scholarly journals Relationship between fatty pancreas and hypertriglyceridemic waist phenotype: a cross-sectional study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Xiaoping Yu ◽  
Dan Wang ◽  
Weiming Xiao ◽  
Xinlin Shi ◽  
Qiang She ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Metabolic Diseases ◽  
Visceral Obesity ◽  
Serum Triglyceride ◽  
Occurrence Rate ◽  
Roc Curve Analysis ◽  
Hypertriglyceridemic Waist ◽  
Fatty Pancreas ◽  
Normal Triglyceride ◽  
Hypertriglyceridemic Waist Phenotype

AbstractHypertriglyceridemic waist phenotype (HTWP) and its quantitative indicator, waist circumference-triglyceride index (WTI), are common quantitative indices of visceral obesity and are closely related to metabolic diseases. The purpose of this study was to investigate the relationship between fatty pancreas (FP) and HTWP in China. FP was diagnosed using trans-abdominal ultrasonography in all participants. According to the waist circumference and serum triglyceride levels, the participants were divided into four phenotype groups: normal waist circumference-normal triglyceride, normal waist circumference-elevated triglyceride, elevated waist circumference-normal triglyceride, and elevated waist circumference-elevated triglyceride (indicating HTWP). Clinical characteristics and biochemical indices were compared among the groups. Receiver operating characteristic (ROC) curves were used to evaluate the utility of WTI as a reference factor for FP screening. The HTWP group had a higher prevalence of metabolic syndrome (84.2%), FP (10.4%), fatty liver (64.5%), and hypertension (15.8%) than the other three phenotype groups. The occurrence rate of HTWP and the median WTI were significantly higher in participants with FP than in those without FP (54.7% vs 21.0%, 222 ± 135 vs 142 ± 141, p < 0.001). In the ROC curve analysis, when the maximum area under the curve was 0.746, the WTI was 107.09 and the corresponding sensitivity and specificity were 90.6% and 51.9%, respectively. HTWP is closely associated with FP and can be used as a reference factor for FP screening.

scholarly journals The hypertriglyceridemic waist phenotype in young adults from the Southern Region of Brazil

2013 ◽  
Vol 29 (5) ◽  
pp. 999-1007 ◽  
Author(s):  
Ricardo Lanzetta Haack ◽  
Bernardo Lessa Horta ◽  
Denise Petrucci Gigante ◽  
Fernando C. Barros ◽  
Isabel Oliveira ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Skin Color ◽  
Family Income ◽  
Southern Region ◽  
Fat Intake ◽  
Hypertriglyceridemic Waist ◽  
Maternity Hospitals ◽  
Hypertriglyceridemic Waist Phenotype ◽  
The City

The present study aimed to assess the prevalence of the hypertriglyceridemic waist phenotype and its associated factors among subjects that have been followed up from birth. In 1982, all maternity hospitals in the city of Pelotas, in the Southern Region of Brazil, were visited and all births were recorded. Babies whose parents lived in the urban area of Pelotas were subsequently followed up on several occasions. A 22 to 23-year follow-up of this birth cohort was carried out in 2004 and 2005. The presence of the hypertriglyceridemic waist phenotype was defined as waist circumference ≥ 90cm and triglyceride levels ≥ 177mg/dL for males, and waist circumference ≥ 85cm and triglyceride levels ≥ 133mg/dL for females. The prevalence of the hypertriglyceridemic waist phenotype was 5.9% and 4.5% among men and women, respectively. Among males, a sedentary lifestyle during leisure time, smoking and obesity were associated with the presence of the hypertriglyceridemic waist phenotype, whereas among females the condition was positively associated with skin color, family income, obesity and dietary fat intake.

scholarly journals HYPERTRIGLYCERIDEMIC WAIST AND ASSOCIATED FACTORS IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS

2020 ◽  
Vol 38 ◽  
Author(s):  
Lílian Caroline de Souza e Silva ◽  
Skalyt Lee Barbosa e Silva ◽  
Ávilla Monalisa Silva de Oliveira ◽  
Jacqueline Rosangela de Araujo ◽  
Ilma Kruze Grande de Arruda ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Cardiovascular Diseases ◽  
Waist Circumference ◽  
Type 1 Diabetes Mellitus ◽  
Lipid Profile ◽  
Associated Factors ◽  
Hypertriglyceridemic Waist ◽  
Hypertriglyceridemic Waist Phenotype

ABSTRACT Objective: To assess the frequency of the hypertriglyceridemic waist phenotype and its associated factors in children and adolescents with type 1 diabetes mellitus. Methods: This is an observational analytical study with individuals with type 1 diabetes mellitus, aged 5 to 18 years, of both genders, followed in a university hospital in the Brazilian Northeast. Weight, height, and waist circumference were measured, and the lipid profile and glycated hemoglobin were analyzed. The hypertriglyceridemic waist phenotype was defined by the simultaneous presence of increased waist circumference (≥90th percentile for age and gender) and elevated serum triglyceride levels (≥75 mg/dL for children and ≥90 mg/dL for adolescents). We also investigated the family history of cardiovascular diseases and diabetes, as well as sociodemographic and behavioral variables. In the statistical inference tests, the proportions were compared by Pearson’s chi-square test and/or Fisher’s exact test, being significant p<0.05. Results: A total of 102 patients were evaluated, most of them females (54.9%) and adolescents (66.7%). The frequency of hypertriglyceridemic waist was 23.5%, which was associated with females (p=0.043), overweight (p=0.023), hypercholesterolemia (p=0.002), high LDL (p=0.001), and borderline VLDL (<0.001). Conclusions: The frequency of the hypertriglyceridemic waist phenotype was associated with females, atherogenic lipid profile, and overweight, indicating the importance of the nutritional monitoring of this population, aiming at reducing future cardiovascular diseases.

Abstract P375: Vitamin D Deficiency is Associated with Hypertriglyceridemic Waist Phenotype

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Maithili Shenoy ◽  
Tushar Tuliani ◽  
Vikas Veeranna ◽  
Sandip Zalawadiya ◽  
Krunal H. Patel ◽  
...  
Keyword(s):  
Vitamin D ◽  
Visceral Obesity ◽  
Cardiovascular Outcomes ◽  
Nutritional Risk ◽  
Categorical Variables ◽  
P Value ◽  
Continuous Variables ◽  
Serum Triglycerides ◽  
Hypertriglyceridemic Waist ◽  
Hypertriglyceridemic Waist Phenotype

Introduction: Hypertriglyceridemic waist phenotype (TGW) is a clinical indicator of visceral obesity. Studies have shown that TGW predicts adverse cardiovascular outcomes. Vitamin D (Vit D) deficiency is a novel and reversible nutritional risk factor for metabolic syndrome and cardiovascular disease. This is the first study of its kind, looking at whether Vit D deficiency predicted TGW. Methods: We did a post-hoc analysis of 2301 subjects from the National Health and Nutrition Examination Survey III (1988-1994). Patients without Vit D, waist circumference (WC) and serum triglycerides (TG) measurements were excluded. TGW was defined as WC ≤85 cm and 90 cm and TG ≤1.5 mmol/l (132 mg/dl) and 2 mmol/l (177 mg/dl) in females and males respectively. Subjects were divided into equal quartiles based on serum vit D levels. Stata 11 was used to perform chi-square test for categorical variables, t-test for continuous variables and univariate and step-wise multivariate logistic and linear regression. Results: Out of 2301 subjects, 35% (798) met the definition of TGW. Patients with TGW were older (61±12 vs. 60±13 yrs, p 0.01), males (43% vs. 56%, p<0.001), dyslipidemic (58% vs. 42%, p<0.001), diabetic (17% vs. 10%, p<0.001), hypertensive (63% vs. 51%, p<0.001) and had lower serum vit D levels (22.1±8.7 vs. 23.2±9.2, p 0.008). Vit D level was negatively associated with TGW (coef -0.024, CI -0.036 to -0.013, p<0.001). Patients having serum vit D level >28 ng/ml (highest quartile) were significantly less likely to have TGW than patients having vit D level <17 ng/ml (lowest quartile) after adjusting for age, sex, race, GFR, calcium, parathyroid hormone, hypertension, hypertension medications, hyperlipidemia, hyperlipidemia medications, diabetes, end stage renal disease and hemodialysis (OR 0.56, CI 0.42-0.75, p<0.001). Conclusion: Vit D deficiency is an independent predictor of TGW. Randomized controlled trials are needed to determine whether supplementation will improve cardiovascular outcomes. Table 1. Vitamin D Quartile Q1 (<17 ng/ml) reference category Odds ratio 95% CI P value Q2 (17-22) 0.84 0.65 to 1.09 0.19 Q3 (23-28) 0.63 0.48 to 0.83 0.001 Q4 (>28) 0.56 0.42 to 0.75 <0.001

scholarly journals Enlarged waist combined with elevated triglycerides (hypertriglyceridemic waist phenotype) and HDL-cholesterol in patients with heart failure

2017 ◽  
Vol 135 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Camila Weschenfelder ◽  
Aline Marcadenti ◽  
Airton Tetelbom Stein ◽  
Catarina Bertaso Andreatta Gottschall
Keyword(s):  
Heart Failure ◽  
Body Mass Index ◽  
Waist Circumference ◽  
Body Mass ◽  
Hdl Cholesterol ◽  
Hypertriglyceridemic Waist ◽  
Significant Difference ◽  
Patients With Heart Failure ◽  
The Mean ◽  
Hypertriglyceridemic Waist Phenotype

ABSTRACT CONTEXT AND OBJECTIVE: The association of serum triglycerides plus waist circumference seems to be a good marker of cardiovascular risk and has been named the “hypertriglyceridemic waist” phenotype. The aim of our study was to investigate the association between the hypertriglyceridemic waist phenotype and HDL-cholesterol among patients with heart failure. DESIGN AND SETTING: Cross-sectional study in a tertiary-level hospital in southern Brazil. METHODS: We included patients with heart failure aged > 40 years. Anthropometric assessment (weight, height, waist and hip circumferences) was performed; body mass index (BMI) and waist-hip ratio were calculated and lipid measurements (serum total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides) were collected. In men and women, respectively, waist circumference ≥ 94 cm and ≥ 80 cm, and triglycerides ≥ 150 mg/dl were considered abnormal and were used to identify the hypertriglyceridemic waist phenotype. Analyses of covariance were used to evaluate possible associations between levels of HDL-cholesterol and the hypertriglyceridemic waist phenotype, according to sex. RESULTS: 112 participants were included, of whom 62.5% were men. The mean age was 61.8 ± 12.3 years and the mean ejection fraction was 40.1 ± 14.7%. Men and woman presented mean HDL-cholesterol of 40.5 ± 14.6 and 40.9 ± 12.7 mg/dl, respectively. The prevalence of the hypertriglyceridemic waist phenotype was 25%. There was a significant difference in mean HDL-cholesterol between men with and without the hypertriglyceridemic waist phenotype (32.8 ± 14.2 versus 42.1 ± 13.7 mg/dl respectively; P = 0.04), even after adjustment for age, body mass index, type 2 diabetes mellitus, use of statins and heart failure etiology. CONCLUSIONS: The hypertriglyceridemic waist phenotype is significantly associated with lower HDL-cholesterol levels in men with heart failure.

scholarly journals The Relationship between Hypertriglyceridemic Waist Phenotype and Early Diabetic Nephropathy in Type 2 Diabetes

2017 ◽  
Vol 7 (4) ◽  
pp. 295-300 ◽  
Author(s):  
Chun-Ming Ma ◽  
Rui Wang ◽  
Xiao-Li Liu ◽  
Na Lu ◽  
Qiang Lu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
Waist Circumference ◽  
Glycosylated Hemoglobin ◽  
Serum Triglyceride ◽  
Hypertriglyceridemic Waist ◽  
The Relationship ◽  
Early Diabetic Nephropathy ◽  
Diabetes Patients

Background/Aims: The aim of this study was to explore the relationship between hypertriglyceridemic waist (HW) phenotype and early diabetic nephropathy in type 2 diabetes. Methods: A cross-sectional study was conducted on 538 type 2 diabetes patients in Qinhuangdao. The HW phenotype was defined as serum triglyceride concentrations ≥1.7 mmol/L and waist circumference ≥90 cm (males) and ≥85 cm (females). Results: The prevalence of the HW phenotype was 34.9%. The prevalence of early diabetic nephropathy was 10.6% in type 2 diabetes patients with normal waist circumference and triglycerides and 24.5% in type 2 diabetes patients with HW phenotype. After adjustment for sex, age, body mass index, hypertension, history of diabetes, and glycosylated hemoglobin A1c, the prevalence of early diabetic nephropathy among type 2 diabetes patients with the HW phenotype was 2.81 (95% confidence interval 1.36-5.80, p = 0.005) times higher than that among type 2 diabetes patients with normal waist circumference and triglycerides. Conclusion: There was a significant correlation between HW phenotype and early diabetic nephropathy in type 2 diabetes.

scholarly journals Piceatannol Is Superior to Resveratrol at Suppressing Adipogenesis in Human Visceral Adipose-Derived Stem Cells

Plants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 366
Author(s):  
In Sil Park ◽  
Youngjin Han ◽  
HyunA Jo ◽  
Ki Won Lee ◽  
Yong Sang Song
Keyword(s):  
Stem Cells ◽  
Metabolic Diseases ◽  
Binding Protein ◽  
Visceral Obesity ◽  
Peroxisome Proliferator ◽  
Adipose Derived Stem Cells ◽  
Fatty Acid Binding ◽  
Chemical Structures ◽  
Visceral Adipose ◽  
Adipogenic Effect

Resveratrol (3,4′,5-trans-trihydroxystilbene) and piceatannol (3,3′,4′,5-trans-tetraphydroxystilbene) are major stilbene compounds that are predominantly present in various natural foods, such as berries and fruits. Both phytochemical compounds are consumed as dietary supplements to prevent various metabolic diseases and for their anti-aging properties. Adipose-derived stem cells from human visceral adipose tissue (vASCs) are a useful in vitro model for evaluating their adipogenic effect. Treatment with resveratrol and piceatannol significantly inhibited lipid accumulation in vASCs. Their effective concentrations were 5, 10, and 20 μM for inhibiting adipogenesis of vASCs. Interestingly, despite the similar chemical structures of the two compounds, piceatannol showed a higher anti-adipogenic effect at 20 μM than resveratrol in vASCs. Moreover, the inhibitory capacity of lipid droplet generation was higher for piceatannol at 20 μM than that of resveratrol. Piceatannol significantly attenuated the expression level of adipogenic markers (e.g., CCAAT/enhanced binding protein α (C/EBPα), peroxisome proliferator-activated receptor γ (PPARγ), and adipocyte fatty acid binding protein (aP2)) compared to resveratrol at the mRNA and protein levels. These results suggest that piceatannol is a superior anti-adipogenic compound compared to resveratrol in the vASC model of visceral obesity.

scholarly journals Waist circumference and waist-hip ratio as screening tools for hypertension in children aged 6–11 years

2019 ◽  
Vol 59 (5) ◽  
pp. 265-70
Author(s):  
Esti Istiqomah ◽  
Dida A. Gurnida ◽  
Dany Hilmanto ◽  
Dzulfikar Djalil Lukmanul Hakim ◽  
Prima Nanda Fauziah
Keyword(s):  
Waist Circumference ◽  
Prevalence Ratio ◽  
Screening Tools ◽  
Hip Circumference ◽  
Roc Curve Analysis ◽  
Anthropometric Parameters ◽  
Predictive Values ◽  
Waist Hip Ratio ◽  
Hypertensive Group ◽  
Hypertension In Children

Background Hypertension in children is associated with obesity. 7 The renin-angiotensin-aldosterone system has been associated with intra-abdominal fat tissue. Anthropometric parameters for determining nutritional status include waist circumference and waist-hip ratio. Many studies have shown that waist circumference and waist-hip ratio are more precise to determine overweight or obese. Objective To determine the usefulness of waist circumference and waist-hip ratio as hypertensive screening tools for children aged 6-11 years. Methods This analytical study with cross-sectional design and multistage cluster sampling method was conducted in August-September 2017 at a primary school in Bandung, West Java, Indonesia. Subjects underwent height, weight, waist circumference, hip circumference, and blood pressure measurements. Receiver operating characteristic (ROC) curve analysis was done to obtain the area under curve (AUC), cut-off point, sensitivity, specificity, and prevalence ratio. Results Subjects were 325 children consisting of 187 males and 138 females. Hypertension was diagnosed in 47 children (37 males and 10 females). Mean waist circumference and waist-hip circumference ratio were significantly higher in the hypertensive group than in the normotensive group. The hypertensive group had a mean waist circumference of 72.6 (SD 12.8) cm, AUC 0.779 (95%CI 0.730 to 0.823; P<0.001), cut-off point >65 cm, sensitivity 66.0%, specificity 76.3%, and prevalence ratio 4.55. This group had mean waist-hip ratio of 0.94 (SD 0.10), AUC 0.724 (95%CI 0.672 to 0.772; P<0.001), waist-hip ratio cut-off >0.91, sensitivity 59.6%, specificity 77.0%, and prevalence ratio 3.73. Conclusion Waist circumference >65 cm or waist-hip ratio >0.91 can be used to screen for hypertension in children aged 6-11 years with negative predictive values of 92.0% and 91.8%, respectively.  

scholarly journals Obesity and dyslipidemia in patients with psoriasis treated at a dermatologic clinic in Manaus

2013 ◽  
Vol 88 (6) ◽  
pp. 913-916 ◽  
Author(s):  
Mônica Santos ◽  
Hannah Monteiro Fonseca ◽  
Alex Panizza Jalkh ◽  
Gabriela Piraice Gomes ◽  
Andrea de Souza Cavalcante
Keyword(s):  
Waist Circumference ◽  
Inflammatory Disease ◽  
Metabolic Diseases ◽  
Life Quality ◽  
Inflammatory Cells ◽  
Chronic Inflammatory Disease ◽  
Dermatology Clinic ◽  
Autoimmune Inflammatory Disease ◽  
Prevalence Of Obesity ◽  
Level Of Significance

BACKGROUND: Psoriasis is a chronic inflammatory disease of multifactorial etiology, with participation of genetic, autoimmune and environmental factors. Recent studies have demonstrated the role of inflammatory cells and mediators in the pathogenesis of psoriasis, which is now defined as a systemic and autoimmune inflammatory disease that may be associated with other diseases of inflammatory nature. OBJECTIVES: To evaluate the occurrence of obesity and dyslipidemia in patients with psoriasis treated at a dermatology clinic in Manaus. METHODS: We performed a prospective descriptive study to assess the prevalence of obesity and dyslipidemia in patients with psoriasis. Besides the recommended dermatological care, a physical examination was performed to measure weight, height and waist circumference. RESULTS: We included 72 patients, 44 (61.1%) female and 28 (38.9%) male, with a mean age of 51.0 years ± 15.9 years. As for body mass index (BMI), 16 (22.2%) were overweight and 20 (27.8%) were obese. In the analysis of waist circumference in relation to gender, we found that 79.5% of women surveyed had central obesity, a percentage statistically higher than that observed among men (42.9%) at the 5% level of significance (p = 0.001). Regarding the diagnosis of dyslipidemia, 29 (65.9%) females and 22 (78.6%) males showed alterations in lipid profile. CONCLUSIONS: The occurrence of dyslipidemia and obesity in patients with psoriasis can affect life quality and expectancy, increasing the risk of systemic and metabolic diseases, which makes periodic investigation of these comorbidities in patients with psoriasis mandatory.

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