A microfluidic device for the batch adsorption of a protein on adsorbent particles

The Analyst ◽  
2017 ◽  
Vol 142 (19) ◽  
pp. 3656-3665 ◽  
Author(s):  
Hoon Suk Rho ◽  
Alexander Thomas Hanke ◽  
Marcel Ottens ◽  
Han Gardeniers
Keyword(s):  
Adsorption Isotherm ◽  
Microfluidic Device ◽  
Batch Adsorption ◽  
Single Experiment ◽  
Microfluidic Platform

A microfluidic platform or “microfluidic batch adsorption device” is presented, which performs two sets of 9 parallel protein incubations with/without adsorbent particles to achieve an adsorption isotherm of a protein in a single experiment.

scholarly journals Adsorption of Phenol from Aqueous Solution Using Activated Carbon prepared from Coconut Shell

2017 ◽  
Vol 29 (1) ◽  
pp. 9-13
Author(s):  
Masuma Sultana Ripa ◽  
Rafat Mahmood ◽  
Sabrina Khan ◽  
Easir A Khan
Keyword(s):  
Aqueous Solution ◽  
Activated Carbon ◽  
Adsorption Isotherm ◽  
Iodine Number ◽  
Chemical Engineering ◽  
Coconut Shell ◽  
Physical Activation ◽  
Batch Adsorption ◽  
Adsorption Model ◽  
Solution Ph

Adsorption separation of phenol from aqueous solution using activated carbon was investigated in this work. The adsorbent was prepared from coconut shell and activated by physical activation method. The coconut shell was first carbonized at 800°C under nitrogen atmosphere and activated by CO2 at the same temperature for one hour. The prepared activated carbon was characterized by Scanning Electron Microscope (SEM) and BET Surface Analyzer and by the determination of iodine number as well as Boehm titration. The iodine number indicates the degree of relative activation of the adsorbent. The equilibrium adsorption isotherm phenol from aqueous solution was performed using liquid phase batch adsorption experiments. The effect of experimental parameters including solution pH, agitation time, particle size, temperature and initial concentration was investigated. The equilibrium data was analyzed using Langmuir and Freundlich adsorption model to describe the adsorption isotherm and estimate the adsorption isotherm parameters. The results indicate the potential use of the adsorbent for removal of phenol from the aqueous solution.Journal of Chemical Engineering, Vol. 29, No. 1, 2017: 9-13

scholarly journals Microfluidic on-demand droplet generation, storage, retrieval, and merging for single-cell pairing

Lab on a Chip ◽  
2019 ◽  
Vol 19 (3) ◽  
pp. 493-502 ◽  
Author(s):  
Hesam Babahosseini ◽  
Tom Misteli ◽  
Don L. DeVoe
Keyword(s):  
Single Cell ◽  
Aqueous Phase ◽  
Microfluidic Device ◽  
Droplet Generation ◽  
Microfluidic Platform ◽  
On Demand

A multifunctional microfluidic platform combining on-demand aqueous-phase droplet generation, multi-droplet storage, and controlled merging of droplets selected from a storage library in a single integrated microfluidic device is described.

scholarly journals Ultrasensitive multi-species detection of CRISPR-Cas9 by a portable centrifugal microfluidic platform

2019 ◽  
Vol 11 (5) ◽  
pp. 559-565 ◽  
Author(s):  
Christopher R. Phaneuf ◽  
Kyle J. Seamon ◽  
Tyler P. Eckles ◽  
Anchal Sinha ◽  
Joseph S. Schoeniger ◽  
...  
Keyword(s):  
Sample Preparation ◽  
Microfluidic Device ◽  
Clinical Sample ◽  
Microfluidic Platform ◽  
Species Detection

Combined activity- and immunoassays for CRISPR/Cas9 on a portable microfluidic device with integrated sample preparation from clinical sample matrices.

scholarly journals A Textile-Based Microfluidic Platform for the Detection of Cytostatic Drug Concentration in Sweat Samples

2020 ◽  
Vol 10 (12) ◽  
pp. 4392 ◽  
Author(s):  
Goran M. Stojanović ◽  
Maja M. Radetić ◽  
Zoran V. Šaponjić ◽  
Marija B. Radoičić ◽  
Milan R. Radovanović ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Cost Effective ◽  
Electrical Contacts ◽  
Cytostatic Drug ◽  
Variable Resistor ◽  
Microfluidic Platform ◽  
Textile Fabrics ◽  
Drug Concentrations ◽  
Artificial Sweat ◽  
Conductive Textile

This work presents a new multilayered microfluidic platform, manufactured using a rapid and cost-effective xurography technique, for the detection of drug concentrations in sweat. Textile fabrics made of cotton and polyester were used as a component of the platform, and they were positioned in the middle of the microfluidic device. In order to obtain a highly conductive textile, the fabrics were in situ coated with different amounts of polyaniline and titanium dioxide nanocomposite. This portable microfluidic platform comprises at least three layers of optically transparent and flexible PVC foils which were stacked one on top of the other. Electrical contacts were provided from the edge of the textile material when a microfluidic variable resistor was actually created. The platform was tested in plain artificial sweat and in artificial sweat with a dissolved cytostatic test drug, cyclophosphamide, of different concentrations. The proposed microfluidic device decreased in resistance when the sweat was applied. In addition, it could successfully detect different concentrations of cytostatic medication in the sweat, which could make it a very useful tool for simple, reliable, and fast diagnostics.

scholarly journals Fabrication of Highly Porous Polymeric Nanocomposite for the Removal of Radioactive U(VI) and Eu(III) Ions from Aqueous Solution

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2940
Author(s):  
Tansir Ahamad ◽  
Mu. Naushad ◽  
Mohd Ubaidullah ◽  
Saad Alshehri
Keyword(s):  
Adsorption Isotherm ◽  
Adsorption Capacity ◽  
Adsorption Kinetics ◽  
Water Solution ◽  
High Surface ◽  
Basic Medium ◽  
Batch Adsorption ◽  
Regeneration Ability ◽  
Contaminated Water ◽  
Polymeric Nanocomposite

In the present study, a polymeric nanocomposite, CoFe2O4@DHBF, was fabricated using 2,4 dihydroxybenzaldehyde and formaldehyde in basic medium with CoFe2O4 nanoparticles. The fabricated nanocomposite was characterized using FTIR, TGA, XRD, SEM, TEM, and XPS analyses. The analytical results revealed that the magnetic nanocomposite was fabricated successfully with high surface area 370.24 m2/g. The fabricated CoFe2O4@DHBF was used as an efficient adsorbent for the adsorption of U(VI) and Eu(III) ions from contaminated water. pH, initial concentration, adsorption time, and the temperature of the contaminated water solution affecting the adsorption ability of the nanocomposites were studied. The batch adsorption results exposed that the adsorption capacity for the removal of U(VI) and Eu(III) was found to be 237.5 and 225.5 mg/g. The adsorption kinetics support that both the metal ions follow second order adsorption kinetics. The adsorption isotherm well fits with the Langmuir adsorption isotherm and the correlation coefficient (R2) values were found to be 0.9920 and 0.9913 for the adsorption of U(VI) and Eu(III), respectively. It was noticed that the fabricated nanocomposites show excellent regeneration ability and about 220.1 and 211.3 mg/g adsorption capacity remains with U(VI) and Eu(III) under optimum conditions.

scholarly journals A droplet microfluidic platform for efficient enzymatic chromatin digestion enables robust determination of nucleosome positioning

Lab on a Chip ◽  
2018 ◽  
Vol 18 (17) ◽  
pp. 2583-2592 ◽  
Author(s):  
Yi Xu ◽  
Jeong-Heon Lee ◽  
Zhaoyu Li ◽  
Liguo Wang ◽  
Tamas Ordog ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Nucleosome Positioning ◽  
Microfluidic Platform

A microfluidic device was designed to efficiently fragment chromatin for downstream epigenetic assays.

scholarly journals Hydrogel-droplet microfluidic platform for high-resolution imaging and sorting of early larval Caenorhabditis elegans

Lab on a Chip ◽  
2015 ◽  
Vol 15 (6) ◽  
pp. 1424-1431 ◽  
Author(s):  
Guillaume Aubry ◽  
Mei Zhan ◽  
Hang Lu
Keyword(s):  
Caenorhabditis Elegans ◽  
High Resolution ◽  
Microfluidic Device ◽  
High Resolution Imaging ◽  
Microfluidic Platform ◽  
C Elegans ◽  
Resolution Imaging

We present a microfluidic device for high-resolution imaging and sorting of early larval C. elegans. The animals are isolated in droplets and temporarily immobilized for imaging using a reversible hydrogel.

A hydrogel sensor-based microfluidic platform for the quantitative and multiplexed detection of fertility markers for point-of-care immunoassays

2019 ◽  
Vol 11 (12) ◽  
pp. 1639-1650 ◽  
Author(s):  
Satish Kalme ◽  
Srinivasan Kandaswamy ◽  
Anusha Chandrasekharmath ◽  
Reeta Katiyar ◽  
Gokul Prasath Rajamanickam ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Point Of Care ◽  
Microfluidic Platform ◽  
Multiplexed Detection ◽  
Hydrogel Particle ◽  
Multiplexed Immunoassay ◽  
Porous Hydrogel

We report a new point-of-care, multiplexed immunoassay platform based on 3D porous hydrogel particle sensors embedded into a plastic microfluidic device.

A droplet-to-digital (D2D) microfluidic device for single cell assays

Lab on a Chip ◽  
2015 ◽  
Vol 15 (1) ◽  
pp. 225-236 ◽  
Author(s):  
Steve C. C. Shih ◽  
Philip C. Gach ◽  
Jess Sustarich ◽  
Blake A. Simmons ◽  
Paul D. Adams ◽  
...  
Keyword(s):  
Single Cell ◽  
Microfluidic Device ◽  
Digital Microfluidics ◽  
Microfluidic Platform ◽  
Cell Assays ◽  
Digital Microfluidic

We have developed a new hybrid droplet-to-digital microfluidic platform (D2D) that integrates droplet-in-channel microfluidics with digital microfluidics for performing multi-step single cell assays.

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