scholarly journals Fabrication and characterization of 3D printing scaffold technology by extract oils from plant and its applications in the cardiovascular blood

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Soheila Naderi ◽  
Akbar Esmaeili
Keyword(s):  
Blood Pressure ◽  
Cell Proliferation ◽  
Zingiber Officinale ◽  
Reduce Blood Pressure ◽  
Polymer Scaffolds ◽  
Release Process ◽  
3D Print ◽  
Natural Protein ◽  
Modified Polymer ◽  
Process Modification

AbstractExtract oils from plants used in 3D polysaccharides modified with natural protein polymer modified polymer scaffolds can help to reduce blood pressure. This study aimed to use extract oils from plant (EOP)as blood pressure-reducing, bind them to magnetic iron nanoparticles (Fe3O4@NPs), then bind them to polymeric 3D print scaffolds [chitosan, polylactic acid, and polyurethane (CS/PLA/PU), modified with natural protein and finally separate them. This method made it possible to investigate different variables for nanoparticles. In this project, synthesis polymer, modified gelatin (Mo-Ge), PEGylation, extract oils from plant loading and release process in nanocarrier with different concentrations were examined and cell proliferation was optimized. The results show that 75% of the extract oils from plant loaded on iron magnetic nanoparticles containing PEGylated polymer scaffolds was released. Cell proliferation was performed for the sample. In this process, modification of scaffolding with polysaccharides modified with natural protein and extract oils from plant increased the efficiency of nanoparticles among the studied Allium sativum and Zingiber officinale. The size of A. sativum and Z. officinale were 29.833 nm and 150.02 nm size, respectively. These behaved very similarly to each other and A. sativum had the biggest effect in lowering blood pressure. The application of extract oils from plant in 3D mode scaffolding has not been studied before and this is the first analysis to do so, using nanoparticles.

scholarly journals Preparation of 3D Print Scaffolds Fe3O4@ Food Oils/Chitosan/Polylactic Acid/Polyurethane Modified Natural Protein Pegylated for Cardiovascular Blood

2021 ◽  
Author(s):  
sholila Naderi ◽  
Akbar Esmaeili
Keyword(s):  
Blood Pressure ◽  
Cell Proliferation ◽  
Polylactic Acid ◽  
Zingiber Officinale ◽  
Reduce Blood Pressure ◽  
Polymer Scaffolds ◽  
Release Process ◽  
3D Print ◽  
Natural Protein ◽  
Process Modification

Abstract Food oils used in 3D polysaccharides modified with natural protein polymer modified polymer scaffolds can help to reduce blood pressure. This study aimed to use food oils as blood pressure-reducing medicine, bind them to magnetic iron nanoparticles, then bind them to polymeric 3D scaffolds (chitosan, polylactic acid and polyurethane), modified with natural protein and finally separate them. This method made it possible to investigate different variables for nanoparticles. In this project, synthesis polymer, food medicinal oils, modified gelatin, PEGylation, food loading and release process in nanocarrier with different concentrations were examined and cell proliferation was optimized. The results show that 75% of the medicine loaded on iron magnetic NPs containing PEGylated polymer scaffolds was released. Cell proliferation was performed for the sample. In this process, modification of scaffolding with polysaccharides modified with natural protein and food oil increased the efficiency of nanoparticles among the studied Allium sativum oil and Zingiber officinale oils. These behaved very similarly to each other and A. sativum had the biggest effect in lowering blood pressure. The application of food medicine oils in 3D mode scaffolding has not been studied before and this is the first analysis to do so, using nanoparticles.

Mindfulness Training Helps to Reduce Blood Pressure

2014 ◽  
Author(s):  
I. Nyklicek ◽  
P. M. C. Mommersteeg ◽  
S. Van Beugen ◽  
C. Ramakers ◽  
G. J. Van Boxtel
Keyword(s):  
Blood Pressure ◽  
Reduce Blood Pressure ◽  
Mindfulness Training

EFEKTIVITAS PEMBERIAN HYDROTHERAPI RENDAM KAKI PADA PENDERITA HIPERTENSI DI BANJAR SRI MANDALA, KELURAHAN DAUHWARU KABUPATEN JEMBRANA

2019 ◽  
Vol 10 (01) ◽  
pp. 33-44
Author(s):  
N.L.G. Sudaryati ◽  
I P. Sudiartawan ◽  
Dwi Mertha Adnyana
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Pressure Measurement ◽  
Blood Pressure Measurement ◽  
Reduce Blood Pressure ◽  
Second Grade ◽  
Control Group ◽  
Hypertensive Patients ◽  
First Category

The aim of the study was to determine the effectiveness of giving hydrotherapi foot soak in hypertensive patients. The study was conducted with one group pretestposttest design without a control group by measuring blood pressure (pretest) before being given an intervention in the form of foot soak hydrotherm against 15 people with hypertension in Banjar Sri Mandala, Dauhwaru Village, Jembrana Subregency. Then do the blood pressure measurement again (posttest) after finishing the intervention. After the study was completed, the results showed that before the hydrotherapi foot bath intervention, there were 0% of patients classified as normal, 13.32% in prehypertension category, 60.08% in hypertension category I and 26.60% in hypertension category II. After the intervention was given, there were 13.32% of the patients classified as normal, 66.68% in the prehypertension category, 20.00% in the first category of hypertension and no patients belonging to the second grade hypertension category. There is a decrease of 20-30 mmHg for systolic blood pressure and 0-10 mmHg for diastolic blood pressure after intervention. Based on the results of the study it can be concluded that the hydrotherapi foot bath is effectively used to reduce blood pressure in hypertensive patients in the Banjar Sri Mandala, Dauhwaru Village, Jembrana District.

Device therapy of resistant hypertension

2013 ◽  
Vol 154 (6) ◽  
pp. 203-208 ◽  
Author(s):  
Gábor Simonyi ◽  
J. Róbert Bedros ◽  
Mihály Medvegy
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Resistant Hypertension ◽  
Carotid Sinus ◽  
Maximum Tolerated Dose ◽  
Reduce Blood Pressure ◽  
Nerve Fibers ◽  
Uncontrolled Hypertension ◽  
Sympathetic Nerve Fibers ◽  
Treatment Of Hypertension

It is well known that hypertension is an independent cardiovascular risk factor. Treatment of hypertension frequently includes administration of three or more drugs. Resistant hypertension is defined when blood pressure remains above target value despite full doses (the patient’s maximum tolerated dose) of antihypertensive medication consisting of at least three different classes of drugs including a diuretic. Pharmacological treatment of hypertension is often unsuccessful despite the increasing number of drug combinations. Uncontrolled hypertension, however, increases the cardiovascular risk. Device treatment of resistant hypertension is currently testing two major fields. One of them the stimulation of baroreceptors in the carotid sinus and the other is radiofrequency ablation of sympathetic nerve fibers around renal arteries to reduce blood pressure in drug resistant hypertension. Orv. Hetil., 2013, 154, 203–208.

PENGARUH PEMBERIAN BELIMBING DAN MENTIMUN TERHADAP PENDERITA HIPERTENSI DI DESA LAU KERSIK KECAMATAN GUNUNG SITEMBER KABUPATEN DAIRI

2019 ◽  
Vol 2 (1) ◽  
pp. 18-23
Author(s):  
Herri Novita Br Tarigan ◽  
Prista Hotmarina Purba
Keyword(s):  
Blood Pressure ◽  
Data Analysis ◽  
Fruit Juice ◽  
Blood Pressure Reduction ◽  
Reduce Blood Pressure ◽  
Pharmacological Therapy ◽  
Hypertensive Patients ◽  
Star Fruit ◽  
Equivalent Time ◽  
Life Threatening

Hypertension is a disease that is not uncommon in the community, including the Bukit Lau Kersik village. People with hypertension often do not show long-term symptoms and can be life-threatening. However, one of the management of hypertension that can be used as non-pharmacological therapy is consuming starfruit juice and cucumber which is quite easy to find in the Bukit Lau Kersik village. This combination of juices contains potassium which can reduce blood pressure in patients with hypertension. This study used Equivalent Time Sample Design with 14 subjects with hypertension in the Bukit Lau Kersik Village, Gunung Sitember Subdistrict, Dairi District. The technique of this research sample used Non-Probability Sampling with Saturated Sampling. The instrument used was a sphygmomanometer and a stethoscope. Bivariate data analysis in this study was the Wilcoxon statistical test. Based on the data analysis performed, the value of p = 0.011 (p= < 0.05) was obtained, meaning that there was a significant relationship between giving star fruit juice and cucumber to hypertensive patients. Then it can be concluded that there is an influence between giving star fruit and cucumber juice to blood pressure reduction in hypertensive patients in Bukit Lau Kersik Village Gunung Sitember Subdistrict, Dairi District in 2019. Suggestion: The factors that affect blood pressure in hypertensive patients and checking blood pressure before drinking star fruit juice and cucumber.

Efektifitas Air Rebusan Daun Seledri Terhadap Perubahan Tekanan Darah Pada Lansia di Posyandu Ngudi Konco Desa Donomulyo Kecamatan Donomulyo Kab. Malang

2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Hartin Suidah ◽  
Ninik Murtiyani ◽  
Arif Susanto ◽  
Yufi Aris Lestari ◽  
Shindy Sofyaning Fitra
Keyword(s):  
Blood Pressure ◽  
Sampling Technique ◽  
The Elderly ◽  
Reduce Blood Pressure ◽  
T Test ◽  
Boiling Water ◽  
Test Design ◽  
Post Test ◽  
Boiled Water ◽  
Paired T Test

ABSTRAKMasih tingginya penderita hipertensi merupakan salah satu masalah yang berpengaruh terhadap gaya hidup dan sikap yang mendorong timbulnya hipertensi. Untuk menangani tekanan darah pada penderita hipertensi umumnya minum obat-obatan dari puskesmas, rutinitas ini sering tidak disukai oleh penderita. Penelitian ini bertujuan untuk mengetahui efektifitas air rebusan daun seledri terhadap perubahan tekanan darah pada lansia di Posyandu Ngudi Konco Desa Donomulyo Kecamatan Donomulyo Kabupaten Malang.Desain penelitian ini Pre-Experimental dengan rancangan One- Group Pre-Post test design. Populasi dalam penelitian ini adalah semua lansia penderita hipertensi di Posyandu Ngudi Konco Desa Donomulyo Kecamatan Donomulyo Kabupaten Malang sebanyak 30 responden. Sampel diambil dengan teknik total sampling. Variabel penelitian yaitu pemberian air rebusan daun seledri sebagai variabel independent dan tekanan darah sebagai variabel dependen. Data yang di dapat melalui lembar observasi tekanan darah kemudian di uji dengan menggunakan uji paired t Test.Hasil uji paired t Test menunjukkan bahwa p = 0,000 α= 0,05 Ho di tolak dan H1 diterima sehingga air rebusan daun seledri efektif terhadap perubahan tekanan darah pada lansia di Posyandu Ngudi Konco Desa Donomulyo Kecamatan Donomulyo Kabupaten Malang.Terdapat penurunan jumlah penderita hipertensi sebelum dan sesudah diberikan air rebusan daun seledri. Responden agar dapat meningkatkan informasi tentang pelaksanaan tekanan darah sehingga dapat mengurangi tekanan darah yang dialami dengan cara non formakologi sehingga responden tidak hanya menggantungkan pada obat-obatan farmakologi dalam menurunkan tekanan darah.Kata kunci : Air Rebusan Daun Seledri, Tekanan Darah, Lansia ABSTRACTStill high hypertension was  one of the problems that affect the lifestyle and attitudes that encourage the emergence of hypertension. To handle blood pressure in people with hypertension generally take  medication from puskesmas, this routine was often disliked by the patient. This study aims to determine the effectiveness of boiling water celery leaves on changes in blood pressure in the elderly at Posyandu Ngudi Konco Donomulyo Village Donomulyo District Malang Regency.The design of this research was  Pre-Experimental with the design of One- Group Pre-Post test design. Population in this research was all elderly patient of hypertension in Posyandu Ngudi Konco Village Donomulyo District Donomulyo Malang Regency as many as 30 respondents. Samples were taken with total sampling technique. The research variable was giving boiled water of celery leaves as independent variable and blood pressure as dependent variable. The data can be through blood pressure observation sheet then tested by using paired t test.The result of paired t - test showed that p = 0.000 α = 0.05 Ho in rejection and H1 accepted so that boiling water celery leaf effective against blood pressure changes in elderly at Posyandu Ngudi Konco Donomulyo Village Donomulyo District Malang Regency. There was a decrease in the number of hypertensive patients before and after being given boiled water of celery leaves. Respondents in order to improve information about the implementation of blood pressure so as to reduce blood pressure experienced by non-formakologi way so that respondents not only rely on pharmacological drugs in lowering blood pressure. Key Words: Water Stew of Celery leaves, Blood Pressure, Elderly

scholarly journals Effect of recreational beach tennis on ambulatory blood pressure and physical fitness in hypertensive individuals (BAH study): rationale and study protocol

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Rodrigo Ferrari ◽  
◽  
Leandro de Oliveira Carpes ◽  
Lucas Betti Domingues ◽  
Alexandre Jacobsen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Physical Fitness ◽  
Ambulatory Blood Pressure ◽  
Training Group ◽  
Reduce Blood Pressure ◽  
Control Group ◽  
Recreational Sports ◽  
Exercise Interventions ◽  
Recreational Beach ◽  
Fitness Parameters

Abstract Background Different physical activities are widely recommended as non-pharmacological therapies to reduce blood pressure. However, the effectiveness of exercise programs is associated with its continuity and regularity, and the long-term adherence to traditional exercise interventions is often low. Recreational sports emerge as an alternative, being more captivating and able to retain individuals for longer periods. Besides, sport interventions have demonstrated improvements in physical fitness components that are associated with a lower incidence of hypertension. However, no studies have investigated the effects of recreational sports on 24 h ambulatory blood pressure. The aim of the present study is to evaluate the effect of beach tennis training on ambulatory blood pressure and physical fitness in individuals with hypertension. Methods This study will be a randomized, single-blinded, two-arm, parallel, and superiority trial. Forty-two participants aged 35–65 years with previous diagnosis of hypertension will be randomized to 12 weeks of beach tennis training group (two sessions per week lasting 45–60 min) or a non-exercising control group. Ambulatory (primary outcome) and office blood pressures, cardiorespiratory fitness, muscle strength/power and quality of life will be assessed at baseline and after the intervention period. Discussion Our conceptual hypothesis is that beach tennis training will reduce ambulatory blood pressure and improve fitness parameters in middle-aged individuals with hypertension. The results of this trial are expected to provide evidences of efficacy of recreational beach tennis practice on blood pressure management and to support sport recommendations for clinical scenario in higher risk populations. Trial registration ClinicalTrials.gov, NCT03909321. Registered on April 10, 2019.

scholarly journals Different blood pressure responses in hypertensive rats following chemerin mRNA inhibition in dietary high fat compared to dietary high-salt conditions

2019 ◽  
Vol 51 (11) ◽  
pp. 553-561 ◽  
Author(s):  
David J. Ferland ◽  
Emma D. Flood ◽  
Hannah Garver ◽  
Steve T. Yeh ◽  
Stanley Riney ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Antisense Oligonucleotides ◽  
Reduce Blood Pressure ◽  
High Salt ◽  
Whole Body ◽  
Sprague Dawley ◽  
High Fat ◽  
Hypertensive Rats ◽  
Blood Pressure Responses ◽  
Antihypertensive Treatments

Chemerin is a contractile adipokine, produced in liver and fat, and removal of the protein by antisense oligonucleotides (ASO) lowers blood pressure in the normal Sprague Dawley rat. In humans, chemerin is positively associated with blood pressure and obesity so we hypothesized that in a model of hypertension derived from high-fat (HF) feeding, the chemerin ASO would reduce blood pressure more than a high-salt (HS) model. Male Dahl S rats were given a HF (60% kcal fat; age 3–24 wk) or HS diet (4% salt; age 20–24 wk to match age and blood pressure of HF animals). Scrambled control, whole body, or liver-specific ASOs that knock down chemerin were delivered subcutaneously once per week for 4 wk with tissue and blood collected 2 days after the last injection. Conscious blood pressure was measured 24 h/day by radiotelemetry. By the end of whole body ASO administration, blood pressure of HF animals had fallen 29 ± 2 mmHg below baseline, while blood pressure of HS-diet animals fell by only 12 ± 4 mmHg below baseline. Administration of a liver-specific ASO to HF Dahl S resulted in a 6 ± 2 mmHg fall in blood pressure below baseline. Successful knockdown of chemerin in both the whole body and liver-specific administration was confirmed by Western and PCR. These results suggest that chemerin, not derived from liver but potentially from adipose tissue, is an important driver of hypertension associated with high fat. This knowledge could lead to the development of antihypertensive treatments specifically targeted to obesity-associated hypertension.

Reno-protective mechanisms of epoxyeicosatrienoic acids in cardiovascular disease

2012 ◽  
Vol 302 (3) ◽  
pp. R321-R330 ◽  
Author(s):  
Ahmed A. Elmarakby
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Animal Models ◽  
Vascular Function ◽  
Organ Damage ◽  
Reduce Blood Pressure ◽  
Experimental Models ◽  
Epoxyeicosatrienoic Acids ◽  
Protective Effects ◽  
Protective Mechanisms

Cardiovascular disease (CVD) is the leading cause of mortality worldwide, and it is well known that end-stage renal disease (ESRD) is a profound consequence of the progression of CVD. Present treatments only slow CVD progression to ESRD, and it is imperative that new therapeutic strategies are developed to prevent the incidence of ESRD. Because epoxyeicosatrienoic acids (EETs) have been shown to elicit reno-protective effects in hypertensive animal models, the current review will focus on addressing the reno-protective mechanisms of EETs in CVD. The cytochrome P-450 epoxygenase catalyzes the oxidation of arachidonic acid to EETs. EETs have been identified as endothelium-derived hyperpolarizing factors (EDHFs) with vasodilatory, anti-inflammatory, antihypertensive, and antiplatelet aggregation properties. EETs also have profound effects on vascular migration and proliferation and promote angiogenesis. The progression of CVD has been linked to decreased EETs levels, leading to the concept that EETs should be therapeutically targeted to prevent end-organ damage associated with CVD. However, EETs are quickly degraded by the enzyme soluble epoxide hydrolase (sEH) to their less active diols, dihydroxyeicosatrienoic acids (DHETs). As such, one way to increase EETs level is to inhibit their degradation to DHETs by using sEH inhibitors. Inhibition of sEH has been shown to effectively reduce blood pressure and organ damage in experimental models of CVD. Another approach to target EETs is to develop EET analogs with improved solubility and resistance to auto-oxidation and metabolism by sEH. For example, stable ether EET analogs dilate afferent arterioles and lower blood pressure in hypertensive rodent animal models. EET agonists also improve insulin signaling and vascular function in animal models of metabolic syndrome.

Sign in / Sign up

Export Citation Format

Share Document