scholarly journals QT Interval Changes in Children With Febrile Convulsion Comparing With Healthy

2021 ◽  
pp. 1-15
Author(s):  
Alireza Teimouri ◽  
◽  
Noor Mohammad Noori ◽  
Ali Khajeh ◽  
◽  
...  
Keyword(s):  
Qt Interval ◽  
Case Control Study ◽  
Age Groups ◽  
Febrile Convulsion ◽  
Case Control ◽  
Healthy Children ◽  
Age Group ◽  
Chi Square ◽  
Pediatric Cardiologist ◽  
Control Study

A temperature-related seizure is a febrile seizure that affects the QT interval. The purpose of this study was to evaluate the changes in the QT interval caused by febrile convulsion compared with healthy children. Method This case-control study considered the distribution of 180 children equally shared between patients and controls. The study was conducted at the "Ali Ebne Abi Talib" Hospital in Zahedan, Iran. The disease diagnosed and confirmed based on standard definitions of febrile convulsion. QT interval measured by ECG and interpreted by a pediatric cardiologist and collected data were analyzed with SPSS 19 considering 0.05 as significant error. Results Among the ECG parameters, HR, R in aVL, S in V3, LVM, QTd, QTc and QTcd were significantly different in children with febrile convulsion compared to the peers. From those who had abnormal QTd, FC children were more frequented but not significant (CHI SQUARE=1.053, p=0.248), when children with FC were more in abnormality regarding QTc (CHI SQUARE=13.032, p<0.001) and QTcd (CHI SQUARE=21.6, P<0.001) significantly. In children with FC, those who were aged less than 12 months, had the highest level of HR but not significant (CHI SQUARE=4.59, p=0.101). Similar trends occurred for R in aVL and S in V3 that were higher in the age group >24 months (p>0.05). LVM had the highest value in the age group of >24 months significantly (CHI SQUARE= 52.674, P<0.001) and the other QT parameters were same in Fc children with different age groups (P>0.05). Conclusion From the study concluded that dispersion corrected QT, corrected QT and dispersion QT changed significantly in children with febrile convulsion in comparing with the healthy children but with constant values in children with FC in different age groups.

scholarly journals A CASE CONTROL STUDY ON DETERMINANTS OF CHILDHOOD ASTHMA IN SCHOOL CHIL-DREN OF CHITRADURGA CITY

2018 ◽  
Vol 10 (3) ◽  
pp. 39
Author(s):  
Prakruthi G. M. ◽  
Bharathi D. R. ◽  
Yogananda R.
Keyword(s):  
Childhood Asthma ◽  
Case Control Study ◽  
Case Control ◽  
Age Group ◽  
Community Based ◽  
Chi Square ◽  
Asthmatic Children ◽  
Chi Square Test ◽  
Strength Of Association ◽  
Control Study

Objective: Asthma is a chronic airway inflammatory disease in which many cells and cellular elements play a role often arising from allergies, subsequently cause shortness of breath, wheezing and coughing it affects children in different ways. To study the sociodemographic characteristics of asthmatic children and compare the predisposing factors of asthma in children.Methods: A Community based Case control study in selected schools in chitradurga for a period of 6 mo. A total of 90 children, among which 30 asthma children and 60 non asthma children were participated. Odds ratio will be calculated to know the strength of association. chi square test will be calculated to the significance.Results: A total of 90 children aged<14 y data. Female children are more exposed to asthma than male. In childhood asthma age group between 10-14years the age group of 10 y(26.7%) and 12 y (26.7%) were more exposed to the asthma.Conclusion: In Chitradurga city, the study area, is of no exception with regard to case control. From the total of 90 children selected for the study majority were found risk factors affected. It was due to their family history, exposure to pet animals, allergy, age group, BMI and sex.

scholarly journals Association of Interleukin-6-174 G/C Gene Promotor Polymorphism with Rheumatoid Arthritis in Adolescence Age Group: A Case-control Study

2021 ◽  
Author(s):  
Sergei Egorovich Khalchitsky ◽  
Marina Vanikovna Sogoyan ◽  
Alexei Nicolaevich Kozhevnikov ◽  
Sergei Valentinovich Vissarionov ◽  
Alexei Georgievich Baindurashvili
Keyword(s):  
Rheumatoid Arthritis ◽  
Real Time ◽  
Case Control Study ◽  
Case Control ◽  
European Population ◽  
Control Group ◽  
Healthy Children ◽  
Chi Square ◽  
Chi Square Test ◽  
Control Study

Introduction: Rheumatoid Arthritis (RA) is a chronic autoimmune disease with unknown pathogenesis. The disease is multifactorial, however, the exact causes of the occurrence, as well as the targets of the autoimmune process, are unknown. Genes candidate for a predisposition to RA are cytokine genes. Of the cytokines, IL-6 is considered a key mediator of systemic and localized inflammation in RA. Aim: The comparative analysis of the frequency distribution of alleles and genotypes IL-6 -174G/C polymorphism in patients with RA and in the control group to determine the genotype most characteristic of this disease. Materials and Methods: This case-control study was conducted in a group of 136 children with RA aged 14 to 18 years. In the control group, there were 143 practically healthy children of similar age without RA and orthopedic pathology. Both groups were tested for polymorphism IL-6 -174G/C using real-time Polymerase Chain Reaction (real-time PCR). The results were statistically processed using the Pearson's Chi-square test. Results: The distribution of -174G/C genotypes in the IL-6 gene is significantly different in patients with RA when compared with the control group. In patients with RA, heterozygous carriers of -174G/C (52.94%) prevail, while in the control group the most numerous group are homozygous carriers of -174G/G (40.56%). Conclusion: As a result of this study, it was possible to identify significant differences in the distribution of the genotypes -174 G/C polymorphism in the IL-6 gene between patients with RA and subjects of the control group. In relation to the European population of the Russian Federation, this polymorphism can serve as a diagnostic marker in the study of the pathogenesis of RA.

scholarly journals Prevalance of anemia in children with acute lower respiratory tract infection: a case control study in children between 6 months to 23 months

2020 ◽  
Vol 7 (7) ◽  
pp. 1573
Author(s):  
Rajakumar N. Marol ◽  
Rohitkumar R. Marol ◽  
Renuka R. Marol
Keyword(s):  
Case Control Study ◽  
Age Groups ◽  
Case Control ◽  
Control Group ◽  
Age Group ◽  
Intervention Measures ◽  
Level 2 ◽  
Very High ◽  
Control Study ◽  
Prevalence Of Anemia

Background: Anemia and ALRI are quite common in infants and toddlers in developing countries. ALRI is a leading cause of mortality in children below 5 years of age and it is important to prevent risk factors for development of ALRI. Present study was conducted to know the prevalence of anemia in children between 6 m to 23 m with ALRI and the relation between ALRI and anemia.Methods: This is a prospective case control study, conducted at Level 2 hospital situated in   backward district over a period of 1 year. Two hundred cases who had ALRI as per WHO criteria and 200 controls  were taken as the study group. Children were divided in to 3 different age groups. Haemoglobin level was estimated in all.Anemia was defined and classified according to WHO criteria.Results: Out of total 200 children both in cases and controls, 128 (64%) were males and 72 (36%) were females. Overall 190 (95%) of cases and 187 (93.5%) of controls had anemia. The prevalence of anemia was uniform in both sexes and all age groups. Children in the age group 6m -11m were more likely to develop ALRI.Conclusions: Prevalance of anemia in children between 6 m to 23 m with ALRI and without ALRI was 93.5% and 95% respectively. Authors cannot declare with affirmation that there was no association between Hb levels and ALRI as prevalence of anemia was very high in control group. Screening all children for anemia and taking proper intervention measures is necessary while treating for other ailments like ALRI.

HUBUNGAN ANTARA USIA, PARITAS, PEKERJAAN DAN INDEK MASSA TUBUH DENGAN KEJADIAN PROLAP ORGAN PANGGUL BERDASARKAN SKOR PELVIC ORGAN PROLAPSE QUANTIFICATION

2019 ◽  
Vol 2 (1) ◽  
pp. 39-44
Author(s):  
Ermawati Ermawati ◽  
Hafni Bachtiar
Keyword(s):  
Pelvic Organ Prolapse ◽  
Case Control Study ◽  
Pelvic Organ ◽  
Case Control ◽  
T Test ◽  
Pelvic Organ Prolapse Quantification ◽  
Chi Square ◽  
Chi Square Test ◽  
Control Study

Prolap organ panggul merupakan kondisi yang mempengaruhi kualitas hidup wanita. Prolaps organ panggul ini dapat disebabkan oleh perlukaan sewaktu proses persalinan, proses penuaan, komposisi jaringan pada seorang wanita, batuk- batuk kronis, atau sering melakukan pekerjaan berat. Pengenalan dini prolaps terkait dengan prognosis pemulihan anatomik dan fungsional organ panggul. Hingga kini, penerapannya dalam dunia klinis belum banyak sehingga pelatihan dan pembelajaran lebih lanjut tentang pelvic organ prolapse quantification (POPQ) jelas diperlukan. Penelitian ini dilakukan dengan metode case control study di polikilinik Obgin RSUP. Dr. M. Djamil Padang mulai bulan September 2013 sampai jumlah sampel terpenuhi sebanyak 98 orang. Dengan 49 orang kelompok kontrol dan 49 orang kelompok kasus .Analisis dilakukan untuk menilai hubungan usia, paritas, pekerjaan dan indek massa tubuh dengan kejadian prolap organ panggul berdasarkan skor POPQ. Data disajikan dalam bentuk tabel. Data diuji dengan t test dan chi square test. Jika p<0,05 menunjukan hasil yang bermakna. Terdapat hubungan yang bermakna antara usia dengan kejadian prolap organ panggul dengan (p<0,05) dan OR 27,871.terdapat hubungan yang bermakna antara paritas dengan kejadian prolap organ panggul dengan (p<0,05) dan OR 52,970.Dari analisa statistik pekerjaan tidak bisa di uji secara statistik.indek massa tubuh tidak terdapat hubungan yang bermakna terhadap kejadian prolap organ panggul.(p>0,05)

Sindrom Penyakit Tropis sebagai Prediktor Terjadinya Malnutrisi Balita di Daerah Pesisir

2020 ◽  
Vol 4 (2) ◽  
pp. 107-119
Author(s):  
Swaidatul Masluhiya AF ◽  
Irma Irma
Keyword(s):  
Confidence Interval ◽  
Case Control Study ◽  
Case Control ◽  
Chi Square ◽  
Control Study

Masalah kesehatan masyarakat yang cukup seriuspada kelompok usia balita sampai saat ini adalah kejadian malnutrisi, hal iniberdampak pada gangguan pertumbuhan dan perkembangan fisik balita. Malnutrisi juga dapat menyebabkan balita menjadi rentan terhadap penyakit infeksi. Beberapa faktor penyebab malnutrisi diantaranya faktor makanan dan penyakit infeksi yang mungkin diderita anak, faktor ketahanan pangan dikeluarga, pola pengasuhan anak, pelayanan kesehatan dan kesehatan lingkungan. Tujuan penelitian ini adalah untuk mengetahui apakah sindrom penyakit tropis merupakan prediktor terjadinya gizi kurang pada balita. Penelitian ini termasuk penelitian observasional analitik dengan rancangan Case Control Study. Populasi dalam penelitian ini adalah seluruh pasangan ibu dan balita yang ada di daerah pesisir kecamatan Nambo Kota Kendari denganteknik simple randam sampling di dapatkan jumlah sampel  sebanyak 164 orang yang terdiri dari dua kelompok yaitu kelompok kasus dan kelompok kontrol dengan perbandingan 1:1. Data dianalisis secara statistik dengan uji Chi square pada tingkat kepercayaan 95% (α=0,05) dengan mempertimbangkan nilai Odd Ratio dan nilai Confidence Interval. Hasil penelitian ini menunjukan bahwa sindrom penyakit tropis (diare dengan р-value = 0,001 dan OR = 4,162, batuk – batuk dengan р-value = 0,001 dan OR = 3,552,ISPAnon pneumoni dengan р-value = 0,004 dan OR = 3,003) merupakan faktor prediktor terjadinya malnutrisi pada balita sedangkan infeksi cacing dengan р-value = 0,056 dan OR= 1,773 bukan merupakan faktor prediktor terjadinya malnutrisi pada balita di daerah pesisir Kecamatan Nambo Kota Kendari

scholarly journals Premedication Does Not Influence the Incidence of Infliximab Infusion Reactions in Pediatric Patients with Inflammatory Bowel Disease—A Single Center Case–Control Study

2021 ◽  
Vol 10 (14) ◽  
pp. 3177
Author(s):  
Edyta Szymanska ◽  
Maciej Dadalski ◽  
Joanna Sieczkowska-Golub ◽  
Dorota Jarzebicka ◽  
Monika Meglicka ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Pediatric Patients ◽  
Case Control Study ◽  
Case Control ◽  
Chi Square ◽  
Infusion Reactions ◽  
Inflammatory Bowel ◽  
The Difference ◽  
Control Study

Background: Infusion reactions (IRs) are the most common adverse events (AEs) of infliximab (IFX) treatment in patients with inflammatory bowel disease (IBD). Prophylactic premedication (PM) with corticosteroids or antihistamines prior to IFX infusions has been used in clinical practice, but its efficacy is not known. The aim of this study was to assess the influence of steroid PM on IR incidence in pediatric patients with IBD receiving IFX. Methods: We performed a case–control study that included pediatric patients with IBD receiving IFX. Patients were divided into four subgroups according to the agent and PM they received: Remicade (original drug) + PM, and two biosimilars—Reshma +/− PM, and Flixabi—PM. At our site, until 2018, PM with steroids was used as a part of standard IFX infusion (PM+); however, since then, this method has no longer been administered (PM−). IRs were divided into mild/severe reactions. Differences between subgroups were assessed with the appropriate chi-square test. Multivariate logistic regression was used to assess associations between PM and IR incidence, correcting for co-medication usage. Results: There were 105 children (55 PM+, 44 male, mean age 15 years) included in the study who received 1276 infusions. There was no difference between the PM+ and PM− subgroups, either in incidence of IR (18.2% vs. 16.0% of patients, p > 0.05) or in percentage of infusions followed by IR (2.02% vs. 1.02% of infusions, p > 0.5). The OR of developing IR when using PM was 0.34, and the difference in IRs ratio in PM+ and PM− patients was not statistically significant (95% CI, 0.034–1.9). There were 11/18 (61.1%) severe IRs (anaphylactic shock) reported in all patients (both PM+ and PM−). Conclusion: At our site, the incidence of IR was low, and PM did not decrease the incidence of IR in pediatric patients with IBD receiving IFX. These results indicate that PM with steroids should not be a standard part of IFX infusion to prevent IR.

scholarly journals Cognitive development of children with Kawasaki disease and the parenting stress of their caregivers in Taiwan: a case–control study

BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e042996
Author(s):  
Liang-Jen Wang ◽  
Zi-Yu Tsai ◽  
Ling-Sai Chang ◽  
Ho-Chang Kuo
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Parenting Stress ◽  
Case Control Study ◽  
Short Form ◽  
Case Control ◽  
Stress Index ◽  
Secondary Outcome ◽  
Healthy Children ◽  
Control Study

ObjectiveKawasaki disease (KD) is an acute form of febrile vasculitis that occurs in early childhood. The multisystemic vasculitis common in patients with KD may influence blood perfusion in the brain, and thus caregivers of children with KD may feel stress with regard to caring for them. Intravenous immunoglobulin (IVIG) infusion is the standard treatment for acute KD, and the most serious complication of KD is coronary artery aneurysms (coronary artery lesion (CAL)). This study aimed to investigate the relationships between KD heterogeneity and the risk of patients’ cognitive impairment or caregivers’ parenting stress.DesignA case–control study with consecutive sampling.SettingA medical centre (Kaohsiung Chang Gung Memorial Hospital, Taiwan).ParticipantsThis study consisted of 176 patients with KD (mean age: 5.5 years, 60.8% boys) and 85 healthy children (mean age: 6.4 years, 54.1% boys).Primary and secondary outcome measuresBased on the children’s age, each patient with KD and control subject was administered an assessment using the Mullen Scales of Early Learning or the Wechsler Intelligence Scale, and parenting function of their caregivers was assessed using the Parenting Stress Index (PSI)-Short Form.ResultsWe observed no significant differences in any developmental index, cognitive function or parenting stress between patients with KD and controls. Among the children with KD, IVIG administration nor CAL was associated with children’s cognitive scores. However, the caregivers of patients who had CAL suffered from greater PSI total scores than those of patients without CAL. Furthermore, the caregivers who had education levels of a master’s degree or above showed less parenting stress than those who had an education level of college or lower.ConclusionCaregivers’ education is associated to parenting stress, and caregivers of patients with KD who developed CAL may feel stress about the unpredictable sequela caused by CAL for their children. Such caregivers may require support to fulfil their parenting roles.

scholarly journals 717. Antibiotic treatment of Shiga toxin-producing Escherichia coli related gastroenteritis and the risk of hemolytic uremic syndrome: a population based matched case-control study in Japan

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S409-S410
Author(s):  
Shota Myojin ◽  
Kyongsun Pak ◽  
Mayumi Sako ◽  
Tohru Kobayashi ◽  
Takuri Takahashi ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Shiga Toxin ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Population Based ◽  
Case Control ◽  
Age Group ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Abstract Background The role of therapeutic intervention, particularly antibiotics, for Shiga toxin-producing Escherichia coli (STEC) related infection is controversial. Methods We performed a population based matched case-control study to assess the association between treatment (antibiotics, antidiarrheal agents and probiotics) for STEC related infections and HUS development. We identified all STEC HUS patients as cases and matched five non-HUS patients as controls using the data from the National Epidemiological Surveillance of Infectious Diseases (NESID) between January 1, 2017, and December 31, 2018. Further medical information was obtained by standardized questionnaires answered by physicians who registered each patient. We used multivariate conditional logistic regression model to evaluate the association between exposures (use of antibiotics, use of antidiarrheal agents, days between disease onset and fosfomycin administration [within two or three days]) and the development of HUS, by matched odds ratios (OR) and 95% confidence intervals (CI). Covariates we used were sex, age group, area code, presence of diarrhea and other factors. We also performed subgroup analyses using age (adults and children) as a stratification factor. Results 7,760 STEC related patients were registered in the NESID. We selected patients who had a record of HUS diagnosis (n=182) and matched controls without HUS (n=910). After collecting standardized paper-based questionnaires, we enrolled 90 HUS patients and 371 non-HUS patients for analysis. In the main analysis, matched OR of fosfomycin was 0.75(0.47-1.20) in all ages, 1.41(0.51-3.88) in adults and 0.58(0.34-1.01) in children. Matched OR of antidiarrheal agents was 2.07(1.07-4.03) in all ages, 1.84(0.32-10.53) in adults, 2.65(1.21-5.82) in children. Matched OR of probiotics was 0.86(0.46-1.61) in all ages, 0.76(0.21-2.71) in adults, 1.00(0.48-2.09) in children. There was no significant association between the timing of fosfomycin use in the first two or five days of illness and HUS development in any age group. Conclusion Our results suggest that fosfomycin might decrease the risk of HUS in children younger than 15 years of age with STEC confirmed bacterial gastroenteritis. Disclosures All Authors: No reported disclosures

ANALISIS FAKTOR RISIKO YANG BERHUBUNGAN DENGAN KEJADIAN PNEUMONIA BALITA DI WILAYAH KERJA UPTD PUSKESMAS BANDA RAYA KOTA BANDA ACEH TAHUN 2019

2020 ◽  
Vol 6 (1) ◽  
pp. 20-28
Author(s):  
Miftahul Jannah ◽  
Asnawi Abdullah ◽  
Melania Hidayat ◽  
Qatratul Asrar
Keyword(s):  
Retrospective Study ◽  
Case Control Study ◽  
Case Control ◽  
P Value ◽  
Chi Square ◽  
Control Study ◽  
Banda Aceh

Latar Belakang: Pneumonia merupakan pembunuh utama balita di seluruh dunia. Berdasarkan Laporan Dinas Kesehatan Banda Aceh tahun 2018, jumlah balita penderita Pneumonia meningkat setiap tahunnya. Kasus Pneumonia balita yang paling banyak terdapat di UPTD Puskesmas Banda Raya. Penelitian ini bertujuan untuk mengetahui faktor risiko yang berhubungan dengan kejadian Pneumonia pada Balita di wilayah kerja UPTD Puskesmas Banda Raya Kota Banda Aceh tahun 2019. Metode: Penelitian ini menggunakan desain Case Control Study atau Retrospective Study. Penelitian ini menggunakan total populasi dengan jumlah sampel adalah 142 anak balita berusia 12–59 bulan. Data dianalisis secara Univariat dan Bivariat. Analisis Bivariat menggunakan Uji Chi-Square dengan derajat kepercayaan 95% (p value0.05). Hasil: Hasil penelitian menunjukkan bahwa faktor risiko yang berhubungan dengan kejadian pneumonia adalah luas ventilasi rumah (OR=15.81; CI 95%=4.70-53.12; p value=0.0001); sedangkan umur balita (OR=1.15; CI 95%=0.54-2.43; p value=0.705); jenis kelamin (OR=1.11; CI 95%=0.57-2.16; p value=0.737); pengetahuan ibu (OR=0.38; CI 95%=0.12-1.24; p value=0.112); dan kepadatan hunian (OR=1.80; CI 95%=0.78-4.13; p value=0.163), tidak terbukti secara signifikan sebagai faktor risiko pneumonia balita di UPTD Puskesmas Banda Raya Kota Banda Aceh. Kesimpulan: Faktor risiko yang berhubungan dengan kejadian Pneumonia balita adalah luas ventilasi rumah. Oleh karena itu diperlukannya sanitasi lingkungan yang sehat sebagai upaya preventif terhadap kejadian Pneumonia, serta memperbaiki pola perilaku hidup bersih dan sehat.

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