scholarly journals User-friendly 3D bioassays with cell-containing hydrogel modules: narrowing the gap between microfluidic bioassays and clinical end-users' needs

Lab on a Chip ◽  
2015 ◽  
Vol 15 (11) ◽  
pp. 2379-2387 ◽  
Author(s):  
Do-Hyun Lee ◽  
Chae Yun Bae ◽  
Seyong Kwon ◽  
Je-Kyun Park

This frontier article reviews recent progress in the development and application of user-friendly 3D bioassay techniques combined with cell-containing hydrogel modules.

10.2196/15146 ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. e15146 ◽  
Author(s):  
Sara Chew ◽  
Pauline Siew Mei Lai ◽  
Chirk Jenn Ng

Background To date, several medication adherence apps have been developed. However, the existing apps have been developed without involving relevant stakeholders and were not subjected to mobile health app guidelines. In addition, the usability and utility of these apps have not been tested with end users. Objective This study aimed to describe the usability and utility testing of a newly developed medication adherence app—Med Assist—among ambulatory care patients in Malaysia. Methods The Med Assist app was developed based on the Theory of Planned Behavior and the Nielson usability model. Beta testing was conducted from March to May 2016 at a primary care clinic in Kuala Lumpur. Ambulatory care patients who scored ≥40% on the electronic health literacy scale, were aged ≥21 years, and were taking two or more long-term medications were recruited. Two rounds of in-depth interviews were conducted with each participant. The first interview, which was conducted upon participant recruitment, was to assess the usability of Med Assist. Participants were asked to download Med Assist on their phone and perform two tasks (register themselves on Med Assist and enter at least one medication). Participants were encouraged to “concurrently think aloud” when using Med Assist, while nonverbal cues were observed and recorded. The participants were then invited for a second interview (conducted ≥7 days after the first interview) to assess the utility of Med Assist after using the app for 1 week. This was done using “retrospective probing” based on a topic guide developed for utilities that could improve medication adherence. Results Usability and utility testing was performed for the Med Assist app (version P4). A total of 13 participants were recruited (6 men, 7 women) for beta testing. Three themes emerged from the usability testing, while three themes emerged from the utility testing. From the usability testing, participants found Med Assist easy to use and user friendly, as they were able to complete the tasks given to them. However, the details required when adding a new medication were found to be confusing despite displaying information in a hierarchical order. Participants who were caregivers as well as patients found the multiple-user support and pill buddy utility useful. This suggests that Med Assist may improve the medication adherence of patients on multiple long-term medications. Conclusions The usability and utility testing of Med Assist with end users made the app more patient centered in ambulatory care. From the usability testing, the overall design and layout of Med Assist were simple and user friendly enough for participants to navigate through the app and add a new medication. From the participants’ perspectives, Med Assist was a useful and reliable tool with the potential to improve medication adherence. In addition, utilities such as multiple user support and a medication refill reminder encouraged improved medication management.


Author(s):  
Federico Cabitza ◽  
Iade Gesso

In the last years, researchers are exploring the feasibility of visual language editors in domain-specific domains where their alleged user-friendliness can be exploited to involve end-users in configuring their artifacts. In this chapter, the authors present an experimental user study conducted to validate the hypothesis that adopting a visual language could help prospective end-users of an electronic medical record define their own document-related local rules. This study allows them to claim that their visual rule editor based on the OpenBlocks framework can be used with no particular training as proficiently as with specific training, and it was found user-friendly by the user panel involved. Although the conclusions of this study cannot be broadly generalized, the findings are a preliminary contribution to show the importance of visual languages in domain-specific rule definition by end-users with no particular IT skills, like medical doctors are supposed to represent.


2007 ◽  
pp. 12-29
Author(s):  
Anette Hallin ◽  
Kristina Lundevall

This chapter presents the mCity Project, a project owned by the City of Stockholm, aiming at creating user-friendly mobile services in collaboration with businesses. Starting from the end-users’ perspective, mCity focuses on how to satisfy existing needs in the community, initiating test pilots within a wide range of areas, from health care and education, to tourism and business. The lesson learned is that user focus creates involvement among end users and leads to the development of sustainable systems that are actually used after they have been implemented. This is naturally vital input not only to municipalities and governments but also for the IT/telecom industry at large. Using the knowledge from mCity, the authors suggest a new, broader de?nition of “m-government” which focuses on mobile people rather than mobile technology.


2020 ◽  
Vol 8 ◽  
Author(s):  
Yoann Bertrand ◽  
Karima Boudaoud ◽  
Michel Riveill

Data leakage can lead to severe issues for a company, including financial loss, damage of goodwill, reputation, lawsuits and loss of future sales. To prevent these problems, a company can use other mechanisms on top of traditional Access Control. These mechanisms include for instance Data Leak Prevention or Information Rights Management and can be referred as Transmission Control. However, such solutions can lack usability and can be intrusive for end-users employees. To have a better understanding of the perception and usage of such mechanisms within business infrastructures, we have conducted in this article an online survey on 150 employees. These employees come from different companies of different sizes and sectors of activity. The results show that whatever the size of the company or its sector of activity, security mechanisms such as access control and transmission control can be considered as quite intrusive and blocking for employees. Moreover, our survey also shows interesting results regarding more acceptable and user-friendly anti-data leakage mechanisms that could be used within companies.


Author(s):  
Sandra Salm ◽  
Judith Mollenhauer ◽  
Carolin Hornbach ◽  
Natalia Cecon ◽  
Antje Dresen ◽  
...  

The aims of this study were (1) to design a user-friendly instrument to assess and optimize patient information material (PIM), (2) to develop an English version, and (3) to test its psychometric properties. The instrument was needed to optimize the top-down developed PIM of the psycho-oncological care programme isPO. First, a literature-based PIM checklist was developed by a team of patient representatives, cancer care experts and professional researchers. Next, the checklist’s reliability and validity were analysed by having cancer survivors assess the initial and optimized version of the isPO-leaflet. The User-friendly Patient Information Material Checklist (UPIM-Check), developed participatorily, was found to be effective for evaluating PIM. It uses a traffic light scale, and suggestions for improvement can be given for each criterion. Its reliability appeared to be excellent (α = 0.927). The optimized leaflet was rated significantly better than the initial one. The UPIM-Check is a reliable and valid instrument, which enables end-users (e.g., patients) to assess and optimize the quality of PIM according to scientific criteria and the needs of end-users. A bottom-up approach was essential for developing and validating the UPIM-Check. End-users constantly contributed with their specific knowledge. Thus, their position as co-researchers was significantly strengthened.


2021 ◽  
Vol 4 ◽  
Author(s):  
Bettina Thalinger ◽  
Kristy Deiner ◽  
Lynsey Harper ◽  
Helen Rees ◽  
Rosetta Blackman ◽  
...  

Environmental DNA (eDNA) analysis utilises trace DNA released by organisms into their environment for species detection and is revolutionising non ‐ invasive species and biodiversity monitoring. However, this technology requires rigorous validation along the whole workflow – from field sampling to statistical analysis – to ensure appropriate and meaningful interpretation of results. Targeted eDNA assays are often validated within a specific system and with particular aims, but without fulfilling predefined criteria. Consequently, their applicability beyond initial development often remains undetermined. Additionally, there tends to be poor understanding of the uncertainties and limitations associated with already published assays and thus potentially inappropriate interpretation of the results they produce. The lack of a “gold standard” limits the incorporation of targeted eDNA assays into species monitoring and policy making by end-users and is therefore key for the future implementation of eDNA-based surveys. Here, we present a framework (https://edna-validation.com/) and user-friendly criteria for the classification of assays, which is based on previous validation efforts. A 5 ‐ level assay validation scale (“incomplete” to “operational”) was defined by reviewing the current eDNA literature and conducting a meta-analysis on sampling, laboratory practices, detection limits, and detection probabilities. The so far published single species eDNA assays were reviewed for their performance in this new framework and we identified steps within the validation process that often remain untouched. Finally, we provide guidance for end ‐ users as to which criteria are most important for validation and suggest how results obtained from assays at different levels of the validation scale should be interpreted.


2008 ◽  
pp. 998-1007
Author(s):  
Panagiotis Kalliaras ◽  
Athanasios-Dimitrios Sotiriou ◽  
P. Papageorgiou ◽  
S. Zoi

This article presents the AVATON system. AVATON aims at providing citizens with ubiquitous user-friendly services, offering personalized, location-aware (GSM Association, 2003), tourism-oriented multimedia information related to the area of the Aegean Volcanic Arc. Towards this end, a uniform architecture is adopted in order to dynamically release the geographic and multimedia content to the end users through enhanced application and network interfaces, targeting different device technologies (mobile phones, PDAs, PCs, and TV sets). Advanced positioning techniques are applied for those mobile user terminals that support them.


2009 ◽  
pp. 3455-3467
Author(s):  
Anette Hallin ◽  
Kristina Lundevall

This chapter presents the mCity Project; a project owned by the City of Stockholm; aiming at creating user-friendly mobile services in collaboration with businesses. Starting from the end-users’ perspective; mCity focuses on how to satisfy existing needs in the community; initiating test pilots within a wide range of areas; from health care and education; to tourism and business. The lesson learned is that user focus creates involvement among end users and leads to the development of sustainable systems that are actually used after they have been implemented. This is naturally vital input not only to municipalities and governments but also for the IT/telecom industry at large. Using the knowledge from mCity; the authors suggest a new; broader definition of “m-government” which focuses on mobile people rather than mobile technology.


Author(s):  
Christophe Giraud-Carrier ◽  
Pavel Brazdil ◽  
Carlos Soares ◽  
Ricardo Vilalta

The application of Machine Learning (ML) and Data Mining (DM) tools to classification and regression tasks has become a standard, not only in research but also in administrative agencies, commerce and industry (e.g., finance, medicine, engineering). Unfortunately, due in part to the number of available techniques and the overall complexity of the process, users facing a new data mining task must generally either resort to trialand- error or consultation of experts. Clearly, neither solution is completely satisfactory for the non-expert end-users who wish to access the technology more directly and cost-effectively. What is needed is an informed search process to reduce the amount of experimentation with different techniques while avoiding the pitfalls of local optima that may result from low quality models. Informed search requires meta-knowledge, that is, knowledge about the performance of those techniques. Metalearning provides a robust, automatic mechanism for building such meta-knowledge. One of the underlying goals of meta-learning is to understand the interaction between the mechanism of learning and the concrete contexts in which that mechanism is applicable. Metalearning differs from base-level learning in the scope of adaptation. Whereas learning at the base-level focuses on accumulating experience on a specific learning task (e.g., credit rating, medical diagnosis, mine-rock discrimination, fraud detection, etc.), learning at the meta-level is concerned with accumulating experience on the performance of multiple applications of a learning system. The meta-knowledge induced by meta-learning provides the means to inform decisions about the precise conditions under which a given algorithm, or sequence of algorithms, is better than others for a given task. While Data Mining software packages (e.g., SAS Enterprise Miner, SPSS Clementine, Insightful Miner, PolyAnalyst, KnowledgeStudio, Weka, Yale, Xelopes) provide user-friendly access to rich collections of algorithms, they generally offer no real decision support to non-expert end-users. Similarly, tools with emphasis on advanced visualization help users understand the data (e.g., to select adequate transformations) and the models (e.g., to tweak parameters, compare results, and focus on specific parts of the model), but treat algorithm selection as a post-processing activity driven by the users rather than the system. Data mining practitioners need systems that guide them by producing explicit advice automatically. This chapter shows how meta-learning can be leveraged to provide such advice in the context of algorithm selection.


2019 ◽  
Vol 23 (2) ◽  
pp. 431-443 ◽  
Author(s):  
Kathryn A. O’Shaughnessy ◽  
Stephen J. Hawkins ◽  
Ally J. Evans ◽  
Mick E. Hanley ◽  
Paul Lunt ◽  
...  

AbstractCoastal urbanisation, energy extraction, food production, shipping and transportation have led to the global proliferation of artificial structures within the coastal and marine environments (sensu “ocean sprawl”), with subsequent loss of natural habitats and biodiversity. To mitigate and compensate impacts of ocean sprawl, the practice of eco-engineering of artificial structures has been developed over the past decade. Eco-engineering aims to create sustainable ecosystems that integrate human society with the natural environment for the benefit of both. The science of eco-engineering has grown markedly, yet synthesis of research into a user-friendly and practitioner-focused format is lacking. Feedback from stakeholders has repeatedly stated that a “photo user guide” or “manual” covering the range of eco-engineering options available for artificial structures would be beneficial. However, a detailed and structured “user guide” for eco-engineering in coastal and marine environments is not yet possible; therefore we present an accessible review and catalogue of trialled eco-engineering options and a summary of guidance for a range of different structures tailored for stakeholders and end-users as the first step towards a structured manual. This work can thus serve as a potential template for future eco-engineering guides. Here we provide suggestions for potential eco-engineering designs to enhance biodiversity and ecosystem functioning and services of coastal artificial structures with the following structures covered: (1) rock revetment, breakwaters and groynes composed of armour stones or concrete units; (2) vertical and sloping seawalls; (3) over-water structures (i.e., piers) and associated support structures; and (4) tidal river walls.


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