The liver fluke Opisthorchis felineus as a group III or group I carcinogen

Opisthorchiasis caused by the liver fluke Opisthorchis felineus is one of the most common helminthic infections in the Russian Federation. The largest area affected by opisthorchiasis felinea occupies almost the entire territory of Western Siberia and extends to northern Kazakhstan and a part of the Ural region. Natural endemic regions of opisthorchiasis also exist in the European part of Russia, and in the regions of Western and Eastern Europe. According to the official statistics of the Russian Federation, up to 40 000 patients with opisthorchiasis are registered annually in the country. Opisthorchiasis felinea affects the hepatobiliary system and causes serious liver disorders, including cancer of the biliary tract. Other parasitoses, opisthorchiasis viverrini and clonorchiasis, are widespread in the Southeast Asia and China. The causative agents of these diseases, liver flukes O. viverrini and Clonorchis sinensis, are officially recognized as Group 1 biological carcinogens and are classified as the main risk factors for cholangiocarcinoma. O. felineus is included in Group 3 of biological carcinogens and is not officially considered carcinogenic to humans. Studies on the carcinogenic potential of this liver fluke and the epidemiology of cholangiocarcinoma in the Russian Federation have started in earnest quite recently. Nevertheless, we have some evidence that infection with O. felineus leads to a precancerous state of the bile duct epithelium. This state, combined with additional risk factors, poses a real risk of cholangiocarcinoma. In our opinion, taking into consideration the accumulated facts, the classification of the carcinogenic potential of O. felineus requires revision. In this review, we focus on the relevant characteristics of the biology and epidemiology of this helminth as well as experimental data on opisthorchiasis felinea; this information might clarify the carcinogenicity of O. felineus to humans.

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Occupational health care in regions with different levels of occupational morbidity in agricultural workers

Hygiene and Sanitation ◽

10.47470/0016-9900-2021-100-5-444-450 ◽

2021 ◽

Vol 100 (5) ◽

pp. 444-450

Author(s):

Galina A. Bezrukova ◽

Anatoly N. Mikerov ◽

Vladimir F. Spirin

Keyword(s):

Health Care ◽

Occupational Health ◽

Working Conditions ◽

Russian Federation ◽

Occupational Diseases ◽

Agricultural Workers ◽

Occupational Health Care ◽

Group Iii ◽

Group I ◽

The Russian Federation

Introduction. In recent years, special attention has been paid to the discrepancy between working conditions in different sectors of the Russian economy and the inadequately low level of registered occupational morbidity (OM). At the same time, as a rule, issues of access to occupational health care that are important for the rural population are not considered due to the lower potential of socio-economic and infrastructural development of rural areas compared to the city. Material and methods. The paper uses updated data on 82 subjects of the Russian Federation on working conditions, the level of OM of agricultural workers, and indicators of occupational health care for the rural population in 2011-2017. Results. The ranking of subjects of the Russian Federation by the level of non-infectious occupational morbidity of agricultural workers was carried out: group I (OM above the national average), group II (OM below the national average), group III (OM is not registered). It is shown that non-detection of occupational diseases in the regions of group III could be due to insufficient provision of rural health care by occupational pathologists (54.2%), low coverage of workers with periodic medical examinations (PME) (76.6%), as well as the absence of occupational health centers (OPC) in 5 territories. of the 18 regions. According to the criteria of availability of occupational pathologists (97.5%) and coverage of PME (95.5%), the highest availability of primary occupational pathology care occurred in the regions of group II. However, the high proportion of occupational diseases identified during self-treatment indicated a formal approach to conducting PME in this group. The most accessible specialized occupational health care was typical for the subjects of the Russian Federation of group I with a high level of OM, on the territory of which the most significant number of OPC functioned with the possibility of extended pre-examination of employees with suspected occupational diseases in a hospital. Conclusion. Along with harmful working conditions, the occupational morbidity of agricultural workers is primarily determined by the availability of specialized occupational health care, namely, occupational health centers’ availability, equipment, and capacity.

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Never seen before? Opisthorchiasis and Clonorchiasis

Zeitschrift für Gastroenterologie ◽

10.1055/a-0751-3078 ◽

2018 ◽

Vol 56 (12) ◽

pp. 1513-1520 ◽

Cited By ~ 4

Author(s):

Christoph Dietrich ◽

Nathan Atkinson ◽

W. Lee ◽

Kerstin Kling ◽

Andreas Neumayr ◽

...

Keyword(s):

South Asia ◽

Liver Fluke ◽

Clonorchis Sinensis ◽

Human Migration ◽

Current Therapy ◽

Parasitic Diseases ◽

Imaging Features ◽

Opisthorchis Felineus ◽

Therapy Options ◽

Liver Flukes

AbstractParasitic diseases are relatively rarely diagnosed and treated in Europe. Therefore, European clinicians are not familiar with their clinical and imaging features. In an era of increased human migration, it is fundamental for clinicians to be able to identify such diseases. We have recently described the features of cystic echinococcosis, schistosomiasis, fascioliasis and ascariasis. Here, we report on the clinical and imaging features as well as on the current therapy options of infections by the small liver flukes: Clonorchis sinensis, Opisthorchis viverrini (Southeast Asian liver fluke) and Opisthorchis felineus (cat liver fluke) and other Opisthorchis species prevalent in South Asia.

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TNF-α -308 G>A and IL10 -1082A>G polymorphisms as potential risk factors for lymphoproliferative disorders in autoimmune rheumatic diseases

Egyptian Journal of Medical Human Genetics ◽

10.1186/s43042-019-0043-0 ◽

2020 ◽

Vol 21 (1) ◽

Cited By ~ 1

Author(s):

Manal Y. Tayel ◽

Aida Nazir ◽

Ibtessam M. Abdelhamid ◽

Myriam A. S. Helmy ◽

Nadia E. Zaki ◽

...

Keyword(s):

Risk Factors ◽

Rheumatic Diseases ◽

Lymphoproliferative Disorders ◽

Group Iii ◽

Autoimmune Rheumatic Diseases ◽

Group I ◽

Tnf Α ◽

Ifn Γ ◽

Tgf Β1 ◽

Distribution Frequency

Abstract Background Chronic inflammation with sustained unregulated immune stimulation in autoimmune rheumatic diseases (ARD) may be a risk factor for developing lymphoproliferative disorders (LPD). Markers of ARD activity as high erythrocyte sedimentation rate or erosive joint diseases and the development of B-symptoms were accounted as risk factors for LPD development. We investigated the association of five inflammatory cytokine genes single nucleotide polymorphisms (SNPs): TNF-α -308G>A; TGF-β1 gene codon 10 T>C and 25 G>C; IL-10 promoter SNPs -1082 A>G, -819T>C, and -592A>C; IL-6 -174G>C; and IFN-γ 874 T>A with the risk of LPD development in ARD patients. The study was conducted on 70 patients divided into group I, 25 ARD patients diagnosed as RA (n = 15) and SLE (n = 10) and with no history of malignancy; group II, 25 patients diagnosed with LPD and had no ARD; and group III, 20 patients diagnosed with both diseases: ARD and LPD. Cytokine genotyping was analyzed by PCR-sequence-specific primer (PCR-SSP). Results ARD+LPD patients had significantly higher frequency of TNF-α -308A allele and AA+AG genotype (high TNF-α producers) and IL-10 -1082A allele and AA genotype (low IL-10 producers) than ARD patients (p = 0.003, p = 0.024, p = 0.003, p = 0.03, respectively) with a significantly increased risk of LPD development in ARD patients expressing the corresponding alleles and genotypes. No significant differences were detected in the distribution frequency of either TGF-β1, IL-6, or IFN-γ SNPs between groups I and III or any of the studied SNPs between groups II and III. The distribution frequency of IL-10 ATA haplotype was significantly increased in group III as compared to group I (p = 0.037). Conclusion The significantly increased frequency of the high-TNF-α- and low-IL-10-producing alleles and genotypes in ARD patients may participate in the provision of a proinflammatory milieu that eventually increases the risk of LPD development.

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Mortality rates and risk factors for asymptomatic deep vein thrombosis in medical patients

Thrombosis and Haemostasis ◽

10.1160/th04-05-0323 ◽

2005 ◽

Vol 93 (01) ◽

pp. 76-79 ◽

Cited By ~ 91

Author(s):

Alain Leizorovicz ◽

Alexander Cohen ◽

Alexander Turpie ◽

Carl-Gustav Olsson ◽

Samuel Goldhaber ◽

...

Keyword(s):

Risk Factors ◽

Deep Vein Thrombosis ◽

Mortality Rates ◽

Hazard Ratio ◽

Group Iii ◽

Vein Thrombosis ◽

Group I ◽

Compression Ultrasound ◽

The Difference ◽

Deep Vein

SummaryThe clinical importance of asymptomatic proximal and distal deep vein thrombosis (DVT) remains uncertain and controversial. The aim of this retrospective,post-hoc analysis was to examine mortality and risk factors for development of proximal DVT in hospitalized patients with acute medical illness who were recruited into a randomized, prospective clinical trial of thromboprophylaxis with dalteparin (PREVENT).We analyzed 1738 patients who had not sustained a symptomatic venous thromboembolic event by Day 21 and who had a complete compression ultrasound of the proximal and distal leg veins on Day 21. We examined the 90-day mortality rates in patients with asymptomatic proximal DVT (Group I, N = 80), asymptomatic distal DVT (Group II, N = 118) or no DVT (Group III, N = 1540).The 90-day mortality rates were 13.75%, 3.39%, and 1.92% for Groups I–III, respectively. The difference in mortality between Group I and Group III was significant (hazard ratio 7.63, 95% CI = 3.8–15.3;p < 0.0001),whereas the difference between Groups II and III did not reach significance (hazard ratio 1.36, 95% CI = 0.41–4.45).The association of asymptomatic proximal DVT with increased mortality remained highly significant after adjusting for differences in baseline demographics and clinical variables. Risk factors significantly associated with the development of proximal DVT included advanced age (p = 0.0005), prior DVT (p = 0.001), and varicose veins (p = 0.04). In conclusion, the high mortality rate in patients with asymptomatic proximal DVT underscores its clinical relevance and supports targeting of asymptomatic proximal DVT as an appropriate endpoint in clinical trials of thromboprophylaxis.

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Is it possible to build an effective program to promote the health and well-being of employees in the workplace in the Russia?

10.33920/med-03-2108-04 ◽

2021 ◽

pp. 46-56

Author(s):

Ivan Aleksandrovich Rybakov

Keyword(s):

Risk Factors ◽

Russian Federation ◽

Preventive Measures ◽

Scientific Evidence ◽

Well Being ◽

Ministry Of Health ◽

Comprehensive Health ◽

Effective Program ◽

The Russian Federation ◽

Health And Well Being

In 2019 The Ministry of Health of the Russian Federation together with experts of the National Research Center of Therapy and Preventive Medicine of the Ministry of Health of the Russian Federation has developed programs to strengthen the health of employees, which include behavioral medicine practices aimed at changing lifestyle and correcting risk factors. Scientific evidence shows the effectiveness of such programs, and new components of programs aimed at improving the well-being of employees can increase the effectiveness of preventive measures. In this article, we will review the domestic and international experience of using comprehensive health and well-being promotion programs to improve the health of employees in Russia.

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The epidemiological situation as a factor determining the strategy for reducing mortality in the Russian Federation

Terapevticheskii arkhiv ◽

10.26442/00403660.2020.01.000510 ◽

2020 ◽

Vol 92 (1) ◽

pp. 4-9 ◽

Cited By ~ 3

Author(s):

S A Boytsov ◽

S A Shalnova ◽

A D Deev

Keyword(s):

Risk Factors ◽

Cardiovascular Diseases ◽

Cause Of Death ◽

Russian Federation ◽

Communicable Diseases ◽

Epidemiological Analysis ◽

Non Communicable Diseases ◽

The Russian Federation ◽

Epidemiological Situation

Chronic non - communicable diseases, mainly cardiovascular diseases, are the leading cause of death worldwide, including in the Russian Federation (RF). The article analyzes the negative and positive trends of the most relevant risk factors for cardiovascular diseases for the period from 2013 to 2017, and also provides a strategy for reducing mortality in the Russian Federation for the period up to 2024 based on data from an epidemiological analysis.

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Association Between Lipoprotein(a) and Risk Factors of Atherosclerosis in Russian Population (Data of Observational ESSE-RF study)

Rational Pharmacotherapy in Cardiology ◽

10.20996/1819-6446-2019-15-5-612-621 ◽

2019 ◽

Vol 15 (5) ◽

pp. 612-621

Author(s):

S. A. Shalnova ◽

M. V. Ezhov ◽

V. A. Metelskaya ◽

S. E. Evstifeeva ◽

V. I. Tarasov ◽

...

Keyword(s):

Risk Factors ◽

Total Cholesterol ◽

Russian Federation ◽

Smoking Status ◽

Skewed Distribution ◽

Female Population ◽

Male And Female ◽

Lipoprotein A ◽

The Russian Federation ◽

Hs Crp

Experimental and clinical data indicate a significant contribution of lipoprotein(a) (Lp[a]) to the atherogenesis. However, the pathophysiological mechanisms of this relationship are not fully understood.Aim. To investigate the distribution of Lp(a) in the population of the regions participating in the Study “Epidemiology of Cardiovascular Diseases in the Regions of the Russian Federation” (ESSE-RF) and to evaluate its associations with cardiovascular risk factors.Material and methods. Representative samples of the male and female population of 7 regions of the Russian Federation, aged from 25 to 64 years, enrolled in the multi-center cross-sectional epidemiological study were analyzed. A total of 10332 people were examined, of whom 3732 were men (36.0%) and 6600 were women (64.0%), the average age was equal in both sexes.Results. The mean value of Lp(a) reached 22.4 mg/dl (standard deviation 21.3 mg/dl) and significantly differed from the median (11.1 mg/dl; interquartile range from 3.9 to 20.2 mg/dl), forming the right-skewed distribution in both male and female population. Lp(a) levels were statistically significantly correlated with the level of low-density lipoproteins cholesterol (LDL-C), ароВ/аpoAI and total cholesterol. Notably, the odds ratios were growing by quintiles, and increased along with increasing lipid values (p<0.0001). Lp(a) levels were also positively associated with high-sensitivity C-reactive protein (hs-CRP) and negatively correlated with blood concentration of glucose and triglycerides (TG). There were no associations with body mass index, waist circumference and smoking status.Conclusion. According to the ESSE-RF data, there are significant positive associations of Lp(a) with the LDL-C level, the ароВ/аpoAI ratio, total cholesterol, and hs-CRP. Negative associations are established with glucose and TG levels. The future studies should be planned with the notion of the Lp(a)’s right-skewed distribution type.

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