scholarly journals Urinary equol levels are positively associated with urinary estradiol excretion in women

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tomoko Fujitani ◽  
Yukiko Fujii ◽  
Zhaoqing Lyu ◽  
Mariko Harada Sassa ◽  
Kouji H. Harada
Keyword(s):  
Mass Spectrometry ◽  
Cross Sectional Study ◽  
Negative Association ◽  
Analysis Of Covariance ◽  
Gas Chromatography Mass Spectrometry ◽  
Sectional Study ◽  
Cross Sectional ◽  
Female Hormone ◽  
Positive Effect ◽  
Reduced Risk

AbstractIsoflavones found in soy products are a promising class of nutrients that may have a positive effect on human health. In particular, the phytoestrogen metabolite equol is associated with a reduced risk of developing female hormone-related diseases. However, the effect of equol on estrogen remains unclear. Equol can modify blood and urinary estradiol (E2) levels. The aim of this cross-sectional study was to examine the associations between urinary estrogen levels, equol levels, and equol production status in Japanese women. We analyzed urine samples from 520 women by gas chromatography-mass spectrometry. Urinary E2 and 4-hydroxylated E2 levels were higher in equol producers (EQP) than in non-EQPs (P < 0.0001 and P=0.00112, respectively). After adjusting for age and tobacco use by analysis of covariance, the association remained significant (β = 0.299, P < 0.0001). Analysis of covariance demonstrated that equol levels in urine were also positively associated with urinary E2 (β = 0.597, P < 0.0001). The log equol concentration showed a significant, but moderate, negative association with the serum E2 concentration (β = − 0.0225, P = 0.0462). Our findings suggest that equol may promote urinary E2 excretion and modify blood E2 levels in women.

scholarly journals Excessive daytime sleepiness with snoring or witnessed apnea is associated with handgrip strength: a population-based study

QJM ◽  
2019 ◽  
Vol 112 (11) ◽  
pp. 847-853
Author(s):  
X Cao ◽  
Y Gu ◽  
J Fu ◽  
T Q C Vu ◽  
Q Zhang ◽  
...  
Keyword(s):  
Body Weight ◽  
Muscle Strength ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Handgrip Strength ◽  
Cross Sectional Study ◽  
Analysis Of Covariance ◽  
Poor Sleep ◽  
Sectional Study ◽  
Cross Sectional

Abstract Background Sarcopenia is emerging as an important public health problem, and evidences have determined that poor sleep is associated with muscle strength, but the potential effects of excessive daytime sleepiness (EDS), snoring and witnessed apnea on handgrip strength have not been evaluated. Aim We aimed to examine the association between EDS, snoring, witnessed apnea and muscle strength in an adult population. Design Cross-sectional study. Methods This cross-sectional study comprised 19 434 adults. Handgrip strength was measured using a handheld digital dynamometer. EDS was assessed by Epworth Sleepiness Scale, snoring and witnessed apnea during sleep were reported through simple yes/no questions. Analysis of covariance was carried out to determine the association between EDS with snoring or witnessed apnea and muscle strength. Results The means (95% confidence interval) for average handgrip strength/body weight (kg/kg) across symptoms categories were 0.396 (0.333–0.472), 0.393 (0.330–0.467), 0.396 (0.333–0.471) and 0.386 (0.325–0.460) (P < 0.0001), respectively. Similar results were observed with maximal handgrip strength/body weight (kg/kg). Conclusions Self-reported EDS accompanied with snoring or apnea is associated with lowest handgrip strength, independently of confounding factors. Whether improvement of EDS, snoring and apnea, can ameliorate age-associated decline in muscle strength warrants further studies.

scholarly journals A cross-sectional study on metabolic similarities and differences between inpatients with schizophrenia and those with mood disorders

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Yoriyasu Uju ◽  
Tetsuto Kanzaki ◽  
Yuki Yamasaki ◽  
Tadayuki Kondo ◽  
Hideki Nanasawa ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Mood Disorders ◽  
Fasting Blood Glucose ◽  
Brain Magnetic Resonance Imaging ◽  
Cross Sectional Study ◽  
Analysis Of Covariance ◽  
Sectional Study ◽  
Cross Sectional ◽  
Schizophrenia Group ◽  
Lifestyle Related Diseases

Abstract Background One of the main causes of death in psychiatric patients is cardiovascular diseases which are closely related with lifestyle-related diseases. Psychiatric disorders include schizophrenia and mood disorders, whose symptoms and treatment medicines are different, suggesting that they might have different metabolic disorders. Thus, we studied the differences of lifestyle-related diseases between schizophrenia and mood disorders in Japan. Methods This cross-sectional study was performed from 2015 to 2017. Study participants were 189 Japanese hospitalized patients (144 schizophrenia group, 45 mood disorders group) in the department of psychiatry at Kohnodai hospital. We examined physical disorders, metabolic status of glucose and lipid, estimated glomerular filtration rate (eGFR) and brain magnetic resonance imaging. We compared these data between schizophrenia and mood disorders groups using analysis of covariance or logistic regression analysis. In comparisons between inpatients with schizophrenia or mood disorders group and the standard, we quoted ‘The National Health and Nutrition Survey in Japan 2015’ by Ministry of Health, Labor and Welfare as the standard. Results eGFR and prevalence of smoking were significantly lower in patients with mood disorder group than those with schizophrenia group by adjustment for age. In comparisons between patients with schizophrenia group or mood disorders group and each standard, the ratio of silent brain infarction (SBI) and cerebral infarction were significantly high in both groups. Schizophrenia group showed significantly higher prevalence of diabetes, low high-density lipoprotein (HDL) cholesterolemia, metabolic syndrome and smoking than the standard. Mood disorders group had significantly high prevalence of low HDL-cholesterolemia compared with the standard. Fasting blood glucose and HbA1c were significantly higher in schizophrenia group and female mood disorders group than the standard. Female mood disorders group had significantly decreased eGFR with increased ratio of eGFR < 60 ml/min than the standard. Conclusions Participants of both groups had increased ratio of SBI and cerebral infarction, accompanied with glucose and lipid disorders. Compared with schizophrenia group, mood disorders group showed significantly low eGFR and prevalence of smoking.

scholarly journals Prevalence and Correlates of Fatigue and Its Association with Quality of Life Among Clinically Stable Older Psychiatric Patients During the COVID-19 Outbreak: A Cross-Sectional Study

2020 ◽  
Author(s):  
Siyun Zou ◽  
Zi-Han Liu ◽  
Xiaona Yan ◽  
Huan Wang ◽  
Yulong Li ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Psychiatric Disorders ◽  
Older Patients ◽  
Psychiatric Patients ◽  
Cross Sectional Study ◽  
Analysis Of Covariance ◽  
Sectional Study ◽  
Cross Sectional ◽  
Insomnia Symptoms

Abstract Background: The pattern of fatigue in older psychiatric patients during the COVID-19 outbreak was unknown. This study examined the prevalence of fatigue and its association with quality of life (QOL) in clinically stable older patients with psychiatric disorders during the COVID-19 outbreak. Methods: This is a multicenter, cross-sectional study. Fatigue, depression, pain, insomnia symptoms, and QOL were assessed with standardized instruments. Results: A total of 1,063 patients were recruited. The prevalence of fatigue was 47.1% (95%CI: 44.1% - 50.1%). Analysis of covariance revealed that QOL was significantly lower in patients with fatigue compared to those without (P=0.011). Multiple logistic regression analysis revealed that more severe depression (OR=1.15, P<0.001), insomnia symptoms (OR=1.08, P<0.001) and pain (OR=1.43, P<0.001) were significantly associated with fatigue.Conclusions: Fatigue was common among clinically stable older patients with psychiatric disorders during the COVID-19 outbreak. Considering its negative impact on QOL, regular assessment of fatigue and appropriate treatment warrant attention in this subpopulation.

scholarly journals Risk Assessment of Phthalate Compounds in Bottled Water Consumed in Isfahan, Iran

2021 ◽  
Author(s):  
F. Esteki ◽  
H. Karimi ◽  
M. Moazeni ◽  
Z. Esfandiari ◽  
M. Zarean ◽  
...  
Keyword(s):  
Public Health ◽  
Risk Assessment ◽  
Water Samples ◽  
Cross Sectional Study ◽  
Bottled Water ◽  
Gas Chromatography Mass Spectrometry ◽  
Sectional Study ◽  
Cross Sectional ◽  
Pet Bottles ◽  
Ethylhexyl Phthalate

Background: Phthalates are main ingredients of polyethylene terephthalate (PET) bottles used for storage of water. These compounds can cause adverse effects on human health. The purpose of this study was the quantification of the amounts of phthalates migrated in bottled water as well as the risk assessment of those compounds. Methods: This cross sectional study was performed on 15 PET bottled water samples of popular brands distributed in Isfahan city, Iran. The samples were immediately sent to laboratory for analysis. Amounts of Phthalic Anhydride (PA), di-2 ethylhexyl phthalate (DEHP), di-buthyl phthalate (DBP), di-ethyl phthalate (DEP), and terphthalic acid (TPA) in bottled water samples were measured using Gas Chromatography-Mass Spectrometry (GC-MS) analysis. Risk assessment of migrated compounds were calculated and com- pared with Hazard Quito (HQ) standards. Results: The ranges of PA, DEHP, DBP, and TPA were 2.3-26, 171-845, 30-2251, and 24-657 ppb, respectively. DEP was not found in none of the analyzed samples. HQ levels of DEHP, TPA, and DBP were more than 1 in bottled water. Conclusion: In the current study, the concentration of DEHP, TPA, and DBP in some bottled water of Isfahan, Iran were higher than the permitted limits. Also, HQ levels of these three migrated compounds were more than 1 in bottled water that is alarming for public health in this region of Iran.

scholarly journals PENGARUH KEPUASAN, KEPERCAYAAN, DAN KOMITMEN TERHADAP LOYALITAS KONSUMEN TELEKOMUNIKASI

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Arnold Japutra
Keyword(s):  
Key Words ◽  
Cross Sectional Study ◽  
Primary Data ◽  
Sectional Study ◽  
Cross Sectional ◽  
Probability Sampling ◽  
Descriptive Research ◽  
Quantitative Descriptive ◽  
Positive Effect

<p>This research is quantitative descriptive research with cross sectional study. The primary data is obtained from students of a university located in Jakarta Barat. The method of sampling is non probability sampling and the technique is judgmental sampling. The sample consisted of 300 respondent. The result of this research shows that there is a positive effect satisfaction to trust, there is a positive effect on trust to commitment, there is a positive effect commitment to loyalty, there is a positive effect satisfaction to loyalty and there is a positive effect trust to loyalty.</p><p> </p><p>Key Words- Satisfaction, Trust, Commitment, Loyalty</p>

Abstract P107: Differences In Hypercholesterolemia Prevalence Between African Americans And Whites: A Cross-sectional Study Using 2017-2018 National Health And Nutrition Examination Surveys Data

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Omar Sajdeya ◽  
Ruba Sajdeya ◽  
Mohamad B Taha ◽  
Mohammad As Sayaideh ◽  
Osama Dasa
Keyword(s):  
African Americans ◽  
National Health ◽  
Diabetes Education ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Health And Nutrition ◽  
The Mean ◽  
Reduced Risk

Importance: African Americans (AA) have a 20% higher risk of CVD death than Whites. Treating hypercholesterolemia (HC) is paramount in CVD primary prevention. Some evidence showed that AA have a lower risk of HC compared to whites. Methods: A cross-sectional study using the 2017-18 National Health and Nutrition Examination Surveys data. Logistic regression analysis was used to compare the prevalence of diagnosed HC in AA and whites aged 18-80 years old. Serum total cholesterol (TC) and high-density lipoprotein (HDL) levels were compared by multiple linear regression. Results: Among 2549 participants, 51.7% were females, and 63.4% were white. The mean (SD) age was 51.6 (19.1) years. AA had a 24 % reduced risk of HC diagnosis than whites after adjusting for age, Body Mass Index (BMI), diabetes, hypertension, and smoking; OR [95%CI]= 0.767 [0.621, 0.923]. There was no difference in TC level (p=0.7242), while HDL was higher among AA (p<0.0001, β=3.83), adjusting for age, gender, BMI, smoking, diabetes, education level, and use of cholesterol medications. Conclusion: Consistent with some evidence, AA had a lower prevalence of HC diagnosis and higher HDL levels.

The association of maternal dietary folate intake and folic acid supplementation with small-for-gestational-age births: a cross-sectional study in Northwest China

2019 ◽  
Vol 122 (04) ◽  
pp. 459-467 ◽  
Author(s):  
Shanshan Li ◽  
Danmeng Liu ◽  
Ruo Zhang ◽  
Fangliang Lei ◽  
Xin Liu ◽  
...  
Keyword(s):  
Folic Acid ◽  
First Trimester ◽  
Northwest China ◽  
Folic Acid Supplementation ◽  
Cross Sectional Study ◽  
Folate Intake ◽  
Sectional Study ◽  
Cross Sectional ◽  
Dietary Folate ◽  
Reduced Risk

AbstractThe effect of maternal folate intake on small-for-gestational-age (SGA) births remains inconclusive. The present study aimed to investigate the associations of maternal folate intake from diet and supplements with the risk of SGA births using data from a cross-sectional study in Shaanxi Province of Northwest China. A total of 7307 women who were within 12 months (median 3; 10th–90th percentile 0–7) after delivery were included. Two-level models were adopted to examine the associations of folate (dietary folate, supplemental folic acid and total folate) intake with the risk of SGA births and birth weight Z score, controlling for a minimum set of confounders that were identified in a directed acyclic graph. Results showed that a higher supplemental folic acid intake during the first trimester was negatively associated with the risk of SGA births (≤60 d v. non-use: OR 0·80; 95 % CI 0·66, 0·96; &gt;60 d v. non-use: OR 0·78; 95 % CI 0·65, 0·94; Ptrend = 0·010; per 10-d increase: OR 0·97; 95 % CI 0·95, 0·99). A higher total folate intake during pregnancy was associated with a reduced risk of SGA births (highest tertile v. lowest tertile: OR 0·77; 95 % CI 0·64, 0·94; Ptrend = 0·010; per one-unit increase in the log-transformed value: OR 0·81; 95 % CI 0·69, 0·95). A similar pattern was observed for the birth weight Z score. Our study suggested that folic acid supplementation during the first trimester and a higher total folate intake during pregnancy were associated with a reduced risk of SGA births.

scholarly journals Association between thyroid cysts and hypertension by atherosclerosis status: a cross-sectional study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yuji Shimizu ◽  
Shin-Ya Kawashiri ◽  
Yuko Noguchi ◽  
Yasuhiro Nagata ◽  
Takahiro Maeda ◽  
...  
Keyword(s):  
Confounding Factor ◽  
Cross Sectional Study ◽  
Sufficient Evidence ◽  
Clinical Implications ◽  
Inverse Association ◽  
Potential Confounding Factor ◽  
Sectional Study ◽  
Hormone Activity ◽  
Cross Sectional ◽  
Positive Effect

AbstractOur recent studies indicate that thyroid cysts have clinical implications. Thyroid cysts could have a positive effect on the supply of thyroid hormones. Both hyperthyroidism and hypothyroidism cause hypertension. Hypothyroidism, but not hyperthyroidism, is a risk factor for atherosclerosis. Therefore, thyroid cysts could be associated with hypertension, and atherosclerosis might influence the association between thyroid cysts and hypertension. To evaluate the clinical significance of thyroid cysts, a cross-sectional study was conducted with 1801 Japanese aged 40–74 years. Thyroid cysts were significantly positively associated with hypertension in participants without atherosclerosis. However, there was a significant inverse association in those with atherosclerosis. The potential confounding factor adjusted odd ratios and 95% confidence intervals (95% CIs) were 1.49 (95% CI 1.17–1.90) for participants without atherosclerosis and 0.49 (95% CI 0.24–0.98) for those with atherosclerosis. The present study demonstrates that thyroid cysts have clinical implications because thyroid cysts support thyroid hormone activity. Our findings provide sufficient evidence to develop a risk assessment for hypertension for the general population, even though further research is required.

Sign in / Sign up

Export Citation Format

Share Document