Binary Dimeric Prodrug Nanoparticles for Self-Boosted Drug Release and Synergistic Chemo-Photodynamic Therapy

2022 ◽  
Author(s):  
Youwei Zhang ◽  
Qing Pei ◽  
Ying Yue ◽  
Zhigang Xie
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Drug Release ◽  
Clinical Performance ◽  
Therapeutic Efficiency ◽  
Normal Tissues ◽  
Carrier Free

Chemotherapy is the major strategy for cancer therapy, but its limited therapeutic efficiency and serious toxicity to normal tissues greatly restrict its clinical performance. Herein, we develop carrier-free self-activated prodrug...

scholarly journals Multifunctional Cargo-Free Nanomedicine for Cancer Therapy

2018 ◽  
Vol 19 (10) ◽  
pp. 2963 ◽  
Author(s):  
Ying Wang ◽  
Pengfei Yang ◽  
Xinrui Zhao ◽  
Di Gao ◽  
Na Sun ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Cancer Therapy ◽  
Drug Release ◽  
Combination Therapy ◽  
Cancer Treatment ◽  
Clinical Applications ◽  
Self Monitoring ◽  
Promising Strategy ◽  
Carrier Free ◽  
Future Challenges

Nanocarriers encapsulating multiple chemotherapeutics are a promising strategy to achieve combinational chemotherapy for cancer therapy; however, they generally use exotic new carriers without therapeutic effect, which usually suffer from carrier-related toxicity issues, as well as having to pass extensive clinical trials to be drug excipients before any clinical applications. Cargo-free nanomedicines, which are fabricated by drugs themselves without new excipients and possess nanoscale characteristics to realize favorable pharmacokinetics and intracellular delivery, have been rapidly developed and drawn much attention to cancer treatment. Herein, we discuss recent advances of cargo-free nanomedicines for cancer treatment. After a brief introduction to the major types of carrier-free nanomedicine, some representative applications of these cargo-free nanomedicines are discussed, including combination therapy, immunotherapy, as well as self-monitoring of drug release. More importantly, this review draws a brief conclusion and discusses the future challenges of cargo-free nanomedicines from our perspective.

Photodynamic therapy-mediated remote control of chemotherapy toward synergistic anticancer treatment

Nanoscale ◽  
2018 ◽  
Vol 10 (30) ◽  
pp. 14554-14562 ◽  
Author(s):  
Yongjuan Li ◽  
Shixian Lv ◽  
Ziyuan Song ◽  
Juanjuan Dang ◽  
Xudong Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Remote Control ◽  
Cancer Therapy ◽  
Drug Release ◽  
Stimuli Responsive ◽  
On Demand ◽  
Release Property ◽  
Anticancer Treatment

Stimuli-responsive nanomedicine (NM) with an on-demand drug release property has demonstrated promising utility toward cancer therapy.

Red and NIR Light-Responsive Polymeric Nanocarriers for On-Demand Drug Delivery

2020 ◽  
Vol 27 (23) ◽  
pp. 3877-3887
Author(s):  
Xinyu He ◽  
Xianzhu Yang ◽  
Dongdong Li ◽  
Ziyang Cao
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Drug Uptake ◽  
Design Strategies ◽  
Polymeric Nanocarriers ◽  
Normal Tissues ◽  
On Demand ◽  
Nir Light

Red and NIR light-responsive polymeric nanocarriers capable of on-demand drug delivery have gained tremendous attention for their great potential in cancer therapy. Various strategies have been applied to fabricate such nanocarriers, and they have demonstrated significant therapeutic efficacy and minimal toxicity to normal tissues. Here, we will review the current developments in various red and NIR light-responsive polymeric nanocarriers with respect to their use in on-demand drug delivery, including facilitation of drug internalization and boosting of drug release at targeted sites. We summarize their components and design strategies, and highlight the mechanisms by which the photoactivatable variations enhance drug uptake and drug release. We attempt to provide new insights into the fabrication of red and NIR light-responsive polymeric nanocarriers for on-demand drug delivery.

Tumor pH-triggered “charge conversion” nanocarriers with on-demand drug release for precise cancer therapy

2020 ◽  
Vol 8 (40) ◽  
pp. 9351-9361
Author(s):  
Bo-Ai Ma ◽  
Chun-Yang Sun
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Drug Release ◽  
X Ray ◽  
On Demand ◽  
Tumor Ph

The pHe-triggered “charge conversion” nanocarriers were developed for combined X-ray-induced photodynamic therapy (X-PDT) and hypoxia-activated chemotherapy.

A self-assembled carrier-free nanosonosensitizer for photoacoustic imaging-guided synergistic chemo–sonodynamic cancer therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 5587-5600 ◽  
Author(s):  
Caihong Dong ◽  
Qvzi Jiang ◽  
Xiaoqin Qian ◽  
Wencheng Wu ◽  
Wenping Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Photoacoustic Imaging ◽  
Sonodynamic Therapy ◽  
Carrier Free ◽  
Self Assembled

Nanosonosensitizer, Ce6-PTX@IR783, successfully realized the photoacoustic imaging-guided synergistic chemo–sonodynamic therapy with ultrasound-trigged controllable drug release and acquired high therapeutic efficacy for cancer.

Advances in the Application of Injectable Thermosensitive Hydrogel Systems for Cancer Therapy

2020 ◽  
Vol 16 (10) ◽  
pp. 1427-1453
Author(s):  
Bingxin Xue ◽  
Ying Qu ◽  
Kun Shi ◽  
Kai Zhou ◽  
Xinlong He ◽  
...  
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Therapeutic Agents ◽  
Local Drug Delivery ◽  
Sustained Drug Release ◽  
Thermosensitive Hydrogel ◽  
Therapeutic Efficiency ◽  
Normal Tissues ◽  
Thermosensitive Hydrogels ◽  
Systemic Side Effects

Systemic administration of anticancer therapeutic agents remains a crucial strategy for clinical cancer therapy. However, poor drug accumulation at tumor sites and severe side effects to normal tissues induced by off-target effects lower their therapeutic efficiency and limit their deep application in clinical settings. How to overcome these issues has continuously raised concerns. Reportedly, injectable thermosensitive hydrogels are good carriers for local drug delivery systems, demonstrating a flowable and injectable sol state at room temperature, easily loading therapeutic agents with large loading contents. Under normal body temperature, these hydrogels are stimulated to undergo a phase transition to an immobile gel state, which serves as a drug reservoir at local injection sites. After intratumoral or peritumoral injection, the localized hydrogel reservoir shows a slow and sustained drug release behavior, and can also targeted deliver therapeutic agents to cancer cells instead of normal cells, improving the therapeutic efficiency and reducing systemic side effects. This review summarizes the development of injectable thermosensitive hydrogel systems, reviews the research application advances of these systems in different therapy strategies for cancer, discusses the present issues and awaits their future in clinical applications.

Expanding the Biotherapeutics Realm via miR-34a: “Potent Clever Little” Agent in Breast Cancer Therapy

2019 ◽  
Vol 20 (8) ◽  
pp. 665-673 ◽  
Author(s):  
Mohsen Mohammady ◽  
Seyed I. Ghetmiri ◽  
Mahtab Baharizade ◽  
Mohammad H. Morowvat ◽  
Susan Torabi
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Tumor Suppressor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Signal Pathways ◽  
Breast Cancer Therapy ◽  
Female Population ◽  
Therapeutic Goals ◽  
Normal Tissues

Background:One of the most prevalent cancers befell to women is considered to be breast cancer (BC). It is also the deadliest among the female population after lung cancer. Additionally, several studies have demonstrated that there is an association between microRNA34-a and breast cancer.Method:We searched PubMed, Web of Science, and Google Scholar up to December 2018. Those studies which have been studied miR-34a and its tumor-suppressing capabilities were considered as the most important topics. Moreover, we extracted articles which were solely focused on microRNA-34a in breast cancer therapy. Finally, 80 articles were included.Results:In comparison with the normal tissues, down-regulation of miR-34a expression is shown considerably in tumor cells. Overexpression of miR-34a acts as a tumor suppressor by transcriptional regulating one of the signaling pathways (TP53), NOTCH, and transforming growth factor beta (TGF-β), Bcl- 2 and SIRT1genes, HDAC1 and HDAC7, Fra-1, TPD52, TLR Via CXCL10. Moreover, drug resistance declines which lead to the apoptosis, cell cycle arrest and senescence. As a result, the proliferation, invasion and metastasis of the tumor are suppressed. The Mrx34 drug contains miR-34a mimic and a lipid vector. MiR-34a as the active ingredient portrays the role of a tumor suppressor. This drug has recently entered the clinical trials studies.Conclusion:These findings suggest a robust cause for developing miR-34a as a therapeutic agent to target BC. In that scenario, miR-34a is strongly useful to introduce new therapeutic goals for BC. Moreover, this review aims to confirm the signal pathways, therapeutic and diagnostic values of miR- 34a in BC and beyond.

The Smart Dual-Stimuli Responsive Nanoparticles for Controlled AntiTumor Drug Release and Cancer Therapy

2020 ◽  
Vol 20 ◽  
Author(s):  
Feng Wu ◽  
Fei Qiu ◽  
Siew Anthony Wai-Keong ◽  
Yong Diao
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Targeted Delivery ◽  
Relevant Information ◽  
Therapeutic Effects ◽  
Stimuli Responsive ◽  
Control Effect ◽  
Chemotherapy Drugs ◽  
Excellent Control

Background: In recent years, the emergence of stimuli-responsive nanoparticles makes drug delivery more efficient. As an intelligent and effective targeted delivery platform, it can reduce the side effects generated during drug transportation while enhancing the treatment efficacy. The stimuli-responsive nanoparticles can respond to different stimuli at corresponding times and locations to deliver and release their drugs and associated therapeutic effects. Objective: This review aims to inform researchers on the latest advances in the application of dual-stimuli responsive nanoparticles in precise drug delivery, with special attention to their design, drug release properties, and therapeutic effects. Syntheses of nanoparticles with simultaneous or sequential responses to two or more stimuli (pH-redox, pH-light, redoxlight, temperature-magnetic, pH-redox-temperature, redox-enzyme-light, etc.) and the applications of such responsivity properties for drugs control and release have become a hot topic of recent research. Methods: A database of relevant information for the production of this review was sourced, screened and analyzed from Pubmed, Web of Science, SciFinder by searching for the following keywords: “dual-stimuli responsive”, “controlled release”, “cancer therapy”, “synergistic treatment”. Results: Notably, the nanoparticles with dual-stimuli responsive function have an excellent control effect on drug delivery and release, playing a crucial part in the treatment of tumors. They can improve the encapsulation and delivery efficiency of hydrophobic chemotherapy drugs, combine chemo-photothermal therapies, apply imaging function in the diagnosis of tumors and even conduct multi-drugs delivery to overcome multi-drugs resistance (MDR). Conclusion: With the development of smart dual-stimuli responsive nanoparticles, cancer treatment methods will become more diverse and effective. All the stimuli-responsive nanoparticles functionalities exhibited their characteristics individually within the single nanosystem.

scholarly journals Precisely Engineering a Carrier-free Hybrid Nanoassembly for Multimodal DNA Damage-augmented Photodynamic Therapy

2021 ◽  
pp. 130838
Author(s):  
Shumeng Li ◽  
Fujun Yang ◽  
Xinxin Sun ◽  
Yuequan Wang ◽  
Xuanbo Zhang ◽  
...  
Keyword(s):  
Dna Damage ◽  
Photodynamic Therapy ◽  
Carrier Free

scholarly journals Combining Dextran Conjugates with Stimuli-Responsive and Folate-Targeting Activity: A New Class of Multifunctional Nanoparticles for Cancer Therapy

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1108
Author(s):  
Manuela Curcio ◽  
Alessandro Paolì ◽  
Giuseppe Cirillo ◽  
Sebastiano Di Pietro ◽  
Martina Forestiero ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Metastatic Cancer ◽  
Stimuli Responsive ◽  
Cancer Disease ◽  
New Class ◽  
Self Assembling ◽  
Redox Responsive ◽  
Potential Applicability ◽  
Mean Size

Nanoparticles with active-targeting and stimuli-responsive behavior are a promising class of engineered materials able to recognize the site of cancer disease, targeting the drug release and limiting side effects in the healthy organs. In this work, new dual pH/redox-responsive nanoparticles with affinity for folate receptors were prepared by the combination of two amphiphilic dextran (DEX) derivatives. DEXFA conjugate was obtained by covalent coupling of the polysaccharide with folic acid (FA), whereas DEXssPEGCOOH derived from a reductive amination step of DEX was followed by condensation with polyethylene glycol 600. After self-assembling, nanoparticles with a mean size of 50 nm, able to be destabilized in acidic pH and reducing media, were obtained. Doxorubicin was loaded during the self-assembling process, and the release experiments showed the ability of the proposed system to modulate the drug release in response to different pH and redox conditions. Finally, the viability and uptake experiments on healthy (MCF-10A) and metastatic cancer (MDA-MB-231) cells proved the potential applicability of the proposed system as a new drug vector in cancer therapy.

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