Atypical Green Luminescence from Raw Cassia Siamea Extract: A Comparison with Red Emitting Tinospora Cordifolia

Cs4PbBr6 is a member of the halide perovskite family that is built from isolated (zero-dimensional) PbBr64- octahedra with Cs+ counter ions. The material exhibits anomalous optoelectronic properties: optical absorption and weak emission in the deep ultraviolet (310 - 375 nm) with efficient luminescence in the green region (~ 540 nm). Several hypotheses have been proposed to explain the giant Stokes shift including: (i) phase impurities; (ii) self-trapped exciton; (iii) defect emission. We explore, using first-principles theory and self-consistent Fermi level analysis, the unusual defect chemistry and physics of Cs4PbBr6. We find a heavily compensated system where the room-temperature carrier concentrations (< 109 cm-3) are more than one million times lower than the defect concentrations. We show that the low-energy Br-on-Cs antisite results in the formation of a polybromide (Br3) species that can exist in a range of charge states. We further demonstrate from excited-state calculations that tribromide moieties are photoresponsive and can contribute to the observed green luminescence. Photoactivity of polyhalide molecules is expected to be present in other halide perovskite-related compounds where they can influence light absorption and emission.

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Intrinsic doping limit and defect-assisted luminescence in Cs4PbBr6

10.26434/chemrxiv.7629467 ◽

2019 ◽

Cited By ~ 1

Author(s):

Young-Kwang Jung ◽

Joaquin Calbo ◽

Ji-Sang Park ◽

Lucy D. Wahlley ◽

Sunghyun Kim ◽

...

Keyword(s):

First Principles ◽

Room Temperature ◽

Stokes Shift ◽

Green Luminescence ◽

Counter Ions ◽

Self Consistent ◽

Deep Ultraviolet ◽

Halide Perovskite ◽

Related Compounds ◽

Level Analysis

Cs4PbBr6 is a member of the halide perovskite family that is built from isolated (zero-dimensional) PbBr64- octahedra with Cs+ counter ions. The material exhibits anomalous optoelectronic properties: optical absorption and weak emission in the deep ultraviolet (310 - 375 nm) with efficient luminescence in the green region (~ 540 nm). Several hypotheses have been proposed to explain the giant Stokes shift including: (i) phase impurities; (ii) self-trapped exciton; (iii) defect emission. We explore, using first-principles theory and self-consistent Fermi level analysis, the unusual defect chemistry and physics of Cs4PbBr6. We find a heavily compensated system where the room-temperature carrier concentrations (< 109 cm-3) are more than one million times lower than the defect concentrations. We show that the low-energy Br-on-Cs antisite results in the formation of a polybromide (Br3) species that can exist in a range of charge states. We further demonstrate from excited-state calculations that tribromide moieties are photoresponsive and can contribute to the observed green luminescence. Photoactivity of polyhalide molecules is expected to be present in other halide perovskite-related compounds where they can influence light absorption and emission.

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Screening, Fabrication and Evaluation of Pharmaceutical Dosage Forms using P-Glycoprotein Modulators

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2017.10.2.8 ◽

2017 ◽

Vol 10 (2) ◽

pp. 3688-3699

Author(s):

Joshi Vedamurthy ◽

Shivakumar Inamdar ◽

Ankit Acharya ◽

Rajesh Kowti

Keyword(s):

Cell Lines ◽

Tinospora Cordifolia ◽

Absorption Enhancement ◽

Synergistic Activity ◽

Capsicum Frutescens ◽

Plumbago Zeylanica ◽

Pharmaceutical Dosage Forms ◽

Holarrhena Antidysenterica ◽

Trachyspermum Ammi

In this project, in vitro absorption enhancement activity of P-gp substrates Fexofenadine (Fx) and Ciprofloxacin (Cp) were evaluated in everted rat gut sac model and Caco-2 cell lines. Verapamil was used as P-gp inhibitor. Piper betel, Trachyspermum ammi, Plumbago zeylanica, Trikatu, Moringaoleifera, Murraya koenigii, Ferulafoitida Zingiber officinale, Cheilocostus speciosus, Capsicum frutescens Operculina turpethum Holarrhena antidysenterica Mesuaferrea, Tinospora cordifolia, and Picrorhiza kurroa, were selected and extracted with 99% alcohol and fresh juices of Citrus limon, Punica granatum seeds were also studied. In-vitro studies depicted that Fexofenadine and Ciprofloxacin absorption was increased greater than 20% in the presence of Operculinaturpethum, Capsicum frutescens, Holarrhena Antidysenterica, Tinospora cordifolia, Trikatu, Trachyspermum ammi, Plumbago zeylanica. The flux of the ciprofloxacin transport was in the range of 9-23 mcg/min and Papp 2.6 × 10-5 cm/sec to 4.1 × 10-5 cm/sec whereas Fexofenadine flux was in the range of 2-7.7 mcg/min and Papp 4.16 × 10–6 cm/sec to 1.62 × 10-5 cm/sec. In vitro antimicrobial activity of ciprofloxacin on selected microbes in presence of extracts also depicted synergistic activity. Histological studies revealed that there is no significant variation observed in the isolated sac in presence of the extracts. CaCo2 cell lines studies showed that, formulation enhanced the absorption of fexofenadine greater than 50%. Tablets were prepared and evaluated using the plant extracts which yielded >20% absorption enhancement of the substrates. In conclusion, tablet formulation containing the alcoholic extracts of Trachyspermum ammi, Plumbago zylanicum, Capsicum frutescens, Operculina turpethum, Holarrhena Antidysenterica, Tinospora cordifolia and Trikatu can act as an absorption enhancer for fexofenadine and ciprofloxacin. The mechanism of action of these herbs could be due to P-gp inhibition. Further clinical studies are needed to prove its efficacy in humans.

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Tinospora cordifolia Aqueous Extract Alleviates Cyclophosphamide- Induced Immune Suppression, Toxicity and Systemic Candidiasis in Immunosuppressed Mice: In vivo Study in Comparison to Antifungal Drug Fluconazole

Current Pharmaceutical Biotechnology ◽

10.2174/1389201019666190722151126 ◽

2019 ◽

Vol 20 (12) ◽

pp. 1055-1063 ◽

Cited By ~ 1

Author(s):

Faris Alrumaihi ◽

Khaled S. Allemailem ◽

Ahmad Almatroudi ◽

Mohammed A. Alsahli ◽

Arif Khan ◽

...

Keyword(s):

Survival Rate ◽

Aqueous Extract ◽

Survival Data ◽

Tinospora Cordifolia ◽

Systemic Candidiasis ◽

Organ Index ◽

Tnf Α ◽

Fungal Load ◽

Enhanced Secretion

Objective: The present study was aimed to evaluate the effect of the aqueous extract of Tinospora cordifolia (AETC) against cyclophosphamide-induced immunosuppression and systemic Candida albicans infection in a murine model. Methods: The protective effect of AETC against cyclophosphamide-induced leukopenia was evaluated by quantitative and qualitative analysis of the leukocytes. The immune-stimulating potential of AETC on macrophages was assessed by determining the levels of secreted cytokines. To determine the direct antifungal activity, AETC or fluconazole was administered to C. albicans infected mice. The efficacy of treatment was assessed by determining the survival rate, kidney fungal burden, the organ index and liver inflammation parameters. Results: Cyclophosphamide administration resulted in substantial depletion of leukocytes, whereas AETC treatment induced the recovery of leukocytes in cyclophosphamide-injected mice. Moreover, AETC treatment of macrophages resulted in enhanced secretion of IFN-γ, TNF-α and IL-1β. C. albicans infected mice treated with AETC at the doses of 50 and 100 mg/kg exhibited 40% and 60% survival rate, whereas the mice treated with fluconazole at a dose of 50 mg/kg showed 20% survival rate. Like survival data, the fungal load was found to be the lowest in the kidney tissues of mice treated with AETC at a dose of 100 mg/kg. Interestingly, mice infected with C. albicans demonstrated improvement in the organ indices and liver functioning after AETC treatment. Conclusion: These results suggest that AETC may potentially be used to rejuvenate the weakened immune system and eliminate systemic candidiasis in mice.

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Potential of Selected Indian Herbs for COVID-19

Current Traditional Medicine ◽

10.2174/2215083806999201125122620 ◽

2020 ◽

Vol 06 ◽

Author(s):

Ravindra Verma ◽

Vaibhav Misra ◽

Dileep Tiwari ◽

Prakash S. Bisen

Keyword(s):

Risk Factors ◽

Withania Somnifera ◽

Epidemiologic Studies ◽

Climatic Conditions ◽

Tinospora Cordifolia ◽

Environmental Threats ◽

Scientific Databases ◽

First Case ◽

Ocimum Tenuiflorum ◽

Novel Coronavirus

Introduction: Many environmental risk factors are associated with some form of chronic inflammation. The spread of COVID-19 across the world has impacted every one of us. The first case of coronavirus was reported on 30 January 2020 in India originating from China. Study Area: India has a tremendous capacity to deal with the coronavirus outbreak because of its high immunity and climatic conditions. Maintaining social distancing and hand washing is not a sufficient step for preventing COVID-19. Indian system of traditional medicine has a potential worth to enhance immunity, which can resist a novel coronavirus. Material & Methods: A detailed study was carried out by analyzing national and international scientific databases (PubMed, SciFinder, ScienceDirect, Scopus, and Web of Science, Mendeley), thesis, and recognized books. Only Indian herbs with high immunity resistant power were analyzed. Epidemiologic studies with information on COVID-19 risk factors and precautions also considered for study purposes. Results: Some herbs like Ocimum tenuiflorum (Tulsi), Glycyrrhiza glabra (Liquorice), Curcuma domestica Vahl (Turmeric), Tinospora cordifolia (Giloy), Withania somnifera (Ashwagandha), Cinnamon (Dalchini), Shoot of Triticumaestivum Linn. (Wheatgrass), Andrographis paniculata (Kalmegh), can help in boosting immunity for COVID-19 disease. Discussion: Despite the shreds of evidence for the efficacy of these herbs in treating coronavirus induced infections; the proper dose with ideal timing for such interventions needs to verify in clinical trials. Researchers must have to take the privilege to explore the potential of herbs to reduce such epidemics of environmental threats.

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Phyto extracts of Carica papaya and Tinospora cordifolia can correct thrombocytopenia in alcoholic decompensate liver cirrhosis : Case Series

Journal of Ayurveda and Integrated Medical Sciences (JAIMS) ◽

10.21760/jaims.v3i01.11648 ◽

2018 ◽

Vol 3 (01) ◽

Author(s):

Ashok Kumar Panda

Keyword(s):

Platelet Count ◽

Cell Activation ◽

Carica Papaya ◽

Advanced Disease ◽

Fibrous Tissue ◽

Case Series ◽

Tinospora Cordifolia ◽

Randomised Control Trial ◽

Days Of Therapy ◽

Leaf Juice

Thrombocytopenia (platelet count less than 150 × 109/L) is a frequent complication of decompensate cirrhosis and is considered as an indicator of advanced disease. Carica papaya leaf juice has beneficial effect in thrombocytopenia associated with dengue. Tinospora cordifolia has been shown to prevent the fibrous tissue deposition of liver by modulation of kupffer cell activation. An attempt was taken to observe the usefulness of extract Carica papaya and Tinospora cordifolia in alcoholic decompensate cirrhosis. A market available product Cariden is easily available to the patients which contains Phyto extracts of Carica papaya 1100mg and Tinospora cordifolia 500mg. Phyto extracts of Carica papaya and Tinospora cordifolia can enhance the platelet count within 15 days and it can normalise the platelet within 90 days of therapy in all three cases. Further randomised control trial is suggested.

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