scholarly journals Cold bubble humidification of low-flow oxygen does not prevent acute changes in inflammation and oxidative stress at nasal mucosa

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lauriana Alves Santana ◽  
Suellen Karoline Moreira Bezerra ◽  
Beatriz Mangueira Saraiva-Romanholo ◽  
Wellington Pereira Yamaguti ◽  
Iolanda de Fátima Lopes Calvo Tibério ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nasal Mucosa ◽  
Oxygen Therapy ◽  
Mucociliary Clearance ◽  
Nasal Cannula ◽  
Compressed Air ◽  
Low Flow ◽  
Cross Sectional ◽  
Nasal Symptoms ◽  
Nasal Inflammation

AbstractSome clinical situations require the use of oxygen therapy for a few hours without hypoxemia. However, there are no literature reports on the effects of acute oxygen therapy on the nasal mucosa. This study aimed to evaluate the acute effects of cold bubble humidification or dry oxygen on nasal Inflammation, oxidative stress, mucociliary clearance, and nasal symptoms. This is a randomized controlled cross-sectional study in which healthy subjects were randomly allocated into four groups: (1) CA + DRY (n = 8): individuals receiving dry compressed air; (2) OX + DRY (n = 8): individuals receiving dry oxygen therapy; (3) CA + HUMID (n = 7): individuals receiving cold bubbled humidified compressed air; (4) OX + HUMID (n = 8): individuals receiving cold bubbled humidified oxygen therapy. All groups received 3 L per minute (LPM) of the oxygen or compressed air for 1 h and were evaluated: total and differential cells in the nasal lavage fluid (NLF), exhaled nitric oxide (eNO), 8-iso-PGF2α levels, saccharin transit test, nasal symptoms, and humidity of nasal cannula and mucosa. Cold bubble humidification is not able to reduced nasal inflammation, eNO, oxidative stress, mucociliary clearance, and nasal mucosa moisture. However, subjects report improvement of nasal dryness symptoms (P < 0.05). In the conclusion, cold bubble humidification of low flow oxygen therapy via a nasal cannula did not produce any effect on the nasal mucosa and did not attenuate the oxidative stress caused by oxygen. However, it was able to improve nasal symptoms arising from the use of oxygen therapy.

Assessment of the Use of Humidified Nasal Cannulas for Oxygen Therapy in Patients with Epistaxis

ORL ◽  
2021 ◽  
pp. 1-5
Author(s):  
Jingjing Liu ◽  
Tengfang Chen ◽  
Zhenggang Lv ◽  
Dezhong Wu
Keyword(s):  
Flow Rate ◽  
Oxygen Therapy ◽  
Preliminary Investigation ◽  
Nasal Cannula ◽  
Low Flow ◽  
Antiplatelet Drugs ◽  
Flow Rates ◽  
The Past ◽  
Oxygen Inhalation ◽  
Significant Difference

<b><i>Introduction:</i></b> In China, nasal cannula oxygen therapy is typically humidified. However, it is difficult to decide whether to suspend nasal cannula oxygen inhalation after the nosebleed has temporarily stopped. Therefore, we conducted a preliminary investigation on whether the use of humidified nasal cannulas in our hospital increases the incidence of epistaxis. <b><i>Methods:</i></b> We conducted a survey of 176,058 inpatients in our hospital and other city branches of our hospital over the past 3 years and obtained information concerning their use of humidified nasal cannulas for oxygen inhalation, nonhumidified nasal cannulas, anticoagulant and antiplatelet drugs, and oxygen inhalation flow rates. This information was compared with the data collected at consultation for epistaxis during these 3 years. <b><i>Results:</i></b> No significant difference was found between inpatients with humidified nasal cannulas and those without nasal cannula oxygen therapy in the incidence of consultations due to epistaxis (χ<sup>2</sup> = 1.007, <i>p</i> &#x3e; 0.05). The same trend was observed among hospitalized patients using anticoagulant and antiplatelet drugs (χ<sup>2</sup> = 2.082, <i>p</i> &#x3e; 0.05). Among the patients with an inhaled oxygen flow rate ≥5 L/min, the incidence of ear-nose-throat (ENT) consultations due to epistaxis was 0. No statistically significant difference was found between inpatients with a humidified oxygen inhalation flow rate &#x3c;5 L/min and those without nasal cannula oxygen therapy in the incidence of ENT consultations due to epistaxis (χ<sup>2</sup> = 0.838, <i>p</i> &#x3e; 0.05). A statistically significant difference was observed in the incidence of ENT consultations due to epistaxis between the low-flow nonhumidified nasal cannula and nonnasal cannula oxygen inhalation groups (χ<sup>2</sup> = 18.428, <i>p</i> &#x3c; 0.001). The same trend was observed between the 2 groups of low-flow humidified and low-flow nonhumidified nasal cannula oxygen inhalation (χ<sup>2</sup> = 26.194, <i>p</i> &#x3c; 0.001). <b><i>Discussion/Conclusion:</i></b> Neither high-flow humidified nasal cannula oxygen inhalation nor low-flow humidified nasal cannula oxygen inhalation will increase the incidence of recurrent or serious epistaxis complications; the same trend was observed for patients who use anticoagulant and antiplatelet drugs. Humidification during low-flow nasal cannula oxygen inhalation can prevent severe and repeated epistaxis to a certain extent.

Development of Nursing Practice Guidelines for Non-humidified Low Flow Oxygen Therapy by Nasal Cannula

2013 ◽  
Vol 19 (1) ◽  
pp. 87 ◽  
Author(s):  
Ae-Ri-Na Nam ◽  
Woo-Hyun Bae ◽  
Mi-Mi Park ◽  
Eun-Jeong Ko ◽  
Byung-Nam Park ◽  
...  
Keyword(s):  
Practice Guidelines ◽  
Oxygen Therapy ◽  
Nursing Practice ◽  
Nasal Cannula ◽  
Low Flow

The clinical practice of high-flow nasal cannula oxygen therapy in adults: A Japanese cross-sectional multicenter survey

2018 ◽  
Vol 56 (3) ◽  
pp. 249-257 ◽  
Author(s):  
Jiro Ito ◽  
Kazuma Nagata ◽  
Susumu Sato ◽  
Akira Shiraki ◽  
Naoki Nishimura ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Oxygen Therapy ◽  
High Flow ◽  
Nasal Cannula ◽  
High Flow Nasal Cannula ◽  
Cross Sectional ◽  
Multicenter Survey

scholarly journals Update on the Role of High-Flow Nasal Cannula in Infants with Bronchiolitis

Children ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 66
Author(s):  
Valentina Fainardi ◽  
Lara Abelli ◽  
Maria Muscarà ◽  
Giovanna Pisi ◽  
Nicola Principi ◽  
...  
Keyword(s):  
Oxygen Therapy ◽  
Severe Disease ◽  
Invasive Mechanical Ventilation ◽  
High Flow ◽  
Nasal Cannula ◽  
Low Flow ◽  
High Flow Nasal Cannula ◽  
Multicenter Studies ◽  
Good Tolerability

Bronchiolitis (BR), a lower respiratory tract infection mainly caused by respiratory syncytial virus (RSV), can be very severe. Presently, adequate nutritional support and oxygen therapy remain the only interventions recommended to treat patients with BR. For years, mild BR cases were treated with noninvasive standard oxygen therapy (SOT), i.e., with cold and poorly or totally non-humidified oxygen delivered by an ambient headbox or low-flow nasal cannula. Children with severe disease were intubated and treated with invasive mechanical ventilation (IMV). To improve SOT and overcome the disadvantages of IMV, new measures of noninvasive and more efficient oxygen administration have been studied. Bi-level positive air way pressure (BiPAP), continuous positive airway pressure (CPAP), and high-flow nasal cannula (HFNC) are among them. For its simplicity, good tolerability and safety, and the good results reported in clinical studies, HFNC has become increasingly popular and is now widely used. However, consistent guidelines for initiation and discontinuation of HFNC are lacking. In this narrative review, the role of HFNC to treat infants with BR is discussed. An analysis of the literature showed that, despite its widespread use, the role of HFNC in preventing respiratory failure in children with BR is not precisely defined. It is not established whether it can offer greater benefits compared to SOT and when and in which infants it can replace CPAP or BiPAP. The analysis of the results clearly indicates the need for multicenter studies and official guidelines. In the meantime, HFNC can be considered a safe and effective method to treat children with mild to moderate BR who do not respond to SOT.

Oxygen therapy at low flow causes oxidative stress in chronic obstructive pulmonary disease: Prevention by N-acetyl cysteine

2005 ◽  
Vol 39 (10) ◽  
pp. 1111-1118 ◽  
Author(s):  
Maria Pia Foschino Barbaro ◽  
Gaetano Serviddio ◽  
Onofrio Resta ◽  
Tiziana Rollo ◽  
Rosanna Tamborra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Obstructive Pulmonary Disease ◽  
Disease Prevention ◽  
Pulmonary Disease ◽  
Oxygen Therapy ◽  
Low Flow ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Acetyl Cysteine

scholarly journals High-flow nasal cannula therapy for adult patients

2016 ◽  
Vol 44 (6) ◽  
pp. 1200-1211 ◽  
Author(s):  
Jian Zhang ◽  
Ling Lin ◽  
Konghan Pan ◽  
Jiancang Zhou ◽  
Xiaoyin Huang
Keyword(s):  
Oxygen Therapy ◽  
Mucociliary Clearance ◽  
High Flow ◽  
Nasal Cannula ◽  
Adult Patients ◽  
Positive Pressure ◽  
High Flow Nasal Cannula ◽  
Fraction Of Inspired Oxygen ◽  
Effective Use ◽  
Inspired Oxygen

High-flow nasal cannula (HFNC) oxygen therapy has several physiological advantages over traditional oxygen therapy devices, including decreased nasopharyngeal resistance, washing out of the nasopharyngeal dead space, generation of positive pressure in the pharynx, increasing alveolar recruitment in the lungs, humidification of the airways, increased fraction of inspired oxygen and improved mucociliary clearance. Recently, the use of HFNC in treating adult critical illness patients has significantly increased, and it is now being used in many patients with a range of different disease conditions. However, there are no established guidelines to direct the safe and effective use of HFNC for these patients. This review article summarizes the available published literature on the positive physiological effects, mechanisms of action, and the clinical applications of HFNC, compared with traditional oxygen therapy devices. The available literature suggests that HFNC oxygen therapy is an effective modality for the early treatment of critically adult patients.

scholarly journals Hubungan Pemberian Terapi Oksigen Sistem Aliran Rendah Dengan Status Fisiologis (Revised Trauma Score) Pada Pasien Trauma Di Rumah Sakit Umum Daerah Ulin Banjarmasin

2019 ◽  
Vol 10 (2) ◽  
pp. 665-674
Author(s):  
Ely Purnama ◽  
Hanura Aprilia
Keyword(s):  
Oxygen Therapy ◽  
Clinical Manifestations ◽  
Low Flow ◽  
Physiological Status ◽  
P Value ◽  
Trauma Patients ◽  
Chi Square ◽  
Cross Sectional ◽  
Revised Trauma Score ◽  
Trauma Score

Latar Belakang: Pemberian terapi oksigenasi sangat perlu dilakukan pada pasien trauma dengan manifestasi klinis pada umumnya adalah sesak nafas sampai penurunan kesadaran yang dapat mempengaruhi fungsi status fisiologis pasien trauma.Tujuan: Untuk mengetahui hubungan pemberian terapi oksigen sistem aliran rendah dengan status fisiologis (Revised Trauma Score) pada pasien trauma di RSUD Ulin Banjarmasin.Metode: Penelitian ini menggunakan metode korelasional, dengan desain Cross Sectional dan teknik pengambilan sampel dengan accidental sampling. Sampel penelitian berjumlah 43 orang. Teknik pengumpulan data menggunakan metode observasi dan perhitungan Revised Trauma Score dan dianalisis dengan menggunakan Uji Chi Square.Hasil: Ada hubungan pemberian terapi oksigen sistem aliran rendah dengan status fisiologis (Revised Trauma Score) pada pasien trauma di RSUD Ulin Banjarmasin yaitu dengan nilai p (0,000) a 0,05.Kesimpulan: Pemberian terapi oksigen sistem aliran rendah dengan nasal kanul mengarah pada status fisiologis ringan dan pemberian dengan sungkup muka non-rebreathing mengarah ke status fisiologis serius. Perlunya penelitian lanjutan dengan kontrol faktor yang dapat mempengaruhi status fisiologis dan spesifikasi trauma yang lebih fokus.Kata kunci: Terapi oksigen, status fisilogis (revised trauma score), TraumaBackground: Giving oxygenation therapy is very necessary to be done in trauma patients with clinical manifestations in general is shortness of breath to decreased consciousness that can affect the physiological status of trauma patients.Objective: To determine the relationship of low flow oxygen therapy with physiological status (Revised Trauma Score) in trauma patients in Ulin Hospital Banjarmasin.Method: This study uses a correlational method, with cross sectional design and sampling techniques with accidental sampling. The research sample consisted of 43 people. Data collection techniques using the method of observation and calculation of the Revised Trauma Score and analyzed using the Chi Square Test.Results: There is a relationship between low-flow oxygen therapy with physiological status (Revised Trauma Score) in trauma patients at Ulin Hospital Banjarmasin, with a p value (0,000) a 0.05.Conclusion: Giving low flow oxygen therapy system with nasal cannula leads to mild physiological status and administration with non-rebreathing facemasks leading to serious physiological status. The need for further research with control factors that can influence physiological status and trauma specifications are more focused.Keywords: Oxygen therapy, physiological status (revised trauma score), Trauma

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