The relationship between bioactive components in breast milk and bone mass in infants

SUMMAYWe studied the relationship between IgA anti–campylobacter flagellin antibodies in breast milk samples and protection of breastfed infants living in a rural Mexican village from campylobacter infection. There were fewer episodes of campylobacter infection (symptomatic and asymptomatic combined) in infants breastfed with milk containing specific anti-flagellin antibodies (1.2/child/year, 95% CI 0.6–1.8) versus non–breastfed children (3.3/child/year, 95% CI 1.8–4.8; P < 0.01). Infants breastfed with milk that was antiflagellin antibody negative by ELISA also had fewer episodes of infection compared with non-breastfed children, but the difference did not reach statistical significance (1.8/child/year, 95% CI 0.7–3.0 versus 3.3/child/year, 95% CI 1.8–4.8, P > 0.05). Breastfeeding has a protective effect against campylobacter infection and is associated with the presence of specific antibodies directed against campylobacter flagellin.

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Seborrheic Dermatitis of Infants: Treatment with Biotin Injections for the Nursing Mother

PEDIATRICS ◽

10.1542/peds.44.6.1014 ◽

1969 ◽

Vol 44 (6) ◽

pp. 1014-1016

Author(s):

Aaron Nisenson

Keyword(s):

Breast Milk ◽

Maternal Nutrition ◽

Seborrheic Dermatitis ◽

Cow’S Milk ◽

Blood Levels ◽

Biotin Deficiency ◽

Nursing Mother ◽

Limited Experience ◽

The Relationship ◽

Breast Fed

Four cases of extensive seborrheic dermatitis or Leiner's disease are presented which dramatically improved after the nursing mother was given injections of biotin. The relationship between seborrheic dermatitis in infants and biotin deficiency is discussed and the literature reviewed. From this review it appears that breast milk is deficient in biotin in comparison to cow's milk. The deficiency is further aggravated by poor maternal nutrition. Infection and diarrhea in the infant may also contribute to low blood levels of biotin. On the basis of this limited experience, injections of biotin to the nursing mother appear to be a useful treatment for the breast-fed infant with extensive seborrheic dermatitis.

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The Pharmacokinetics of Ketamine in the Breast Milk of Lactating Women: Quantification of ketamine and metabolites

10.22541/au.161325028.80476344/v1 ◽

2021 ◽

Author(s):

Philip Wolfson ◽

Rob Cole ◽

Kara Lynch ◽

Cassandra Yun ◽

Jason Wallach ◽

...

Keyword(s):

Breast Milk ◽

Postpartum Depression ◽

Emotional Disorders ◽

Pharmacokinetic Analysis ◽

Emotional Difficulties ◽

Lactating Women ◽

Treatment Of Depression ◽

Mother And Child ◽

Pharmacologic Treatments ◽

The Relationship

Abstract: There is no available data on the secretion and concentration of ketamine and its metabolites in breastmilk. There are statements in the literature made as to the safety of the use of ketamine in lactating women, though these are unsupported. This information is pertinent for the treatment of breastfeeding women who may have depression, PTSD, postpartum depression, and other emotional difficulties and would benefit from ketamine treatment. The objective of this study was to measure the presence and concentration of ketamine in breastmilk and three of its metabolites. We have provided a longitudinal pharmacokinetic analysis of the presence of ketamine and several of its major metabolites (norketamne, dehydronorketamine and hydronorketamine) in 4 women receiving 2 different intramuscular doses of ketamine—0.5mg/kg and 1.0mg/kg. Our results demonstrate the insignificance of ketamine’s presence In breast milk after a 12-hour period of suspension. Given ketamine’s proven record of effectiveness for the treatment of depression, and its intermittent use for this purpose, our data support the safety of its administration for the treatment of postpartum depression (PPD)and other emotional disorders during a woman’s chosen period to provide breast milk to her child without significant interruption or exposure. This provides the necessary data for the study of ketamine assisted psychotherapy as a potential treatment of postpartum emotional disorders without the loss of the relationship between mother and child which breast feeding so vitally provides. We review conventional pharmacologic treatments involved in the treatment of PPD.

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HUBUNGAN TINGKAT PENGETAHUAN IBU DAN DUKUNGAN SUAMI TERHADAP KEBERHASILAN PEMBERIAN ASI EKSKLUSIF

JURNAL KESEHATAN MERCUSUAR ◽

10.36984/jkm.v2i1.23 ◽

2019 ◽

Vol 2 (1) ◽

pp. 5

Author(s):

Eka Putri Primasari

Keyword(s):

Breast Milk ◽

Exclusive Breastfeeding ◽

Statistical Test ◽

P Value ◽

Test Results ◽

Cross Sectional ◽

Level Of Knowledge ◽

Cross Sectional Design ◽

The Relationship ◽

Low Rate

Abstract: Breast milk is the best food for babies, especially in the first month of life. Breast milk contains all nutrients to build and provide the energy needed by the baby. The low rate of breastfeeding is a threat to child development. Several factors related to the success of exclusive breastfeeding are the level of knowledge of the mother and husband's support. The purpose of this study was to determine the relationship between the level of knowledge of mothers and husband's support towards the success of exclusive breastfeeding in Lubuk Kilangan Puskesmas in 2017. This study was analytical with a cross sectional design. The population in this study amounted to 153 respondents. A sample of 31 respondents obtained by simple ramdom sampling. Data were analyzed bivariate. The statistical test results obtained p-value = 0,000. It can be concluded that there is a relationship between the knowledge of mothers about exclusive breastfeeding and husband's support for the success of exclusive breastfeeding.

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Exclusive Breastfeeding Related to Diarrhea Occurrence in Babies Aged 0-6 Months Old at Sudiang Community Health Center, Makassar

Community Medicine and Education Journal ◽

10.37275/cmej.v3i1.169 ◽

2022 ◽

Vol 3 (1) ◽

pp. 202-208

Author(s):

Balqis Dwiyanti Haedar ◽

Rauly Ramadhani ◽

Andi Sitti Rahma

Keyword(s):

Breast Milk ◽

Community Health ◽

Health Center ◽

Exclusive Breastfeeding ◽

High School Graduates ◽

Community Health Center ◽

Cross Sectional ◽

A Value ◽

Cross Sectional Design ◽

The Relationship

Exclusive breastfeeding is a condition in which infants are only given breast milk without the addition of other fluids and foods. until the baby reaches 6 months old. Breast milk strengthen the immune system in infants so they can avoid various diseases including diarrhea. This study aims to determine the relationship between exclusive breastfeeding and the incidence of diarrhea in infants aged 0-6 months in the Sudiang Community Health Center. This research is an analytical survey research with a cross-sectional design. This research was conducted at the Sudiang Health Center, Makassar City in the period November 1st to December 31st, 2019. The total respondents were 89 mothers with babies aged 0-6 months. The results showed that most of the respondents were mothers with male babies (61%), most of the mothers' education was high school graduates (46%), housewives (75%) with low economic background (56%). Exclusive breastfeeding related to the incidence of diarrhea in children aged 0-6 months in the Sudiang Community Health Center with a value of p <0.05 (p = 0.001). In addition, no significant relationship on maternal nipple hygiene to diarrhea in children aged 0-6 months p <0.05 (p = 0.075). In conclusion, this study showed there is a relationship between exclusive breastfeeding and the incidence of diarrhea in children aged 0-6 months in Sudiang Health Center. There is a relationship between hand hygiene and the incidence of diarrhea in children aged 0-6 months in Sudiang Health Center, Makassar.

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The Relationship Of Insulin‑Like Growth Factor 1 With Bone Mass In Obese Female

STRADA JURNAL ILMIAH KESEHATAN ◽

10.30994/sjik.v9i2.423 ◽

2020 ◽

Vol 9 (2) ◽

pp. 1041-1046

Author(s):

Adek Ardiansyah ◽

Lilik Herawati ◽

Damayanti Tinduh

Keyword(s):

Growth Factor ◽

Bone Mass ◽

Fasting Blood Glucose ◽

Cross Sectional Study ◽

Insulin Like Growth Factor ◽

Obese Women ◽

Cross Sectional ◽

Obese Female ◽

Relationship Of ◽

The Relationship

This study aimed to analyze the relationship of insulin-like growth factor 1 with bone mass in obese female. This study used a cross sectional study method using 30 obese women aged 19-23 years, body mass index (BMI) 25-35 kg / m2, normal blood pressure, normal resting heart rate (RHR), normal hemoglobin (Hb). and fasting blood glucose (FBG) <100 mg / dL. Measurement of IGF-1 levels used the Enzym Link Immunosorbent Assay (ELISA) method. Measurement of bone mass using TANITA (Body Composition Analyzer DC3607601 (2) -1604 FA, TANITA Corporation of America, Inc., USA). The data analysis technique used the Pearson product-moment test with Statistical Package for Social Science (SPSS). The results showed that mean levels of IGF-1 (1.17 ± 0.10) ng / mL and bone mass (2.49 ± 0.06) kg (r = 0.712, P ≤ 0.001). Our findings suggest that there was a positive correlation between IGF-1 levels and bone mass

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Dynamic Associations of Milk Components With the Infant Gut Microbiome and Fecal Metabolites in a Mother–Infant Model by Microbiome, NMR Metabolomic, and Time-Series Clustering Analyses

Frontiers in Nutrition ◽

10.3389/fnut.2021.813690 ◽

2022 ◽

Vol 8 ◽

Author(s):

Yosuke Komatsu ◽

Daiki Kumakura ◽

Namiko Seto ◽

Hirohisa Izumi ◽

Yasuhiro Takeda ◽

...

Keyword(s):

Breast Milk ◽

Gut Microbiome ◽

Lactation Period ◽

Bioactive Components ◽

Fecal Microbiome ◽

Breastfed Infants ◽

H Nmr ◽

Milk Components ◽

Infant Gut Microbiome ◽

Infant Feces

Background: The gut microbiome and fecal metabolites of breastfed infants changes during lactation, and are influenced by breast milk components. This study aimed to investigate dynamic associations of milk components with the infant gut microbiome and fecal metabolites throughout the lactation period in a mother–infant model.Methods: One month after delivery, breast milk and subsequent infant feces were collected in a pair for 5 months from a mother and an exclusively breastfed infant. Composition of the fecal microbiome was determined with 16S rRNA sequencing. Low-molecular-weight metabolites, including human milk oligosaccharides (HMOs), and antibacterial proteins were measured in feces and milk using 1H NMR metabolomics and enzyme-linked immunosorbent assays. The association of milk bioactive components with the infant gut microbiome and fecal metabolites was determined with Python clustering and correlation analyses.Results: The HMOs in milk did not fluctuate throughout the lactation period. However, they began to disappear in infant feces at the beginning of month 4. Notably, at this time-point, a bifidobacterium species switching (from B. breve to B. longum subsp. infantis) occurred, accompanied by fluctuations in several metabolites including acetate and butyrate in infant feces.Conclusions: Milk bioactive components, such as HMOs, might play different roles in the exclusively breastfed infants depending on the lactation period.

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