Pengaruh Pemberian Terapi Oksigen Hiperbarik Terhadap Kadar Kolesterol Total Pada Tikus Putih (Rattus novergicus) Jantan Galur Wistar Yang Di Induksi Diet Tinggi Lemak

2018 ◽  
Vol 16 (1) ◽  
pp. 1 ◽  
Author(s):  
AZRUL HILDAN SAFRIZAL
Keyword(s):  
Cardiovascular Disease ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
High Fat Diet ◽  
Oxygen Therapy ◽  
Total Cholesterol Level ◽  
High Fat ◽  
Cholesterol Levels

<p>The pattern and lifestyle of today's society with the presence of an interner facility makes people spend more time sitting out than on exercise and increased consumption of high-fat foods may increase the risk of cardiovascular disease. An effective therapy is needed in preventing the occurrence of cardiovascular disease. Hyperbaric oxygen now starts to develop for the treatment of several diseases, which in turn can increase the gene forming antioxidant enzymes and ROS. To determine effect of hyperbaric oxygen therapy on total cholesterol levels of wistar white rats (Rattusnovergicus) induced bye high fat. The study was carried out in an expeative post test only group control of three groups. One group is given standard feed. All groups induced high-fat diet and standard feed. Of the two groups induced, one group was given hyperbaric oxygen therapy with a dose of 3 x 30 minutes for six days on day 7 at a blood test to determine total cholesterol levels<strong>. </strong>One way Anova parametric statistic test showed that p = 0.007 &lt; α proved hypothesis that hyperbaric oxygen therapy giving effect to total cholesterol level of white mice of jantangalurist rings induced by high fat diet. Total cholesterol was significantly different between K (-) and K (+) and between K (-) and P. It was found that hyperbaric oxygen therapy had an effect on total cholesterol level dose of 3x30 minutes for six days.</p>

scholarly journals Efek jus belimbing pada kadar Total Kolesterol Rattus norvegicus yang diberi diet tinggi lemak

2019 ◽  
Vol 17 (1) ◽  
pp. 24
Author(s):  
PUTRI DIANA MAULIYAH ULFA ◽  
INDRI NGESTI RAHAYU ◽  
IGM ANTARA HAMBARSIKA
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Rattus Norvegicus ◽  
High Fat Diet ◽  
Total Cholesterol Level ◽  
Standard Diet ◽  
High Fat ◽  
Experimental Animals ◽  
Cholesterol Levels ◽  
Experimental Group

<p>Background: Hypercholesterolemia is a condition in which increased cholesterol concentration in the blood exceeds normal values. Consuming fats and foods rich in cholesterol can increase total cholesterol levels in the blood and cause cholesterol buildup in the arteries. Starfruit (Averrhoa bilimbi L.) has saponin and flavonoid compounds which are expected to play a role in reducing total cholesterol levels. The aim of this study is to determine the effect of star fruit juice (Averrhoa bilimbi L.) to total cholesterol blood levels of male Wistar strain (Rattus norvegicus) with a high-fat diet. Method: Experimental study with post-test only control group design. Twenty-four male white rats (Rattus norvegicus) of the Wistar strain are divided into 3 groups: the experimental group which is given standard diet for 28 days; group of experimental animals who were given a high-fat diet for 28 days; the experimental group treated with a high-fat diet for 28 days and on the 15<sup>th</sup>  until 28<sup>th</sup> days were given starfruit juice (Averrhoa bilimbi L.) with a dose of 4ml/200grwieght/day. On the 29th day, it is measuredtotal cholesterol levels for all groups of experimental animals. Results: The One-Way ANOVA test shows a significant increase in the average of total cholesterol levels (p = 0,009) in group of experimental animals that are given a high-fat diet (x = 60,625± 3,462mg/dL) compared to groups of experimental animals given standard diet (x = 50± 8,468mg/dL). There is a increase in the average in cholesterol level of the experimental group given a high-fat diet and the starfruit juice (Averrhoa bilimbi L.) (x = 65,5 ± 8,960) compared to the mean total cholesterol level of group of animals given a high-fat diet (x = 60,625± 3,462). However, there is no significant increase (p = 0,201). Conclusion: Administration of starfruit juice (Averrhoa bilimbi L.) was not significantly difference in statistics on average of cholesterol level to male wistar rat (Rattus norvegicus) induced by high fat diet</p><p>Keywords: high fat diet, starfruit juice, total cholesterol level</p>

scholarly journals Total Cholesterol Level of Hypercholesterolemia Male Wistar Rats (Rattus norvegicus) with Ethanol Extracts of Purple Sweet Potato Leaf (Ipomoea batatas (L.) Lam)

2018 ◽  
Vol 5 (1) ◽  
pp. 33
Author(s):  
Siti Fatimah ◽  
Desto Arisandi ◽  
Meirina Sindi Saputri
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Sweet Potato ◽  
Rattus Norvegicus ◽  
Total Cholesterol Level ◽  
High Fat ◽  
Cholesterol Levels ◽  
Male Wistar Rats ◽  
Purple Sweet Potato ◽  
Ethanol Extracts

The increase in total cholesterol level increases the risk of cardiovascular disease. Sweet potato leaves are a food that contains polyphenols, flavonoids, quercetin, tannin, and fiber that effectively lower total cholesterol levels. This study aims to analyze the effect of ethanol extracts of leaf purple sweet potato on serum total cholesterol levels of rats fed a high-fat diet. An experimental study with design pre and posttest carried out on 10 male Wistar rats (Rattus norvegicus) fed a high-fat, which are 2 groups: 1 group the control hypercholesterolemia and 1 group ethanol extracts of leaf purple sweet potato. Dose based on leaves of quercetin that is equal to 2 mg/kgBB. The average content of quercetin ethanol extracts of leaf purple sweet potato was analyzed to obtain 14,08 mg/100g. Ethanol extracts of leaf purple sweet potato are given for 14 days by way of on the sonde. Serum total cholesterol was determined by the CHOD-PAP method. The data obtained were analyzed descriptively.The result of this study obtained the average total cholesterol level of white blood rats before giving ethanol extracts of leaf purple sweet potato that is 189,89 mg/dl, whereas after administration of ethanol extracts of leaf purple sweet potato dose 2 mg/kgBB that is 131,92 mg/dl. The decrease in total cholesterol level of white rats after giving ethanol extracts of leaf purple sweet potato with dose 2 mg/kgBB that is 30,52 %.

Tracking of Serum Cholesterol Levels in a Multiracial Sample of Preschool Children

PEDIATRICS ◽  
1992 ◽  
Vol 90 (1) ◽  
pp. 80-86 ◽  
Author(s):  
David S. Freedman ◽  
Tim Byers ◽  
Karen Sell ◽  
Sarah Kuester ◽  
Eva Newe1l ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Initial Level ◽  
Total Cholesterol Level ◽  
Relative Weight ◽  
Cholesterol Levels ◽  
Final Measurement ◽  
Subsequent Measurement ◽  
Initial Measurement

The relation of an initial measurement of serum total cholesterol to subsequent levels over a (mean) 13-month interval was examined in a multiracial (white, Hispanic, American Indian, and black) sample of 1680 one- to four-year-olds. Although the relation of the initial level to the final measurement (r = .54) did not vary by race, sex, relative weight, or changes in relative weight, the association increased with age at the time of the initial measurement (eg, r .64 among 4-year-olds). Based on the initial and final total cholesterol determinations, the within-person standard deviation was 21 mg/dL and the coefficient of variation was 13%. Although the final total cholesterol level was within 5 mg/dL of the initial level for 18% of the children, the two determinations differed by ≥25 mg/dL for about 35% of the children and by ≥50 mg/dL for about 8%. Of the 149 children who had an initial cholesterol level ≥200 mg/dL, 34% (about five times the expected number) had a follow-up level that was similarly elevated whereas 25% had a subsequent measurement below 170 mg/dL. The results indicate that although an initial cholesterol level in early life is moderately predictive of subsequent levels, it may be difficult to interpret a single total cholesterol determination because of substantial within-person variability.

scholarly journals GAMBARAN KADAR KOLESTEROL TOTAL PADA PECANDU KOPI KECAMATAN POASIA KOTA KENDARI

2018 ◽  
Vol 10 (1) ◽  
pp. 53-61
Author(s):  
Satya Darmayani ◽  
Anita Rosanty ◽  
Dian Rahmayani
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Coffee Consumption ◽  
Young Age ◽  
High Total Cholesterol ◽  
Purposive Sampling ◽  
Cholesterol Levels ◽  
Coffee Beans ◽  
Unhealthy Diet

One of the effects of coffee consumption that still questionable is the increase of total cholesterol levels. The content of cafestol in coffee beans could be expected to block the process of β-oxidation of cholesterol that increases cholesterol levels in the blood. This study aimed to describe the normal total cholesterol levels and high total cholesterol levels in coffee addicts in the working area of Puskesmas Poasia, Subdistrict of Poasia. The research sample amounted 38 people taken by purposive sampling. The results showed that the total cholesterol levels test in coffee addicts obtained as many as 14 people (36.84%) with normal total cholesterol levels and as many as 24 people (63.16%) had a high total cholesterol level, but from 24 people of the coffee addicts, there are 4 of them in young age and allowed the possibility of an increase in cholesterol levels become faster due to genetic, lifestyle and unhealthy diet. It concluded that of the 38 people of coffee addicts who tested the cholesterol levels, the number of coffee addicts with high total cholesterol levels more than coffee addicts with normal total cholesterol levels. Therefore, it suggested people to reduce consumption of coffee, especially those for coffee addicts.

scholarly journals Effect of Boiled Water Parasite Kapok (Dendrophthoe pentandra) Leaves on Total Cholesterol Levels and Histopathology of Hepar of Hypercholesterolemic Mice

2019 ◽  
Vol 967 ◽  
pp. 51-55
Author(s):  
Andi Mu'nisa ◽  
Yusminah Hala ◽  
A. Mushawwir Taiyeb ◽  
Dwi Kesuma Sari
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Male Mice ◽  
Animal Group ◽  
Treatment Groups ◽  
Cholesterol Levels ◽  
Boiled Water ◽  
Paraffin Method ◽  
Determine Effect

This study aims to determine effect of boiled water parasite kapok (Dendrophthoe pentandra) leaves on the total cholesterol level and histopathology of hepar of hypercholesterolemic mice (mus musculus). This study used 20 ICR male mice divided into 4 treatment groups namely normal mice group, hypercholesterolemic mice group, mice group with boiled water kapok parasite at a dose of 400 mg/kg BW, and 800 mg/kg BW, respectivelly. The animal group was given boiled water kapok parasite after standard feeding and cholesterol feed for 2 weeks. The parameters observed in this study were total cholesterol levels, the amount of fat granules in the liver tissue of mice which were observed in the form of liver-preserved preparations made by paraffin method. The results showed that the administration of parasitic kapok (Dendrophthoe pentandra) at a dose of 400 mg/kg BW and 800 mg/kg BW had an effect on decreasing the total cholesterol level of mice and the histopathology of hepar of showed improvement after the therapy.

scholarly journals The Comparison of Total Cholesterol Level in DMPA and Combination Injection Contraception Users

2020 ◽  
Vol 6 (2) ◽  
pp. 117
Author(s):  
Rara Yumna Elfrida ◽  
Gadis Meinar Sari ◽  
Sri Ratna Dwiningsih ◽  
Pudji Lestari
Keyword(s):  
Side Effects ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Sampling Technique ◽  
The Body ◽  
Bivariate Analysis ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Hormonal Content

Introduction: Hormonal injection contraception is the most widely used method of contraception in Indonesia. In long-term use, one of the side effects of injection contraception is changes in lipid metabolism in the body caused by the accumulation of hormones in the body. Two types of injectional contraception are widely used in Indonesia, namely combined injection and DMPA injection; different hormonal content has various side effects on the lipid profile. This study aimed to compare the total cholesterol level between acceptors of DMPA injection and combined injection.Methods: This study used an observational analytic method with a cross-sectional approach. The sample size is 60 respondents, including 30 DMPA injection acceptors and 30 combination injection acceptors. The sampling method uses a purposive sampling technique The independent variable in this study was the total cholesterol level of the acceptor, and the dependent variable was the acceptor of DMPA injection and the combination injection acceptor. Analysis of research data used the Independent T-test with α=0.05.Results: The results of the bivariate analysis found significant differences in total cholesterol levels in the DMPA injection contraception acceptor and combination injection with p= 0.037. It was found that overall cholesterol levels of DMPA injection acceptors were higher.Conclusion: There is a difference in total cholesterol levels in the DMPA injection contraception acceptor with a combination injection contraception acceptor.

scholarly journals Anti-hypercholesterolemic effect of Zingiber montanum extract

F1000Research ◽  
2019 ◽  
Vol 7 ◽  
pp. 1798
Author(s):  
Swandari Paramita ◽  
Meiliati Aminyoto ◽  
Sjarif Ismail ◽  
Enos Tangke Arung
Keyword(s):  
Total Cholesterol ◽  
Plant Extracts ◽  
High Fat Diet ◽  
High Cholesterol ◽  
High Fat ◽  
Group 4 ◽  
Cholesterol Levels ◽  
Group 6 ◽  
Diet Control ◽  
Group 2

Background: High cholesterol levels (hypercholesterolemia) has been recognized to cause various disease, most notably the cardiovascular disease. Unfortunately, most anti-hypercholesterolemic drugs deliver several side effects for patients, by which medicinal plants have begun to attract attention for treating hypercholesterolemia. Among others, Zingiber montanum (J.König) Link ex A.Dietr. has traditionally been taken for treating health problems caused by high cholesterol levels. Hence, this work aimed at investigating anti-hypercholesterolemic effects offered by the plant. Methods: This study was conducted on 30 male Wistar rats. During experiments, the subjects were divided into 6 groups (n=5), i.e. no treatment (Group 1, control); high-fat diet (Group 2, control); high-fat diet with simvastatin (Group 3); high-fat diet with plant extracts (Group 4-6 with 100, 200, and 400 mg/kg BW, respectively). After 4 weeks of treatments, blood samples were collected from each group. Then, plasma concentrations of triglycerides, total cholesterol, high density lipoproteins (HDL), and low density lipoproteins (LDL) were measured. Results: There were significant differences in total cholesterol (p=0.000), LDL (p=0.000) and triglycerides (p=0.001) for Groups 4-6 (high-fat diet treated with different plant extract doses) in comparison with Group 2 (high-fat diet, control). Meanwhile, there were no significant differences in HDL levels (p=0.830) between Group 2 (high-fat diet, control) and other groups. The results also showed significant differences in total cholesterol and LDL for subjects treated with plant extracts (Group 4, 100 mg/kg BW, p=0.000;  Group 5, 200 mg/kg BW, p=0.000; Group 6, 400 mg/kg BW, p=0.000) compared to Group 2 (high-fat diet, control). Then, treatments with 400 mg/kg BW (Group 6) discovered significant reductions in total cholesterol, LDL, and triglycerides (p=0.030). Conclusion: Therefore, Z. montanum has been discovered to deliver anti-hypercholesterolemic effects to experimental subjects, making it potential to act as a natural source of anti-hypercholesterolemic agents.

scholarly journals Benefit of cinnamon (Cinnamomum burmannii) in lowering total cholesterol level after consumption of high-fat containing foods in white mice (Mus musculus) models

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 168
Author(s):  
Annisa Pulungan ◽  
Yunita Sari Pane
Keyword(s):  
Total Cholesterol ◽  
Mus Musculus ◽  
Total Cholesterol Level ◽  
Simple Random Sampling ◽  
Negative Control ◽  
The Body ◽  
High Fat ◽  
Cinnamon Extract ◽  
Cholesterol Levels ◽  
Cinnamomum Burmannii

Background: Hypercholesterolemia is a condition where cholesterol levels in the body exceed the normal range. In Indonesia, the development of traditional medicine is carried out by examining plants known for their medicinal qualities, including cinnamon (Cinnamomum burmannii). There are many nutritional components contained in cinnamon, such as cinnamaldehyde. This has been suggested as a substance that can reduce cholesterol and triglyceride levels. This study was conducted to determine the efficacy of cinnamon in reducing total cholesterol levels of mice (Mus musculus) given high-fat feed. Methods: This is an experimental study with a pre-post control study design. The groupings were performed by a simple random sampling method. There were five groups (n=6/group): 1) Negative control (aquadest); 2) positive control of high-fat containing food (HFC; quail's yolk); 3) HFC + cinnamon extract (CE; dose 2mg/20g body weight (BW); 4) HFC + CE (dose 4mg/20gBW); 5) HFC + CE (dose 8mg/20gBW). The study was conducted for 28 days. The intervention of CE started on day 15 and ended on day 28. Measurement of total cholesterol and BW of mice was performed on days 0, 14 and 28. Results: A decrease in the total cholesterol of mice (p = 0.001) was found in the groups that consumed CE. However, there was not a significant change between groups in mice BW (p = 0.419). Conclusions: Providing cinnamon extract (Cinnamomum burmannii) for 28 days could decrease total cholesterol levels in mice compared to those not given cinnamon extract when consuming high-fat containing foods.

scholarly journals PENGARUH PEMBERIAN JUS BUAH BELIMBING WULUH (AVERRHOA BILIMBI L.) TERHADAP KADAR KOLESTEROL LDL DARAH TIKUS PUTIH (RATTUS NORVEGICUS) JANTAN GALUR WISTAR DENGAN DIET TINGGI LEMAK

2019 ◽  
Vol 8 (2) ◽  
pp. 35-41
Author(s):  
Kartika Dwi Rahminiwati ◽  
◽  
IGM Antara Hambarsika ◽  
Fitri Handajani ◽  
◽  
...  
Keyword(s):  
Cholesterol Level ◽  
High Fat Diet ◽  
Ldl Cholesterol ◽  
Positive Control ◽  
Negative Control ◽  
Positive Control Group ◽  
Control Group ◽  
High Fat ◽  
Cholesterol Levels ◽  
The Mean

A high-fat diet can increase lipoprotein levels, total cholesterol, (Low Density Lipoprotein) LDL, and triglycerides. Starfruit has saponin and flavonoid compounds which are expected to reducing LDL cholesterol levels. The aim of the study was to determine the effect of starfruit juice on lowering the blood cholesterol LDL of Wistar rats fed with high-fat diet. Experimental study with post-test only control group design. As many as 24 male white rats from the Wistar strain were divided into 3 groups: negative control groups (K-) that were given standard feed for 28 days; positive control group (K+) who were given a high-fat diet for 28 days; the treatment group (KP) was given a high-fat diet for 28 days and on the 15th day 28th they were given a starfruit juice with a dose of 4ml / 200grBB / day. Day 29 measured LDL cholesterol. The statistic test showed a significant increase in LDL cholesterol levels (p=0.001) in the positive control group (x=12.125±2.642 mg/dL) compared to the negative control group (x=7.625±1.506 mg/dL). There was no significant different the mean cholesterol level of the treatment group (x=11±1.927) compared to the mean LDL cholesterol level of the positive control group (x=12.125±2.642). A high-fat diet significantly increases the mean LDL cholesterol level. Starfruit juice did not significantly reduce LDL cholesterol level.

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