribute to the knowledge of potential pathways between stressful work and coronary heart disease.

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Associations of resistin with inflammatory and fibrinolytic markers, insulin resistance, and metabolic syndrome in middle-aged and older Chinese

Acta Endocrinologica ◽

10.1530/eje-08-0427 ◽

2008 ◽

Vol 159 (5) ◽

pp. 585-593 ◽

Cited By ~ 37

Author(s):

Qibin Qi ◽

Jing Wang ◽

Huaixing Li ◽

Zhijie Yu ◽

Xingwang Ye ◽

...

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Plasminogen Activator Inhibitor ◽

Population Based ◽

Model Assessment ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Factor Α

ObjectiveResistin increases insulin resistance (IR) in mice. However, the role of resistin in human disease remains controversial. We aimed to assess plasma resistin levels and their associations with inflammatory and fibrinolytic markers, IR and metabolic syndrome (MetS) among Chinese.Design and methodsPlasma resistin was measured in a population-based cross-sectional survey of 3193 Chinese aged from 50 to 70 years in Beijing and Shanghai.ResultsThe median resistin concentration was 8.60 ng/ml (interquartile range, 5.78–14.00) among all participants, and it was higher in women than in men (P=0.008). Resistin was correlated weakly with body mass index, waist circumference, high-density lipoprotein (HDL) cholesterol (negatively), homeostatic model assessment of IR and tumor necrosis factor-α receptor 2 (TNFR2; r=0.04, 0.07, –0.09 and 0.06 respectively, all P<0.05), and more highly with C-reactive protein (CRP), interleukin (IL)6 and plasminogen activator inhibitor (PAI)1 (r=0.12, 0.12 and 0.21 respectively, all P<0.001), but only HDL cholesterol, CRP, IL6, TNFR2, and PAI1 remained significantly associated with resistin in multiple regression analysis (all P<0.05). Furthermore, elevated resistin levels were associated with the higher prevalence of IR and MetS. However, the significant relationships disappeared after adjustment for inflammatory and fibrinolytic markers especially PAI1.ConclusionsThis study suggests that resistin is more strongly associated with inflammatory and fibrinolytic markers than with obesity or IR status. The associations of resistin with IR and MetS could largely be explained by inflammatory and fibrinolytic markers especially PAI1 levels.

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