scholarly journals Predicting anemia using NIR spectrum of spent dialysis fluid in hemodialysis patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Valentina Matović ◽  
Branislava Jeftić ◽  
Jasna Trbojević-Stanković ◽  
Lidija Matija
Keyword(s):  
Near Infrared ◽  
Binding Capacity ◽  
Nir Spectroscopy ◽  
Hemoglobin Concentration ◽  
Hemodialysis Patients ◽  
Mean Corpuscular Hemoglobin ◽  
Iron Saturation ◽  
On Line ◽  
Spent Dialysate ◽  
Iron Binding Capacity

AbstractAnemia is commonly present in hemodialysis (HD) patients and significantly affects their survival and quality of life. NIR spectroscopy and machine learning were used as a method to detect anemia in hemodialysis patients. The aim of this investigation has been to evaluate the near-infrared spectroscopy (NIRS) as a method for non-invasive on-line detection of anemia parameters from HD effluent by assessing the correlation between the spectrum of spent dialysate in the wavelength range of 700–1700 nm and the levels of hemoglobin (Hb), red blood cells (RBC), hematocrit (Hct), iron (Fe), total iron binding capacity (TIBC), ferritin (FER), mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC) in patient blood. The obtained correlation coefficient (R) for RBC was 0.93, for Hb 0.92, for Fe 0.94, for TIBC 0.96, for FER 0.91, for Hct 0.94, for MCV 0.92, for MCHC 0.92 and for MCH 0.93. The observed high correlations between the NIR spectrum of the dialysate fluid and the levels of the studied variables support the use of NIRS as a promising method for on-line monitoring of anemia and iron saturation parameters in HD patients.

scholarly journals Effect of Interleukin and Hepcidin in Anemia of Chronic Diseases

Anemia ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-5 ◽  
Author(s):  
Maha F. Yacoub ◽  
Hala Fouad Ferwiz ◽  
Fadwa Said
Keyword(s):  
Chronic Diseases ◽  
Binding Capacity ◽  
Hemoglobin Concentration ◽  
Normal Subjects ◽  
Integrated System ◽  
Mean Corpuscular Hemoglobin ◽  
Chronic Infections ◽  
Anemia Of Chronic Disease ◽  
Red Cell Indices ◽  
Iron Binding Capacity

Background. Anemia of chronic disease (ACD) also termed as the anemia of inflammation has been found to be associated with inflammations, chronic infections, and cancers, particularly in old age. Recent studies revealed that interleukin-6 (IL-6), a proinflammatory cytokine, and hepcidin, an antimicrobial hepatic peptide, play a key role in ACD pathogenesis. Patients and Methods. The study included 40 subjects with chronic diseases and 40 normal subjects of the same age group. Red cell indices, levels of IL-6 and hepcidin, and iron profile were measured in all participants using Bayer ADVIA 120, VITROS 5600, Integrated System/2008, and ELISA assay, respectively. Results. The level of hemoglobin was considerably less in patients of chronic diseases referred to as “cases” than the normal subjects or “controls” (8.7 ± 1.5 vs. 13.2 ± 0.9). Red blood corpuscle (RBC) count, hematocrit (HCT) level, serum iron, mean corpuscular hemoglobin concentration (MCHC), and serum total iron-binding capacity (TIBC) were found to be significantly lower in the cases as compared to controls (p<0.001). Serum IL-6 and hepcidin levels were substantially higher in the cases than in the controls (p<0.001 and p<0.02, respectively). Conclusion. This study detected a significant increase in serum IL-6 and hepcidin levels in patients with ACD than the controls. These findings offer an insight into the role played by both cytokine and peptide in the pathogenesis of ACD and thus provide a rationale for future use of novel drugs inhibiting their effects on iron metabolism.

scholarly journals Glucose concentration monitoring using near infrared spectrum of spent dialysis fluid in hemodialysis patients

2020 ◽  
pp. 90-90
Author(s):  
Valentina Matovic ◽  
Jasna Trbojevic-Stankovic ◽  
Branislava Jeftic ◽  
Lidija Matija
Keyword(s):  
Glucose Concentration ◽  
Near Infrared ◽  
Nir Spectroscopy ◽  
Hemodialysis Patients ◽  
Maintenance Hemodialysis ◽  
Diabetic Patients ◽  
Dialysis Fluid ◽  
Major Health Problem ◽  
Hemodialysis Treatment ◽  
Spent Dialysate

Introduction/Objective. Diabetic nephropathy leading to end-stage renal disease is a major health problem worldwide. Hemodialysis treatment is associated with glycemia variations. Diabetic patients on hemodialysis might benefit from a noninvasive online glycemia monitoring system. The aim of this study was to assess the glucose concentration from the matrix of the spent dialysate fluid using Near infrared (NIR) Spectroscopy. Methods. Blood samples and spent dialysate have been collected in the 15th minute of the hemodialysis treatment from 15 patients. The spent dialysis fluid has been characterized by a NIR spectrometer in the range of 900-1300 nm. In order to apply the artificial neural network (ANN) and train it, the MATLNFTOOL program was used. The testing and training of the ANN were executed using the NIR spectrum of the spent dialysis fluid as input, and the glucose concentration as output. Results. A significant correlation in excess of 93% between the NIR spectrum of the spent dialysate and the blood glucose concentration (3-9 mmol/l) has been found. Conclusions. NIR spectroscopy is a noninvasive and reliable method of glycemia monitoring which can be used in maintenance hemodialysis patients.

scholarly journals Iron Metabolism Modification During Repeated Show Jumping Event in Equine Athletes

2017 ◽  
Vol 17 (1) ◽  
pp. 197-204 ◽  
Author(s):  
Giuseppe Piccione ◽  
Maria Rizzo ◽  
Francesca Arfuso ◽  
Daniele Bruschetta ◽  
Elisabetta Giudice ◽  
...  
Keyword(s):  
Health Status ◽  
Physical Performance ◽  
Binding Capacity ◽  
Iron Status ◽  
Recovery Period ◽  
Hemoglobin Concentration ◽  
Repeated Measure ◽  
Iron Binding ◽  
Iron Binding Capacity ◽  
Show Jumping

Abstract In athletic horse the evaluation of iron status is of great importance to improve physical performance and health status of animal. The aim of this study was to evaluate the changes of iron indices following show jumping. Ten regularly trained Italian Saddlebred horses aged 7-8 years (mean body weight 467±12 kg) were subjected to three days jumping competition. Blood samples were collected at 5 time points: T0 (the day before competitions), T1 (immediately after exercise at day 1), T2 (immediately after exercise at day 2), T3 (immediately after exercise at day 3) and during the recovery period T4 (24 h after day 3). On each blood sample the values of red blood cell (RBC), hemoglobin concentration (Hb), hematocrit (Hct), serum iron, ferritin, transferrin, total iron-binding capacity (TIBC) and unsaturated iron-binding capacity (UIBC) were assessed. One-way repeated measure analysis of variance (ANOVA) showed a statistical significant effect of exercise (P<0.05) on all studied parameters. The application of Bonferroni’s post-hoc comparison showed a statistical significant increase in all studied parameters after exercise. These results provide new information about the changes in iron profile of jumper horse following exercise allowing for better evaluation of the health status and physical performance of this athlete horse.

scholarly journals Effects of Lead on Hemopoeitic and Iron Status in Iraqi Workers at Lead Batteries Factory

2013 ◽  
Vol 10 (2) ◽  
pp. 388-395
Author(s):  
Baghdad Science Journal
Keyword(s):  
Aminolevulinic Acid ◽  
Early Stage ◽  
Binding Capacity ◽  
Iron Status ◽  
Hemoglobin Concentration ◽  
Blood Lead ◽  
Significant Negative Correlation ◽  
Control Group ◽  
Lead Levels ◽  
Iron Binding Capacity

The present study aimed to evaluate the effect of lead exposure on hemopoetic system (through the index delta-Aminolevulinic acid dehydratase ?-ALAD activity & hemoglobin concentration (Hb) ) and on iron status (levels of iron Fe, Ferritin Fr, Total iron binding capacity TIBC, percentage of transferine saturation TF%) in 44 Iraqi worker at lead batteries factory. Workers divided into two groups: smokers(n=21) mean aged (37.33±4.82 year)and non smokers(n=23) mean aged(40.78±7.89 year) and 45 healthy subjects mean aged (33.97±5.08)as control group . Activity of ?-ALAD ratio shows significant decrease (p ? 0.05) ,while Hb and hematocrit Hct were non significant (p ? 0.05) in smoker workers more than non smoker as compared to control . The results show a non significant decrease (p ? 0.05) in the sera levels of iron S.Fe, TS%, Fr in all workers as compared to control , the amount of decreasing for smoker more than non smoker except ferritin levels. A significant increases in the level of TIBC in workers as compared to control, this elevation is more in smoker than non smoker workers. In smoker workers, there was a significant positive correlation between the blood lead levels BLLs and Hb, Hct,TIBC whereas a significant negative correlation was observed between BLLs and S.Fe, TS%. In conclusion, the results of this study reveal the importance of monitoring the level of iron status in smoker peoples who dealing or exposure to lead due to the probability injured with anemia and used ?-ALAD ratio to predict the efficiency of their heme synthesis as a new marker for the diagnosis of early stage of anemia.

On-line application of visible and near infrared reflectance spectroscopy to predict physical and sensory characteristics of beef quality

2009 ◽  
Vol 2009 ◽  
pp. 135-135
Author(s):  
N Prieto ◽  
D W Ross ◽  
E A Navajas ◽  
G Nute ◽  
R I Richardson ◽  
...  
Keyword(s):  
Near Infrared ◽  
Nir Spectroscopy ◽  
Reflectance Spectroscopy ◽  
Sensory Characteristics ◽  
Infrared Reflectance ◽  
Near Infrared Reflectance Spectroscopy ◽  
Beef Quality ◽  
Near Infrared Reflectance ◽  
On Line ◽  
Meat Samples

Visible and near infrared reflectance spectroscopy (Vis-NIR) has been widely used by the industry research-base for large-scale meat quality evaluation to predict the chemical composition of meat quickly and accurately. Meat tenderness is measured by means of slow and destructive methods (e.g. Warner-Bratzler shear force). Similarly, sensory analysis, using trained panellists, requires large meat samples and is a complex, expensive and time-consuming technique. Nevertheless, these characteristics are important criteria that affect consumers’ evaluation of beef quality. Vis-NIR technique provides information about the molecular bonds (chemical constituents) and tissue ultra-structure in a scanned sample and thus can indirectly predict physical or sensory parameters of meat samples. Applications of Vis-NIR spectroscopy in an abattoir for prediction of physical and sensory characteristics have been less developed than in other fields. Therefore, the aim of this study was to test the on-line Vis-NIR spectroscopy for the prediction of beef quality characteristics such as colour, instrumental texture, water holding capacity (WHC) and sensory traits, by direct application of a fibre-optic probe to the M. longissimus thoracis with no prior sample treatment.

Idiopathic hemochromatosis: serum ferritin concentrations during therapy by phlebotomy.

1982 ◽  
Vol 28 (8) ◽  
pp. 1806-1808 ◽  
Author(s):  
P J Garry ◽  
J H Saiki
Keyword(s):  
Serum Ferritin ◽  
Iron Absorption ◽  
Binding Capacity ◽  
Hemoglobin Concentration ◽  
Total Iron ◽  
Ferritin Iron ◽  
Idiopathic Hemochromatosis ◽  
Total Body ◽  
Almost All ◽  
Iron Binding Capacity

Abstract We report the case of a 54-year-old man who presented with symptoms of idiopathic hemochromatosis, an inherited disorder involving regulation of iron absorption. These symptoms usually do not appear until total body iron content reaches 15 g, about threefold normal. Therapy involves mobilization and removal of excess stored iron through weekly or twice-weekly phlebotomies of 500 mL, until the hemoglobin concentration becomes less than 110 g/L and remains there for several weeks, or until serum ferritin concentrations indicate that almost all the stored iron has been removed (ferritin less than 12 micrograms/L). Here, concentrations of ferritin in serum were used as an index to iron overload and removal of stored iron. We report changes in hemoglobin, serum ferritin, iron, and total iron-binding capacity during the course of removing by phlebotomy more than 20 g of iron from a patient with idiopathic hemochromatosis.

scholarly journals Estimation of Secondary Soil Properties by Fusion of Laboratory and On-Line Measured Vis–NIR Spectra

2019 ◽  
Vol 11 (23) ◽  
pp. 2819 ◽  
Author(s):  
Muhammad Abdul Munnaf ◽  
Said Nawar ◽  
Abdul Mounem Mouazen
Keyword(s):  
Soil Properties ◽  
Real Time ◽  
Measurement Accuracy ◽  
Near Infrared ◽  
Diffuse Reflectance Spectroscopy ◽  
Spectral Response ◽  
Nir Spectroscopy ◽  
Accurate Estimation ◽  
Line Measurement ◽  
On Line

Visible and near infrared (vis–NIR) diffuse reflectance spectroscopy has made invaluable contributions to the accurate estimation of soil properties having direct and indirect spectral responses in NIR spectroscopy with measurements made in laboratory, in situ or using on-line (while the sensor is moving) platforms. Measurement accuracies vary with measurement type, for example, accuracy is higher for laboratory than on-line modes. On-line measurement accuracy deteriorates further for secondary (having indirect spectral response) soil properties. Therefore, the aim of this study is to improve on-line measurement accuracy of secondary properties by fusion of laboratory and on-line scanned spectra. Six arable fields were scanned using an on-line sensing platform coupled with a vis–NIR spectrophotometer (CompactSpec by Tec5 Technology for spectroscopy, Germany), with a spectral range of 305–1700 nm. A total of 138 soil samples were collected and used to develop five calibration models: (i) standard, using 100 laboratory scanned samples; (ii) hybrid-1, using 75 laboratory and 25 on-line samples; (iii) hybrid-2, using 50 laboratory and 50 on-line samples; (iv) hybrid-3, using 25 laboratory and 75 on-line samples, and (v) real-time using 100 on-line samples. Partial least squares regression (PLSR) models were developed for soil pH, available potassium (K), magnesium (Mg), calcium (Ca), and sodium (Na) and quality of models were validated using an independent prediction dataset (38 samples). Validation results showed that the standard models with laboratory scanned spectra provided poor to moderate accuracy for on-line prediction, and the hybrid-3 and real-time models provided the best prediction results, although hybrid-2 model with 50% on-line spectra provided equally good results for all properties except for pH and Na. These results suggest that either the real-time model with exclusively on-line spectra or the hybrid model with fusion up to 50% (except for pH and Na) and 75% on-line scanned spectra allows significant improvement of on-line prediction accuracy for secondary soil properties using vis–NIR spectroscopy.

On-Line Monitoring of Melt-Extrusion Transesterification of Ethylene Vinylacetate Copolymers by near Infrared Spectroscopy and Chemometrics

2002 ◽  
Vol 10 (3) ◽  
pp. 195-202 ◽  
Author(s):  
Tsuyoshi Furukawa ◽  
Yasuo Kita ◽  
Shigehiro Sasao ◽  
Kimihiro Matsukawa ◽  
Masahiro Watari ◽  
...  
Keyword(s):  
Near Infrared ◽  
Nir Spectroscopy ◽  
Principal Component ◽  
Intensity Change ◽  
Melt Extrusion ◽  
Peak Intensity ◽  
Fibre Optic Probe ◽  
On Line ◽  
Significant Intensity ◽  
Optic Probe

The melt-extrusion transesterification of ethylene/vinylacetate (EVA) copolymer to ethylene/vinylalcohol (EVAL) copolymers has been monitored by on-line near infrared (NIR) spectroscopy. A total of 60 NIR spectra were measured within 37 minutes after the initial addition of octanol (reagent) and catalyst (sodium methoxide) at the exit of the extruder by use of a fibre-optic probe. The most significant intensity change is observed for a band at 7089 cm−1 due to the first overtone of an OH stretching mode of the EVAL copolymers. We can monitor the progress of the reaction by plotting the peak intensity at 7089 cm−1 only. A principal component analysis (PCA) was carried out for the series of NIR spectra in the 7300–6900 cm−1 region. A score plot of PCA factor 1 is almost identical with the plot of the peak intensity at 7089 cm−1. Calibration models for predicting the vinyl acetate content in EVA copolymers have been developed by use of partial least squares (PLS) regression. The correlation coefficient and standard error of prediction are 0.96 and 0.85%, respectively, indicating that the described technique can be used to monitor the transesterification reaction.

Long-Length Fiber Optic Near-Infrared (NIR) Spectroscopy Probes for On-Line Quality Control of Processed Land Animal Proteins

2018 ◽  
Vol 72 (8) ◽  
pp. 1170-1182 ◽  
Author(s):  
Ana Garrido-Varo ◽  
Ana Sánchez-Bonilla ◽  
Francisco Maroto-Molina ◽  
Cecilia Riccioli ◽  
Dolores Pérez-Marín
Keyword(s):  
Near Infrared ◽  
Fiber Optic ◽  
Nir Spectroscopy ◽  
Conveyor Belt ◽  
Animal Origin ◽  
Processing Plant ◽  
Fiber Optic Cable ◽  
Operating Modes ◽  
On Line ◽  
Dynamic Operating

This research was conducted using a spectral database comprising 346 samples of processed animal proteins (PAPs) with a range of compositions, analyzed using a Fourier transform near-infrared spectroscopy multichannel instrument (Matrix-F, Bruker Optics) coupled to a 100 m fiber optic cable. Using both its static and dynamic operating modes (on a conveyor belt), simulating the movement of the product in the plant, the predictive capabilities of both modes of analysis were assessed and compared, for the purposes of predicting moisture, protein, and ashes. The results show that both exhibit highly similar degrees of precision and accuracy for predicting these parameters. This research provides a foundation of scientific-technical knowledge, hitherto unknown, regarding the “on-line” incorporation of an instrument (equipped with a 100 m fiber optic cable) into a processing plant of by-products of animal origin.

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