High-intensity Exercise Modifies the Effects of Stanozolol on Brain Oxidative Stress in Rats

2015 ◽  
Vol 36 (12) ◽  
pp. 984-991 ◽  
Author(s):  
D. Camiletti-Moirón ◽  
V. Aparicio ◽  
E. Nebot ◽  
G. Medina ◽  
R. Martínez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Intensity ◽  
High Intensity Exercise ◽  
Brain Oxidative Stress

Effects of high-amount–high-intensity exercise on in vivo platelet activation: Modulation by lipid peroxidation and AGE/RAGE axis

2013 ◽  
Vol 110 (12) ◽  
pp. 1232-1240 ◽  
Author(s):  
Francesca Santilli ◽  
Natale Vazzana ◽  
Pierpaolo Iodice ◽  
Stefano Lattanzio ◽  
Rossella Liani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Exercise Training ◽  
Platelet Activation ◽  
High Intensity ◽  
Plasma Levels ◽  
High Intensity Exercise ◽  
Similar Amount ◽  
Activation Markers

SummaryPhysical activity is associated with cardiovascular risk reduction, but the effects of exercise on platelet activation remain controversial. We investigated the effects of regular high-amount, high intensity aerobic exercise on in vivo thromboxane (TX)-dependent platelet activation and plasma levels of platelet-derived proteins, CD40L and P-selectin, and whether platelet variables changes may be related to changes in high-density lipoprotein (HDL) and in the extent of oxidative stress and oxidative stress-related inflammation, as reflected by urinary isoprostane excretion and endogenous soluble receptor for advanced glycation end-products (esRAGE), respectively. Urinary excretion of 11-dehydro-TXB2 and 8-iso-prostaglandin (PG)F2α and plasma levels of P-selectin, CD40L and esRAGE were measured before and after a eight-week standardised aerobic high-amount–high-intensity training program in 22 sedentary subjects with low-to-intermediate risk. Exercise training had a clear beneficial effect on HDL cholesterol (+10%, p=0.027) and triglyceride (-27%, p=0.008) concentration. In addition, a significant (p<0.0001) decrease in urinary 11-dehydro-TXB2 (26%), 8-iso-PGF2α (21 %), plasma P-selectin (27%), CD40L (35%) and a 61% increase in esRAGE were observed. Multiple regression analysis revealed that urinary 8-iso-PGF2α [beta=0.33, SEM=0.116, p=0.027] and esRAGE (beta=-0.30, SEM=31.3, p=0.046) were the only significant predictors of urinary 11-dehydro-TXB2 excretion rate over the training period. In conclusion, regular high-amount–high-intensity exercise training has broad beneficial effects on platelet activation markers, paralleled and possibly associated with changes in the lipoprotein profile and in markers of lipid peroxidation and AGE/RAGE axis. Our findings may help explaining why a similar amount of exercise exerts significant benefits in preventing cardiovascular events.

scholarly journals Pulmonary Oxidative Stress is not Increased by Short-period High Intensity Exercise in Healthy Young Subjects

2011 ◽  
Vol 26 (2) ◽  
pp. 287-290 ◽  
Author(s):  
Sayaka DOMEN ◽  
Shunsuke TAITO ◽  
Kana KONISHI ◽  
Makoto TAKAHASHI ◽  
Kiyokazu SEKIKAWA ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Intensity ◽  
High Intensity Exercise ◽  
Short Period ◽  
Young Subjects

Pre-exercise low-level laser therapy improves performance and levels of oxidative stress markers in mdx mice subjected to muscle fatigue by high-intensity exercise

2015 ◽  
Vol 30 (6) ◽  
pp. 1719-1727 ◽  
Author(s):  
Andreia Aparecida de Oliveira Silva ◽  
Ernesto Cesar Pinto Leal-Junior ◽  
Katia de Angelis Lobo D’Avila ◽  
Andrey Jorge Serra ◽  
Regiane Albertini ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Muscle Fatigue ◽  
Laser Therapy ◽  
High Intensity ◽  
High Intensity Exercise ◽  
Low Level Laser Therapy ◽  
Mdx Mice ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Level Laser

Effective Nutritional Ergogenic Aids

1999 ◽  
Vol 9 (2) ◽  
pp. 229-239 ◽  
Author(s):  
Elizabeth Applegate
Keyword(s):  
Oxidative Stress ◽  
High Intensity ◽  
Ergogenic Aids ◽  
Cellular Component ◽  
High Intensity Exercise ◽  
Amino Acid Supplementation ◽  
Intense Exercise ◽  
Short Term ◽  
Glycogen Stores ◽  
High Effort

Athletes use a variety of nutritional ergogenic aids to enhance performance. Most nutritional aids can be categorized as a potential energy source, an anabolic enhancer, a cellular component, or a recovery aid. Studies have consistently shown that carbohydrates consumed immediately before or after exercise enhance performance by increasing glycogen stores and delaying fatigue. Protein and amino acid supplementation may serve an anabolic role by optimizing body composition crucial in strength-related sports. Dietary antioxidants, such as vitamins C and E and carotenes, may prevent oxidative stress that occurs with intense exercise. Performance during high-intensity exercise, such as sprinting, may be improved with short-term creatine loading, and high-effort exercise lasting 1-7 min may be improved through bicarbonate loading immediately prior to activity. Caffeine dosing before exercise delays fatigue and may enhance performance of high-intensity exercise.

scholarly journals PO-133 Effects of different concentrations of hydrogen on oxidative stress in rats with high intensity exercise

2018 ◽  
Vol 1 (4) ◽  
Author(s):  
Xue Geng ◽  
Zhihui Li ◽  
Lin Zhang ◽  
Chenggang Zhang
Keyword(s):  
Oxidative Stress ◽  
Free Radicals ◽  
Oxidative Damage ◽  
High Intensity ◽  
Statistical Difference ◽  
The Body ◽  
High Intensity Exercise ◽  
High Concentration ◽  
Significant Difference ◽  
Exercise Induced

Objective Exercise-induced oxidative stress is due to the massive increase in free radicals caused by strenuous exercise, which exceeds the ability of self-clearing. It is one of the main causes of sports injury and sports fatigue. Eliminating excessive production of free radicals is the key to alleviating exercise induced oxidative damage. Therefore, the purpose of this study is to study the effect of hydrogen on exercise-induced oxidative damage, to explore its possible mechanism and to explore the best dose of hydrogen with different concentrations. Methods 40 male SD rats (200±20g) were randomly divided into five groups(n=8):sedentary, exercise control, low concentration hydrogen with exercise(H1), medium concentration hydrogen with exercise(H2), high concentration hydrogen with exercise(H3). The rats performed high-intensity exercise for 4 weeks, except the sedentary. rats that with Low, medium and high concentration hydrogen were placed in a hydrogen atmosphere with a concentration of 0.5%, 1% and 1.5% for 1 h immediately after each exercise (keeping the concentration of oxygen and nitrogen in the environment the same as those in the air). The rats were weighed weekly during the experiment. The next day after 4 weeks of training, the samples were collected, and the contents of total superoxide dismutase (T-SOD), catalase (CAT), total antioxidant capacity (T- AOC) and malondialdehyde (MDA) were determined respectively. Results The weight of exercise control was significantly lower than sedentary in the third and fourth weeks of exercise (P<0.05). Compared to sedentary rats, there was no significant difference in the weight of rats between H1, H2 and H3 group. The contents of T-AOC, CAT and T-SOD in exercise control were significantly higher than those in sedentary (P<0.05). The content of CAT in H2 group was significantly decreased compared with exercise control (P<0.01). Compared with exercise control, the T-AOC and T-SOD in the H2 group showed a downward trend but no statistical difference (P>0.05), there was no significant difference between the above indexes, compared with sedentary. In addition, there was no difference in T-SOD and CAT content between H1 group and exercise control; Compared with exercise control, there was no significant difference in T-SOD, T-AOC and CAT in H3 group. At the MDA level, each exercise group increased significantly compared with the sedentary (P<0.05), and the MDA levels in the H1, H2, and H3 groups were decreased compared with the exercise control, but there was no statistical difference. Conclusions It can be seen from the above results that different concentrations of hydrogen intervention can improve the weight loss of rats after intensive exercise. More importantly, the dosage and effect of 1% concentration of hydrogen is easier to remove the excessive radicals produced by intense exercise in the body, avoid the aggravation of oxidative stress, and have very good therapeutic effect. It provides a theoretical basis for the further study of the application of hydrogen in exercise oxidative damage. 

scholarly journals PENGARUH EXERCISE INTENSITAS TINGGI TERHADAP KETEBALAN ENDOMETRIUM MENCIT (MUS MUSCULUS)

2021 ◽  
Vol 3 (1) ◽  
pp. 24
Author(s):  
Aizah Ari Setyana Yuli ◽  
Gadis Meinar Sari ◽  
Ashon Sa’adi
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
High Intensity ◽  
Endometrial Thickness ◽  
Reactive Oxygen ◽  
Exercise Group ◽  
High Intensity Exercise ◽  
Control Group ◽  
Oxygen Species ◽  
Group Data

Abstrak Latar Belakang : Exercise dapat menyebabkan terbentuknya reactive oxygen species (ROS). Ketidakseimbangan antara antioksidan endogen dan ROS dapat menyebabkan stres oksidatif. Stres oksidatif dapat menyebabkan infertilitas pada wanita melalui berbagai mekanisme. Endometrium yang tidak sempurna karena ROS tidak dapat mendukung embrio dan perkembangannya. Penelitian ini bertujuan untuk menganalisa perbedaan ketebalan endometrium pada mencit yang exercise intensitas tinggi. Metode : Penelitian ini true experimental dengan rancangan randomized posttest only design. Besar sampel adalah 7 ekor tiap kelompok, yang terdiri dari 2 kelompok. Kelompok kontrol dan  kelompok exercise intensitas tinggi. Data yang didapatkan adalah ketebalan endometrium mencit. Hasil : hasil uji mann-whitney menunjukkan hasil yang signifikan dengan P=0,006. Kesimpulan : exercise intensitas tinggi dapat mempengaruhi ketebalan endometrium.. Abstract Background: Reactive Oxygen Species (ROS) is formed by exercise. Oxidative stress is caused by an imbalance between endogenous antioxidants and ROS. Oxidative stress  causes infertility in women through mechanisms. Because of  ROS, endometrium can not support the embryo and its development. This research aim to analyze different of endometrial thickness mice with high intensity exercise. Methods: This research is true experimental researh with randomized posttest only design. The sample size is 7 female mice each group, devided into 2 groups. The control group, and the high-intensity exercise group. Data obtained from mice endometrial thickness Results: mann-whitney  gave significant result at level p=0.006. Conclusion: high intensity exercise can effect the thickness of the endometrium.

scholarly journals The Impact of Aspirin Intake on Lactate Dehydrogenase, Arterial Stiffness, and Oxidative Stress During High‐Intensity Exercise: A Pilot Study

2020 ◽  
Vol 72 (1) ◽  
pp. 101-113 ◽  
Author(s):  
Sang Ho Lee ◽  
Elizabeth J. Pekas ◽  
Seungyong Lee ◽  
Ronald J. Headid ◽  
Song-Young Park
Keyword(s):  
Oxidative Stress ◽  
Lactate Dehydrogenase ◽  
Arterial Stiffness ◽  
High Intensity ◽  
Pulse Wave ◽  
Augmentation Index ◽  
High Intensity Exercise ◽  
Placebo Control ◽  
Blood Levels ◽  
And Oxidative Stress

AbstractAspirin is a common nonsteroidal anti-inflammatory drug used to reduce fever, pain, and inflammation. However, aspirin’s anti-inflammatory properties may also prevent increased levels of blood lactate dehydrogenase, vascular arterial stiffness and oxidative stress induced by high-intensity exercise. The purpose of this study was to investigate the effects of 4 weeks of aspirin supplementation on lactate dehydrogenase activity, lactate, arterial stiffness, and antioxidant capacity during high-intensity exercise in Taekwondo athletes. Participants were randomly divided into two groups: aspirin supplementation (n = 10) and placebo-control (n = 10). Blood levels of lactate dehydrogenase (LDH) enzyme activity and lactate were assessed to examine muscle damage and carotid-to-radial pulse wave velocity and the augmentation index were measured to examine arterial stiffness. Blood levels of superoxide dismutase, malondialdehyde, and glutathione peroxidase were assessed to determine antioxidant capacity and levels of oxidative stress. There were significant group × time interactions for enzyme activity of LDH (Δ-60 ± 24.36 U/L) and carotid-to-radial pulse wave velocity (Δ-1.33 ± 0.54 m/s), which significantly decreased (p < 0.05) following aspirin supplementation compared to placebo-control. Superoxide dismutase (Δ359 ± 110 U/gHb) and glutathione peroxidase (Δ28.2 ± 10.1 U/gHb) significantly decreased while malondialdehyde (0Δ3.0 ± 0.1 mmol/mL) significantly increased (p < 0.05) in the placebo-control group compared to the supplementation group. However, there were no changes in lactate concentration levels or augmentation index. These results reveal that low-dose aspirin supplementation would be a useful supplementation therapy to prevent high-intensity exercise training-induced increases in oxidative damage, inflammation, skeletal muscle fatigue, and arterial stiffness in elite Taekwondo athletes.

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