The Impact of Herbivores on Regeneration in Four Trees From Arid Australia.

1995 ◽  
Vol 17 (2) ◽  
pp. 213 ◽  
Author(s):  
TD Auld

The size distributions of populations of four semi-arid perennial trees were investigated within Kinchega National Park in western NSW. For Acacia ligulata, A, loderi and Alectryon oleifolius, it appears that regeneration has been eliminated or at best severely limited at most sites. Some regeneration has occurred through recruitment of vegetative suckers in Casuarina pauper. Currently these vegetative recruits have high survival rates under both rabbit and kangaroo grazing, although such grazing frequently reduces the height of vegetative suckers back to ground level. Survival of seedlings of Acacia ligulata was very limited, with highest survival when mammals were excluded. There was no survival of seedlings of Casuarina pauper in the presence of rabbits and survival was poor when rabbits were excluded. Many seedlings of both species die through desiccation. The survival data from seedlings and vegetative suckers reinforce the patterns observed in the size distribution of populations. Within Kinchega National Park, control of rabbits is essential to initiate regeneration. A reduction in the total grazing pressure (especially rabbits, sheep, cattle and goats) is necessary in critical dry periods on semi-arid and arid grazing land if regeneration of perennials is to be encouraged.

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e043844
Author(s):  
Natalia Araujo ◽  
Samantha Morais ◽  
Ana Rute Costa ◽  
Raquel Braga ◽  
Ana Filipa Carneiro ◽  
...  

IntroductionProstate cancer is the most prevalent oncological disease among men in industrialised countries. Despite the high survival rates, treatments are often associated with adverse effects, including metabolic and cardiovascular complications, sexual dysfunction and, to a lesser extent, cognitive decline. This study was primarily designed to evaluate the trajectories of cognitive performance in patients with prostate cancer, and to quantify the impact of the disease and its treatments on the occurrence of cognitive decline.MethodsParticipants will be recruited from two main hospitals providing care to approximately half of the patients with prostate cancer in Northern Portugal (Portuguese Institute of Oncology of Porto and São João Hospital Centre), and will comprise a cohort of recently diagnosed patients with prostate cancer proposed for different treatment plans, including: (1) radical prostatectomy; (2) brachytherapy and/or radiotherapy; (3) radiotherapy in combination with androgen deprivation therapy and (4) androgen deprivation therapy (with or without chemotherapy). Recruitment began in February 2018 and is expected to continue until the first semester of 2021. Follow-up evaluations will be conducted at 1, 3, 5, 7 and 10 years. Sociodemographic, behavioural and clinical characteristics, anxiety and depression, health literacy, health status, quality of life, and sleep quality will be assessed. Blood pressure and anthropometrics will be measured, and a fasting blood sample will be collected. Participants’ cognitive performance will be evaluated before treatments and throughout follow-up (Montreal Cognitive Assessment and Cube Test as well as Brain on Track for remote monitoring). All participants suspected of cognitive impairment will undergo neuropsychological tests and clinical observation by a neurologist.Ethics and disseminationThe study was approved by the Ethics Committee of the hospitals involved. All participants will provide written informed consent, and study procedures will be developed to ensure data protection and confidentiality. Results will be disseminated through publication in peer-reviewed journals and presentation in scientific meetings.


2017 ◽  
Vol 83 (10) ◽  
pp. 1122-1126
Author(s):  
Tigran Karamanukyan ◽  
Andrea Pakula ◽  
Maureen Martin ◽  
Ashwitha Francis ◽  
Ruby Skinner

Geriatric trauma has historically been associated with poor outcomes, particularly in the setting of severe polytrauma. Although geriatric trauma protocols are common, there are limited data on their impact in patients with high injury severity. In this study, we sought to investigate the impact of a geriatric injury protocol on outcomes in patients with severe trauma acuity. Ninety-eight geriatric patients (age ≥65) admitted to our trauma center with injury severity scores (ISS) ≥15 comprised the study cohort. The mean age was 75 ± 7.7 yrs. The mean ISS was 25 ± 9.2, and the mean geriatric trauma outcome score was 150 ± 3. Mortality was 17 per cent and 70 per cent were due to central nervous system injury. When patients with nonsurvivable injuries or advanced directives resulting in early care withdrawal were excluded, the mortality was 6 per cent. Extremes of age did not impact mortality [(>80 years, 21%) vs (65–79, 16%, P = 0.5)]. Most patients (53%) were discharged home. The application of our geriatric trauma protocol led to favorable results despite high injury acuity. These data suggest that even at the extremes of age, a large percentage of patients can be expected to survive. A prospective validation of these findings is warranted.


Author(s):  
Diane R Nelson ◽  
Paul J Bartels ◽  
Stephen R Fegley

Abstract A major inventory of tardigrades in the Great Smoky Mountains National Park was conducted and we compared tardigrade species composition in moss and lichen samples and analysed environmental correlates of tardigrade community structure. We also compared these tardigrades with those collected from soil. The basic dataset from tree mosses and lichens consisted of 336 samples, 9200 individuals and 43 species. The supplemental dataset from rock mosses and lichens consisted of 29 samples, 811 individuals, and 41 species. Collectively, there were 57 species present in mosses and lichens. Eleven species were found uniquely on rock habitats. Two-way ANOVAs for various community metrics showed no significant differences between substrate (moss versus lichen) or height (ground level versus breast height); however, there were significant differences between ATBI plots. Tardigrade communities were not significantly different between mosses and lichens, but soil tardigrade communities were quite distinct from these moss/lichen communities. We analysed the impact of 17 environmental variables on community structure using partition tree analyses. SOx deposition explained most of the variation in species richness and evenness in moss tardigrades. Forest disturbance regime had the greatest impact on abundance in lichen tardigrades. Other environmental factors influencing community structure are discussed.


FLORESTA ◽  
2014 ◽  
Vol 44 (4) ◽  
pp. 589 ◽  
Author(s):  
Emerson Delano Lopes ◽  
Cláudio Lúcio Fernandes Amaral ◽  
Adalberto Brito Novaes

Avaliou-se a produção de mudas de Eucalyptus urophylla, E. camaldulensis e Corymbia citriodora em blocos prensados e em dois modelos de tubetes por meio da avaliação da sobrevivência e do crescimento inicial das mudas. A sobrevivência foi avaliada aos sessenta dias e o crescimento inicial em altura e diâmetro ao nível do solo ao décimo mês pós-plantio. Foi utilizado o delineamento em blocos casualizados com cinco repetições. Mudas de E. urophylla e E. camaldulensis produzidas nos blocos e nos dois modelos de tubetes e mudas de C. citriodora produzidas nos dois modelos de tubetes obtiveram altas taxas de sobrevivência. Já as mudas de C. citriodora produzidas nos blocos apresentaram a menor média de sobrevivência no estudo. As médias de crescimento inicial das mudas de E. urophylla produzidas nos blocos e tubetes de 50 cm3 foram superiores às encontradas para mudas produzidas em tubetes de 35 cm3. Para E. camaldulensis e C. citriodora, as médias de crescimento inicial foram semelhantes nos três recipientes. Recomenda-se a produção de mudas de E. urophylla em tubetes de 50 cm3 ou em blocos prensados. As mudas de E. camaldulensis podem ser produzidas nos três recipientes, e C. citriodora nos tubetes de 50 e 35 cm3.Palavras-chave: Qualidade de mudas; desempenho pós-plantio. AbstractPerformance in the field of Eucalyptus urophylla, Eucalyptus camaldulensis and Corymbia citriodora produced in different containers. We evaluated the production of Eucalyptus urophylla, E. camaldulensis and Corymbia citriodora in pressed blocks and two tubes models by the evaluation of survival and early growth of seedlings. We assessed survival at sixty days and initial growth in height and diameter at ground level to the tenth month after planting. We used a randomized block design with five replications. Seedlings of E. urophylla and E. camaldulensis produced in blocks, and in two tube models, and seedlings of C. citriodora produced in two tube models had high survival rates. On the other hand, seedlings of C. citriodora produced in blocks presented the lowest survival mean. The initial seedling growth mean of E. urophylla produced in blocks and tubes of 50 cm3 were higher than for seedlings grown in tubes of 35 cm3. In relation to E. camaldulensis and C. citriodora the average initial growth were similar in the three containers. Production of seedlings of E. urophylla is recommended in tubes of 50 cm3 or in compressed blocks, E. camaldulensis seedlings can be produced in three containers, and C. citriodora in tubes of 50 and 35 cm3.Keywords: Seedling quality; post-planting performance.


2020 ◽  
pp. 096914132092121
Author(s):  
László Tabár ◽  
Tony Hsiu-Hsi Chen ◽  
Amy Ming-Fang Yen ◽  
Peter B Dean ◽  
Robert A Smith ◽  
...  

Objectives To explain apparent differences among mammography screening services in Sweden using individual data on participation in screening and with breast cancer–specific survival as an outcome. Methods We analysed breast cancer survival data from the Swedish Cancer Register on breast cancer cases from nine Swedish counties diagnosed in women eligible for screening. Data were available on 38,278 breast cancers diagnosed and 4312 breast cancer deaths. Survival to death from breast cancer was estimated using the Kaplan–Meier estimate, for all cases in each county, and separately for cases of women participating and not participating in their last invitation to screening. Formal statistical comparisons of survival were made using proportional hazards regression. Results All counties showed a reduction in the hazard of breast cancer death with participation in screening, but the reductions for individual counties varied substantially, ranging from 51% (95% confidence interval 46–55%) to 81% (95% confidence interval 74–85%). Survival rates in nonparticipating women ranged from 53% (95% confidence interval 40–65%) to 74% (95% confidence interval 72–77%), while the corresponding survival in women participating in screening varied from 80% (95% confidence interval 77–84%) to 86% (95% confidence interval 83–88%), a considerably narrower range. Conclusions Differences among counties in the effect of screening on breast cancer outcomes were mainly due to variation in survival in women not participating in screening. Screening conferred similarly high survival rates in all counties. This indicates that the performance of screening services was similar across counties and that detection and treatment of breast cancer in early-stage reduces inequalities in breast cancer outcome.


Micromachines ◽  
2022 ◽  
Vol 13 (1) ◽  
pp. 113
Author(s):  
Xiufang Liu ◽  
Wenjun Zhang ◽  
Yanshu Jing ◽  
Shasha Yi ◽  
Umar Farooq ◽  
...  

Sonoporation employs ultrasound accompanied by microbubble (MB) cavitation to induce the reversible disruption of cell membranes and has been exploited as a promising intracellular macromolecular delivery strategy. Due to the damage to cells resulting from strong cavitation, it is difficult to balance efficient delivery and high survival rates. In this paper, a traveling surface acoustic wave (TSAW) device, consisting of a TSAW chip and a polydimethylsiloxane (PDMS) channel, was designed to explore single-cell sonoporation using targeted microbubbles (TMBs) in a non-cavitation regime. A TSAW was applied to precisely manipulate the movement of the TMBs attached to MDA-MB-231 cells, leading to sonoporation at a single-cell level. The impact of input voltage and the number of TMBs on cell sonoporation was investigated. In addition, the physical mechanisms of bubble cavitation or the acoustic radiation force (ARF) for cell sonoporation were analyzed. The TMBs excited by an ARF directly propelled cell membrane deformation, leading to reversible perforation in the cell membrane. When two TMBs adhered to the cell surface and the input voltage was 350 mVpp, the cell sonoporation efficiency went up to 83%.


2013 ◽  
Vol 31 (7) ◽  
pp. 868-875 ◽  
Author(s):  
Giovanni Corso ◽  
Joana Carvalho ◽  
Daniele Marrelli ◽  
Carla Vindigni ◽  
Beatriz Carvalho ◽  
...  

Purpose The prognosis of gastric cancer (GC) is poor, and the molecular pathogenesis players are vastly unknown. Surgery remains the primary option in GC treatment. The aim of this study was to investigate the impact of somatic CDH1 alterations in prognosis and survival of patients with GC. Patients and Methods A series of patients with sporadic and familial GC (diffuse and intestinal; n = 246) were analyzed for somatic CDH1 mutations, promoter hypermethylation, and loss of heterozygosity (LOH) by polymerase chain reaction sequencing. E-cadherin protein expression was determined by immunohistochemistry. Associations between molecular, clinicopathologic, and survival data were analyzed. Results CDH1 somatic alterations were found in approximately 30% of all patients with GC. Both histologic types of sporadic GC displayed LOH in 7.5%, mutations in 1.7%, and hypermethylation in 18.4% of patients. Primary tumors from hereditary diffuse GC, lacking germline CDH1 alterations, showed exclusively CDH1 promoter hypermethylation in 50% of patients. Familial intestinal GC (FIGC) tumors showed LOH in 9.4% and hypermethylation in 17.0%. CDH1 alterations did not associate with a particular pattern of E-cadherin expression. Importantly, the worst patient survival rate among all GCs analyzed was seen in patients with tumors carrying CDH1 structural alterations, preferentially those belonging to FIGC families. Conclusion CDH1 somatic alterations exist in all clinical settings and histotypes of GC and associate with different survival rates. Their screening at GC diagnosis may predict patient prognosis and is likely to improve management of patients with this disease.


2019 ◽  
Vol 34 (02) ◽  
pp. 182-187 ◽  
Author(s):  
Erkman Sanri ◽  
Sinan Karacabey

Introduction:High-quality chest compressions (CCs) are associated with high survival rates and good neurological outcomes in cardiac arrest patients. The 2015 American Heart Association (AHA; Dallas, Texas USA) Guidelines for Resuscitation defined and recommended high-quality CCs during cardiopulmonary resuscitation (CPR). However, CPR providers struggle to achieve high-quality CCs. There is a debate about the use of backboards during CPR in literature. Some studies suggest backboards improve CC quality, whereas others suggest that backboards can cause delays. This is the first study to evaluate all three components of high-quality CCs: compression depth, recoil depth, and rate, at the same time with a high number of subjects. This study evaluated the impact of backboards on CC quality during CPR. The primary outcome was the difference in successful CC rates between two groups.Methods:This was a randomized, controlled, single-blinded study using a high-fidelity mannequin. The successful CC rates, means CC depths, recoil depths, and rates achieved by 6th-grade undergraduate medical students during two minutes of CPR were compared between two randomized groups: an experimental group (backboard present) and a control group (no backboard).Results:Fifty-one of all 101 subjects (50.5%) were female, and the mean age was 23.9 (SD = 1.01) years. The number and the proportion of successful CCs were significantly higher in the experimental group (34; 66.7%) when compared to the control group (19; 38.0%; P = .0041). The difference in mean values of CC depth, recoil depth, and CC rate was significantly higher in the experiment group.Conclusion:The results suggest that using a backboard during CPR improves the quality of CCs in accordance with the 2015 AHA Guidelines.Sanri E, Karacabey S. The impact of backboard placement on chest compression quality: a mannequin study. Prehosp Disaster Med. 2019;34(2):182–187


2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 870.2-871
Author(s):  
D. Khanna ◽  
C. Zhao ◽  
L. Chung ◽  
G. Coghlan ◽  
R. Saggar ◽  
...  

Background:Although patients with CTD-PAH comprise approximately one third of the overall PAH population, the literature on survival outcomes in CTD-PAH patients overall and by CTD subtype is limited by small sample sizes. We conducted a meta-analysis of more than 4,000 patients with CTD-PAH enrolled in observational registries.Objectives:To determine survival rates in patients with CTD-PAH overall and by CTD subtypes.Methods:The PubMed and EMBASE databases were searched for English-only articles published between January 1, 2000 and November 25, 2019. Inclusion criteria were multicenter registries of adults with WHO group 1 pulmonary hypertension (PAH); conducted in 2000 or later; and survival data for ≥30 patients with CTD-PAH. Meta-analysis of survival was performed using a random-effects model. Survival was estimated for CTD-PAH overall; for CTD-PAH stratified by registries primarily conducted before and after 2010 to assess the impact of new therapies, as well as combination therapy approaches targeting multiple pathways; and for CTD subtypes (systemic sclerosis [SSc] and systemic lupus erythematosus [SLE]).Results:Nineteen registries met inclusion criteria and reported data on 4,008 patients with CTD-PAH. Of these patients, 1,485 had SSc, 456 had SLE, and CTD subtype was not specified in 2,067. CTD-PAH patients had a mean age of 55 years and 87% were female. Most patients (70%) had functional class III or IV disease and the mean 6-minute walk distance at enrollment was 327 m. Among registries that enrolled patients of all PAH etiologies (N=7,829), survival rates in the CTD-PAH subpopulation (n=2113), were 83%, 73%, and 62% at 1-, 2-, and 3- years, respectively. These survival rates were lower than those reported for the overall PAH population: 88%, 79%, and 72% at 1-, 2-, and 3- years, respectively. Numerically higher survival rates at 1-, 2-, and 3- years were observed in CTD-PAH patients treated in 2010 and later: 85% vs 90%, 74% vs 82%, and 65% vs 73%. Among all CTD-PAH patients, survival rates were lower for patients with SSc compared to those with SLE: 88% vs 92%, 75% vs 90%, 67% vs 87% at 1-, 2-, and 3- years, respectively (Figure).Conclusion:Patients with CTD-PAH have a substantial risk of death, however, CTD-PAH patients treated within the last ten years have numerically higher survival rates than those treated earlier. This may be related to increased screening for PAH, especially in SSc (leading to earlier diagnosis) and/or the availability of new treatment approaches. Consistent with clinical observations, patients with SSc have worse survival rates than those with SLE. Given the high risk of mortality in these patients, early detection and upfront aggressive treatment are warranted.References:Acknowledgments:This analysis was funded by Actelion Pharmaceuticals.Disclosure of Interests:Dinesh Khanna Shareholder of: Eicos, Grant/research support from: NIH NIAID, NIH NIAMS, Consultant of: Acceleron, Actelion, Bayer, BMS, Boehringer-Ingelheim, Corbus, Galapagos, Genentech/Roche, GSK, Mitsubishi Tanabi, Sanofi-Aventis/Genzyme, UCB Pharma, Carol Zhao Shareholder of: Actelion Pharmaceuticals US, Inc., Employee of: Actelion Pharmaceuticals US, Inc., Lorinda Chung Grant/research support from: United Therapeutics, Boehringer Ingelheim, Consultant of: Bristol-Myers Squibb, Boehringer Ingelheim, Mitsubishi Tanabe, Eicos Sciences, Gerry Coghlan Grant/research support from: Johnson & Johnson, Consultant of: Bayer, Johnson & Johnson, GlaxoSmithKline, Speakers bureau: Bayer, Johnson & Johnson, GlaxoSmithKline, Rajan Saggar Grant/research support from: Actelion, Gilead Science, United Therapeutics, Consultant of: Actelion, Gilead Science, United Therapeutics, Speakers bureau: Actelion, Gilead Science, United Therapeutics, Stephen Mathai Consultant of: Actelion, Liquidia, Arena, United Therapeutics, Mehul Shah Shareholder of: Actelion Pharmaceuticals US, Inc, Employee of: Actelion Pharmaceuticals US, Inc, John Hartney Shareholder of: Actelion Pharmaceuticals US, Inc, Employee of: Actelion Pharmaceuticals US, Inc, Vallerie McLaughlin Grant/research support from: Reata Pharmaceutics, SoniVie, United Therapeutics, Bayer, Acceleron, Actelion Pharmaceuticals US, Inc., Consultant of: Actelion Pharmaceuticals US, Inc., Acceleron, Arena Pharmaceuticals, Bayer, Caremark, CiVi Biopharma, United Therapeutics


HortScience ◽  
1998 ◽  
Vol 33 (3) ◽  
pp. 517f-518
Author(s):  
Jeanine M. Davis

To produce large elephant garlic (Allium ampeloprasum L.) bulbs in the southeastern United States, stock cloves must be planted in the fall. During extremely cold winters, however, winter survival rates can be very low. A 2-year study was undertaken to examine practices to increase winter survival rates. Two clove sizes (≤20 g or >20 g), three nitrogen rates (112, 224, and 336 kg/ha), and three planting methods (flat, mulched, and hilled) were tested in a RCB design with four replications. For all planting methods, cloves were set in a shallow trench and covered with soil to ground level. This was also the flat treatment. For the mulched treatment, 7 cm of straw was spread on top. For the hilled treatment, soil was mounded 10 to 15 cm high over the ground level. Cloves were planted in early October and harvested in mid-June. Use of large planting stock cloves increased winter survival rates during the harsh winter, but had no effect during the mild winter. Both years, winter survival was reduced with the flat treatment. Yields of marketable bulbs were 4 to 5 times higher when >20 g cloves were planted than when ≤20 g cloves were used. Nitrogen rate and planting method had no effect on yields. The >20 g cloves also produced larger bulbs than the smaller cloves. Of the three planting methods, the flat treatment produced the smallest bulbs. Bulbs were much larger following the mild winter than the harsh winter.


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