Electrocardiography Parameters Changes in Epilepsy and Febrile Convulsion Children Compared with Controls

2020 ◽  
Author(s):  
Noor Mohammad Noori ◽  
Alireza Teimouri ◽  
Ali Khajeh
Keyword(s):  
Neurological Diseases ◽  
Febrile Convulsion ◽  
Qt Dispersion ◽  
Healthy Children ◽  
S Wave ◽  
Qtc Dispersion ◽  
Autonomic Changes ◽  
Cardiac Functions ◽  
Definition Of ◽  
Patients With Epilepsy

AbstractEpilepsy and febrile convulsion are the most common neurological diseases with significant effect on cardiac functions. The study aimed to evaluate electrocardiography parameters alterations in epilepsy and febrile convulsion children compared with controls. In this comparison study, 270 children analyzed who shared equally in epilepsy, febrile convulsion, and healthy that aged from 0.5 to 5 years. The participants were collected from Ali ibn Abi Talib Hospital of Zahedan, Iran. Epilepsy confirmed based on definition of having at least two unprovoked seizures in 24 hours. Febrile convulsion was confirmed based on its definition by the International League against Epilepsy. Healthy children selected from those referred to the hospital with fever and without any underline diseases. Electrocardiography was performed by a pediatric cardiologist. Data were analyzed using SPSS 19 with p < 0.05 significant level. Heart rate was higher in epilepsy (129.64 ± 27.63) compared with control (108.78 ± 26.01) and febrile convulsion (125.79 ± 25.38; X 2 = 28.701, p < 0.001). S wave in lead V1 was higher in controls (0.72 ± 0.36) compared with epilepsy (0.58 ± 0.45) and febrile convulsion (0.58 ± 0.36). QT dispersion and QTc dispersion levels were higher in epilepsy than febrile convulsion children that both were higher than controls. Concluded that R in aVL, LV mass (LVM), QT dispersion, and QTc dispersion were higher significantly in epilepsy compared with febrile convulsion children. To maintain a good strategic treatment in patients with epilepsy and febrile convulsion, there is a need to assess alternations in ECG parameters, especially QT interval changes that lead to better comprehensive autonomic changes.

Electrocardiography Findings in Children with Febrile Convulsion

2020 ◽  
Author(s):  
Noor Mohammad Noori ◽  
Ali Khajeh ◽  
Alireza Teimouri
Keyword(s):  
Age Groups ◽  
Febrile Convulsion ◽  
Qt Dispersion ◽  
Left Ventricular ◽  
Healthy Children ◽  
Sex Distribution ◽  
Electrocardiographic Changes ◽  
Electrocardiogram Ecg ◽  
Control Study ◽  
International League

AbstractFebrile convulsion (FC) is a seizure associated with body temperature that leads to electrocardiography changes. The study aimed to study electrocardiographic changes in children with FC as compared with healthy children. In this case–control study, 90 children aged 6 to 60 months were matched with equal healthy ones in “Ali Ebne Abi Talib” hospital in Zahedan, Iran. FC was confirmed by a neurologist based on its definition by the International League Against Epilepsy. Electrocardiogram (ECG) was captured by a pediatric cardiologist. Data were analyzed using SPSS 19. Sex distribution in groups was similar (p = 0.232). QT correction (QTc) was normal in 97.8 and 76.7% of controls and FC children, respectively (p < 0.001). QT dispersion (QTd) was normal in all controls when it was prolonged in 0.6% of children (p< 0.316). Calculated QT (QTcd) prolonged in controls and FC of 4.4 and 27.8% of children, respectively (p < 0.001). RR interval (p = 0.001), heart rate (p< 0.001), S in V1 (p = 0.004), R in aVL (p = 0.007), S in V3(p< 0.001), left ventricular mass (LVM) (p< 0.001), QTd (p< 0.001), QTc max (p< 0.001), and QTcd (p< 0.001) were significant. Means of LVM were 46.00 ± 1.86, 47.22 ± 2.24, and 51.45 ± 2.41 for age groups of <12, 12–24, and >24 months, respectively (p < 0.001). We conclude that QTd, QTc, and QTcd were higher in FC compared with those of healthy children. The rate of FC in children with higher level of QTcd increased compared with controls.

Adjacent QT dispersion: A good predictor of ventricular arrhythmias after myocardial infarction

Open Medicine ◽  
2008 ◽  
Vol 3 (2) ◽  
pp. 179-182 ◽  
Author(s):  
Mohammad Ostovan ◽  
Shahdad Khosropanah ◽  
Shohreh Hooshmand
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Qt Interval ◽  
Regional Variation ◽  
Ventricular Arrhythmias ◽  
Qt Dispersion ◽  
Maximum Difference ◽  
Simple Method ◽  
Qtc Dispersion ◽  
Surface Electrocardiogram

AbstractThe 12-lead surface electrocardiogram adjacent QTc dispersion, which is the maximum difference of corrected QT interval between two adjacent leads, is a simple method to determine regional variation in repolarization and refractoriness. The aim of this study is to evaluate adjacent QTc dispersion as a marker of susceptibility to ventricular arrhythmias after myocardial infarction. A total of 135 consecutive patients with acute myocardial infarction were enrolled in the study. Adjacent QTc, measured by lens magnifier, was calculated on the first, second and third days after acute myocardial infarction. On the second day after acute myocardial infarction, adjacent QTc dispersion was significantly greater in patients with ventricular arrhythmias (P < 0.001). Adjacent QTc dispersion on the first and fifth day after acute myocardial infarction was not associated with development of ventricular arrhythmias. On the second day after acute myocardial infarction, adjacent QTc dispersion is a simple and feasible method for prediction of ventricular arrhythmias.

scholarly journals Prolonged QTc Dispersion Correlates with Coronary Artery Disease in Acute ST Elevated Myocardial Infarction (STEMI)

2013 ◽  
Vol 5 (2) ◽  
pp. 173-181 ◽  
Author(s):  
NI Sharafat ◽  
M Khalequzzaman ◽  
M Akhtaruzzaman ◽  
AK Choudhury ◽  
S Hasem ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Qt Dispersion ◽  
Qtc Dispersion ◽  
Group I ◽  
The Mean ◽  
Group Ii ◽  
Artery Disease ◽  
Vessel Score ◽  
Vessel Involvement

Background: It has been found that there is strong association of QT dispersion and QT dispersion ratio with extent and severity of coronary artery disease. Qualitative importance of QTc dispersion on the base line ECG in patients with MI is recognized clinically but quantification of this phenomenon is less commonly used in clinical practice, which might be a better independent risk predictor of this group of patients. Methods: A total of 100 patients were selected, Study populations sub-divided into two groups on the basis of QTc dispersion. In group I (comparison group): QTc dispersion is <60 milliseconds (msec) in group II (study group) : QTc dispersion e”60milliseconds(msec). 50 patients in each group. QT dispersion was calculated on standard resting 12 lead ECGs. QT interval was measured from the beginning of the inscription of the QRS complex to the point at which the T wave returned to the isoelectric line. Angiographic severity of coronary artery disease was assessed by- Vessel score, Friesinger score and Leaman score. Interpretation of coronary angiogram was reviewed by at least two cardiologists. . Results: The mean vessel score for group I patients was 1.16±0.68 and that of group II patients was 2.30±0.64 and the mean difference was statistically significant (p<0.05). Patients those had single vessel involvement had mean QTc dispersion 57.05, patients those had double vessel disease mean QTc dispersion was 102.00 and patients those had triple vessel involvement had mean QTc dispersion 177.60. There was a strong positive correlation with the QTc dispersion and increasing number of vessel involvement (Pearson’s correlation coefficient). The mean Friesinger score for group I patients was 4.84±2.56 and that of group II patients was 9.80±2.60. The mean difference was significantly (p<0.05) higher in group II patients. There was a strong positive correlation between the QTc dispersion and Leaman score (Pearson’s correlation coefficient). In group I patients 56% had insignificant coronary artery disease and 44% had significant coronary artery disease defined by Friesinger index (n=100). In group II patients 6% had Insignificant coronary artery disease & had 94% significant coronary artery disease. Conclusion: QTc dispersion>60 ms had independent predictive value for the severity of coronary artery disease. The greater the QTc dispersion the higher the number of coronary artery involvement. We observed that there is a positive correlation between prolonged QT dispersion and coronary artery disease severity in terms of Vessel score, Friesinger score, Leaman score. DOI: http://dx.doi.org/10.3329/cardio.v5i2.14322 Cardiovasc. j. 2013; 5(2): 173-181

scholarly journals QT Interval Changes in Children With Febrile Convulsion Comparing With Healthy

2021 ◽  
pp. 1-15
Author(s):  
Alireza Teimouri ◽  
◽  
Noor Mohammad Noori ◽  
Ali Khajeh ◽  
◽  
...  
Keyword(s):  
Qt Interval ◽  
Case Control Study ◽  
Age Groups ◽  
Febrile Convulsion ◽  
Case Control ◽  
Healthy Children ◽  
Age Group ◽  
Chi Square ◽  
Pediatric Cardiologist ◽  
Control Study

A temperature-related seizure is a febrile seizure that affects the QT interval. The purpose of this study was to evaluate the changes in the QT interval caused by febrile convulsion compared with healthy children. Method This case-control study considered the distribution of 180 children equally shared between patients and controls. The study was conducted at the "Ali Ebne Abi Talib" Hospital in Zahedan, Iran. The disease diagnosed and confirmed based on standard definitions of febrile convulsion. QT interval measured by ECG and interpreted by a pediatric cardiologist and collected data were analyzed with SPSS 19 considering 0.05 as significant error. Results Among the ECG parameters, HR, R in aVL, S in V3, LVM, QTd, QTc and QTcd were significantly different in children with febrile convulsion compared to the peers. From those who had abnormal QTd, FC children were more frequented but not significant (CHI SQUARE=1.053, p=0.248), when children with FC were more in abnormality regarding QTc (CHI SQUARE=13.032, p<0.001) and QTcd (CHI SQUARE=21.6, P<0.001) significantly. In children with FC, those who were aged less than 12 months, had the highest level of HR but not significant (CHI SQUARE=4.59, p=0.101). Similar trends occurred for R in aVL and S in V3 that were higher in the age group >24 months (p>0.05). LVM had the highest value in the age group of >24 months significantly (CHI SQUARE= 52.674, P<0.001) and the other QT parameters were same in Fc children with different age groups (P>0.05). Conclusion From the study concluded that dispersion corrected QT, corrected QT and dispersion QT changed significantly in children with febrile convulsion in comparing with the healthy children but with constant values in children with FC in different age groups.

scholarly journals Respiratory-related brain pulsations are increased in epilepsy—a two-centre functional MRI study

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Janne Kananen ◽  
Heta Helakari ◽  
Vesa Korhonen ◽  
Niko Huotari ◽  
Matti Järvelä ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Functional Mri ◽  
Coefficient Of Variation ◽  
Spectral Power ◽  
Neurological Diseases ◽  
Epileptiform Activity ◽  
High Specificity ◽  
Full Band ◽  
Drug Naïve ◽  
Patients With Epilepsy

Abstract Resting-state functional MRI has shown potential for detecting changes in cerebral blood oxygen level-dependent signal in patients with epilepsy, even in the absence of epileptiform activity. Furthermore, it has been suggested that coefficient of variation mapping of fast functional MRI signal may provide a powerful tool for the identification of intrinsic brain pulsations in neurological diseases such as dementia, stroke and epilepsy. In this study, we used fast functional MRI sequence (magnetic resonance encephalography) to acquire ten whole-brain images per second. We used the functional MRI data to compare physiological brain pulsations between healthy controls (n = 102) and patients with epilepsy (n = 33) and furthermore to drug-naive seizure patients (n = 9). Analyses were performed by calculating coefficient of variation and spectral power in full band and filtered sub-bands. Brain pulsations in the respiratory-related frequency sub-band (0.11–0.51 Hz) were significantly (P &lt; 0.05) increased in patients with epilepsy, with an increase in both signal variance and power. At the individual level, over 80% of medicated and drug-naive seizure patients exhibited areas of abnormal brain signal power that correlated well with the known clinical diagnosis, while none of the controls showed signs of abnormality with the same threshold. The differences were most apparent in the basal brain structures, respiratory centres of brain stem, midbrain and temporal lobes. Notably, full-band, very low frequency (0.01–0.1 Hz) and cardiovascular (0.8–1.76 Hz) brain pulses showed no differences between groups. This study extends and confirms our previous results of abnormal fast functional MRI signal variance in epilepsy patients. Only respiratory-related brain pulsations were clearly increased with no changes in either physiological cardiorespiratory rates or head motion between the subjects. The regional alterations in brain pulsations suggest that mechanisms driving the cerebrospinal fluid homeostasis may be altered in epilepsy. Magnetic resonance encephalography has both increased sensitivity and high specificity for detecting the increased brain pulsations, particularly in times when other tools for locating epileptogenic areas remain inconclusive.

QT dispersion in acute rheumatic fever

2006 ◽  
Vol 16 (2) ◽  
pp. 141-146 ◽  
Author(s):  
Tugcin Bora Polat ◽  
Yalim Yalcin ◽  
Celal Akdeniz ◽  
Cenap Zeybek ◽  
Abdullah Erdem ◽  
...  
Keyword(s):  
Rheumatic Fever ◽  
Acute Rheumatic Fever ◽  
Qt Dispersion ◽  
Control Group ◽  
Healthy Children ◽  
Rheumatic Carditis ◽  
Normal Children ◽  
A Value ◽  
The Mean

Background:Disturbances of conduction are well known in the setting of acute rheumatic fever. The aim of this study is to investigate the QT dispersion as seen in the surface electrocardiogram of children with acute rheumatic fever.Methods:QT dispersion was quantitatively evaluated in 88 children with acute rheumatic fever. Patients were divided into two groups based on the absence or presence of carditis. As a control group, we studied 36 healthy children free of any disease, and matched for age with both groups. Repeat echocardiographic examinations were routinely scheduled in all patients at 3 months after the initial attack to study the evolution of valvar lesions.Results:The mean QT dispersion was significantly higher in children with rheumatic carditis. But there was no statistical difference between children without carditis and normal children. Among the children with carditis, the mean dispersion was higher in those with significant valvar regurgitation. Dispersion of greater than 55 milliseconds had a sensitivity of 85%, and specificity of 70%, in predicting rheumatic carditis, while a value of 65 milliseconds or greater had sensitivity of 81% specificity of 85% in predicting severe valvar lesions in acute rheumatic carditis. At follow-up examination, a clear reduction on the QT dispersion was the main finding, reflecting an electrophysiological improvement.Conclusions:These observations suggest that QT dispersion is increased in association with cardiac involvement in children with acute rheumatic fever.

scholarly journals HEALTHY PEDIATRIC ATHLETES HAVE SIGNIFICANT BASELINE LIMB ASYMMETRIES ON COMMON RETURN TO SPORT PERFORMANCE TESTS

2019 ◽  
Vol 7 (3_suppl) ◽  
pp. 2325967119S0004
Author(s):  
John Magill ◽  
Heather Myers ◽  
Valentine Esposito ◽  
Michael Messer ◽  
Trevor Lentz ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Acl Reconstruction ◽  
Linear Regression Analysis ◽  
Return To Sport ◽  
Sport Performance ◽  
Interquartile Range ◽  
Healthy Children ◽  
Performance Tests ◽  
Limb Asymmetry ◽  
Definition Of

Purpose/Hypothesis: Return to sport (RTS) after anterior cruciate ligament (ACL) reconstruction in children is associated with a much higher risk (˜30%) of subsequent ACL injury than in adults. Most RTS testing protocols use Limb Symmetry Indices (LSI) on physical performance tests (PPTs). This assumes that both lower extremities should be equal. We hypothesized that in the pediatric population, baseline limb asymmetry exists, limiting the clinical utility of LSIs. Since LSI > 90% is often used as a clinical cutoff for RTS, we defined a test as valid if 80% of healthy volunteers had an LSI > 90%. Number of Subjects: 63 Materials/Methods: This study included healthy volunteers ages 6-18 [mean age = 10.7 +/- 3.2 years; 34 females (54%)]. Pubertal Maturity Observation Scores (PMOS), sex, age, height, weight, and body mass index (BMI) were collected. Subjects performed ten PPTs: lower quarter Y-balance, stork balance, stork balance on BOSU, single leg squat (SLS), SLS on BOSU, clockwise and counterclockwise quadrant single leg hop (SLH), forward SLH, timed SLH, and triple crossover SLH. Subjects performed the items in the same order, but were randomly assigned the starting test and the starting limb. We developed a composite score for each limb by averaging trials, then calculated the absolute value of the side-to-side difference, and normalized this difference to the test mean to obtain a percentage side-to-side difference (%STS). Multivariable linear regression analysis was performed to assess the effect of age on limb symmetry while correcting for BMI, PMOS and sex. Results: %STS were not normally distributed for any PPT, therefore data were reported as medians and interquartile ranges. All PPTs showed baseline limb asymmetry, and none met our definition of validity. The most symmetric PPT was the clockwise quadrant hop test (%STS in females, median = 9.85, interquartile range = 4.63 – 18.7; %STS in males, median = 6.9, interquartile range = 3.64 – 14.04). The stork balance on BOSU test had the greatest limb asymmetry (%STS in females, median 41.4, interquartile range 10.1 – 71.3; %STS in males, median 47.6, interquartile range 18.2 – 66.7). PMOS was strongly correlated with age (Pearson’s? = 0.83), and was excluded as a predictor variable. Age was an independent predictor of %STS only for the stork test (B = -1.15, 95% CI = -1.92 to -0.38, p = 0.004), with older subjects having less limb asymmetry. Conclusions: Healthy children have significant baseline limb asymmetries on PPTs that are commonly used for RTS decision making after ACL reconstruction. None of the PPTs evaluated in this study met our definition of clinical validity. Limb symmetry was typically not affected by subject age. Clinical Relevance: In light of these results, limb symmetry indices (LSI) should be utilized with caution in this population. Functional recovery may be better assessed by comparison to age and sex-specific norms. [Figure: see text]

EFFECTS OF ELECTRIC POLARIZABILITY OF NUCLEI IN LOW-ENERGY COLLISIONS AND ACTION RADIUS OF THE POLARIZATION POTENTIAL

1992 ◽  
Vol 07 (12) ◽  
pp. 2713-2739 ◽  
Author(s):  
V. V. PUPYSHEV ◽  
O. P. SOLOVTSOVA
Keyword(s):  
Potential Scattering ◽  
Polarization Potential ◽  
Low Energy ◽  
S Wave ◽  
Energy Potential ◽  
Electric Polarizability ◽  
Correct Definition ◽  
Starting Point ◽  
Identical Zero ◽  
Definition Of

Recent works devoted to investigating the role of electric polarizability of nuclei in elastic and nucleosynthesis reactions are critically and constructively reviewed, in order to formulate some problems of the low-energy potential scattering theory. Possible methods for solving these problems are outlined. One of the problems, a correct definition of the range of action of the polarization potential, is discussed in detail. An intuitively clear conception of this radius — the lower bound of the distance range, where the polarization potential may be replaced by identical zero — is used as a starting point. The fact that this bound should be defined in each concrete case is demonstrated by the results obtained by exploration of the pp reaction and the S-wave π±d-elastic collisions. Also discussed are numerical and analytical methods for finding the action radius depending on the studied function, the accuracy required for its evaluation, the scattering energy and the sign of the Coulomb potential.

Inferring earth structure from combined measurements of rotational and translational ground motions

Geophysics ◽  
2009 ◽  
Vol 74 (6) ◽  
pp. WCD41-WCD47 ◽  
Author(s):  
Moritz Bernauer ◽  
Andreas Fichtner ◽  
Heiner Igel
Keyword(s):  
Seismic Tomography ◽  
Wave Speed ◽  
Ground Motions ◽  
Regional Scale ◽  
S Wave ◽  
Tomographic Images ◽  
Teleseismic Tomography ◽  
Local Structures ◽  
Novel Variant ◽  
Definition Of

We introduce a novel variant of seismic tomography that is based on colocated measurements of rotational and translational ground motions. Our aim is to assess whether rotations may be incorporated successfully into seismic inverse problems to produce better resolved and more realistic tomographic images. Our methodology is based on the definition of apparent S-wave speed as the ratio of rms velocity and rotation amplitudes. The principal advantages of this definition are that (1) no traveltimes measurements are needed and (2) the apparent S-wave speed is independent of source magnitude and source timing. We derive finite-frequency kernels for apparent S-wave speed by using a combination of the adjoint method and ray approximation. The properties of these kernels as a function of frequency bandwidth can be illustrated along with their usefulness for seismic tomography. In multifrequency synthetic inversions, we consider local crosshole tomography and regional-scale earthquake tomography. Our results indicate that S-wave speed variations can be retrieved accurately from colocated rotation and translation measurements, suggesting that our methodology is a promising extension of conventional seismic tomography. Further, apparent S-wave speed can be used to increase vertical resolution in teleseismic tomography for local structures.

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