Associations of resistin with inflammatory and fibrinolytic markers, insulin resistance, and metabolic syndrome in middle-aged and older Chinese

ObjectiveResistin increases insulin resistance (IR) in mice. However, the role of resistin in human disease remains controversial. We aimed to assess plasma resistin levels and their associations with inflammatory and fibrinolytic markers, IR and metabolic syndrome (MetS) among Chinese.Design and methodsPlasma resistin was measured in a population-based cross-sectional survey of 3193 Chinese aged from 50 to 70 years in Beijing and Shanghai.ResultsThe median resistin concentration was 8.60 ng/ml (interquartile range, 5.78–14.00) among all participants, and it was higher in women than in men (P=0.008). Resistin was correlated weakly with body mass index, waist circumference, high-density lipoprotein (HDL) cholesterol (negatively), homeostatic model assessment of IR and tumor necrosis factor-α receptor 2 (TNFR2; r=0.04, 0.07, –0.09 and 0.06 respectively, all P<0.05), and more highly with C-reactive protein (CRP), interleukin (IL)6 and plasminogen activator inhibitor (PAI)1 (r=0.12, 0.12 and 0.21 respectively, all P<0.001), but only HDL cholesterol, CRP, IL6, TNFR2, and PAI1 remained significantly associated with resistin in multiple regression analysis (all P<0.05). Furthermore, elevated resistin levels were associated with the higher prevalence of IR and MetS. However, the significant relationships disappeared after adjustment for inflammatory and fibrinolytic markers especially PAI1.ConclusionsThis study suggests that resistin is more strongly associated with inflammatory and fibrinolytic markers than with obesity or IR status. The associations of resistin with IR and MetS could largely be explained by inflammatory and fibrinolytic markers especially PAI1 levels.

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Plasma Carboxy-Terminal Provasopressin (Copeptin): A Novel Marker of Insulin Resistance and Metabolic Syndrome

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2008-2278 ◽

2009 ◽

Vol 94 (7) ◽

pp. 2558-2564 ◽

Cited By ~ 79

Author(s):

Umer Saleem ◽

Mahyar Khaleghi ◽

Nils G. Morgenthaler ◽

Andreas Bergmann ◽

Joachim Struck ◽

...

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Odds Ratio ◽

Density Lipoprotein ◽

Model Assessment ◽

Cross Sectional ◽

Logistic Regression Models ◽

Bottom Quartile ◽

Novel Biomarkers ◽

Carboxy Terminal

Context: Stress-mediated hypothalamic-pituitary-adrenal axis activation, regulated by arginine vasopressin (AVP), may have a role in the pathophysiology of metabolic syndrome (MetSyn). Objective: The objective of the study was to investigate whether plasma C-terminal provasopressin fragment (copeptin), a surrogate for circulating AVP, was associated with measures of insulin resistance and presence of MetSyn. Design, Setting, and Participants: This was a multicenter, community-based study, investigating novel biomarkers for vascular disease. Participants included 1293 African-Americans (AA) (64 ± 9 yr) and 1197 non-Hispanic whites (NHW) (59 ± 10 yr) belonging to hypertensive sibships. Main Outcome Measures: Plasma copeptin levels were measured by an immunoluminometric assay. MetSyn was defined per Adult Treatment Panel III criteria. Generalized estimating equations were used to assess whether plasma copeptin was associated with measures of insulin resistance and MetSyn. Results: The prevalence of MetSyn was 50% in AA and 49% in NHW. In each group, after adjustment for age and sex, plasma copeptin levels significantly correlated with body mass index, fasting plasma glucose and insulin, homeostasis model assessment of insulin resistance, triglycerides, and (inversely) high-density lipoprotein cholesterol (P < 0.05 for each variable). In multivariable logistic regression models that adjusted for age, sex, smoking, statin use, serum creatinine, education, physical activity, and diuretic use, plasma copeptin levels in the highest quartile were associated with an increased odds ratio of having MetSyn compared with bottom quartile: odds ratio (95% confidence interval) in AA, 2.07 (1.45–2.95); in NHW, 1.74 (1.21–2.5). Conclusions: Our findings indicate a novel cross-sectional association between plasma copeptin and measures of insulin resistance and MetSyn.

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Prevalence of metabolic syndrome in 25—45-year-old Novosibirsk dwellers

Terapevticheskii arkhiv ◽

10.17116/terarkh2016881051-56 ◽

2016 ◽

Vol 88 (10) ◽

pp. 51-56 ◽

Cited By ~ 6

Author(s):

M I Voevoda ◽

N A Kovalkova ◽

Yu I Ragino ◽

N Yu Travnikova ◽

D V Denisova

Keyword(s):

Metabolic Syndrome ◽

International Diabetes Federation ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Research Society ◽

Population Based ◽

Blood Cholesterol ◽

Cross Sectional ◽

Detection Evaluation ◽

Population Based Survey

Aim. To study the prevalence of metabolic syndrome (MS) and its components in a 25—45-year-old Novosibirsk population. Subjects and methods. The Novosibirsk Research Institute of Internal and Preventive Medicine conducted a cross-sectional population-based survey in one of the typical districts of Novosibirsk in 2013—2015. The survey covered 346 men and 408 women. The criteria of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (NCEP-ATP III, 2001), the International Diabetes Federation (IDF, 2005), the Joint Interim Statement (JIS, 2009), and the All-Russian Research Society of Cardiologists (ARRSC, 2009) were used to detect MS. According to the ARRSC criteria, MS was recorded if a waist circumference (WC) was >80 cm for women and >94 cm for men in conjunction with 2 of the following criteria: a blood pressure ≥130/85 mm Hg, triglycerides (TG) ≥1.7 mmol/l, high-density lipoprotein (HDL) cholesterol

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Rice and noodle consumption is associated with insulin resistance and hyperglycaemia in an Asian population

British Journal Of Nutrition ◽

10.1017/s0007114513003486 ◽

2013 ◽

Vol 111 (6) ◽

pp. 1118-1128 ◽

Cited By ~ 25

Author(s):

Yasmin L. M. Zuñiga ◽

Salome A. Rebello ◽

Puay Leng Oi ◽

Huili Zheng ◽

Jeannette Lee ◽

...

Keyword(s):

Insulin Resistance ◽

Cell Function ◽

Fasting Glucose ◽

Asian Population ◽

Hdl Cholesterol ◽

Population Based ◽

Model Assessment ◽

Homa Index ◽

Cross Sectional ◽

High Consumption

High consumption of refined grains, particularly white rice, has been reported to be associated with a higher risk of type 2 diabetes. Therefore, in the present study, we evaluated the association between rice and noodle consumption and markers of glucose homeostasis, inflammation and dyslipidaemia in an Asian population. We carried out a population-based cross-sectional study in 2728 Singaporean Chinese men and women aged between 24 and 92 years. Rice and noodle intake was assessed using a validated FFQ and studied in relation to glycaemic (fasting glucose, glycated Hb, homeostasis model assessment (HOMA) index for insulin resistance (HOMA-IR) and HOMA index for β-cell function (HOMA-β)), inflammatory (plasma adiponectin and C-reactive protein (CRP)) and lipid (fasting TAG and HDL-cholesterol (HDL-C)) markers. We used multiple linear regression analyses with adjustment for total energy intake and sociodemographic, anthropometric (BMI and waist:hip ratio) and lifestyle factors. Higher rice consumption was found to be associated with higher fasting glucose concentrations (0·81 % higher values per portion increment; 95 % CI 0·09, 1·54) and HOMA-IR (4·62 %; 95 % CI 1·29, 8·07). Higher noodle consumption was also found to be significantly associated with higher fasting glucose concentrations (1·67 %; 95 % CI 0·44, 2·92), HOMA-IR (6·17 %; 95 % CI 0·49, 12·16) and fasting TAG concentrations (9·17 %; 95 % CI 3·44, 15·22). No significant association was observed between rice and noodle consumption and adiponectin, CRP and HDL-C concentrations or HOMA-β in the fully adjusted model. These results suggest that high consumption of rice and noodles may contribute to hyperglycaemia through greater insulin resistance and that this relationship is independent of adiposity and systemic inflammation.

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Insulin Resistance and Its Association with Metabolic Syndrome in Korean Children

BioMed Research International ◽

10.1155/2017/8728017 ◽

2017 ◽

Vol 2017 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Jinkyung Cho ◽

Haeryun Hong ◽

Soohyun Park ◽

Shinuk Kim ◽

Hyunsik Kang

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Body Fat ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Healthy Children ◽

Model Assessment ◽

Fat Percentage ◽

Cross Sectional ◽

Korean Children

Background. This study investigated the association between insulin resistance (IR) and metabolic syndrome (MetS) in children. Methods. A cross-sectional study involving 1036 healthy children aged between 7 and 13 years was conducted. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated as an index of IR. Participants were classified according to the HOMA-IR quartiles. Results. Incremental, linear trends were found in age (p<0.001), body mass index (BMI) (p<0.001), body fat (p<0.001), waist circumference (p<0.001), resting blood pressures (BP) (p<0.001), triglycerides (TG) (p<0.001), total cholesterol (TC) (p<0.001), high density lipoprotein-cholesterol (HDL-C) (p<0.001), FBG (p<0.001), and insulin (<0.001) according to incremental HOMA-IR categories (from the 1st to 4th quartile). Compared with children in the 1st HOMA-IR quartile, children in the 4th HOMA-IR quartile had significantly higher odd ratios (ORs) of abnormalities in systolic (p=0.051) and diastolic BP (p=0.005), FBG (p<0.001), TG (p<0.001), TC (p=0.016), and HDL-C (p=0.006) even after adjustments for age, gender, BMI, and body fat percentage. Children in the 3rd HOMA-IR quartile had significant abnormalities in FBG (p<0.001), TG (p=0.001), and HDL-C (p=0.010) even after adjustments for the covariates. Conclusion. The current findings suggest that IR is significantly associated with the clustering of MetS risk factors in children in Korea.

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Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men

Acta Endocrinologica ◽

10.1530/eje-09-0496 ◽

2009 ◽

Vol 161 (6) ◽

pp. 947-954 ◽

Cited By ~ 74

Author(s):

David M Lee ◽

Martin K Rutter ◽

Terence W O'Neill ◽

Steven Boonen ◽

Dirk Vanderschueren ◽

...

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Parathyroid Hormone ◽

Population Based ◽

Community Dwelling ◽

Model Assessment ◽

Middle Aged ◽

Cross Sectional ◽

The Metabolic Syndrome ◽

The Relationship

ObjectivesLow serum 25-hydroxyvitamin D (25(OH)D) and elevated parathyroid hormone (PTH) levels have been linked to insulin resistance, the metabolic syndrome (MetS) and its components. Data in healthy, community-dwelling Europeans are lacking, and previous studies have not excluded subjects receiving drug treatments that may distort the relationship between 25(OH)D/PTH and MetS. The aim of our analysis was to examine the association of 25(OH)D and PTH with Adult Treatment Panel III-defined MetS in middle-aged and older European men.DesignThis was a population-based, cross-sectional study of 3369 men aged 40–79 years enrolled in the European Male Ageing Study.ResultsAfter exclusion of subjects with missing data, 3069 men with a mean (±s.d.) age of 60±11 years were included in the analysis. Age-adjusted 25(OH)D levels were inversely associated with waist circumference, systolic blood pressure (BP), triglycerides, and glucose (all P<0.01). Age-adjusted PTH levels were only associated with waist and diastolic BP (both P<0.05). After adjusting for age, centre, season and lifestyle factors the odds for MetS decreased across increasing 25(OH)D quintiles (odds ratios 0.48 (95% confidence intervals 0.36–0.64) highest versus lowest quintile; Ptrend<0.001). This relationship was unchanged after adjustment for PTH, but was attenuated after additional adjustment for homoeostasis model assessment of insulin resistance (0.60 (0.47–0.78); Ptrend<0.001). There was no association between PTH and MetS.ConclusionsOur results demonstrate an inverse relationship between 25(OH)D levels and MetS, which is independent of several confounders and PTH. The relationship is partly explained by insulin resistance. The clinical significance of these observations warrants further study.

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Relationship between metabolic syndrome and its components and cardiovascular disease in middle-aged and elderly Chinese population: a national cross-sectional survey

BMJ Open ◽

10.1136/bmjopen-2018-027545 ◽

2019 ◽

Vol 9 (8) ◽

pp. e027545 ◽

Cited By ~ 1

Author(s):

Wenzhen Li ◽

Fujian Song ◽

Xiaojun Wang ◽

Dongming Wang ◽

Dajie Chen ◽

...

Keyword(s):

Cardiovascular Disease ◽

Metabolic Syndrome ◽

Chinese Population ◽

Large Scale ◽

International Diabetes Federation ◽

Density Lipoprotein ◽

Heart Association ◽

Population Based ◽

Cross Sectional Survey ◽

Cross Sectional

ObjectivesTo assess the relationship between metabolic syndrome (MetS) and its components and cardiovascular disease (CVD) according to different criteria of MetS, as well as whether the estimated association between MetS and CVD was affected by different definitions of MetS among the Chinese population.DesignPopulation-based, cross-sectional study.SettingData were from a large-scale national stroke screening survey, China National Stroke Screening and Prevention Project.ParticipantsA nationally representative sample of 109 551 Chinese adults aged ≥40 years in 2014–2015 were included.Primary outcome measuresCVD conditions (stroke, coronary heart disease (CHD) and atrial fibrillation (AF)) diagnosed by clinicians were self-reported.ResultsORs after adjusting for CHD, stroke, AF and CVD in those with MetS using the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criterion were 1.56 (95% CI 1.48 to 1.63), 1.23 (95% CI 1.17 to 1.30), 1.14 (95% CI 1.08 to 1.21) and 1.40 (95% CI 1.35 to 1.45); 1.51 (95% CI 1.44 to 1.58), 1.20 (95% CI 1.14 to 1.26), 1.09 (95% CI 1.04 to 1.15) and 1.34 (95% CI 1.29 to 1.38) with the American Heart Association/National Heart, Lung, and Blood Institute criterion; and 1.41 (95% CI 1.35 to 1.48), 1.24 (95% CI 1.19 to 1.30), 1.12 (95% CI 1.06 to 1.18) and 1.31 (95% CI 1.27 to 1.35) with the International Diabetes Federation criterion, respectively. Elevated blood pressures were all highly related to the prevalence of stroke and AF, and reduced high-density lipoprotein-cholesterol was associated with a higher OR for CHD than other individual components of MetS.ConclusionsMetS is significantly associated with CVD, and the prevalence of CVD was more evident when MetS was defined according to the NCEP ATP III criterion. Developing effective public health strategies for the prevention, detection and treatment of MetS should be an urgent priority to reduce the burden of CVD in China.

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SAT-656 Both Neutrophil and Monocyte Ratios to High Density Lipoprotein Cholesterol Are Superior Biomarkers of Metabolic Syndrome

Journal of the Endocrine Society ◽

10.1210/jendso/bvaa046.277 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

Author(s):

Neeraj Ramakrishnan ◽

Ganesh Jialal ◽

Ishwarlal Jialal

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

High Density Lipoprotein ◽

Density Lipoprotein ◽

High Density ◽

Model Assessment ◽

Roc Curve Analysis ◽

Cross Sectional ◽

Effective Measure ◽

Anti Inflammatory

Abstract Metabolic Syndrome (MetS) continues to be a significant problem globally, affecting nearly 35% of adults in the USA. Whilst there is no ideal biomarker that captures this disorder high sensitivity C-reactive protein (hsCRP) is the most widely accepted measure.We examined the ratios between the phagocytes, neutrophils(PMN)and monocytes, to high density lipoprotein (HDL) and adiponectin, two anti-inflammatory proteins, in patients with nascent MetS without the confounding of T2DM, ASCVD, smoking or lipid therapy to determine if they were valid biomarkers of MetS. Patients with nascent MetS(n=58) and matched controls(n=44) were recruited from Sacramento County. Patients with diabetes, cardiovascular diseases, inflammation (hsCRP >10mg/L or leukocytosis), smoking, anti-inflammatory and hypolipidemic drug therapies were excluded. Fasting blood samples were obtained for complete blood counts, basic metabolic panel, lipid profile, insulin adiponectin, leptin and chemerin. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated from glucose and insulin levels. Ratios of PMN and monocytes to HDL-C and Adiponectin were calculated and compared statistically. PMN: HDL-C and Monocyte: HDL-C, increased in patients with MetS compared to controls (p<0.0001 and p=0.001 respectively).Also the PMN: Adiponectin and monocyte: Adiponectin ratios were significantly increased in MetS (p=0.006 and 0.02 respectively). All ratios increased with increasing severity of MetS (p=0.01). Receiver Operating Characteristic (ROC) curve analysis showed that both the PMN/HDL-C and monocyte: HDL-C area under the curve(AUC)(0.85 and 0.84 respectively) significantly added to the CRP AUC(0.75), p=0.01 for both. Neither leukocyte: Adiponectin AUC was significant compared to hsCRP. Also both ratios to HDL-C correlated with cardio-metabolic features of MetS, hsCRP and insulin resistance(HOMA-IR) (p<0.05). Whilst the PMN:HDL-C ratio correlated with leptin, and chemerin the monocyte: HDL-C ratio correlated significantly with chemerin only (p<0.05) Our cross-sectional study indicates that ratios of neutrophils and monocytes to HDL-C are significantly increased in patients with nascent MetS, increase with severity of MetS, correlate positively with inflammation and insulin resistance and both ratios appear to be better predictors of MetS than hsCRP. In conclusion, they provide a cost-effective measure of Metabolic Syndrome and should be confirmed in larger data bases and prospective studies.

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Metabolic Syndrome in Estonia: Prevalence and Associations with Insulin Resistance

International Journal of Endocrinology ◽

10.1155/2012/951672 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 10

Author(s):

Triin Eglit ◽

Tarvo Rajasalu ◽

Margus Lember

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

National Cholesterol Education Program ◽

Population Based ◽

Model Assessment ◽

Metabolic Abnormalities ◽

Adult Treatment Panel ◽

Homeostasis Model Assessment ◽

Cross Sectional ◽

Weighted Prevalence

Recently, it has been suggested that metabolic syndrome should be considered a premorbid condition in younger individuals. We evaluated the prevalence of metabolic syndrome in Estonia and compared the characteristic profiles between morbid metabolic syndrome (previously established diabetes, hypertension, or dyslipidaemia) and premorbid metabolic syndrome subgroups. Our study was a cross-sectional, population-based sample of the general population in Estonia aged 20–74 years (n=495). Metabolic syndrome was diagnosed by National Cholesterol Education Program Adult Treatment Panel III criteria. Insulin resistance was estimated using the homeostasis model assessment (HOMA-IR). The crude and weighted prevalence of metabolic syndrome was 27.9% and 25.9%, respectively. Despite being significantly younger, the premorbid subgroup showed similar levels of insulin resistance as the morbid subgroup (mean HOMA-IR ± SD2.73±1.8versus2.97±2.1,P=0.5). The most important attribute of metabolic syndrome is insulin resistance, which already characterises metabolic syndrome in the early stages of its metabolic abnormalities.

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Prevalence of High HDL Cholesterol and Its Associated Factors Among Tunisian Women of Childbearing Age: A Cross-Sectional Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18105461 ◽

2021 ◽

Vol 18 (10) ◽

pp. 5461

Author(s):

Fatma Ben Cherifa ◽

Jalila El Ati ◽

Radhouene Doggui ◽

Myriam El Ati-Hellal ◽

Pierre Traissac

Keyword(s):

Associated Factors ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Protective Role ◽

Lifestyle Factors ◽

Women Of Childbearing Age ◽

Childbearing Age ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Biological Variables

The protective role of high high-density lipoprotein cholesterol (HDL-C) against cardiovascular risk has been questioned recently. Due to the increasing trend of cardiovascular diseases (CVD) in Tunisia, this study aimed to determine the prevalence of high HDL-C and its associated factors in Tunisian women of childbearing age. A cross-sectional survey was conducted among a subsample of 1689 women, aged 20 to 49 years, in the Great Tunis region. Data on socio-demographic and lifestyle factors were collected by a questionnaire. Overall adiposity was assessed by body mass index (BMI). All biological variables were assayed in blood samples coated with anticoagulant ethylene diamine tetra acetic acid (EDTA) by enzymatic methods. Stata software (2015) was used for data management and statistical analysis. High HDL-C values were recorded in 26.6% of selected women. After adjustment for all socio-demographic and lifestyle factors, age, hypertension, and smoking were negatively associated with high HDL-C levels, while family history of cancer was positively associated with high HDL-C in women. An additional investigation on the relationship between high HDL-C and cancer risk should be performed due to controversial results.

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Serum paraoxonase-1 activity is associated with light to moderate alcohol consumption: the PREVEND cohort study

American Journal of Clinical Nutrition ◽

10.1093/ajcn/nqy217 ◽

2018 ◽

Vol 108 (6) ◽

pp. 1283-1290 ◽

Cited By ~ 5

Author(s):

Eke G Gruppen ◽

Stephan J L Bakker ◽

Richard W James ◽

Robin P F Dullaart

Keyword(s):

Alcohol Consumption ◽

Linear Regression Analysis ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

High Sensitivity ◽

Population Based ◽

Cross Sectional Study ◽

Paraoxonase 1 ◽

Phenyl Acetate ◽

Cross Sectional

ABSTRACT Background Paraoxonase-1 (PON-1) is a high-density lipoprotein (HDL)-associated enzyme with antioxidative properties, which may protect against the development of cardiovascular disease. Alcohol consumption increases HDL cholesterol, but the extent to which alcohol consumption gives rise to higher serum PON-1 activity is uncertain. Objective In a population-based study, we determined the relation of serum PON-1 activity with alcohol consumption when taking account of HDL cholesterol and apolipoprotein A-I (apoA-I), its major apolipoprotein. Design A cross-sectional study was performed in 8224 participants of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort. Alcohol consumption was categorized as 1) no/rarely (25.3%); 2) 0.1–10 g/d (49.3%); 3) 10–30 g/d (20.1%); and 4) >30 g/d (5.2%) with 1 drink equivalent to 10 g alcohol. Serum PON-1 activity was measured as its arylesterase activity (phenyl acetate as substrate). Results Median serum PON-1 activity was 50.8, 53.1, 54.4, and 55.7 U/L in the 4 categories of alcohol consumption, respectively (P < 0.001). Its increase paralleled the increments in HDL cholesterol and apoA-I. Notably, there was no further increase in PON-1 activity, HDL cholesterol, and apoA-I when alcohol consumption was increased from 10–30 g/d to >30 g/d. Multivariable linear regression analysis demonstrated that PON-1 activity was related to alcohol consumption independently from clinical covariates, high sensitivity C-reactive protein, and lipid concentrations, including HDL cholesterol (P < 0.001 for each category of alcohol consumption with no alcohol consumption as the reference category). Notably, as inferred from standardized β-coefficients, there was no difference in PON-1 activity between 10–30 g alcohol/d and >30 g alcohol/d. Conclusions Alcohol consumption is associated with an increase in serum PON-1 activity, but its effect seems to reach a plateau with alcohol consumption of 10–30 g/d.

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