Size and distribution of the iron oxide nanoparticles in SBA-15 nanoporous silica via SANS study

Abstract Structural characteristics of nanocomposite series consisting of iron oxide nanoparticles (NPs) embedded in the regular pores of amorphous silica matrix (SBA-15) were investigated by means of small angle neutron scattering (SANS). By virtue of unique neutron properties, insight into the inner structure and matter organization of this kind of systems was facilitated for the first time. Based on rigorous experimental support, fundamental model describing the neutron scattering intensity distribution was proposed by assuming general composite structural features. Model application to SANS data confirmed the presence of iron oxide NPs in the body of examined matrices, providing additional information on their shape, concentration and size distribution. Scattering superposition principle employed in the model conception allows for tailoring its fundamental characteristics, and renders it a potent and versatile tool for a wide range of applications.

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Anodic Titanium Dioxide Nanotubes for Magnetically Guided Therapeutic Delivery

Scientific Reports ◽

10.1038/s41598-019-49513-2 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 6

Author(s):

Morteza Hasanzadeh Kafshgari ◽

Delf Kah ◽

Anca Mazare ◽

Nhat Truong Nguyen ◽

Monica Distaso ◽

...

Keyword(s):

Titanium Dioxide ◽

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Hela Cells ◽

Release Kinetics ◽

Drug Loading ◽

Oxide Nanoparticles ◽

Site Specific ◽

Therapeutic Drugs ◽

Wide Range

Abstract Hollow titanium dioxide (TiO2) nanotubes offer substantially higher drug loading capacity and slower drug release kinetics compared to solid drug nanocarriers of comparable size. In this report, we load TiO2 nanotubes with iron oxide nanoparticles to facilitate site-specific magnetic guidance and drug delivery. We generate magnetic TiO2 nanotubes (TiO2NTs) by incorporating a ferrofluid containing Ø ≈ 10 nm iron oxide nanoparticles in planar sheets of weakly connected TiO2 nanotubes. After thermal annealing, the magnetic tubular arrays are loaded with therapeutic drugs and then sonicated to separate the nanotubes. We demonstrate that magnetic TiO2NTs are non-toxic for HeLa cells at therapeutic concentrations (≤200 µg/mL). Adhesion and endocytosis of magnetic nanotubes to a layer of HeLa cells are increased in the presence of a magnetic gradient field. As a proof-of-concept, we load the nanotubes with the topoisomerase inhibitor camptothecin and achieve a 90% killing efficiency. We also load the nanotubes with oligonucleotides for cell transfection and achieve 100% cellular uptake efficiency. Our results demonstrate the potential of magnetic TiO2NTs for a wide range of biomedical applications, including site-specific delivery of therapeutic drugs.

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Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System

Materials ◽

10.3390/ma12030465 ◽

2019 ◽

Vol 12 (3) ◽

pp. 465 ◽

Cited By ~ 39

Author(s):

Shoeb Ansari ◽

Eleonora Ficiarà ◽

Federico Ruffinatti ◽

Ilaria Stura ◽

Monica Argenziano ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Magnetic Iron Oxide Nanoparticles ◽

Close Link ◽

Wide Range ◽

Methods Of Synthesis ◽

The Central Nervous System

Magnetic Nanoparticles (MNPs) are of great interest in biomedicine, due to their wide range of applications. During recent years, one of the most challenging goals is the development of new strategies to finely tune the unique properties of MNPs, in order to improve their effectiveness in the biomedical field. This review provides an up-to-date overview of the methods of synthesis and functionalization of MNPs focusing on Iron Oxide Nanoparticles (IONPs). Firstly, synthesis strategies for fabricating IONPs of different composition, sizes, shapes, and structures are outlined. We describe the close link between physicochemical properties and magnetic characterization, essential to developing innovative and powerful magnetic-driven nanocarriers. In conclusion, we provide a complete background of IONPs functionalization, safety, and applications for the treatment of Central Nervous System disorders.

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An experimental study and multi-compartmental modelling of the distribution in, and elimination from the body of iron oxide nanoparticles deposited in the lower airways during long-term repeated inhalation exposures of rats

Toxicology Letters ◽

10.1016/j.toxlet.2015.08.588 ◽

2015 ◽

Vol 238 (2) ◽

pp. S195

Author(s):

M. Sutunkova ◽

L. Konysheva ◽

B. Katsnelson ◽

L. Privalova ◽

V. Gurvich ◽

...

Keyword(s):

Experimental Study ◽

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

The Body ◽

Oxide Nanoparticles ◽

Compartmental Modelling ◽

Lower Airways

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Interaction between immunoglobulin G and peroxidase-like iron oxide nanoparticles: Physicochemical and structural features of the protein

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics ◽

10.1016/j.bbapap.2019.140300 ◽

2020 ◽

Vol 1868 (1) ◽

pp. 140300 ◽

Cited By ~ 1

Author(s):

Anna V. Bychkova ◽

Mariia V. Lopukhova ◽

Luybov A. Wasserman ◽

Pavel G. Pronkin ◽

Yevgeniy N. Degtyarev ◽

...

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Immunoglobulin G ◽

Structural Features ◽

Oxide Nanoparticles

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Iron Oxide Nanoparticles as Imaging and Therapeutic Agents for Atherosclerosis

Seminars in Thrombosis and Hemostasis ◽

10.1055/s-0039-3400247 ◽

2020 ◽

Vol 46 (05) ◽

pp. 553-562

Author(s):

Joshua Talev ◽

Jagat Rakesh Kanwar

Keyword(s):

Iron Oxide ◽

Cardiovascular Diseases ◽

Iron Oxide Nanoparticles ◽

Imaging Techniques ◽

Therapeutic Agents ◽

Oxide Nanoparticles ◽

Future Prospects ◽

Wide Range ◽

Theranostic Applications

AbstractAtherosclerosis is the major cause of cardiovascular diseases and is the leading cause of mortality worldwide. Iron oxide nanoparticles have emerged as potential diagnostic and therapeutic agents for a wide range of conditions. To date, the theranostic applications of iron oxide nanoparticles have been studied mainly in cancer, but atherosclerosis has not received the same attention. Therefore, it appears appropriate to review the current and future applications of iron oxide nanoparticles for the diagnosis and therapy of atherosclerosis. This review will first discuss current imaging techniques for the diagnosis of atherosclerosis as well as their limitations. It will then discuss the role of nanotechnology for molecular imaging of atherosclerosis and the benefits of this approach as well as reviewing current developments in the field including single, bi-, and tri-modal imaging. Next, it will discuss the role of nanotechnology for therapies of atherosclerosis with a focus on nanotheranostics, concluding with a look at the challenges faced by nanoparticle-based imaging and therapy of atherosclerosis as well as a look at future prospects.

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Remote Actuation of Apoptosis in Liver Cancer Cells via Magneto-Mechanical Modulation of Iron Oxide Nanoparticles

Cancers ◽

10.3390/cancers11121873 ◽

2019 ◽

Vol 11 (12) ◽

pp. 1873 ◽

Cited By ~ 7

Author(s):

Oleg Lunov ◽

Mariia Uzhytchak ◽

Barbora Smolková ◽

Mariia Lunova ◽

Milan Jirsa ◽

...

Keyword(s):

Iron Oxide ◽

Liver Cancer ◽

Cancer Cells ◽

Iron Oxide Nanoparticles ◽

Magnetic System ◽

Short Pulse ◽

Magnetic Nanomaterials ◽

Oxide Nanoparticles ◽

Liver Cancer Cells ◽

Wide Range

Lysosome-activated apoptosis represents an alternative method of overcoming tumor resistance compared to traditional forms of treatment. Pulsed magnetic fields open a new avenue for controlled and targeted initiation of lysosomal permeabilization in cancer cells via mechanical actuation of magnetic nanomaterials. In this study we used a noninvasive tool; namely, a benchtop pulsed magnetic system, which enabled remote activation of apoptosis in liver cancer cells. The magnetic system we designed represents a platform that can be used in a wide range of biomedical applications. We show that liver cancer cells can be loaded with superparamagnetic iron oxide nanoparticles (SPIONs). SPIONs retained in lysosomal compartments can be effectively actuated with a high intensity (up to 8 T), short pulse width (~15 µs), pulsed magnetic field (PMF), resulting in lysosomal membrane permeabilization (LMP) in cancer cells. We revealed that SPION-loaded lysosomes undergo LMP by assessing an increase in the cytosolic activity of the lysosomal cathepsin B. The extent of cell death induced by LMP correlated with the accumulation of reactive oxygen species in cells. LMP was achieved for estimated forces of 700 pN and higher. Furthermore, we validated our approach on a three-dimensional cellular culture model to be able to mimic in vivo conditions. Overall, our results show that PMF treatment of SPION-loaded lysosomes can be utilized as a noninvasive tool to remotely induce apoptosis.

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Kiruna-Type Ore as a Novel Precursor for Large-Scale Production of Small Uniform Iron Oxide Nanoparticles

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2020.18438 ◽

2020 ◽

Vol 20 (10) ◽

pp. 6525-6531

Author(s):

Majid Mostaghelchi ◽

Jani Kotakoski ◽

Christian Rentenberger ◽

Christian L. Lengauer

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Large Scale ◽

Critical Size ◽

Raw Material ◽

Oxide Nanoparticles ◽

Scale Production ◽

X Ray ◽

Mechanical Attrition ◽

Wide Range

The wide range of actual and potential applications of nanoparticles, highlight the necessity of a reliable production method for both quality and quantity of the products. Mechanical attrition is one of the first well-known techniques used to produce nanoparticles. However, these approaches have been restricted to produce uniform particles below the critical size of 15 nm because of the attrition balance limit. This paper introduces the magnetite–silicate raw material of a Kiruna-type ore deposit as a novel precursor, which enables the production of small iron oxide nanoparticles below the critical size by mechanical attrition. X-ray fluorescence (XRF), powder X-ray diffractometry (pXRD), dynamic light scattering (DLS) and transmission electron microscopy (TEM) were used for characterization of the precursor and obtained nanoparticles. The results indicate that the particles with a mean diameter of 10.7(2.7) nm consist of mainly less than one crystallite. The significant size reduction below the attrition balance limit can be attributed to the quartz content of the raw material, which operated as supporting micro-balls for transferring the energy during the milling process.

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