scholarly journals Targeted proteolytic products of τ and α-synuclein in neurodegeneration

2021 ◽  
Author(s):  
Yuxing Xia ◽  
Grace M. Lloyd ◽  
Benoit I. Giasson
Keyword(s):  
Cerebrospinal Fluid ◽  
Neurodegenerative Diseases ◽  
Protein Aggregation ◽  
Future Development ◽  
Proteolytic Cleavage ◽  
Therapeutic Interventions ◽  
The Future ◽  
Proteolytic Activities

Abstract CNS pathological inclusions comprising τ or α-synuclein (αSyn) define a spectrum of neurodegenerative diseases, and these can often present concurrently in the same individuals. The aggregation of both proteins is clearly associated with neurodegeneration and the deleterious properties of each protein is further supported by mutations in each gene (MAPT and SNCA, respectively) resulting in disease. The initiating events in most sporadic neurodegenerative diseases are still unclear but growing evidence suggests that the aberrant proteolytic cleavage of τ and αSyn results in products that can be toxic and/or initiate aggregation that can further spread by a prion-like mechanism. The accumulation of some of these cleavage products can further potentiate the progression of protein aggregation transmission and lead to their accumulation in peripheral biofluids such as cerebrospinal fluid (CSF) and blood. The future development of new tools to detect specific τ and αSyn abnormal cleavage products in peripheral biofluids could be useful biomarkers and better understand of the role of unique proteolytic activities could yield therapeutic interventions.

scholarly journals Anti-Human Trafficking Campaigns

2018 ◽  
Vol 24 (2) ◽  
pp. 104-122 ◽  
Author(s):  
Natalia Szablewska ◽  
Krzysztof Kubacki
Keyword(s):  
Literature Review ◽  
Human Trafficking ◽  
Social Marketing ◽  
Systematic Literature Review ◽  
Thematic Analysis ◽  
Future Development ◽  
Evidence Base ◽  
Vulnerable Groups ◽  
The Future

This study aims to systematically identify and review studies on anti-human trafficking campaigns published in peer-reviewed journals to determine the extent to which such campaigns have been critically and rigorously evaluated so as to guide future policies and practice in this area and to identify the main characteristics, problems, and challenges associated with the campaigns in the identified studies. This systematic literature review identified 16 studies that have assessed anti-human trafficking campaigns but found that none of these included outcome, process, or impact evaluations. As identified in our study, anti-human trafficking campaigns tend to rely on advertising techniques to target vulnerable groups and the wider public, with the primary aim of informing and educating. Further, a thematic analysis of the studies identified problems in eight areas that require attention in the future development of anti-human trafficking campaigns: stereotyping, compounding human trafficking with migration, conflating prostitution with human trafficking, sexualization/erotization of women, victimization, role of anti-human trafficking organizations, data shortcomings, and oversimplification of human trafficking. Studies presenting the results of evaluations of social marketing anti-human trafficking campaigns are urgently needed to show which social marketing tools work and to provide an evidence base for future campaigns.

The future development of bacteria fighting medical devices: the role of graphene oxide

2016 ◽  
Vol 13 (11) ◽  
pp. 1013-1019 ◽  
Author(s):  
Valentina Palmieri ◽  
Massimiliano Papi ◽  
Claudio Conti ◽  
Gabriele Ciasca ◽  
Giuseppe Maulucci ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Medical Devices ◽  
Future Development ◽  
The Future

scholarly journals COMPETITIVENESS OF BULGARIAN ORGANIC PRODUCTS

2019 ◽  
Vol 17 (Suppl.1) ◽  
Author(s):  
Georgi Aleksiev
Keyword(s):  
Future Development ◽  
Agricultural Sector ◽  
Internal Market ◽  
Domestic Market ◽  
Competitive Position ◽  
Export Orientation ◽  
Organic Products ◽  
The Future

The production of organic products in Bulgaria is constantly growing and the role of this type of production in the development of the agricultural sector cannot be ignored. Bulgarian bio-products have an export orientation and a very small part are traded in the domestic market, which also determines the importance of their competitiveness for the future development of the sector. The purpose of this study is to analyze the competitive position of Bulgarian bio-products. In order to achieve its goal, the research has to solve the following tasks: to analyze the trade with organic products in Bulgaria; to evaluate the potential for development of trade in bio-products in the internal market; to evaluate the competitiveness of Bulgarian organic products.

scholarly journals THE ROLE OF EMBROIDERY AND HOME WORK IN THE DEVELOPMENT OF ENTREPRENEURSHIP IN UZBEKISTAN

2021 ◽  
Vol 02 (05) ◽  
pp. 93-97
Author(s):  
Nilufar Mustaqimovna Rakhmatova ◽  
Keyword(s):  
Future Development ◽  
Social Conditions ◽  
Domestic Labor ◽  
Domestic Production ◽  
Self Employment ◽  
Home Work ◽  
The Future ◽  
The Creation

This article discusses the creation of favorable economic and social conditions for the revival of forgotten traditional handicrafts in Uzbekistan in recent years and the future development of its surviving varieties. In the Soviet era, domestic labor was initially opposed for political and ideological reasons, but later, under the notion of “self-employment,” domestic production was not strongly opposed, but not enough attention was paid to its development.

8 The Exclusive Economic Zone

2015 ◽  
Author(s):  
Andreone Gemma
Keyword(s):  
United Nations ◽  
International Law ◽  
Future Development ◽  
Controversial Issue ◽  
Exclusive Economic Zone ◽  
Law Of The Sea ◽  
Legal Regime ◽  
The Future ◽  
United Nations Convention

The role of the Economic Exclusive Zone (EEZ) in the international law of the sea remains a controversial issue two decades after the 1982 United Nations Convention on the Law of the Sea (LOSC) came into force. This chapter examines the evolution of the concept and its juridical nature, and the legal regime applicable to the EEZ. It considers the future development of the EEZ legal regime, exploring the principal controversial features that may influence its course.

Role of medicinal plants against neurodegenerative diseases

2021 ◽  
Vol 22 ◽  
Author(s):  
Ritika Luthra ◽  
Arpita Roy
Keyword(s):  
Medicinal Plants ◽  
Neurodegenerative Diseases ◽  
Molecular Mechanisms ◽  
Environmental Changes ◽  
Inflammatory Responses ◽  
Vital Role ◽  
Significant Loss ◽  
Therapeutic Interventions ◽  
Inflammatory Stress

: Diseases with a significant loss of neurons, structurally and functionally are termed as neurodegenerative diseases. Due to the present therapeutic interventions and progressive nature of diseases, a variety of side effects have risen up, thus leading the patients to go for an alternative medication. The role of medicinal plants in such cases has been beneficial because of their exhibition via different cellular and molecular mechanisms. Alleviation in inflammatory responses, suppression of the functionary aspect of pro-inflammatory cytokines like a tumor, improvement in antioxidative properties is among few neuroprotective mechanisms of traditional plants. Variation in transcription and transduction pathways play a vital role in the preventive measures of plants in such diseases. Neurodegenerative diseases are generally caused by depletion of proteins, oxidative and inflammatory stress, environmental changes and so on, with aging being the most important cause. Natural compounds can be used in order to treat neurodegenerative diseases Medicinal plants such as Ginseng, Withania somnifera, Bacopa monnieri, Ginkgo biloba, etc. are some of the medicinal plants for prevention of neurological symptoms. This review deals with the use of different medicinal plants for the prevention of neurodegenerative diseases.

scholarly journals Role of Protein Aggregation in Neurodegenerative Diseases

10.5772/54487 ◽  
2013 ◽  
Author(s):  
Yusuf Tutar ◽  
Aykut zgur ◽  
Lutfi Tutar
Keyword(s):  
Neurodegenerative Diseases ◽  
Protein Aggregation

scholarly journals Legal technologies as instruments of civil aviation safety improvement in conditions of the fight against COVID-2019

2021 ◽  
Vol 12 (32) ◽  
pp. 444-459
Author(s):  
Oksana Myronets ◽  
Viktor Olefir ◽  
Ivan Golosnichenko ◽  
Yuriy Pyvovar
Keyword(s):  
Conceptual Framework ◽  
Future Development ◽  
Aviation Safety ◽  
Civil Aviation ◽  
Dialectical Method ◽  
Effective Implementation ◽  
Current State ◽  
Safety Improvement ◽  
The Future

Purpose of the paper is to determine current issues and prospective directions of the legal technologies’ use for civil aviation safety improvement and future development under modern COVID-2019, post-pandemic challenges and conditions of the new world’s order. By using the dialectical method, the current conceptual framework and issues of the legal technologies as instruments of civil aviation safety improvement have been formulated. The formal-dogmatic method contributed to the development of the authors’ explanation of the current state, issues, challenges, and practical role of the legal technologies for the further improvement of civil aviation safety under the fight against COVID-2019. In the paper modern challenges to the legal technologies’ use for civil aviation safety improvement in pandemic and post-pandemic conditions have been analyzed. Prospects of the legal technologies’ effective implementation for the future civil aviation safety improvement in conditions of pandemic, post-pandemic and new world’s order have been suggested.

Sign in / Sign up

Export Citation Format

Share Document