scholarly journals Relationship between total cholesterol level and tuberculosis risk in a nationwide longitudinal cohort

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yong Suk Jo ◽  
Kyungdo Han ◽  
Dahye Kim ◽  
Jung Eun Yoo ◽  
Yuji Kim ◽  
...  

AbstractThe association between the total cholesterol level and tuberculosis (TB) risk has been controversial. Our study aimed to evaluate whether total cholesterol level can predict the risk of TB. Data from 5,000,566 subjects who participated in a health screening exam in 2009 were investigated using the Korean National Health Insurance Service database (2009–2018). Cox hazard regression analyses were used to evaluate TB risk according to the quartile of total cholesterol levels. During an average of 8.2 years of follow-up, 32,078 cases of TB occurred. There was a significant inverse association between the total cholesterol level and TB risk. Compared with subjects in the highest quartile, those in the lowest quartile had a 1.35-fold increased TB risk (95% confidence interval = 1.31–1.39). The association between total cholesterol level and TB risk was more apparent in young subjects (age < 65 years), those without diabetes mellitus (DM), and those without obesity (p for interaction < 0.001 for age group, DM, and body mass index). Although there was a significant inverse association between total cholesterol level and TB risk in subjects who did not use a statin, no significant association was observed between the total cholesterol level and TB risk in subjects who used a statin. A low total cholesterol level was significantly associated with an increased risk of TB, even after adjusting for confounders, especially in patients younger than 65 years, those without DM or obesity, and those who did not use a statin.

PEDIATRICS ◽  
1992 ◽  
Vol 90 (1) ◽  
pp. 80-86 ◽  
Author(s):  
David S. Freedman ◽  
Tim Byers ◽  
Karen Sell ◽  
Sarah Kuester ◽  
Eva Newe1l ◽  
...  

The relation of an initial measurement of serum total cholesterol to subsequent levels over a (mean) 13-month interval was examined in a multiracial (white, Hispanic, American Indian, and black) sample of 1680 one- to four-year-olds. Although the relation of the initial level to the final measurement (r = .54) did not vary by race, sex, relative weight, or changes in relative weight, the association increased with age at the time of the initial measurement (eg, r .64 among 4-year-olds). Based on the initial and final total cholesterol determinations, the within-person standard deviation was 21 mg/dL and the coefficient of variation was 13%. Although the final total cholesterol level was within 5 mg/dL of the initial level for 18% of the children, the two determinations differed by ≥25 mg/dL for about 35% of the children and by ≥50 mg/dL for about 8%. Of the 149 children who had an initial cholesterol level ≥200 mg/dL, 34% (about five times the expected number) had a follow-up level that was similarly elevated whereas 25% had a subsequent measurement below 170 mg/dL. The results indicate that although an initial cholesterol level in early life is moderately predictive of subsequent levels, it may be difficult to interpret a single total cholesterol determination because of substantial within-person variability.


2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
M Iguchi ◽  
N Masunaga ◽  
M Ishii ◽  
Y An ◽  
A Fujino ◽  
...  

Abstract Background Hyperlipidemia is a well-established risk factor for cardiovascular disease. However, low cholesterol is also reported to be associated with poor outcome in patients with chronic disease, which is called “cholesterol paradox”, and the association of cholesterol level with the incidence of clinical outcomes in patients with atrial fibrillation (AF) remains unclear. Methods In the Fushimi AF Registry, a community-based prospective survey of the AF patients in Fushimi-ku, Kyoto, Japan, follow-up data and baseline total cholesterol levels were available in 3,054 patients. We excluded 767 patients who were taking statins, and 2,267 patients were included in the analyses. We defined low cholesterol as total cholesterol &lt;150 mg/dl, and examined the incidence of all-cause death, stroke/systemic embolism (SE), heart failure (HF) hospitalization, and major bleeding. Results Patients with low cholesterol (N=464 (20.4%)) were older, more often male, and had higher prevalence of low body weight (&lt;50 kg), permanent/persistent AF, prior stroke/SE, HF, chronic kidney disease, and anemia (hemoglobin &lt;11 g/dl). CHA2DS2-VASc score was higher in patients with low cholesterol (low cholesterol vs others; 3.6±1.6 vs 3.2±1.7: P&lt;0.001). Prescription of oral anti-coagulants was comparable between the groups (50.0% vs 54.5%: P=0.09). During the median follow-up of 1,805 days, the incidence of all-cause death, stroke/SE, HF hospitalization, and major bleeding was significantly higher in patients with low cholesterol (all-cause death, 10.9 vs 3.8 /100 person-years; stroke/SE, 3.4 vs 1.9 /100 person-years; HF hospitalization, 4.7 vs 2.5 /100 person-years; major bleeding, 2.7 vs 1.4 /100 person-years) (Figure 1). After adjustment for the components of CHA2DS2-VASc score, low body weight, permanent/persistent AF, chronic kidney disease, anemia, and prescription of oral anti-coagulants, low cholesterol was significantly associated with the incidence of all-cause death and stroke/SE, but not with that of HF hospitalization or major bleeding (Figure 2, model 3). Total cholesterol levels were still significantly and inversely associated with the incidence of all-cause death (hazard ratio, 0.94; 95% confidence interval, 0.92–0.96 for 10 mg/dl increase) and stroke/SE (hazard ratio, 0.96; 95% confidence interval, 0.92–0.999 for 10 mg/dl increase), when analyzed as continuous variables. Subgroup analysis revealed that the risk of low cholesterol for all-cause death was more pronounced in female (interaction P, 0.049), patient without prior stroke/SE (interaction P, 0.01), those without HF (interaction P, 0.01), and those without vascular disease (interaction P, 0.001). The risk for stroke/SE was more pronounced in patients without vascular disease (interaction P, 0.01). Conclusion Low total cholesterol level was significantly associated with the incidence of all-cause and stroke/SE in AF patients not taking statins, suggesting the existence of cholesterol paradox in AF. FUNDunding Acknowledgement Type of funding sources: Private grant(s) and/or Sponsorship. Main funding source(s): Boehringer Ingelheim, Bayer Healthcare, Pfizer, Bristol-Myers Squibb, Astellas Pharma, AstraZeneca, Daiichi-Sankyo, Novartis Pharma, MSD, Sanofi-Avent


2018 ◽  
Vol 16 (1) ◽  
pp. 1 ◽  
Author(s):  
AZRUL HILDAN SAFRIZAL

<p>The pattern and lifestyle of today's society with the presence of an interner facility makes people spend more time sitting out than on exercise and increased consumption of high-fat foods may increase the risk of cardiovascular disease. An effective therapy is needed in preventing the occurrence of cardiovascular disease. Hyperbaric oxygen now starts to develop for the treatment of several diseases, which in turn can increase the gene forming antioxidant enzymes and ROS. To determine effect of hyperbaric oxygen therapy on total cholesterol levels of wistar white rats (Rattusnovergicus) induced bye high fat. The study was carried out in an expeative post test only group control of three groups. One group is given standard feed. All groups induced high-fat diet and standard feed. Of the two groups induced, one group was given hyperbaric oxygen therapy with a dose of 3 x 30 minutes for six days on day 7 at a blood test to determine total cholesterol levels<strong>. </strong>One way Anova parametric statistic test showed that p = 0.007 &lt; α proved hypothesis that hyperbaric oxygen therapy giving effect to total cholesterol level of white mice of jantangalurist rings induced by high fat diet. Total cholesterol was significantly different between K (-) and K (+) and between K (-) and P. It was found that hyperbaric oxygen therapy had an effect on total cholesterol level dose of 3x30 minutes for six days.</p>


2018 ◽  
Vol 10 (1) ◽  
pp. 53-61
Author(s):  
Satya Darmayani ◽  
Anita Rosanty ◽  
Dian Rahmayani

One of the effects of coffee consumption that still questionable is the increase of total cholesterol levels. The content of cafestol in coffee beans could be expected to block the process of β-oxidation of cholesterol that increases cholesterol levels in the blood. This study aimed to describe the normal total cholesterol levels and high total cholesterol levels in coffee addicts in the working area of Puskesmas Poasia, Subdistrict of Poasia. The research sample amounted 38 people taken by purposive sampling. The results showed that the total cholesterol levels test in coffee addicts obtained as many as 14 people (36.84%) with normal total cholesterol levels and as many as 24 people (63.16%) had a high total cholesterol level, but from 24 people of the coffee addicts, there are 4 of them in young age and allowed the possibility of an increase in cholesterol levels become faster due to genetic, lifestyle and unhealthy diet. It concluded that of the 38 people of coffee addicts who tested the cholesterol levels, the number of coffee addicts with high total cholesterol levels more than coffee addicts with normal total cholesterol levels. Therefore, it suggested people to reduce consumption of coffee, especially those for coffee addicts.


2019 ◽  
Vol 967 ◽  
pp. 51-55
Author(s):  
Andi Mu'nisa ◽  
Yusminah Hala ◽  
A. Mushawwir Taiyeb ◽  
Dwi Kesuma Sari

This study aims to determine effect of boiled water parasite kapok (Dendrophthoe pentandra) leaves on the total cholesterol level and histopathology of hepar of hypercholesterolemic mice (mus musculus). This study used 20 ICR male mice divided into 4 treatment groups namely normal mice group, hypercholesterolemic mice group, mice group with boiled water kapok parasite at a dose of 400 mg/kg BW, and 800 mg/kg BW, respectivelly. The animal group was given boiled water kapok parasite after standard feeding and cholesterol feed for 2 weeks. The parameters observed in this study were total cholesterol levels, the amount of fat granules in the liver tissue of mice which were observed in the form of liver-preserved preparations made by paraffin method. The results showed that the administration of parasitic kapok (Dendrophthoe pentandra) at a dose of 400 mg/kg BW and 800 mg/kg BW had an effect on decreasing the total cholesterol level of mice and the histopathology of hepar of showed improvement after the therapy.


2018 ◽  
Vol 5 (1) ◽  
pp. 33
Author(s):  
Siti Fatimah ◽  
Desto Arisandi ◽  
Meirina Sindi Saputri

The increase in total cholesterol level increases the risk of cardiovascular disease. Sweet potato leaves are a food that contains polyphenols, flavonoids, quercetin, tannin, and fiber that effectively lower total cholesterol levels. This study aims to analyze the effect of ethanol extracts of leaf purple sweet potato on serum total cholesterol levels of rats fed a high-fat diet. An experimental study with design pre and posttest carried out on 10 male Wistar rats (Rattus norvegicus) fed a high-fat, which are 2 groups: 1 group the control hypercholesterolemia and 1 group ethanol extracts of leaf purple sweet potato. Dose based on leaves of quercetin that is equal to 2 mg/kgBB. The average content of quercetin ethanol extracts of leaf purple sweet potato was analyzed to obtain 14,08 mg/100g. Ethanol extracts of leaf purple sweet potato are given for 14 days by way of on the sonde. Serum total cholesterol was determined by the CHOD-PAP method. The data obtained were analyzed descriptively.The result of this study obtained the average total cholesterol level of white blood rats before giving ethanol extracts of leaf purple sweet potato that is 189,89 mg/dl, whereas after administration of ethanol extracts of leaf purple sweet potato dose 2 mg/kgBB that is 131,92 mg/dl. The decrease in total cholesterol level of white rats after giving ethanol extracts of leaf purple sweet potato with dose 2 mg/kgBB that is 30,52 %.


2020 ◽  
Vol 6 (2) ◽  
pp. 117
Author(s):  
Rara Yumna Elfrida ◽  
Gadis Meinar Sari ◽  
Sri Ratna Dwiningsih ◽  
Pudji Lestari

Introduction: Hormonal injection contraception is the most widely used method of contraception in Indonesia. In long-term use, one of the side effects of injection contraception is changes in lipid metabolism in the body caused by the accumulation of hormones in the body. Two types of injectional contraception are widely used in Indonesia, namely combined injection and DMPA injection; different hormonal content has various side effects on the lipid profile. This study aimed to compare the total cholesterol level between acceptors of DMPA injection and combined injection.Methods: This study used an observational analytic method with a cross-sectional approach. The sample size is 60 respondents, including 30 DMPA injection acceptors and 30 combination injection acceptors. The sampling method uses a purposive sampling technique The independent variable in this study was the total cholesterol level of the acceptor, and the dependent variable was the acceptor of DMPA injection and the combination injection acceptor. Analysis of research data used the Independent T-test with α=0.05.Results: The results of the bivariate analysis found significant differences in total cholesterol levels in the DMPA injection contraception acceptor and combination injection with p= 0.037. It was found that overall cholesterol levels of DMPA injection acceptors were higher.Conclusion: There is a difference in total cholesterol levels in the DMPA injection contraception acceptor with a combination injection contraception acceptor.


2018 ◽  
Vol 12 (1) ◽  
pp. 73
Author(s):  
Maruni Wiwin Diarti ◽  
Yunan Jiwintarum ◽  
Ida Ayu Reka

Abstract: A traditional black coffee powder is one of the beverages that excessively consumed by communities. The increasing of total cholesterol level in blood is influenced by the habit of consuming coffee. Coffee has chemicals that can cause some health problems, namely cafestol and kahweol. The objective study was to determine the effect of patient preparation against the result of total cholesterol levels examination on the consumers of traditional black coffee powder. This research was analytic observational. The sample was capillary blood of consumers’ a traditional black coffee as many as 30 people. Statistical analysis utilized Mann-Whitney U Test with 95% confidence level (α = 0,05). The findings indicated the average deviation of total cholesterol level after fasting 12,86 mg / dL and mean difference after giving coffee 7 cups 18,46 mg / dL. Mann Whitney Test found significant value 0.001 <α = 0.05 which means there is an influence of patient preparation against the result of total cholesterol levels examination on the consumers of traditional black coffee powder.Keywords: Total Cholesterol Level; Consumers of Traditional Black Coffee Powder.


Jurnal GIZIDO ◽  
2019 ◽  
Vol 11 (01) ◽  
pp. 1-7
Author(s):  
Nonce Nova Legi ◽  
Mirna Kawulusan ◽  
Marstevi Olivia Gedoan

Hypercholesterolemia is an increase in total cholesterol levels in the blood beyond the normal limits. Excess cholesterol levels in the blood will have an impact on degenerative diseases. Brown rice (oryza nivara) is a rice rich in vitamins, minerals and contain water soluble fiber that can help bind cholesterol, then throw it out of the body. Regular consumption of brown rice is very beneficial for health that can reduce levels of LDL. The aim of this research is to know the effectiveness of brown rice rice to total cholesterol level in hypercholesterolemia patient in Vilage Sea Pineleng District of Minahasa Regency. The type of this research is Quasi Eksperimen with One Group of Pretest and Posttest Design. The sample in this study is the entire population of hypercholesterolemia patients recorded in Posbindu Village Sea Pineleng District Minahasa regency that meets the inclusion criteria. Rice brown rice is given for 8 consecutive days every morning, day and night. Total cholesterol levels were measured before and after administration of brown rice. Data analysis using Paired t-test. The results showed that the total cholesterol level before the study was the highest of 360 mg / dl, the lowest was 216 mg / dl, and after the highest total cholesterol was 298 mg / dl, the lowest was 164 mg / dl. The result of statistical test shows that p = 0,019 (p <0,05), which means that there is difference of total cholesterol before and after giving of rice of red rice to hypercholesterolemia patient in Vilage Sea Pineleng Sub-district of Minahasa Regency.


2021 ◽  
Vol 15 (1) ◽  
pp. 39-47
Author(s):  
Widiyono Widiyono ◽  
Atik Aryani ◽  
Vitri Dyah Herawati

The effectiveness of Bay leaf (Syzygium polyanthum) to decrease blood total cholesterol level among elderly with HypercholesterolemiaBackground: Total cholesterol levels will gradually increase with age. In the elderly, uncontrolled cholesterol will be a risk factor for life-threatening diseases such as stroke and cardiovascular disease. Observing the adverse effects of hypercholesterolemia, appropriate intervention needed. The treatment of Hypercholesterolemia by using complementary herbal therapy as bay leaves. Bay leaves also contain quercetin, which is a flavonoid that plays a role in strong antioxidants because it can prevent oxidation of LDL (Low Density Lipoprotein). Flavonoids can also prevent fat deposition on the walls of blood vessels.Purpose : To determine the effect of bay leaf (Syzygium polyanthum)  on reducing the cholesterol levels among elderly with Hypercholesterolemia, Method: A quasi-experimental One Group pretest-posttest design without control. The sampling taken by purposive sampling. The number of samples of this study were 29 participants.The cholesterol levels measured using a GCU (Glucose Cholesterol Urid acid), which was calibrated and had good accuracy. The statistical test used is the Paired sample t-test. As for the making of a concoction of bay leaves at each dose of administration by; as much as 10 bay leaves boiled with 400ml of water until the remaining 200ml. 400 ml per day provide in morning and evening and the therapy takes out for 1 full a month and ends with a blood examination evaluation with GCU.Results : The analysis showing that there was a significant difference in the mean cholesterol levels before and after being given the bay leaf stew with a p value of 0.001, which means that there was an effect of the provision of bay leaf boiled water on reducing cholesterol levels.Conclusion: The bay leaf is a complementary herbal therapy that is cheap and can find everywhere in Indonesia also is a non-invasive treatment. This intervention expected as alternative a non-pharmacological therapeutic method in overcoming hypercholesterolemia in the elderly.Keywords: Bay leaf (Syzygium polyanthum); Total cholesterol level; Elderly; HypercholesterolemiaPendahuluan: Kadar kolestrol total akan meningkat secara bertahap seiring bertambahnya usia. Pada lansia, kolesterol yang tidak terkontrol akan menjadi berbagai faktor risiko penyakit yang mengancam jiwa seperti stroke dan penyakit kardiovaskuler. Mencermati dampak buruk dari hiperkolesterolemia maka diperlukan intervensi yang tepat. Mengatasi hiperkolesterolemia dapat dilakukan dengan pengunaan terapi komplementer herbal berupa pemberian air rebusan daun salam. Daun salam juga mengandung quercetin, yaitu Flavonoid yang berperan dalam antioksidan kuat karena mampu mencegah oksidasi LDL (Low Density Lipoprotein). Flavonoid juga dapat mencegah pengendapan lemak pada dinding pembuluh darah.Tujuan : Mengetahui pengaruh pemberian air rebusan dalam salam terhadap penurunan kadar kolesterol lanisa yang mengalami Hipercholesterolemia.Metode : Penelitian  quasy eksperimental dan menggunakan rancangan One Group pretest-posttest design without Control. Teknik pengambilan sampel dilakukan dengan secara purposive sampling. Jumlah sampel penelitiannya 29 partisipan. Kadar kolesterol pada partisipan diukur dengan menggunakan alat cek kolesterol GCU (Glukosa Colesterol Urid acid) yang sudah dikalibrasi dan memiliki akurasi yang baik. Uji statistic yang digunakan yakni uji Paired sample t-test. Adapun pembuatan ramuan daun salam pada setiap dosis pemberian dengan cara; rebus sebanyak 10 lembar daun salam dengan 400ml air hingga tersisa 200ml.400 ml per hari berikan pagi dan sore dan terapi berlangsung selama 1 bulan penuh dan diakhiri dengan evaluasi pemeriksaan darah dengan GCU.Hasil : Menunjukan bahwa ada perbedaan rerata kadar kolesterol yang bermakna sebelum dan sesudah diberikan rebusan daun salam dengan nilai p value 0,001 yang berarti ada pengaruh pemberian air rebusan daun salam terhadap penurunan kadar kolesterol.Simpulan: Pemberian rebusan air daun salam merupakan terapi komplementer herbal yang murah, mudah, dapat dilakukan dimanapun dan kapanpun dan merupakan tindakan non-invasif. Intervensi ini diharapkan dapat dimanfaatkan sebagai metode terapi non farmakalogi dalam mengatasi hiperkolesterolemia pada lansia.


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