Unbiased, comprehensive analysis of Japanese health checkup data reveals a protective effect of light to moderate alcohol consumption on lung function

AbstractThe overall effect of lifestyle habits, such as alcohol consumption, on general health remains controversial and it is important to clarify how such habits affect aging-related health impairments. To discover novel impacts of lifestyle on general health, we employed a mathematical approach to perform a comprehensive, unbiased, cross-sectional analysis of data from 6036 subjects who participated in a Japanese health checkup. Notably, we found that moderate alcohol consumption was positively correlated with lung function, muscle mass, and strength. Health checkup data were collected periodically from the same subjects. These people were light to moderate drinkers who had high health awareness and were basically free of major underlying diseases. We next analyzed 5 years of data from 1765 of these subjects. We found that higher baseline alcohol consumption, as well as increased alcohol intake over 5 years attenuated time-related deterioration of forced vital capacity without affecting total lung volume. This effect was independent of smoking. Our study suggests a possible protective effect of moderate amounts of alcohol on lung function, due to increased muscle mass/strength and forced vital capacity.

Download Full-text

Socio-demographic profile and lung function status among tobacco wor

Asian Journal of Medical and Biological Research ◽

10.3329/ajmbr.v3i2.33570 ◽

2017 ◽

Vol 3 (2) ◽

pp. 205-210

Author(s):

Md Ekramul Haque ◽

Md Shah Golam Nabi ◽

Sumon Chandra Debnath ◽

Irfan Nowroze Noor ◽

Monalisa Monwar ◽

...

Keyword(s):

Lung Function ◽

Forced Vital Capacity ◽

Vital Capacity ◽

Tobacco Industry ◽

Simple Random Sampling ◽

Total Sample ◽

Cross Sectional ◽

Male And Female ◽

Demographic Profile ◽

Significant Difference

This cross-sectional study was conducted to assess the lung function status and socio-demographic profile of the tobacco workers. The study place was Akij Tobacco Industry which is situated in Sharsa Upazila under Jessore District of Bangladesh. The period of the study extending from January to December 2014. Tobacco worker who had worked in Akij Tobacco Industry, both male and female and working period more than one year. The total sample size was 203 and simple random sampling was done to select the workers on the basis of their identification number. Data were collected through face to face interviews using a semi-structured questionnaire and lung function status measured by the spirometer. About one-third (34.0%) of the workers was in the age group 40-60 years and mean age were35.8 ± 0.2 years. Of them the majority (54.1%) were male, 89.2% were married, and 48.3% were illiterate. More than half (53.2%) of the worker from the joint family and maximum (53.7%) respondents were in the income group 5000-10000 taka, 39.4% of the worker lived in katcha house and 95.5% were using the sanitary latrine. Approximately half (49.7%) of workers were working for more than 10 years and 66.5% of the workers were working daily for 6-8 hours. More than half (52.7%) of the workers were consuming tobacco product in which 62.3% used to smoke and 31.1% exposed to smokeless tobacco. The mean ± SD forced vital capacity in the 1st second (FEV1) was 2.25 ± 0.12 whereas forced vital capacity (FVC) was 2.59 ± 0.27 and the FEV1/FVC ratio was 87.16 ± 4.91.There was no significant (p>0.05) difference between male and female in their lung function status. There was a significant difference (p<0.05) was found between in mean score of FEV1/FVC ratio and the total working period. From the public health point of view, preventive measures need to be taken to control the dusty environment and wearing of personal protective masks.Asian J. Med. Biol. Res. June 2017, 3(2): 205-210

Download Full-text

Effects of different sitting postures on forced vital capacity in healthy school children

Bangladesh Medical Research Council Bulletin ◽

10.3329/bmrcb.v45i2.42541 ◽

2019 ◽

Vol 45 (2) ◽

pp. 117-121 ◽

Cited By ~ 1

Author(s):

Mohammad Fazlul Haque ◽

Shahin Akhter ◽

Nayeema Tasnim ◽

Mahmudul Haque ◽

Sujat Paul ◽

...

Keyword(s):

Lung Function ◽

School Children ◽

Forced Vital Capacity ◽

Vital Capacity ◽

Mean Value ◽

Body Posture ◽

Repeated Measure ◽

Cross Sectional ◽

Sitting Posture ◽

Significant Difference

Background: Lung function varies with the different body posture of normal individuals. Normal healthy school children adopt different body posture which influences their lung function. This cross sectional observational study was done to assess the effects of different sitting postures on lung function like forced vital capacity (FVC) in healthy school children. Methods: This study was conducted in the Department of Physiology, Chittagong Medical college, Chittagong and K S Nazu Miah High school, Khondokia, Younus Nagar, Hathazari, Chittagong during July 2015 to June 2016. A total of 88 subjects of which 42 male and 46 female students aged between 14-16 years studying in class eight to ten were included by purposive sampling method. FVC were recorded by portable digital spirometer (HI-101, Japan). Data were taken in normal upright sitting, kyphotic and at slumped sitting posture. Unpaired and paired t test and repeated measure ANOVA tests were done using SPSS for windows version 20. Results: The mean value of FVC were significantly (p<0.001) changed in different sitting posture. Kyphotic sitting posture showed no significant difference (p>0.05) comparing to normal upright sitting posture. Regarding slumped sitting posture comparing to normal upright showed significant low values (p<0.001). Female subjects showed significant low FVC (p<0.001) comparing to male subjects. Conclusion: The results of this study suggest that the lung function like FVC is significantly decreased in slumped sitting posture. Bangladesh Med Res Counc Bull 2019; 45: 117-121

Download Full-text

ILD-specific health-related quality of life in systemic sclerosis-associated ILD compared with IPF

BMJ Open Respiratory Research ◽

10.1136/bmjresp-2020-000598 ◽

2020 ◽

Vol 7 (1) ◽

pp. e000598

Author(s):

Michael T Durheim ◽

Anna-Maria Hoffmann-Vold ◽

Tomas M Eagan ◽

Arnt-Ove Hovden ◽

May Brit Lund ◽

...

Keyword(s):

Quality Of Life ◽

Systemic Sclerosis ◽

Interstitial Lung Disease ◽

Lung Function ◽

Forced Vital Capacity ◽

Vital Capacity ◽

Health Related Quality ◽

Related Quality ◽

Health Related

IntroductionIdiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease (SSc-ILD) are fibrotic ILDs with divergent disease populations. Little is known about health-related quality of life (HRQL) in SSc-ILD relative to IPF.MethodsWe used the Kings Brief Interstitial Lung Disease Questionnaire (K-BILD) to compare HRQL in a cross-sectional study of 57 patients with IPF and 29 patients with SSc-ILD. Analysis of covariance was used to adjust for age, gender and lung function.ResultsThe unadjusted mean K-BILD score was 63.1 (95% CI 57.1 to 69.1) among patients with SSc-ILD, as compared with 54.7 (51.8–57.5) among those with IPF (p=0.005). However, this difference in HRQL was attenuated after adjustment for age, gender and lung function. In a multivariable model, only forced vital capacity was associated with K-BILD scores. K-BILD scores were correlated with both forced vital capacity and with other relevant HRQL measures, regardless of ILD diagnosis.DiscussionPatients with SSc-ILD may have better ILD-specific quality of life than patients with IPF, but this difference appears to be driven primarily by better lung function. These results underscore the impact of lung function on HRQL in fibrotic ILD and the utility of K-BILD to assess HRQL in SSc-ILD.

Download Full-text

The protective effect of moderate alcohol consumption on ischemic stroke

Clinical Cornerstone ◽

10.1016/s1098-3597(99)90041-8 ◽

1999 ◽

Vol 1 (6) ◽

pp. 56 ◽

Cited By ~ 1

Author(s):

R.L. Sacco ◽

M. Elkind ◽

B. Boden-Albala

Keyword(s):

Ischemic Stroke ◽

Alcohol Consumption ◽

Protective Effect ◽

Moderate Alcohol Consumption

Download Full-text

Impact of Lung Biopsy on Lung Function in Idiopathic Pulmonary Fibrosis

Respiration ◽

10.1159/000509557 ◽

2020 ◽

pp. 1-8

Author(s):

Pierre-Henri Aussedat ◽

Nader Chebib ◽

Kais Ahmad ◽

Jean-Charles Glerant ◽

Gabrielle Drevet ◽

...

Keyword(s):

Lung Function ◽

Idiopathic Pulmonary Fibrosis ◽

Pulmonary Fibrosis ◽

Forced Vital Capacity ◽

Lung Biopsy ◽

Vital Capacity ◽

Forced Expiratory Volume ◽

Surgical Lung Biopsy ◽

Before And After ◽

The Impact

Background: Video-assisted surgical lung biopsy (SLB) is performed in 10–30% of cases to establish the diagnosis of idiopathic pulmonary fibrosis (IPF). Objectives: The aim of the study was to analyze the impact of SLB on lung function in patients eventually diagnosed with IPF. Methods: This is an observational, retrospective, monocentric study of all consecutive patients eventually diagnosed with IPF in multidisciplinary discussion who underwent SLB over 10 years in a specialized center. The primary end point was the variation in forced vital capacity (FVC) before and after the SLB. The secondary end points were the variations in forced expiratory volume in one second (FEV1), total lung capacity (TLC), carbon monoxide diffusion capacity (DLCO), and morbidity and mortality associated with the SLB. Results: In 118 patients who underwent SLB and were diagnosed with IPF, a relative decrease in FVC of 4.8% (p < 0.001) was found between measurements performed before and after the procedure. The mean FVC decrease was 156 ± 386 mL in an average period of 185 days, representing an annualized decline of 363 ± 764 mL/year. A significant decrease was also observed after SLB in FEV1, TLC, and DLCO. Complications within 30 days of SLB occurred in 14.4% of patients. Two patients (1.7%) died within 30 days, where one of them had poor lung function. Survival at 1 year was significantly poorer in patients with FVC <50% at baseline. Conclusion: In this uncontrolled study in patients ultimately diagnosed with IPF, SLB was followed by a significant decline in FVC, which appears to be numerically greater than the average decline in the absence of treatment in the literature. Summary at a Glance: This study evaluated the change in lung function in 118 consecutive patients diagnosed with idiopathic pulmonary fibrosis by surgical lung biopsy. Forced vital capacity decreased by 156 ± 386 mL in a mean of 185 days between the last measurement before and first measurement after biopsy, representing an annualized decline of 363 ± 764 mL/year.

Download Full-text

Forced Vital Capacity and Quality of Life: BOLD Study Cross-Sectional Analysis

10.1183/13993003.congress-2021.pa976 ◽

2021 ◽

Author(s):

Emmanouil Bagkeris ◽

Jaymini Patel ◽

Christer Janson ◽

Andre Amaral ◽

Peter Burney

Keyword(s):

Quality Of Life ◽

Forced Vital Capacity ◽

Vital Capacity ◽

Cross Sectional ◽

Cross Sectional Analysis ◽

Sectional Analysis

Download Full-text

Serum 25-hydroxyvitamin D levels and lung function in adults with asthma: the HUNT Study

European Respiratory Journal ◽

10.1183/09031936.00069714 ◽

2014 ◽

Vol 45 (4) ◽

pp. 1019-1026 ◽

Cited By ~ 15

Author(s):

Tricia L. Larose ◽

Arnulf Langhammer ◽

Yue Chen ◽

Carlos A. Camargo ◽

Pål Romundstad ◽

...

Keyword(s):

Allergic Rhinitis ◽

Lung Function ◽

Vital Capacity ◽

Forced Expiratory Volume ◽

Health Study ◽

Linear Regression Models ◽

Cross Sectional ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Hunt Study

The association between vitamin D status and lung function in adults with asthma remains unclear.We studied this cross-sectional association and possible modification by sex and allergic rhinitis in 760 adults (aged 19–55 years) with self-reported asthma in the Nord-Trøndelag Health Study. Serum 25-hydroxyvitamin D (25(OH)D) level <50 nmol·L−1was considered deficient. Lung function measurements included forced expiratory volume in 1 s (FEV1) % predicted, forced vital capacity (FVC) % predicted and FEV1/FVC ratio. Multiple linear regression models were used to estimate adjusted regression coefficients (β) and 95% confidence intervals.44% of asthma adults had serum 25(OH)D levels <50 nmol·L−1. Its associations with lung function measures seemed to be modified by sex and allergic rhinitis (p<0.03 for three-way interaction term). Overall, a serum 25(OH)D level <50 nmol·L−1was not associated with lung function measurements in subjects with allergic rhinitis in this asthma cohort. In men with asthma but without allergic rhinitis, however, a serum 25(OH)D level <50 nmol·L−1was significantly associated with lower FEV1/FVC ratio (β=−8.60%; 95% CI: −16.95%– −0.25%).Low serum 25(OH)D level was not associated with airway obstruction in most asthma adults with the exception of men with asthma but without allergic rhinitis.

Download Full-text

Determinants of restrictive lung function in asbestos-induced pleural fibrosis

Journal of Applied Physiology ◽

10.1152/jappl.1990.68.5.1932 ◽

1990 ◽

Vol 68 (5) ◽

pp. 1932-1937 ◽

Cited By ~ 40

Author(s):

D. A. Schwartz ◽

J. R. Galvin ◽

C. S. Dayton ◽

W. Stanford ◽

J. A. Merchant ◽

...

Keyword(s):

Lung Function ◽

Sheet Metal ◽

Forced Vital Capacity ◽

Vital Capacity ◽

Pleural Thickening ◽

Metal Workers ◽

Pleural Fibrosis ◽

Diffuse Pleural Thickening ◽

Parenchymal Injury ◽

Restrictive Lung Function

We evaluated whether restrictive lung function among asbestos-exposed individuals with pleural fibrosis was caused by radiographically inapparent parenchymal inflammation and/or parenchymal fibrosis. All 24 study participants were sheet metal workers who were nonsmokers with normal parenchyma on posteroanterior chest radiograph. These subjects had either normal pleura (n = 7), circumscribed plaques (n = 9), or diffuse pleural thickening (n = 8). After controlling for age, years in the trade, and pack-years of smoking, we found that sheet metal workers with diffuse pleural thickening had a lower forced vital capacity (P less than 0.001), total lung capacity (P less than 0.01), and CO-diffusing capacity of the lung (P less than 0.05) than those with normal pleura. Similarly, sheet metal workers with circumscribed plaques were found to have a reduced forced vital capacity; however, because of the small number of study subjects, this difference (regression coefficient = -11.0) was only marginally significant (P = 0.06). Although circumscribed plaque and diffuse pleural thickening were both associated with a lymphocytic alveolitis and a higher prevalence of parenchymal fibrosis on high-resolution computerized tomography (HRCT) scan, neither a lymphocytic alveolitis nor the finding of parenchymal fibrosis on HRCT scan influenced the relationship between pleural fibrosis and restrictive lung function. We conclude that pleural fibrosis is associated with restrictive lung function and abnormally low diffusion that appears to be independent of our measures of parenchymal injury (chest X-ray, bronchoalveolar lavage, and HRCT scan).(ABSTRACT TRUNCATED AT 250 WORDS)

Download Full-text