Comparing the validity of continuous metabolic syndrome risk scores for predicting pediatric metabolic syndrome: the CASPIAN-V study

2019 ◽  
Vol 32 (4) ◽  
pp. 383-389 ◽  
Author(s):  
Mehri Khoshhali ◽  
Ramin Heshmat ◽  
Mohammad Esmaeil Motlagh ◽  
Hasan Ziaodini ◽  
Mahdi Hadian ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Principal Component ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Risk Scores ◽  
Cross Sectional ◽  
Z Scores ◽  
Iranian Children

Abstract Background The aim of this study was to compare the validity of various approaches to pediatric continuous metabolic syndrome (cMetS) scores including siMS scores (2 waist/height + fasting blood glucose [FBG]/5.6 + triglycerides [TG]/1.7 + systolic blood pressure [BP]/130 + high-density lipoprotein [HDL]/1.02), Z-scores, principal component analysis (PCA) and confirmatory factor analysis (CFA) for predicting metabolic syndrome (MetS). Methods This nationwide cross-sectional study was conducted on 4200 Iranian children and adolescents aged 7–18 years. The cMetS was computed using data on HDL, cholesterol, TGs, FBG, mean arterial pressure (MAP) and waist circumference (WC). The areas under the receiver operating characteristic curves (AUCs) were used to compare the performances of different cMetS scores. Results Data of 3843 participants (52.4% boys) were available for the current study. The mean (standard deviation [SD]) age was 12.6 (3) and 12.3 (3.1) years for boys and girls, respectively. The differences in AUC values of cMetS scores were significant based on the Delong method. The AUCs (95% confidence interval [CI]) were for Z-scores, 0.94 (0.93, 0.95); first PCA, 0.91 (0.89, 0.93); sum PCA, 0.90 (0.88, 0.92), CFA, 0.79 (0.76, 0.3) and also for siMS scores 1 to 3 as 0.93 (0.91, 0.94), 0.92 (0.90, 0.93), and 0.91 (0.90, 0.93), respectively. Conclusions The results of our study indicated that the validity of all approaches for cMetS scores for predicting MetS was high. Given that the siMS scores are simple and practical, it might be used in clinical and research practice.

scholarly journals The Association of Vitamin D with Metabolic Syndrome in Adults with Prediabetes

2021 ◽  
Vol 32 (2) ◽  
pp. 170-174
Author(s):  
Md Shahed Morshed ◽  
Tahniyah Haq ◽  
Shahjada Selim ◽  
Habibul Ghani ◽  
Ibrahim Faisal ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
High Performance ◽  
Fasting Blood Glucose ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Glycerol Phosphate ◽  
Chromatography Method ◽  
Cross Sectional ◽  
Liquid Chromatography Method

Background: Vitamin D may play important role in the pathogenesis of several components of metabolic syndrome (MS). The aim of this study was to observe the association of vitamin D with MS and its components in Bangladeshi adults with prediabetes. Methods: This cross-sectional study was done among 117 newly detected nonpregnant adults with prediabetes [age (years): 36.30±9.99; BMI (kg/ m2): 28.89±4.35, mean±SD; M/F: 23/94] based on American Diabetes Association 2018 criteria. Metabolic syndrome was diagnosed by any three of five criteria: central obesity; elevated blood pressure, fasting blood glucose & triglyceride (TG) and lower HDL cholesterol. Glucose was measured by glucose oxidase, lipid by glycerol phosphate dehydrogenase-peroxidase and vitamin D by high performance liquid chromatography method. Vitamin D <20 ng/ml was considered as deficiency (VDD). Results: Among all the variables only TG was significantly higher in patients with VDD than those without VDD (³20 ng/ml) [163.0 (135.50, 224.50) vs. 143.50 (101.25, 190.0), median (IQR), p=0.048]. There were no significant correlations [p=NS for all] and associations of vitamin D with MS or its components in linear and logistic regression [p=NS for all]. Conclusions: Except TG vitamin D has no associations with MS or its components in Bangladeshi adults with prediabetes. Bangladesh J Medicine July 2021; 32(2) : 170-174

scholarly journals Study of renal functions in metabolic syndrome and its correlation with various parameters

2020 ◽  
Vol 8 (3) ◽  
pp. 960
Author(s):  
Anand N. ◽  
Vidya T. A.
Keyword(s):  
Metabolic Syndrome ◽  
Renal Function ◽  
Diastolic Pressure ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Cross Sectional ◽  
Renal Functions ◽  
Cholesterol Levels

Background: Metabolic syndrome includes a constellation of various metabolic abnormalities that have been associated with cardiovascular disease, stroke and all-cause mortality in the general population. It has now been established that it is also associated with renal dysfunction. This study was done to assess renal function in metabolic syndrome in Indian population as well as its correlation with different parameters of the metabolic syndrome.Methods: A cross-sectional study was conducted in a university hospital from 2014 - 2015. Renal functions were studied in 100 obese individuals, 50 with and 50 without metabolic syndrome after informed consent and the results were analysed.Results: 100 obese individuals, 50 with and 50 without metabolic syndrome were compared. All underwent a physical examination and relevant investigations. All parameters of renal function showed significant derangement in cases as compared to controls. 38 patients (76%) among the cases (N=50) of metabolic syndrome had altered renal functions versus 9 patients (18%) among controls (n=50). Individually, there was a significant correlation of altered renal function (reduced estimated glomerular filtration rate eGFR and presence of microalbuminuria) with fasting blood glucose and systolic blood pressure (p=0.001), diastolic pressure (p=0.003) and triglyceride levels (p=0.036). High density lipoprotein-cholesterol levels did not show a significant correlation.Conclusions: Obese individuals with metabolic syndrome have significant derangement of renal functions as compared to those without metabolic syndrome. Most parameters of the syndrome are also independently associated with alteration of renal functions.

scholarly journals Psychosocial job conditions and biomarkers of cardiovascular disease: A cross-sectional study in the Swedish CArdioPulmonary bioImage Study (SCAPIS)

2022 ◽  
pp. 140349482110640
Author(s):  
Mia Söderberg ◽  
Helena Eriksson ◽  
Kjell Torén ◽  
Göran Bergström ◽  
Eva Andersson ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Ldl Cholesterol ◽  
High Strain ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Diastolic Hypertension ◽  
Low Hdl ◽  
Job Conditions

Aims: The aim of this study was to investigate associations between psychosocial work exposure and the presence of biological and imaging biomarkers of cardiovascular disease. Methods: This cross-sectional study was conducted in a sub-cohort of the Swedish CArdioPulmonary bioImage Study (SCAPIS). Psychosocial exposure was evaluated with the job demand–control model, and analysed according to the standard categorization: high strain, active, passive and low strain (reference). Biomarkers (blood pressure, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, coronary artery calcification (CAC) and metabolic syndrome) were measured, or derived through measurements, from clinical examinations. Gender-specific prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated with regression models and adjusted for age, education, smoking, physical activity, general life stress and body mass index (BMI). Results: The analyses included 3882 participants (52.5% women). High strain (high demands–low control) was linked to increased PR for low HDL cholesterol in women, adjusted for all covariates (PR 1.76; 95% CI 1.25–2.48). High strain was also related to moderately increased PR for metabolic syndrome in men, after adjustments for all covariates except BMI (PR 1.25; 95% CI 1.02–1.52). In addition, passive work (low demands–low control) was associated with diastolic hypertension in women (fully adjusted: PR 1.29; 95% CI 1.05–1.59). All relationships between psychosocial factors and LDL cholesterol or CAC (both genders), or hypertension (men), were non-significant. Conclusions: Poor psychosocial job conditions was associated with the presence of low HDL cholesterol and diastolic hypertension in women, and metabolic syndrome in men. These findings contribute to the knowledge of potential pathways between stressful work and coronary heart disease.

scholarly journals Metabolic Syndrome in Bangladeshi Menopausal Women

2016 ◽  
Vol 34 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Muna Shalima Jahan ◽  
Syed Muhammad Baqui Billah
Keyword(s):  
Metabolic Syndrome ◽  
Rural Area ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Blood Analysis ◽  
Cross Sectional ◽  
Increased Risk ◽  
Menopausal Women ◽  
Post Menopausal

Objective: To assess the factors of metabolic syndrome (MetS) in post menopausal women in Bangladesh.Methods: Menopausal women are at increased risk of metabolic syndrome (MetS). This cross-sectional study on 64 willing post menopausal women from an urban and a rural area of Bangladesh was done. The socio-epidemiologic factors with anthropometric examination, blood pressure recording and fasting blood analysis for triglyceride (TG), high density lipoprotein (HDL), sugar were studied.Results: Prevalence of MetS was 50.0% (95% CI= 39.9%- 60.1%) among menopausal women, seventy five percent of them were urban. Low HDL cholesterol prevailed in almost 96% respondents followed by high TG (51%), obesity (28.0%), high fasting blood sugar (FBS, 27.1%) and hypertension (HTN, 16.9%). On logistic regression, age (OR=1.6, 95% CI: 1.3-1. 9), male sex (OR=2.5, 95% CI: 1.4-4.2) and exercise (OR=1.9, 95% CI: 1.2-2.9) produced significantly higher odds of being associated with MetS; rural area (OR=1.4, 95% CI: 1.0-2.1) and sedentary occupation (OR=1.7, 95% CI: 0.9-3.0) were associated just insignificantly. Though higher income, better education, good physical movement and knowledge of MetS produced protective odds, they were not significant.Conclusions: The study suggests that MetS is highly prevalent among Bangladeshi menopausal women. Further studies are needed to identify risk factors and for effective preventive measures to control this metabolic disease.J Bangladesh Coll Phys Surg 2016; 34(1): 15-20

scholarly journals Metabolic syndrome and associated factors among severely ill psychiatric and non-psychiatric patients: a comparative cross-sectional study in Eastern Ethiopia

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Dilnessa Fentie ◽  
Tariku Derese ◽  
Bekele Yazie ◽  
Yibeltal Getachew
Keyword(s):  
Metabolic Syndrome ◽  
Psychiatric Disorders ◽  
Psychiatric Patients ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Mitigation Strategies ◽  
Sectional Study ◽  
Cross Sectional ◽  
Eastern Ethiopia

Abstract Background Metabolic syndrome is a major public health challenge in both developed and developing countries. The burden of this disease is high, even in patients with psychiatric disorders. However, very little is known about the association between metabolic syndrome and psychiatric illness in Ethiopia. Therefore, the aim of this study was to investigate the magnitude of metabolic syndrome and its components among psychiatric clients. Methods A comparative cross-sectional study was undertaken between psychiatric patients and age—and sex-matched non-psychiatric controls at the Dilchora referral hospital. The study included 192 study participants (96 psychiatric patients and 96 non- psychiatric controls from general medical and surgical patients). The National Cholesterol Education Program: Adult Treatment Panel III criteria were used to diagnose metabolic syndromes. The data were cleaned and analyzed using the Statistical Package for Social Sciences, Version 21. All intergroup comparisons for continuous data were performed using an independent sample t-test, whereas categorical data were analyzed using the Chi-square test. Logistic regression analysis was used to identify the association between metabolic syndrome and the associated variables. Results The magnitude of metabolic syndrome among psychiatric patients was 36.5% (95%CI: 27.6, 47.4) compared to non-psychiatric control patients, 21.9% (95%CI: 13.5, 30.3), p = 0.02. The prevalence of MetS components, such as waist circumference (25.0% vs. 14.3%), lower-high density lipoprotein level (35.4% vs. 20.8%), higher systolic blood pressure (41.7% vs. 29.2%) and higher fasting blood glucose (40.6% vs. 18.8%) showed statistically significant differences between the exposed and non-exposed groups. Age greater than 50 years (AOR: 2.8, CI: 1.14, 20.0, p < 0.05); being female (AOR: 7.4, CI: 2.0, 27.6, p < 0.05), being urban residence (AOR: 6.4, CI: 2.2, 20.6, p < 0.05), ever alcohol intake (AOR: 5.3, CI: 1.3, 21.2), being physically inactive (AOR: 3.52, CI: 1.1, 12.9, p < 0.05) and family history of hypertension (AOR: 2.52, CI: 1.1, 12.2, p < 0.05) were independent predictors of metabolic syndrome (p < 0.05). Conclusions There is a high burden of metabolic syndrome and its components in patients with severe psychiatric disorders. Therefore, screening and mitigation strategies for metabolic syndrome and their components should be implemented in the management of psychiatric disorders.

Prevalence and predictors of metabolic syndrome among healthy Saudi Adults

2012 ◽  
Vol 12 (2) ◽  
pp. 78-80 ◽  
Author(s):  
Abdullah M Alzahrani ◽  
Abdullah M Karawagh ◽  
Fahad M Alshahrani ◽  
Tariq A Naser ◽  
Almoutaz Alkhier Ahmed ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
National Guard ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Gulf Region ◽  
Cross Sectional ◽  
Important Health ◽  
High Triglyceride

The prevalence of metabolic syndrome was determined as a cross-sectional study among 600 healthy Saudi adults (52% males and 58% aged 35–50 years) attending National Guard clinics using the definition proposed by National Cholesterol Education Program Adult Treatment Panel III. The prevalence of metabolic syndrome was 21%. Only one third of the participants had normal weight (body mass index = 18.5–24.9). Central obesity based on waist circumferences was noted in 21% of males and 22% of females. Low high-density lipoprotein-C showed the highest prevalence (29%) followed by high triglyceride (24%). About 14% of participants had impaired fasting blood glucose (≥ 110 mg/dl). Only 6% had high blood pressure (≥ 130/85 mmHg). More than three quarters (77.3%) of the respondents had > 1 component of metabolic syndrome. In conclusion, metabolic syndrome needs to be addressed as an important health problem in the Gulf region.

scholarly journals SLEEP DURATION AND METABOLIC SYNDROME IN OBESE ADOLESCENTS

2021 ◽  
Vol 16 (1) ◽  
pp. 33
Author(s):  
Nur Aisiyah Widjaja ◽  
Rendi Aji Prihaningtyas ◽  
Roedi Irawan ◽  
Meta Herdiana Hanindita
Keyword(s):  
Metabolic Syndrome ◽  
Sleep Duration ◽  
Fasting Blood Glucose ◽  
International Diabetes Federation ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Obese Adolescents ◽  
Glucose Levels

Shorter sleep duration is a risk factor for obesity and metabolic syndrome. Previous studies conducted on diff erent races showed inconsistent results. The purpose of this study was to analyze the diff erences in sleep duration in obese adolescents who suff er from metabolic syndrome compared with obese adolescents who do not suff er from metabolic syndrome. A cross sectional study was carried out on 59 obese adolescents who visited the Pediatric Nutrition and Metabolic Disease Clinic in Dr. Soetomo General Academic Hospital, Surabaya. Subjects were selected using total sampling techniques who met the inclusion and exclusion criteria in August-November 2018. Anthropometry (weight, height and waist circumference), blood pressure, and blood tests (HDL cholesterol levels, triglycerides, and fasting blood glucose levels) were held to determine obesity according to CDC 2000 and metabolic syndrome according to International Diabetes Federation. The diff erence in sleep duration in obese adolescents suff ering from metabolic syndrome and without metabolic syndrome analyzed using Chi square test. A total of 27 subjects (45.8%) suff ered from metabolic syndrome. Most obese adolescents (57,6%) have suffi cient sleep duration (≥ 8 hours/day). There was no sleep duration diff erences in obese adolescents suff ering and not suff ering from metabolic syndrome (p> 0.05).

scholarly journals Síndrome metabólica em militares de uma unidade da polícia de Aracaju, Sergipe

2016 ◽  
Vol 26 (3) ◽  
pp. 24160 ◽  
Author(s):  
Ilva Santana Santos Fontes ◽  
Clarissa Gomes Sampaio ◽  
Carla Geane Dos Santos ◽  
Angela Maria Melo Sá Barros ◽  
Diego Santos Fontes ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Univariate Analysis ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Periodic Review ◽  
Chi Square ◽  
Cross Sectional ◽  
June July ◽  
The Military

Aims: To assess the prevalence of metabolic syndrome and its components in the military officers of a police unit in Aracaju, Sergipe.Methods: A cross-sectional study involving a military police unit located in Aracaju, capital of Sergipe state, Brazil, was conducted in the period June-July 2016. All active military policemen in the unit who agreed to participate were selected for the study. To participate, they were asked to sign the consent form and should not be on leave, departure, vacation, or transfer process to another unit. For data collection a questionnaire with demographic information was used, and a form was filled with anthropometric data and results of laboratory tests carried out during the medical routine periodic review. Metabolic syndrome was defined according to criteria of the National Cholesterol Education Program's Adult Treatment Panel III. Univariate analysis was performed to examine associations between the variables of interest, using the Pearson's chi-square test and adopting the value of p< 0.05 as statistically significant.Results: During the study period 115 military policemen were stationed in the unit under study and 96 (83.5%) among them met the criteria for inclusion in the study. Of these, the majority were male (96.6%) with children (84.4%), married (52.2%), had education level through high school (35.4%), self-reported brown (61.5%), earned between five and six minimum wage (42.7%), were aged between 36 and 45 years (59.1%), and were soldiers (53.1%). A total of seven (7.3%) among the study participants had metabolic syndrome. Regarding the components of metabolic syndrome, increased waist circumference indicating risk for cardiovascular disease was identified in 34.4% of the participants; overweight was identified in 57.3%; hypertension in 11.5%; high triglycerides in 29.5%; decreased level of high-density lipoprotein cholesterol in 60.4%; and high fasting blood glucose in 31.3%. The corporal rank was associated with metabolic syndrome: a military with corporal rank had a risk eleven times higher of having criteria for metabolic syndrome compared to other ranks (odds ratio 11.86; 95% confidence interval 10.88-12.84; p=0.005).Conclusions: The military policemen of the investigated sample had a lower prevalence of metabolic syndrome when compared to other Brazilian studies. The corporal rank had a higher risk of developing metabolic syndrome, which should be investigated in more depth by studies that look for the relationship between functional characteristics of each military rank and presence of clinical and laboratory components of metabolic syndrome.

scholarly journals Magnesium intake and prevalence of metabolic syndrome in adults: Tehran Lipid and Glucose Study

2012 ◽  
Vol 15 (4) ◽  
pp. 693-701 ◽  
Author(s):  
Parvin Mirmiran ◽  
Sakineh Shab-Bidar ◽  
Firoozeh Hosseini-Esfahani ◽  
Golaleh Asghari ◽  
Somayeh Hosseinpour-Niazi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Menopausal Status ◽  
Fasting Blood Glucose ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Dietary Factors ◽  
Inverse Association ◽  
Dietary Intakes ◽  
Cross Sectional

AbstractObjectiveWe examined the association of metabolic syndrome (MetS) and its components with dietary intakes of Mg in Tehran adults.DesignIn a cross-sectional study, dietary intakes were assessed using a valid and reliable FFQ. MetS was defined according to the modified guidelines of the National Cholesterol Education Program Adult Treatment Panel III. Waist circumference (WC) was coded according to the newly introduced cut-off points for Iranian adults (≥95 cm for both genders).SettingParticipants of the Tehran Lipid and Glucose Study (2006–2008).SubjectsAdults (n2504; 1120 men and 1384 women) aged 18–74 years.ResultsThe mean age of participants was 40·8 (sd14·6) years and 38·2 (sd13·5) years for men and women, respectively. The reported mean intake of Mg was 349 (sd109) mg/d. After adjustment for confounding factors, dietary Mg intake was inversely associated with fasting blood glucose (β= −0·08,P= 0·006), TAG (β= −0·058,P= 0·009) and WC (β= −0·013,P= 0·006); however, there were no associations between dietary Mg and diastolic blood pressure, systolic blood pressure or HDL cholesterol. An association was observed between MetSZ-score and Mg intake (crudeβ= −0·017,P= 0·001), independent of age, gender, smoking, physical activity and BMI; this association was attenuated following further adjustment for dietary factors and menopausal status (β= −0·034,P= 0·061).ConclusionsOur findings suggest a significant inverse association between dietary Mg, MetS and its components.

scholarly journals Association of breastfeeding and risk of metabolic syndrome and its components in postmenopausal parous women: Korea national health and nutrition examination survey (2010 ~ 2016)

2021 ◽  
Vol 79 (1) ◽  
Author(s):  
Jusuk Lee ◽  
Taehong Kim
Keyword(s):  
Metabolic Syndrome ◽  
Laboratory Data ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Korean Women ◽  
Cross Sectional ◽  
Increased Risk ◽  
Nationally Representative ◽  
Study Participants

Abstract Background Understanding the relationship between breastfeeding (BF) and metabolic syndrome (Mets) is important for maternal long-term health benefits and disease prevention. This study aimed to examine the association between BF and Mets and its components among postmenopausal parous Korean women. Methods This cross-sectional study on 10,356 Korean women used nationally representative data from the KNHANES from 2010 to 2016. Anthropometric, laboratory data and manual BP were measured. A multivariate logistic regression analysis was conducted to examine the association of BF with Mets and its components after adjusting for potential confounding variables. A p-value < 0.05 was to be considered statistically significant. Results Mets was present in 42% of the study participants. The BF group had low household income and education level. The prevalence of Mets in the BF group was higher than that in the non-BF group (42.69% vs. 34.76%, p <  0.001). BF was associated with increased risk of Mets (odds ratio [OR]: 1.4, 95% confidence interval [CI]: 1.18–1.65, p <  0.001). The BF group was at higher risks for diabetes (OR: 1.5, 95%CI: 1.14–1.98), hypertension (OR: 1.32, 95%CI: 1.03–1.68), hypertriglyceridemia (OR: 1.42, 95%CI: 1.02–1.99) and low high-density lipoprotein cholesterol (OR: 1.32, 95%CI: 1.06–1.65). Conclusion In this study, BF did not affect decreasing the prevalence of Mets and its components.

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