Haemophilia Registry of the Medical Committee of the Swiss Haemophilia Society

2009 ◽  
Vol 29 (S 01) ◽  
pp. S16-S18 ◽  
Author(s):  
B. Brand ◽  
N. von der Weid
Keyword(s):  
Quality Control ◽  
Infectious Diseases ◽  
Mutation Analysis ◽  
Clinical Data ◽  
Age Groups ◽  
Treatment Modalities ◽  
Global Survey ◽  
On Demand ◽  
Per Capita ◽  
Severity Of The Disease

SummaryThe Swiss Haemophilia Registry of the Medical Committee of the Swiss Haemophilia Society was established in 2000. Primarily it bears epidemiological and basic clinical data (incidence, type and severity of the disease, age groups, centres, mortality). Two thirds of the questions of the WFH Global Survey can be answered, especially those concerning use of concentrates (global, per capita) and treatment modalities (on-demand versus prophylactic regimens). Moreover, the registry is an important tool for quality control of the haemophilia treatment centres.There are no informations about infectious diseases like hepatitis or HIV, due to non-anonymisation of the data. We plan to incorporate the results of the mutation analysis in the future.

Haemophilia Registry of the Medical Committee of the Swiss Haemophilia Society

2010 ◽  
Vol 30 (S 01) ◽  
pp. S15-S18 ◽  
Author(s):  
N. von der Weid
Keyword(s):  
Quality Control ◽  
Emergency Room ◽  
Cause Of Death ◽  
National Level ◽  
Bleeding Disorders ◽  
Mortality Statistics ◽  
Global Survey ◽  
On Demand ◽  
Treatment Centre ◽  
Year 2000

SummaryThe Swiss Haemophilia Registry of the Medical Committee of the Swiss Haemophilia Society started in 1996 but was set as an internet-based, double password-protected facility in the year 2000. With the inclusion of patients’ data from two new centres in 2009, we assume a coverage rate of about 90% of all patients with inherited bleeding disorders in our country. Data concerning the phenotype and genotype of the disorder, its severity, its therapy, the prevalence of inhibitors are readily available to the registered users, allowing quality control of haemophilia therapy at a national level, but also rapid care of the patient visiting the emergency room of another treatment centre. Basing on the available data, about two thirds of the WFH global survey can be answered; the mortality statistics shows that bleeding remains a cause of death in haemophiliacs, also in the 21th century. The Registry allows for comparisons with international datasets, especially with respect to treatment (prophylaxis vs. on-demand therapy), factor consumption and costs.

Results of Surveillance Studies of Infectious Fish Diseases in Freshwater Aquaculture of Ukraine

2015 ◽  
Vol 2 (2) ◽  
pp. 32-38 ◽  
Author(s):  
N. Matvienko ◽  
A. Vashchenko ◽  
I. Tsiganok ◽  
L. Buchatsky
Keyword(s):  
Rainbow Trout ◽  
Infectious Diseases ◽  
Cell Cultures ◽  
Standardized Test ◽  
Age Groups ◽  
Infectious Pancreatic Necrosis Virus ◽  
Test System ◽  
Rainbow Trout Oncorhynchus Mykiss ◽  
Freshwater Aquaculture ◽  
Pancreatic Necrosis Virus

Aim. To investigate the epizootic state of fi sheries in Ukraine; to study the biological specifi cities of viral and bacterial isolates of fi sh in freshwater aquaculture. Methods. The epizootic state of fi sheries was defi ned ac- cording to the surveillance plan for fi sheries, virological (biosampling of sensitive fi sh species, virus isolation on sensitive passaged cell cultures), serological (enzyme immunoassay, virus neutralization test using sensitive passaged cell cultures) and molecular-biological (reverse transcriptase polymerase chain reaction − RTPCR) methods of investigation were used. The pathogenicity of the isolated bacteria was studied in the biosample. The identifi cation was performed using Bergey’s Manual. The express-identifi cation of bacteria was performed using the standardized test-system API 20E Bio Merieux (France). Results. The IPNV isolates of rainbow trout were fi rst isolated in the fi sheries of different forms of ownership in the western regions of Ukraine (Volyn, L’viv, Transcarpathian, Chernivtsi regions). It was demonstrated that different age groups of carp are infested with the virus in the fi sheries of L’viv, Donetsk, Chernihiv, Kyiv, and Odesa regions which testifi es to a wide spread of the virus in Ukraine. Out of fi sh infectious diseases the red spot-like disease and the swim bladder infl ammation of carp, the diseases of young trout and sturgeon were detected in the investigated fi sheries of Ukraine. Conclusions. The epizootic data were used to estimate the condition of the fi sheries in Ukraine in terms of fi sh infectious diseases. An infectious pancreatic necrosis virus, new for Ukraine, was revealed. It was found to affect rainbow trout (Oncorhynchus mykiss , Walbaum, 1792) and the spread of SVCV in carp fi sheries was demonstrated. As for bacterial fi sh diseases, the decrease in the epizootic situation was described along with considerable extension of the range of species of bacterial pathogens of fi sh. Annual systematic monitoring and measures of preventing the introduction of the agents of infectious diseases are the guarantee of protection of the specialized fi sheries of Ukraine.

To evaluate the efficacy of Jalaukavacharana followed by Khadira Prayoga in Vicharchika w.s.r to Eczema

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Kulkarni Sharad ◽  
Syeda Ather Fathima ◽  
Naveen B. S.
Keyword(s):  
Incidence Rate ◽  
Clinical Features ◽  
Skin Disease ◽  
Skin Disorder ◽  
Age Groups ◽  
High Rate ◽  
Main Line ◽  
Treatment Modalities ◽  
Skin Disorders

Vicharchika (Eczema) is a skin disorder with predominance of Pitta Kapha Dosha, with clinical features like Kandu, Srava, Pidaka, Shyavata, Rookshata, Raji, Ruja and Daha mainly in the extremities. It is the second commonest skin disease affecting all age groups, with incidence rate of 2-3% and high rate of recurrence. Ayurveda emphasizes Shodhana therapy as the main line of treatment in skin disorders. Raktamokshana is indicated as Rakta is mainly involved in Vicharchika. In the present study, two treatment modalities were selected to find out which is more appropriate.

scholarly journals Correlation between age, sex, and severity of Coronavirus disease-19 based on chest computed tomography severity scoring system

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Shimaa Farghaly ◽  
Marwa Makboul
Keyword(s):  
Computed Tomography ◽  
Scoring System ◽  
Fatal Outcome ◽  
Age Groups ◽  
Significant Risk ◽  
Chest Ct ◽  
Age Group ◽  
Severity Scoring ◽  
Chest Computed Tomography ◽  
Severity Of The Disease

Abstract Background Coronavirus disease 2019 (COVID-19) is the most recent global health emergency; early diagnosis of COVID-19 is very important for rapid clinical interventions and patient isolation; chest computed tomography (CT) plays an important role in screening, diagnosis, and evaluating the progress of the disease. According to the results of different studies, due to high severity of the disease, clinicians should be aware of the different potential risk factors associated with the fatal outcome, so chest CT severity scoring system was designed for semi-quantitative assessment of the severity of lung disease in COVID-19 patients, ranking the pulmonary involvement on 25 points severity scale according to extent of lung abnormalities; this study aims to evaluate retrospectively the relationship between age and severity of COVID-19 in both sexes based on chest CT severity scoring system. Results Age group C (40–49 year) was the commonest age group that was affected by COVID-19 by 21.3%, while the least affected group was group F (≥ 70 years) by only 6.4%. As regards COVID-RADS classification, COVID-RADS-3 was the most commonly presented at both sexes in all different age groups. Total CT severity lung score had a positive strong significant correlation with the age of the patient (r = 0.64, P < 0.001). Also, a positive strong significant correlation was observed between CT severity lung score and age in both males and females (r = 0.59, P < 0.001) and (r = 0.69, P < 0.001) respectively. Conclusion We concluded that age can be considered as a significant risk factor for the severity of COVID-19 in both sexes. Also, CT can be used as a significant diagnostic tool for the diagnosis of COVID-19 and evaluation of the progression and severity of the disease.

scholarly journals Survival Associations between Patient Age and Treatment Modality in Olfactory Neuroblastoma: A Retrospective Population-Based Study

2021 ◽  
Vol 10 (12) ◽  
pp. 2685
Author(s):  
Andre J. Burnham ◽  
Phillip A. Burnham ◽  
Edwin M. Horwitz
Keyword(s):  
Treatment Modality ◽  
Age Groups ◽  
Olfactory Neuroblastoma ◽  
Population Based ◽  
Treatment Modalities ◽  
Long Term Outcomes ◽  
Patient Age ◽  
Population Based Study ◽  
Patient Âgé

Olfactory neuroblastoma (ONB) is a rare neuroepithelial-derived malignancy that usually presents in the nasal cavity. The rarity of ONB has led to conflicting reports regarding associations of patient age and ONB survival and outcome. Moreover, long-term outcomes of chemotherapy and other treatment modalities are speculated. Here, we aimed to compare survival outcomes across age groups through time and determine associations between treatment modality and survival. In this retrospective population-based study, we analyzed the SEER 2000–2016 Database for patients with ONB tumors. Using Kaplan–Meier survival analysis, a significant effect of age and cancer-specific survival (CSS) was observed; geriatric ONB patients had the lowest CSS overall. Generalized linear models and survival analyses demonstrated that CSS of the pediatric patient population was similar to the geriatric group through 100 months but plateaued thereafter and was the highest of all age groups. Radiation and surgery were associated with increased CSS, while chemotherapy was associated with decreased CSS. GLM results showed that tumor grade, stage and lymph node involvement had no CSS associations with age or treatment modality. Our results provide insight for future investigations of long-term outcomes associated with ONB patient age and treatment modality, and we conclude that survival statistics of ONB patients should be analyzed in terms of trends through time rather than fixed in time.

FEATURES OF THE COEFFICIENT OF VARIATION OF HEMATOLOGICAL INDICATORS IN PERSONS OF MIDDLE, ELDERLY AND SENILE AGE WITH PNEUMONIA

2021 ◽  
pp. 102-106
Author(s):  
С. А. Рукавишникова ◽  
Т. А. Ахмедов ◽  
А.С. Пушкин ◽  
У.Р. Сагинбаев ◽  
Д.П. Пискунов ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Older Persons ◽  
Risk Group ◽  
Age Groups ◽  
Biological Variation ◽  
The Body ◽  
Blood Analysis ◽  
Internal Environment ◽  
Severity Of The Disease ◽  
Hematological Indicators

Пневмония занимает лидирующие позиции по смертности среди всех инфекционных заболеваний. Установлено, что к достоверной группе риска по уровню заболеваемости и смертности от данной нозологической формы относятся лица старше 60 лет, причем с возрастом тяжесть протекания заболевания только возрастает. Согласно литературным данным, одной из причин снижения адаптационных возможностей лиц пожилого возраста является феномен «возрастного десинхроноза», проявляющийся значительными колебаниями параметров внутренней среды организма. Цель работы - сравнительный анализ коэффициентов внутри-и межиндивидуальной биологической вариации. Для этого проведено ретроспективное исследование клинического анализа крови у пациентов, страдающих пневмонией неуточненной этиологии, в разрезе трех возрастных групп - средней, пожилой и старческой. Обнаружены особенности биологической вариации в зависимости от возраста, выявленные отличия были обоснованы в соответствии с имеющимися теориями. Pneumonia is the leading mortality rate among all infectious diseases. It has been established that the reliable risk group for morbidity and mortality from this nosology includes persons over 60 years of age, and with age the severity of the disease only increases. According to literary data, one of the reasons for the decline in adaptation capabilities of older persons is the phenomenon of «age desinhronosis», which manifests itself in significant fluctuations in the parameters of the internal environment of the body. The purpose of this work was to compare the coefficients of intra- and interindividual biological variation. For this purpose, a retrospective study of clinical blood analysis in patients suffering from pneumonia of unspecified etiology was carried out in terms of three age groups: medium, elderly and senile. Features of biological variation depending on age have been found, the differences identified have been justified according to available theories.

Cost of therapy for cystic fibrosis in different age groups with consideration to the respiratory tract infection and complications

2021 ◽  
Vol 31 (2) ◽  
pp. 238-249
Author(s):  
E. G. Furman ◽  
V. V. Shadrina ◽  
T. Yu. Maksimycheva ◽  
V. D. Sherman ◽  
E. I. Kondratyeva
Keyword(s):  
Cystic Fibrosis ◽  
Respiratory Tract ◽  
Pharmacoeconomic Analysis ◽  
Age Groups ◽  
Eradication Therapy ◽  
Cost Savings ◽  
Hypothetical Patient ◽  
Severity Of The Disease ◽  
Cost Of Drugs ◽  
The Cost

Despite the low prevalence of cystic fibrosis (CF), the costs of treating this disease are significant for the healthcare system. The aim of this economic study was to assess the total cost of drugs per year for children with CF, depending on age and course of the disease.Methods. For this pharmacoeconomic analysis, groups of “hypothetical” patients were formed according to the characteristics of the course of CF, taking into account the required volume of basic CF therapy, antibiotic therapy, and complications.Results. The cost of basic treatment for CF patients of different ages and disease progression in the hypothetical patient models can vary greatly. The cost of CF therapy increases significantly with age and Pseudomonas aeruginosa respiratory infection, especially in the patients with chronic infection, concomitant polyposis sinusitis, and low nutritional status.Conclusion. Patients with CF require regular follow-up with control of the microflora of the respiratory tract and effective eradication therapy for P. aeruginosa and other pathogenic microorganisms. Reducing infection rates and the severity of the disease can lead to significant cost savings.

scholarly journals A Comparative Study of Deep Neck Abscess with Regards to Anatomical Location and Age Groups Using CT and Clinical Data

2012 ◽  
Vol 66 (4) ◽  
pp. 309
Author(s):  
Chan Ho Park ◽  
Jong Kyu Han ◽  
Young Tong Kim ◽  
Hyeong Cheol Shin ◽  
Hyung Hwan Kim ◽  
...  
Keyword(s):  
Comparative Study ◽  
Clinical Data ◽  
Age Groups ◽  
Anatomical Location ◽  
Neck Abscess ◽  
Deep Neck Abscess

scholarly journals Varicella disease after introduction of varicella vaccine in the US, 1995-2000

2002 ◽  
Vol 6 (7) ◽  
Author(s):  
N Noah
Keyword(s):  
Herpes Zoster ◽  
Infectious Diseases ◽  
Early Life ◽  
Varicella Vaccine ◽  
Age Distribution ◽  
Age Groups ◽  
Subsequent Development ◽  
Effective Vaccine ◽  
Routine Immunisation ◽  
The Us

Chickenpox is now one of the last of the infectious diseases of childhood that remain mostly uncontrolled. An effective vaccine has been available for many years but has not been used for routine immunisation in many countries. This is because the effect of giving the vaccine in early life on the subsequent development of herpes zoster is not known; high immunisation rates are important to ensure that the age distribution does not shift towards older age groups in whom the disease is more serious; and the disease is generally considered innocuous, especially in childhood when about 95% of infections occur.

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