Proanthocyanidin-crosslinked collagen/konjac glucomannan hydrogel with improved mechanical properties and MRI trackable biodegradation for potential tissue engineering scaffolds

2020 ◽  
Vol 8 (2) ◽  
pp. 316-331 ◽  
Author(s):  
Jinlin Chen ◽  
Zhongyuan Cai ◽  
Qingrong Wei ◽  
Dan Wang ◽  
Jun Wu ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Konjac Glucomannan ◽  
Tissue Engineering Scaffolds ◽  
Hydrogel Scaffold ◽  
Non Invasive ◽  
Natural Components

Integration of various qualities of excellent biocompatibility, improved mechanical properties, tailored biodegradation and functional bioactivities into a collagen-based hydrogel scaffold with all natural components, monitored by non-invasive MRI.

A novel biocompatible double network hydrogel consisting of konjac glucomannan with high mechanical strength and ability to be freely shaped

2015 ◽  
Vol 3 (9) ◽  
pp. 1769-1778 ◽  
Author(s):  
Zhiyong Li ◽  
Yunlan Su ◽  
Baoquan Xie ◽  
Xianggui Liu ◽  
Xia Gao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Cell Adhesion ◽  
Mechanical Strength ◽  
Synthetic Polymer ◽  
Natural Polymer ◽  
Tissue Engineering Scaffolds ◽  
Adhesion Properties ◽  
High Mechanical Strength ◽  
Double Network

A novel physically linked double-network (DN) hydrogel was prepared by natural polymer KGM and synthetic polymer PAAm. The DN hydrogels exhibit good mechanical properties, cell adhesion properties, and can be freely shaped, making such hydrogels promising for tissue engineering scaffolds.

Microcellular Injection Molding of Thermoplastic Polyurethane (TPU) Scaffolds Using Carbon Dioxide and Water as Co-Blowing Agents

2013 ◽  
Author(s):  
Hao-Yang Mi ◽  
Xin Jing ◽  
Lih-Sheng Turng ◽  
Xiang-Fang Peng
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Thermoplastic Polyurethane ◽  
Dynamic Mechanical Properties ◽  
Skin Layer ◽  
Tissue Engineering Scaffolds ◽  
Blowing Agents ◽  
Microcellular Injection Molding ◽  
Noticeable Reduction ◽  
Free Transport

In this study, a novel microcellular injection foaming method employing supercritical CO2 (scCO2) and water as co-blowing agents was developed to produce thermoplastic polyurethane (TPU) tissue engineering scaffolds with a uniform porous structure and no solid skin layer. Various characterization techniques were applied to investigate the cell morphology, crystallization behavior, and static and dynamic mechanical properties of solid molded samples, foamed samples using CO2 or water as a single blowing agent, and foamed samples using both CO2 and water as co-blowing agents. Compared with CO2 foamed scaffolds, scaffolds produced by the co-blowing method exhibit much more uniform cell morphologies without a noticeable reduction in mechanical properties. Moreover, these TPU scaffolds have almost no skin layer, which permits free transport of nutrients and waste throughout the samples, which is highly desirable in tissue engineering. The effect of these blowing agents on the shear viscosity of various samples is also reported.

Microscopic Methods for Characterization of Selected Surface Properties of Biodegradable, Nanofibrous Tissue Engineering Scaffolds

2017 ◽  
Vol 890 ◽  
pp. 213-216 ◽  
Author(s):  
Adrian Chlanda ◽  
Ewa Kijeńska ◽  
Wojciech Święszkowski
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Young’S Modulus ◽  
Young's Modulus ◽  
Force Spectroscopy ◽  
Operating Mode ◽  
Tissue Engineering Scaffolds ◽  
Force Microscopy ◽  
Atomic Force

Biodegradable polymeric fibers with nanoand submicron diameters, produced by electrospinning can be used as scaffolds in tissue engineering. It is necessary to characterize their mechanical properties especially at the nanoscale. The Force Spectroscopy is suitable atomic force microscopy mode, which allows to probe mechanical properties of the material, such as: reduced Young's modulus, deformation, adhesion, and dissipation. If combined with standard operating mode: contact or semicontact, it will also provide advanced topographical analysis. In this paper we are presenting results of Force Spectroscopy characterization of two kinds of electrospun fibers: polycaprolactone and polycaprolactone with hydroxyapatite addition. The average calculated from Johnson-Kendall-Roberts theory Young's modulus was 4 ± 1 MPa for pure polymer mesh and 20 ± 3 MPa for composite mesh.

A Brief Review of the Modelling of the Time Dependent Mechanical Properties of Tissue Engineering Scaffolds

2010 ◽  
Vol 6 ◽  
pp. 19-33 ◽  
Author(s):  
N.K. Bawolin ◽  
W.J. Zhang ◽  
Xiong Biao Chen
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Treatment Process ◽  
Effective Properties ◽  
Critical Role ◽  
Time Dependent ◽  
Tissue Engineering Scaffolds ◽  
Wide Range ◽  
Scaffold Degradation

The functionality of tissue scaffolds in vivo plays a critical role in the treatment process. Due to the time dependent nature of the mechanical properties of the constituent phases of the scaffold, a wide range of mechanical property histories may be observed during the treatment process, possibly influencing outcomes. The critical nature of the mechanical properties in load bearing applications indicates a need for the simultaneous modelling of both scaffold degradation and tissue regeneration with time, and the resulting effective properties of the tissue engineering construct. To this end, a review of the literature is conducted to identify the various existing approaches to modelling scaffold degradation, tissue behavior, and the dependency of the two processes on one another.

scholarly journals Fabrication and Characterization of the Core-Shell Structure of Poly(3-Hydroxybutyrate-4-Hydroxybutyrate) Nanofiber Scaffolds

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Wentai Guo ◽  
Zifeng Yang ◽  
Xiusen Qin ◽  
Yingqi Wei ◽  
Chuangkun Li ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Tissue Repair ◽  
Composite Scaffold ◽  
Testing Machine ◽  
Measuring System ◽  
Core Shell ◽  
Tissue Engineering Scaffolds ◽  
Biomedical Fields

Tissue engineering scaffolds with nanofibrous structures provide positive support for cell proliferation and differentiation in biomedical fields. These scaffolds are widely used for defective tissue repair and drug delivery. However, the degradation performance and mechanical properties of scaffolds are often unsatisfactory. Here, we successfully prepared a novel poly(3-hydroxybutyrate-4-hydroxybutyrate)/polypyrrole (P34HB-PPy) core-shell nanofiber structure scaffold with electrospinning and in situ surface polymerization technology. The obtained composite scaffold showed good mechanical properties, hydrophilicity, and thermal stability based on the universal material testing machine, contact angle measuring system, thermogravimetric analyzer, and other methods. The results of the in vitro bone marrow-derived mesenchymal stem cells (BMSCs) culture showed that the P34HB-PPy composite scaffold effectively mimicked the extracellular matrix (ECM) and exhibited good cell retention and proliferative capacity. More importantly, P34HB is a controllable degradable polyester material, and its degradation product 3-hydroxybutyric acid (3-HB) is an energy metabolite that can promote cell growth and proliferation. These results strongly support the application potential of P34HB-PPy composite scaffolds in biomedical fields, such as tissue engineering and soft tissue repair.

Sign in / Sign up

Export Citation Format

Share Document