The β3-adrenergic agonist (BRL35135A) acutely increases oxygen consumption and plasma intermediate metabolites in sheep

2011 ◽  
Vol 51 (10) ◽  
pp. 881 ◽  
Author(s):  
Samadi ◽  
M. Jois ◽  
F. R. Dunshea ◽  
B. J. Leury
Keyword(s):  
Fatty Acids ◽  
Oral Dose ◽  
Treatment Time ◽  
Co2 Production ◽  
Receptor Subtypes ◽  
Adrenergic Agonist ◽  
Esterified Fatty Acids ◽  
Adrenergic Antagonist ◽  
Intermediate Metabolites ◽  
Plasma Metabolite

There is evidence that an atypical adrenoreceptor subtype is involved in mediating some of the physiological effects of catecholamines, particularly in some adipose tissue sites. Therefore, three experiments were conducted to determine the metabolic and energetic responses to oral administration of the purported β3-agonist BRL35135A in ruminant lambs. The post-prandial increase in O2 consumption (0.109 versus 0.139 L/min) and CO2 production (0.102 versus 0.127 L/min) at 30 min after feeding was greater (P < 0.05) in the lambs receiving 5 mg of the BRL35135A. Treatment × time interactions over the period between –50 and 220 min indicate significant increases in plasma non-esterified fatty acids (P < 0.001), glucose (P < 0.001) and lactate (P = 0.024) in lambs consuming a single oral dose of 5 mg BRL35135A. In a subsequent experiment there were similar interactions over the period between –120 and 1440 min for non-esterified fatty acids (P < 0.001), glucose (P < 0.001) and lactate (P < 0.001) in lambs consuming a lower oral dose of 1 mg BRL35135A. The effects of BRL35135A on plasma non-esterified fatty acids (P = 0.95), glucose (P = 0.84) and lactate (P = 0.68) were not modified by the β1- and β2-adrenergic antagonist alprenolol suggesting that the effects were mediated via β3-adrenergic receptor subtypes. In conclusion, these experiments indicate that BRL35135A is acutely active in sheep when given with feed, as indicated by increases in respiratory gas exchange and plasma metabolite concentrations.

scholarly journals Growth Performance and Plasma Metabolites of Grazing Beef Cattle Backgrounded on Buffel or Buffel-Desmanthus Mixed Pastures

Animals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2355
Author(s):  
Felista W. Mwangi ◽  
Christopher P. Gardiner ◽  
Glen Walker ◽  
Trevor J. Hall ◽  
Bunmi S. Malau-Aduli ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Weight Gain ◽  
Beef Cattle ◽  
Dry Matter ◽  
Metabolite Profile ◽  
Dry Season ◽  
Plasma Metabolites ◽  
Buffel Grass ◽  
Esterified Fatty Acids ◽  
Plasma Metabolite

Dietary crude protein and dry matter digestibility are among the major factors limiting feed intake and weight gain of cattle grazing native and improved pastures in the subtropics of Northern Australia during the dry season. Incorporating a suitable legume into grasses improves pasture quality and cattle weight gain, but only a limited number of legume pastures can establish and persist in cracking clay soils. This study aimed to evaluate the effect of Desmanthus inclusion in buffel grass (Cenchrus ciliaris) pastures on the plasma metabolite profile and growth performance of grazing beef cattle during the dry season. We hypothesised that backgrounding steers on buffel grass-Desmanthus mixed pastures would elicit significant changes in plasma glucose, bilirubin, creatinine, non-esterified fatty acids and β-hydroxybutyrate, resulting in higher liveweight gains than in steers on buffel grass only pastures. Four hundred tropical composite steers were assigned to buffel grass only (n = 200) or buffel grass oversown with Desmanthus (11.5% initial sward dry matter) pastures (n = 200) and grazed for 147 days during the dry season. Desmanthus accounted for 6.2% sward dry matter at the end of grazing period. Plasma metabolites results showed that changes in β-hydroxybutyrate, creatinine, bilirubin, glucose and non-esterified fatty acids were within the expected normal range for all the steers, indicating that with or without Desmanthus inclusion in the diet of grazing steers, animal health status was not compromised. It was also evident that Desmanthus inclusion in buffel grass pastures had no impact on the plasma metabolite profile, liveweight and daily weight gain of grazing steers. Therefore, our tested hypothesis of higher changes in plasma metabolite profile and higher liveweight gains due to backgrounding on low-level buffel grass-Desmanthus mixed pastures does not hold.

scholarly journals The Effect of B-Adrenergic Agonist Injection and Feeding Energy Level on Blood Plasma Non-Esterified Fatty Acids in The Lactating Dairy Ewe

2012 ◽  
Vol 26 (4) ◽  
pp. 73
Author(s):  
Ali Agus ◽  
Francois Bocquier ◽  
Anne Ferlay ◽  
Yves Chilliard
Keyword(s):  
Fatty Acids ◽  
Energy Level ◽  
Blood Plasma ◽  
Adrenergic Agonist ◽  
Esterified Fatty Acids

Artikel dalam bentuk PDF

Effect of Propolis-Supplemented Diet on Body Composition and Endocrine Function of Adipose Tissue

2020 ◽  
Vol 19 (2) ◽  
pp. 217-221
Author(s):  
Maria Jesús Lisbona-González ◽  
Candela Reyes-Botella ◽  
Esther Muñoz-Soto ◽  
Maria Victoria Olmedo-Gaya, ◽  
Jorge Moreno-Fernandez ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Body Composition ◽  
Adipose Tissue ◽  
Endocrine Function ◽  
Control Group ◽  
Albino Rats ◽  
Standard Diet ◽  
Reduced Body ◽  
Esterified Fatty Acids ◽  
Wistar Albino Rats

Adipose tissue is an endocrine organ and has central role in interaction with other organs or tissues while propolis can induce lipolysis. Therefore, the aim of this study is to provide detailed information about adipose tissue homeostasis modifications and body composition during propolis supplement consumption. Twenty male Wistar albino rats (8 weeks) were divided into two groups of 10 animals each and fed for 90 days with two different types of diets: standard for the control group (diet C) and standard diet + 2% propolis (diet P). Thyroid hormones did not show differences, while ghrelin and adiponectin decreased in the group that was fed propolis. Insulin, leptin, and non-esterified fatty acids also increased along with reduced body weight and fat, in addition to increased lean mass when propolis was in the diet. We conclude that propolis could decrease ghrelin and adiponectin but increase non-esterified fatty acids and insulin secretion, which improves body composition.

scholarly journals 51 Intranasal oxytocin improves plasma non-esterified fatty acids but not distance walked or cortisol concentrations at weaning

2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 29-30
Author(s):  
Kirsten Nickles ◽  
Alejandro E Relling ◽  
Anthony J Parker
Keyword(s):  
Fatty Acids ◽  
Body Weight ◽  
Repeated Measures ◽  
Production Costs ◽  
Calf Growth ◽  
Beef Calves ◽  
Esterified Fatty Acids ◽  
Randomized Design ◽  
Affect Body Weight ◽  
Global Positioning

Abstract Beef calves express behaviors such as walking and vocalizing to a greater extend during weaning. These behaviors increase production costs due to compromised calf growth, health, and welfare. Oxytocin treatment reduces anxious behaviors and attenuates the HPA axis, thus the objective of this experiment was to evaluate the effects of oxytocin on calf growth, cortisol, and distance walked at weaning. A total of 20 Angus x Simmental heifer calves were randomly allotted to each treatment group (n = 10), intranasal oxytocin or saline (OXT, CON). All calves were administered the respective intranasal treatment at weaning (day 0), and then placed in the same pasture. Calves were weighed and blood sampled on days 0, 1, 7, and 14. Blood samples were used to quantify non-esterified fatty acids (NEFA), β-hydroxybutyrate, and cortisol. Each heifer was fitted with a global positioning system collar that recorded calf location every 10 seconds for 16 h on days 0, 7, and 14. To further evaluate calf behavior, observations were made on days 0, 7, and 14 using instantaneous scan sampling from 0730 to 0830, 1200 to 1300, and 1700 to 1800 h. Data were analyzed using a completely randomized design with repeated measures model (SAS 9.4). Providing calves with intranasal oxytocin on the day of weaning did not have an effect on the distance walked, observed behavior, body weight, β-hydroxybutyrate, or cortisol concentrations, however, there was a day effect (P &lt; 0.05) for these variables. Intranasal oxytocin treatment did affect NEFA concentrations, as calves in the CON group had greater NEFA concentrations on day 1 compared with calves in the OXT group (P &lt; 0.05). These data imply that intranasal oxytocin could have the capacity to decrease mobilization of NEFA, but this change was not enough to affect body weight 14 days after weaning.

Effects of endogenous and exogenous catecholamines on LPS-induced neutrophil trafficking and activation

1999 ◽  
Vol 276 (1) ◽  
pp. L1-L8 ◽  
Author(s):  
Edward Abraham ◽  
Debra J. Kaneko ◽  
Robert Shenkar
Keyword(s):  
Systemic Circulation ◽  
Mrna Levels ◽  
Adrenergic Stimulation ◽  
Neutrophil Accumulation ◽  
Adrenergic Agonist ◽  
Nitric Oxide Synthase Inhibitor ◽  
Adrenergic Agents ◽  
Adrenergic Antagonist ◽  
Tnf Α ◽  
Synthase Inhibitor

Endotoxemia produces elevations in catecholamine levels in the pulmonary and systemic circulation as well as rapid increases in neutrophil number and proinflammatory cytokine expression in the lungs. In the present experiments, we examined the effects of endogenous and exogenous adrenergic stimulation on endotoxin-induced lung neutrophil accumulation and activation. Levels of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and macrophage inflammatory protein (MIP)-2 mRNAs were increased in lung neutrophils from endotoxemic mice compared with those present in lung neutrophils from control mice or in peripheral blood neutrophils from endotoxemic or control mice. Treatment with the β-adrenergic antagonist propranolol before endotoxin administration did not affect trafficking of neutrophils to the lungs or the expression of IL-1β, TNF-α, or MIP-2 by lung neutrophils. Administration of the α-adrenergic antagonist phentolamine before endotoxemia did not alter lung neutrophil accumulation as measured by myeloperoxidase (MPO) levels but did result in significant increases in IL-1β, TNF-α, and MIP-2 mRNA expression by lung neutrophils compared with endotoxemia alone. Administration of the α1-adrenergic agonist phenylephrine before endotoxin did not affect trafficking of neutrophils to the lungs but was associated with significantly increased expression of TNF-α and MIP-2 mRNAs by lung neutrophils compared with that found after endotoxin alone. In contrast, treatment with the α2-adrenergic agonist UK-14304 prevented endotoxin-induced increases in lung MPO and lung neutrophil cytokine mRNA levels. The suppressive effects of UK-14304 on endotoxin-induced increases in lung MPO were not affected by administration of the nitric oxide synthase inhibitor N-nitro-l-arginine methyl ester. These data demonstrate that the initial accumulation and activation of neutrophils in the lungs after endotoxemia can be significantly diminished by α2-adrenergic stimulation. Therapy with α2-adrenergic agents may have a role in modulating inflammatory pulmonary processes associated with sepsis-induced acute lung injury.

Sign in / Sign up

Export Citation Format

Share Document