Studies on trichostrongylosis of sheep plasma volume, haemoglobin concentration, and blood cell count

1963 ◽  
Vol 14 (3) ◽  
pp. 349 ◽  
Author(s):  
CH Gallagher

The plasma volume of worm-free crossbred wether lambs was found to vary from 33 to 56 ml/kg during normal growth from 8 to 12 months of age. An inverse relationship was found to exist between plasma volume relative to body weight and body weight for lambs of this age. Infection of lambs with Trichostrongylus colubriformis, even when fatal, did not produce any alteration of plasma volume except that due to change in body weight. For all determinations made on all 26 sheep used, the mean plasma volumes were: 13–25 kg body weight, 46.83 ± 3.7 ml/kg; 26–30 kg body weight, 43.2 ± 3.2 ml/ kg; 31–38 kg body weight, 41.2 ± 3.8 ml/kg. The differences in plasma volume between the three body weight ranges were statistically significant (P < 0.001). The clinical syndrome in these experimental cases of trichostrongylosis was characterized by unthriftiness with failure to grow normally, loss of weight, and emaciation. None of the sheep showed diarrhoea. All infected sheep developed a moderate to severe degree of anaemia due to decreased numbers of erythrocytes. It is concluded that diarrhoea is an incidental clinical sign in trichostrongylosis, and is not essential for the disease to terminate fatally. The data presented suggest that water loss is not an important component of the syndrome.

2005 ◽  
Vol 129 (1) ◽  
pp. 89-91 ◽  
Author(s):  
Mordechai Lorberboym ◽  
Naomi Rahimi-Levene ◽  
Helena Lipszyc ◽  
Chun K. Kim

Abstract Context.—Polycythemia describes an increased proportion of red blood cells in the peripheral blood. In absolute polycythemia, there is increased red cell mass (RCM) with normal plasma volume, in contrast with apparent polycythemia, in which there is increased or normal RCM and decreased plasma volume. In order to deliver the appropriate treatment it is necessary to differentiate between the two. Objective.—A retrospective analysis of RCM and plasma volume data are presented, with special attention to different methods of RCM interpretation. Design.—The measurements of RCM and plasma volume in 64 patients were compared with the venous and whole-body packed cell volume, and the incidence of absolute and apparent polycythemia was determined for increasing hematocrit levels. Measurements of RCM and plasma volume were performed using chromium 51–labeled red cells and iodine 125–labeled albumin, respectively. The measured RCM of each patient was expressed as a percentage of the mean expected RCM and was also defined as being within or outside the range of 2 SD of the mean. The results were also expressed in the traditional manner of mL/kg body weight. Results.—Twenty-one patients (13 women and 8 men) had absolute polycythemia. None of them had an increased plasma volume beyond 2 SD of the mean. When expressed according to the criteria of mL/kg body weight, 17 of the 21 patients had abnormally increased RCM, but 4 patients (19%) had a normal RCM value. Twenty-eight patients had apparent polycythemia. The remaining 15 patients had normal RCM and plasma volume. Conclusions.—The measurement of RCM and plasma volume is a simple and necessary procedure in the evaluation of polycythemia. In obese patients, the expression of RCM in mL/kg body weight lacks precision, considering that adipose tissue is hypovascular. The results of RCM are best described as being within or beyond 2 SD of the mean value.


1979 ◽  
Vol 27 (6) ◽  
pp. 913 ◽  
Author(s):  
JL Barnett ◽  
RA How ◽  
WF Humphreys

Age, sex and seasonal related changes in body weight and blood parameters were determined for T caninus and T. vulpecula, whose distribution overlapped in part of the study area. In T. caninus age-related changes occurred in body weight, mean plasma glucose and protein concentrations and haematocrit. Seasonal changes occurred in plasma glucose and protein concentrations, haemoglobin concentration and red blood cell count. There were sexual dimorphisms in haematocrit, haemoglobin concentration and red blood cell count in both species; the mean values were greater in males. T. vulpecula also exhibited a sexual dimorphism in body weight (males > females). The only seasonal change in T. vulpecula was in haemoglobin concentration. Comparison of the species as adults showed that T. caninus had higher mean levels of body weight, haematocrit and haemoglobin concentration, while plasma lipid concentration and red blood cell counts were greater in T vulpecula. These species differences may be a reflection of the diets of the two species. In addition the measured parameters showed greater seasonal variation in T. caninus, a K-selected species, than in T. vulpecula, which is more r-selected.


1979 ◽  
Vol 27 (6) ◽  
pp. 927 ◽  
Author(s):  
JL Barnett ◽  
RA How ◽  
WF Humphreys

Body weight and six blood parameters were determined in T. caninus and T. vulpecula from their preferred and peripheral habitats. Habitat had a large effect on T. caninus. Of the seven parameters measured, six (body weight, red blood cell count, haemoglobin concentration, haematocrit and plasma protein and lipid concentrations) were higher in the population from the peripheral habitat than in that from the preferred habitat. Only body weight was different in T. vulpecula, being higher in the peripheral than in the preferred habitat population. There were differences between T. caninus and T. vulpecula in four of the measured parameters (body weight, haematocrit, haemoglobin concentration and red blood cell count) irrespective of habitat, whereas plasma lipid concentration was the same in T. caninus from peripheral habitat and T. vulpecula, but differed in T. caninus between habitats. Four parameters showed significant seasonal variation in preferred-habitat T. caninus, three in peripheral-habitat T. caninus and one in T. vulpecula. However, the pattern of seasonal change in peripheral-habitat T. caninus was more similar to that in T. vulpecula than to that in preferred-habitat T. caninus, suggesting a physiological shift in peripheral-habitat T. caninus towards that of the more r-selected T. vulpecula. No differences were found between resident and dispersing T. caninus. T. caninus which had lost a pouch young and failed to maintain another in the same year had lower haematocrit and plasma lipid concentration than females in other reproductive states. It is suggested that the measurement of physiological responsiveness of populations may aid the understanding of adaptive strategies.


1964 ◽  
Vol 207 (1) ◽  
pp. 223-227 ◽  
Author(s):  
N. A. Marcilese ◽  
R. M. Valsecchi ◽  
H. D. Figueiras ◽  
H. R. Camberos ◽  
J. E. Varela

Blood volumes of 51 horses of three different breeds were determined by means of radioisotopes Cr51 and Fe59. The mean values obtained in 34 determinations for 31 Thoroughbred English race horses are as follows: total blood volume, 10.31; plasma volume, 6.33; and red cell volume 3.98 liters/100 kg body weight for a hematocrit of 42.7%. The results for 6 saddle horses are: 7.75, 5.25, and 2.53, respectively, for a hematocrit of 37.3%. The results in 14 draft horses are: 6.14, 4.35, and 1.82 for a hematocrit of 33.5%. The differences observed in the blood volume values of the three breeds are statistically significant. In our opinion, these differences are due to their physiological qualities, according to the breed.


Author(s):  
Syam K. Venugopal ◽  
Syam K. Venugopal ◽  
Syam K. Venugopal ◽  
Syam K. Venugopal ◽  
Syam K. Venugopal

Six dogs each with open and closed-cervix pyometra (Group I and II) were medically managed with mifepristone @ 2.5mg/kg body weight orally twice daily for five days, followed by cloprostenol @ 5?g/kg body weight subcutaneously on every alternate day after ensuring cervical patency, till complete evacuation of uterus was assessed by ultrasonography. Haematological and serum biochemical values were estimated on the day of presentation. The treatment response was assessed by reviewing both haematological and serum biochemical values further on days 3, 7, 14 and 21 of treatment. The mean total erythrocyte count (TEC), haemoglobin concentration and volume of packed red cells (VPRC) were significantly lower and mean total leucocyte count (TLC) was significantly higher in all animals of both groups during the day of presentation. The values significantly improved after initiation of treatment. Total thrombocyte count, serum total protein, albumin, BUN and serum creatinine levels were within the normal range. TEC, TLC, Hb concentration, VPRC could be used for prognostic markers of treatment evaluation in canine pyometra.


1976 ◽  
Vol 35 (2) ◽  
pp. 229-244 ◽  
Author(s):  
M. S. Malhotra ◽  
Umesh Chandra ◽  
R. M Rai ◽  
Y. Venkataswamy ◽  
K. Sridharan

1. Food intake and energy expenditure were determined on 500 soldiers drawn from infantry, artillery and engineer units of the Indian army, for 3 months during winter..2. The units were located in two different regions of India at altitudes varying from sea level to 2300 m..3. The energy requirements were assessed from the actual food intake as well as from energy expenditure and from the changes in body-weight and skinfold thickness..4. The nutritional adequacy of the diet was assessed from clinical examination and changes in blood haemoglobin concentration..5. The mean energy expenditure was found to be 15.39 MJ (3679 kcal) and on this basis the energy requirement was 16.61 MJ (3970 kcal); energy intake was found to be 16.47 MJ (3936 kcal)..6. The energy contributed by protein, fat and carbohydrate was 0.115, 0.240 and 0.645 of the total intake respectively..7. There was no significant change in body-weight, blood haemoglobin level and skinfold thickness on this mean daily intake.


2020 ◽  
Vol 45 (5) ◽  
pp. 192-198
Author(s):  
N. Okwelum ◽  
W. Mustapha ◽  
B. O. Oluwatosin

The aim of this study was to determine the biochemical and haematological profiles of Kalahari Red goats reared in the tropical environment. The Kalahari Red goats were imported into Nigeria from South Africa by the Federal University of Agriculture Abeokuta, Nigeria. The study was carried out on fifty animals of both sexes. The animals were managed under semi-intensive system where they were allowed to go out and graze on paddocks during some part of the day and brought back to the pens in the evening. The goats were fed with concentrate and grazed on sown pastures of Chloris gayana and Stylosanthes amata. Water Rwas given ad-libitum. The serum biochemical analysis was determined using Randox analysis kits. The sex of each animal was noted and recorded. The packed cell volume, haemoglobin concentration, red blood cell count, white blood cell count, neutrophils, lymphocytes, monocytes, eosinophils and basophils were determined as haematological parameters while total protein, albumin, globulin, sodium, potassium, calcium and phosphorus were determined in serum analysis. The results showed that there was no significant (p>0.05) difference in all the haematological parameters determined across sex. There were significant (p<0.05) differences in total protein and albumin across sex of which the mean values were higher in the female goats. The value of the mean total protein in the female goats was 5.93±0.88 while the value was 5.31±0.23 in the male goats. It can be concluded that sex did not have any influence on the haematology but had association on only the protein component of the serum biochemistry. This result obtained can be used as a reference value for Kalahari Red goats reared in the tropics and under similar nutrition.


2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Elena Babalj Banskolieva ◽  
Risto Grozdanovski ◽  
Katerina Spaseska Gjurovska ◽  
Marko Ilievski ◽  
Biljana Filipovska ◽  
...  

Abstract Background and Aims It is well known that haemoglobin significantly increases after haemodialysis and it is associated with the rate of weight loss during dialysis. However, it has been shown that the increase in haemoglobin is not always proportional to the rate of body weight loss during haemodialysis (ultrafiltration). The purpose of the study was to investigate the correlation between haemoglobin changes, body weight loss and plasma volume changes during haemodialysis Method A prospective study was performed on 92 patients in mid-week treatments. Pre-dialysis and post-dialysis haemoglobin and weight were measured. 27 patients were excluded because clinical instability, no change or a decrease in Hb and low pre-dialysis haemoglobin (&lt; 9 g/dL). The correlation was statistically significant between %ΔPV and ΔHb in both groups (R2=0.59), whereas the correlation between %ΔBW and ΔHb was lower (R2=0.19). So, analysis show that only 19% of the variability in haemoglobin is explained by %ΔBW, and that 59% of the variability in haemoglobin is explained by %ΔPV. Results The mean age was 61.16 ± 13.11 year. The men were 52 (56%). The mean pre-dialysis Hb was 11.31 ± 1.16 g/dL, the mean post-dialysis Hb level was 12.53 ± 1.47 g/dL. The mean absolute change of haemoglobin (ΔHb g/dL) and percent of change of haemoglobin (%ΔHb) were 1.22 ± 0.76 and 9.44 ± 5.31, respectively. Average percent of weight change (%ΔBW) was - 2.44 ± 1.01. Percent of plasma volume change was - 9.22 ± 5.46. The patients were divided in two groups according post-dialysis haemoglobin level: Group A with haemoglobin Hb &lt; 13 g/dL (64 patients) and group B with Hb ≥13 g/dL (28 patients). The mean time average haemoglobin concentration (TAC Hb) in all patients was 11.68 ± 1.11 g/dL.(Predicted Hb TAC was calculated according Krisper′s formula) In both groups there was an increase in %ΔHb, but in the group with post dialysis Hb ≥ 13 g/dL, %ΔHb was greater than in group B with post dialysis Hb &lt; 13 g/dL (13.08 ± 5.11 versus 7.87± 4.61, P = 0.000) despite the relatively small difference of %ΔBW between the two groups (- 2.85 ± 0.95 versus - 2.23 ± 1.02; P = 0.010). However, the difference in %ΔPV between the two groups was significant (- 12.90 ± 5.63 versus - 7.61 ± 4.57; P &lt; 0.000). Conclusion The intradialytic changes in haemoglobin levels are predominantly determined by changes in plasma volume. Changes in body weight are of little predictive value in evaluation of variation of haemoglobin levels. TAC Hb determination should be performed in patients with large variations in plasma volume, because the plasma volume has very little effect on TAC Hb.


2016 ◽  
Vol 10 (1) ◽  
pp. 21-29
Author(s):  
Amadu Kayode Salau ◽  
◽  
Musa Toyin Yakubu ◽  
Adenike Temidayo Oladiji ◽  
◽  
...  

Background: This study investigated the protective effects of aqueous extracts of Anogeissus leiocarpus (DC) Guill & Perr (Combretaceae) and Terminalia avicennioides Guill & Perr (Combretaceae) root barks, as well as their 1:1 (w/w) mixture on liver redox and haematological parameters of diethylnitrosamine-treated rats. Methods: Rats were orally administered distilled water, diethylnitrosamine (30 mg/kg body weight once a week on weeks 3 and 4), curcumin (200 mg/kg body weight), extracts and 1:1 mixture (200, 400 and 800 mg/kg body weight) for 4 weeks. Malondialdehyde, markers of oxidative stress and hematological indices were evaluated. Results: The extracts and their mixture significantly (P<0.05) reversed the diethylnitrosamine-induced alterations in the levels of liver malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glucose 6-phosphate dehydrogenase, glutathione, vitamin C and platelet counts. The other haematological parameters (red blood cell count, haemoglobin concentration, packed cell volume, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, white blood cell count, lymphocyte count and neutrophil count) were not affected by diethylnitrosamine and extracts. Conclusion: The extracts possess antioxidant, hepatoprotective and haemoprotective activities that compared well with curcumin. These activities were better exhibited by the mixture than the individual extracts.


2019 ◽  
Vol 15 (02) ◽  
pp. 14-17
Author(s):  
K K Hadiya ◽  
A J Dhami ◽  
D V Chaudhari ◽  
P M Lunagariya

This study was initiated on 24 prepubertal Holstein x Kankrej crossbred heifers of nearly identical age (7-9 months) and body weight (130-140 kg) at University farm to evaluate the effect of high plane of nutrition on blood biochemical and minerals profile and the age at puberty. Twelve heifers were managed under routine farm feeding (control) and the rest 12 under ideal optimum feeding regime (treatment) that included extra 1 kg concentrate, 30 g min mix and ad-lib dry fodder. The body weight and ovarian ultrasonography together with blood sampling was carried out at monthly interval from 10 to 18 months of age to study the ovarian dynamics and blood biochemical changes. High plane of nutrition to growing heifers was beneficial in reducing the age of onset of puberty (by 2-3 months) compared to routine farm fed group. The mean plasma total protein and cholesterol concentrations showed a rising trend with significant variations from 10 to 16 months of age, where it got mostly stabilized indicating adult profile. The activity of enzymes GOT and GPT also rose gradually and significantly from 10 months till 14-15 months of age, and thereafter it remained more or less static till 18 months of age. The levels of both these enzymes were higher, with lower protein and cholesterol, in control than the treatment group from 15-16 months of age onwards. The mean plasma levels of both calcium and phosphorus increased gradually and significantly with advancing age till 16-17 months of age, with little higher values in supplemented than a control group. The plasma levels of zinc, iron, copper, and cobalt also showed rising trend with significant differences between 10th and 12th-14th months of age, and from 15th to 18th months of age the levels were statistically the same in all the groups with slightly higher values in the treatment group.


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