scholarly journals Role of a Cytoplasmic Dual-function Glycosyltransferase in O2Regulation of Development inDictyostelium

2009 ◽  
Vol 284 (42) ◽  
pp. 28896-28904 ◽  
Author(s):  
Zhuo A. Wang ◽  
Hanke van der Wel ◽  
Yusuf Vohra ◽  
Therese Buskas ◽  
Geert-Jan Boons ◽  
...  
Keyword(s):  
Dual Function

scholarly journals Moonlighting in Bacillus subtilis: The Small Proteins SR1P and SR7P Regulate the Moonlighting Activity of Glyceraldehyde 3-Phosphate Dehydrogenase A (GapA) and Enolase in RNA Degradation

2021 ◽  
Vol 9 (5) ◽  
pp. 1046
Author(s):  
Inam Ul Haq ◽  
Sabine Brantl
Keyword(s):  
Bacillus Subtilis ◽  
Antisense Rna ◽  
Rna Binding ◽  
Rna Degradation ◽  
Metabolic Enzyme ◽  
Dual Function ◽  
Small Proteins ◽  
Moonlighting Proteins ◽  
Rnase Y

Moonlighting proteins are proteins with more than one function. During the past 25 years, they have been found to be rather widespread in bacteria. In Bacillus subtilis, moonlighting has been disclosed to occur via DNA, protein or RNA binding or protein phosphorylation. In addition, two metabolic enzymes, enolase and phosphofructokinase, were localized in the degradosome-like network (DLN) where they were thought to be scaffolding components. The DLN comprises the major endoribonuclease RNase Y, 3′-5′ exoribonuclease PnpA, endo/5′-3′ exoribonucleases J1/J2 and helicase CshA. We have ascertained that the metabolic enzyme GapA is an additional component of the DLN. In addition, we identified two small proteins that bind scaffolding components of the degradosome: SR1P encoded by the dual-function sRNA SR1 binds GapA, promotes the GapA-RNase J1 interaction and increases the RNase J1 activity. SR7P encoded by the dual-function antisense RNA SR7 binds to enolase thereby enhancing the enzymatic activity of enolase bound RNase Y. We discuss the role of small proteins in modulating the activity of two moonlighting proteins.

scholarly journals Analysing the Influence of Industrial Value - Added of Small and Micro-sized Firms on Regional FDI in Indonesia

2021 ◽  
Vol 5 (3) ◽  
pp. 157-165
Author(s):  
Celine Canes ◽  
Vanessa Aurelia ◽  
Juan Phillip Yoel Tanesia ◽  
Albert Hasudungan ◽  
Erica Lukas
Keyword(s):  
Capital Accumulation ◽  
Random Effect ◽  
Value Added ◽  
Dual Function ◽  
Robust Standard Error ◽  
The Government ◽  
Role Of The Government ◽  
Fdi Determinants ◽  
Portfolio Investments

The role of Foreign Direct Investment (FDI) has only grown in tandem with globalization, as it plays a dual function by improving capital accumulation whilst simultaneously growing total factor yield, which puts it at an advantage over foreign aids and foreign portfolio investments. Using panel data from 34 Indonesian provinces over the 2015 - 2019 period, this research examined the determinants of provincial FDI and its impact on regional economic development in Indonesia. The random effect method with robust standard error was used to regress the model, and the variables found to be positively significant were the ratio of industrial value added for micro sized firms to regional GDP, as well as the growth rate of industrial value added for small sized firms. Our analysis revealed that micro-sized firms tend to have much higher industrial value added compared to small-sized firms, and that these firms tend to cluster in Western Indonesia. The role of the government should be to foster the growth and competitiveness of small and micro-sized firms, especially for regions where the industrial value added is still low. Further study is suggested on the determinants of industrial value added at the provincial level, as well as more comprehensive research on FDI determinants with a larger dataset.

scholarly journals The effect of cigarette smoking on endothelial damage and atherosclerosis development – modeled and analyzed using Petri nets

2017 ◽  
Vol 27 (2) ◽  
pp. 211-228 ◽  
Author(s):  
Kaja Chmielewska ◽  
Dorota Formanowicz ◽  
Piotr Formanowicz
Keyword(s):  
Oxidative Stress ◽  
Petri Nets ◽  
Tobacco Smoke ◽  
Endothelial Damage ◽  
Dual Function ◽  
Contributing Factors ◽  
Atherosclerotic Plaque Formation ◽  
Atherosclerosis Development ◽  
The Impact

Abstract Atherosclerosis as one of the crucial causes of cardiovascular diseases (CVD) is the leading reason of death worldwide. One of the contributing factors to this phenomenon is endothelial dysfunction, which is associated with the impact of various agents and their interactions. Tobacco smoke is one of the well known factors here. For better understanding of its significance a model of its impact on atherosclerotic plaque formation has been proposed. The model contains selected aspects of the influence of tobacco smoke, dual function of nitric oxide (NO) (influence of various mechanisms on NO bioavailability), oxidative stress which promotes low density lipoproteins oxidation, macrophages significance and other mechanisms leading to an aggravation of the endothelial disturbances. The model has been built using Petri nets theory and the analysis has been based on t-invariants. This approach allowed to confirm the important role of inflammation and oxidative stress in atherosclerosis development and moreover it has shown the considerable influence of the cigarette smoke.

Introductory remarks

1971 ◽  
Vol 261 (839) ◽  
pp. 275-277 ◽  
Keyword(s):  
Dual Function ◽  
Glandular Tissue ◽  
Chromaffin Granules ◽  
Adrenergic Neurons ◽  
Eightieth Birthday ◽  
The Past ◽  
Biochemical Studies ◽  
Adrenergic Systems ◽  
Chromaffin Tissue

The proposal to have this meeting arose from biochemical studies. But we believe that the results obtained have wider implications in the field of physiology and cytology. Biochemists have taken a part in the study of events occurring at the synapse ever since the transmitter theory was first enunciated. In fact, one of the first successes of the new theory was a biochemical one: the interpretation of the action of physostigmine as an inhibition of an enzyme, now called acetylcholinesterase (Loewi & Navratil 1926). However, until recently the role of the biochemist in the study of synaptic transmission has been an ancillary one. He has provided information on the enzymic equipment of neurons, especially the equipment with enzymes involved in transmitter formation, and he has also studied transmitter inactivation. But now, in the past year or two, the biochemists have also begun to share in the study of the events that occur during transmission. These recent observations were made on adrenergic neurons. To the student of adrenergic systems the transmitter theory has been particularly relevant. The catecholamines have a dual function. In the chromaffin tissue they are secreted as true hormones, and at the endings of adrenergic neurons they are released as transmitters. It was this link that Dr Arnold Welch and I had in mind when we wrote the paper in which we described our early observations on chromaffin granules. We ended the discussion of this paper, dedicated to Otto Loewi on the occasion of his eightieth birthday, with the sentence: ‘Such an interpretation would be in harmony with a concept that regards “ secretion” from glandular tissue and “ liberation” from nerves as events that are fundamentally related’ (Blaschko & Welch 1953).

Spalt modifies EGFR-mediated induction of chordotonal precursors in the embryonic PNS of Drosophila promoting the development of oenocytes

Development ◽  
2001 ◽  
Vol 128 (5) ◽  
pp. 711-722 ◽  
Author(s):  
T.E. Rusten ◽  
R. Cantera ◽  
J. Urban ◽  
G. Technau ◽  
F.C. Kafatos ◽  
...  
Keyword(s):  
Nervous System ◽  
Cell Fate ◽  
System Development ◽  
Cell Types ◽  
Nervous System Development ◽  
Dual Function ◽  
Evolutionarily Conserved ◽  
A Cell ◽  
And Migration

Genes of the spalt family encode nuclear zinc finger proteins. In Drosophila melanogaster, they are necessary for the establishment of head/trunk identity, correct tracheal migration and patterning of the wing imaginal disc. Spalt proteins display a predominant pattern of expression in the nervous system, not only in Drosophila but also in species of fish, mouse, frog and human, suggesting an evolutionarily conserved role for these proteins in nervous system development. Here we show that Spalt works as a cell fate switch between two EGFR-induced cell types, the oenocytes and the precursors of the pentascolopodial organ in the embryonic peripheral nervous system. We show that removal of spalt increases the number of scolopodia, as a result of extra secondary recruitment of precursor cells at the expense of the oenocytes. In addition, the absence of spalt causes defects in the normal migration of the pentascolopodial organ. The dual function of spalt in the development of this organ, recruitment of precursors and migration, is reminiscent of its role in tracheal formation and of the role of a spalt homologue, sem-4, in the Caenorhabditis elegans nervous system.

scholarly journals Necessary borders for negotiation: the role of translation

2017 ◽  
Vol 9 (2) ◽  
pp. 64
Author(s):  
David Ar Rouz
Keyword(s):  
Language Learning ◽  
Dual Function ◽  
European Language ◽  
Social Distinction ◽  
European Institutions ◽  
The Social ◽  
Translation Services ◽  
Migration Flows ◽  
The Eu

Translation is usually deemed to help bridge gaps but seldom thought of as a means of strengthening or, at least, highlighting borders. The present article uses the example of translations involving the Breton language in order to show that translation may favour negotiation by both helping negotiators to understand each other and having them recognise the social border that makes them different. The article explains firstly the author’s understanding of borders and negotiation. Secondly, the case of translation from and into Breton is examined. And finally, the discussion is extended to the European institutions, where European language policy also illustrates the dual function of translation in negotiation. The example of Breton evidences that translation fosters social distinction, language development and cooperation. At the EU level, the same roles are assumed by translation services and they contribute moreover to the legitimacy of the institutions and to the exercise of democracy. Such a conclusion invites to consider translation as an adequate means to manage language and cultural differences, even compared to language learning. It may be used, then, to deal with pressing issues such as the current migration flows to Europe.

scholarly journals Stage-Specific Secretion of HMGB1 in Cartilage Regulates Endochondral Ossification

2007 ◽  
Vol 27 (16) ◽  
pp. 5650-5663 ◽  
Author(s):  
Noboru Taniguchi ◽  
Kenji Yoshida ◽  
Tatsuo Ito ◽  
Masanao Tsuda ◽  
Yasunori Mishima ◽  
...  
Keyword(s):  
Endochondral Ossification ◽  
Skeletal Development ◽  
High Mobility ◽  
Immunohistochemical Analysis ◽  
Dual Function ◽  
Hmgb1 Protein ◽  
Tissue Organization ◽  
Extracellular Release ◽  
Extracellular Factor

ABSTRACT High mobility group box 1 protein (HMGB1) is a chromatin protein that has a dual function as a nuclear factor and as an extracellular factor. Extracellular HMGB1 released by damaged cells acts as a chemoattractant, as well as a proinflammatory cytokine, suggesting that HMGB1 is tightly connected to the process of tissue organization. However, the role of HMGB1 in bone and cartilage that undergo remodeling during embryogenesis, tissue repair, and disease is largely unknown. We show here that the stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification. We analyzed the skeletal development of Hmgb1 −/− mice during embryogenesis and found that endochondral ossification is significantly impaired due to the delay of cartilage invasion by osteoclasts, osteoblasts, and blood vessels. Immunohistochemical analysis revealed that HMGB1 protein accumulated in the cytosol of hypertrophic chondrocytes at growth plates, and its extracellular release from the chondrocytes was verified by organ culture. Furthermore, we demonstrated that the chondrocyte-secreted HMGB1 functions as a chemoattractant for osteoclasts and osteoblasts, as well as for endothelial cells, further supporting the conclusion that Hmgb1 −/− mice are defective in cell invasion. Collectively, these findings suggest that HMGB1 released from differentiating chondrocytes acts, at least in part, as a regulator of endochondral ossification during osteogenesis.

scholarly journals Muslim Women’s Roles in Early Childhood Education

2019 ◽  
Vol 13 (2) ◽  
pp. 264-280
Author(s):  
Munirah Munirah
Keyword(s):  
Early Childhood ◽  
Early Childhood Education ◽  
Early Childhood Development ◽  
Muslim Women ◽  
Childhood Development ◽  
Future Research ◽  
Dual Function ◽  
Childhood Education ◽  
Role Of Women

The role of Muslim women in early childhood education is very urgent in education because women are the first source of knowledge for children. There are many supporting and inhibiting factors for the role of Muslim women executors. This study aims to find the role of female educators in Islam as a dual function that functions as a teacher, parent, and community member. The research method uses qualitative with a phenomenological approach. The findings show the role of Muslim women is not ideal, including the role of women as educators in schools, parents, and education experts. Women's awareness of  early childhood education is still very low. Suggestions for future research to dig deeper into the causes of the role of women is still low, and influence government policy in increasing the role of Muslim women or non-Muslim women. Keywords: Role of Muslim Women, Early Childhood Education References: Britto, P. R., Lye, S. J., Proulx, K., Yousafzai, A. K., Matthews, S. G., Vaivada, T., … Bhutta, Z. A. (2017). Nurturing care: promoting early childhood development. The Lancet, 389(10064), 91–102. https://doi.org/10.1016/S0140-6736(16)31390-3 Edy, E., Ch, M., Sumantri, M. S., & Yetti, E. (2018). Pengaruh keterlibatan orang-tua dan pola asuh terhadap disiplin anak. Jurnal Pendidikan Usia Dini, 12(1). https://doi.org///doi.org/10.21009/jpud.122.03 Fauzia, S. N. (2017). Perilaku keagamaan Islam pada anak usia dini. Jurnal Pendidikan Usia Dini, 11(2). https://doi.org/://doi.org/10.21009/jpud.092.07 Frejka, T., Goldscheider, F., & Lappegård, T. (2018). The two-part gender revolution, women’s second shift and changing cohort fertility. Comparative Population Studies, 43, 99–130. https://doi.org/10.12765/CPoS-2018-09en Islamiyati, I. (2018). Hubungan kerjasama orang tua dengan perkembangan anak usia dini di kelompok bermain. Jurnal Pendidikan Usia Dini, 12(1). https://doi.org/://doi.org/10.21009//jpud.121.06 Jamhari, I. R. (2003). Citra Perempuan dalam Islam. Jakarta: Gramedia Pustaka Utama. Jum’ah, A. (2006). ). Sayyidinā Muhammad Rasulillah ila al-‘Alamin. Cairo: Dār al-Farouk. Kementrian Pendidikan dan Kebudayaan. (2013). Petunjuk Teknis Penyelenggaraan Pendidikan Anak Usia Dini. Jakarta: Direktorat Pembinaan Pendidikan Anak Usia Dini. Khan, M. Z. (2003). Woman in Islam and Her Role in Human Development. In The Muslim World. Retrieved from http://onlinelibrary.wiley.com/doi/10.1111/j.1478-1913.1914.tb01384.x/abstract Kohli, R., Lin, Y. C., Ha, N., Jose, A., & Shini, C. (2019). A way of being: Women of color educators and their ongoing commitments to critical consciousness. Teaching and Teacher Education, 82, 24–32. https://doi.org/10.1016/j.tate.2019.03.005 Mansur. (2009). Pendidikan Anak Usia Dini dalam Islam. Jakarta: Pustaka Pelajar. Masnipal. (2013). Siap Menjadi Guru dan Pengelola PAUD Professional. Jakarta: PT Elex Media Komputindo. Megawangi, R. (1996). Perkembangan Teori Feminisme Masa Kini dan Mendatang serta Kaitannya dengan Pemikiran Keislaman, dalam Man-sur Fakih, et. al. Membincang Feminisme: Diskur-sus Gender Persfektif Islam. Jakarta: Risalah Gusti. Miles, M. B., & Huberman, A. M. (1984). Qualitative Data Analysis. London: Sage Publication. Moeslichatoen. (2004). Metode Pengajaran di Taman Kanak-kanak. Jakarta: PT Rineka Cipta. Shihab, M. Q. (2001). Tafsîr al-Mishbâh. Jakarta: Lentera Hati. Siregar, N. M. (2018). Peningkatan kecerdasan interpersonal melalui aktivitas fisik anak usia 4-5 tahun. Jurnal Pendidikan Usia Dini, 12(2). https://doi.org/://doi.org/10.21009/jpud.122.10 Sujiono, Y. N. (2012). Konsep Dasar Pendidikan Anak Usia Dini. Jakarta: PT Indeks. Sumantri, M., & Syaodih, N. (2006). Perkembangan Peserta Didik. Jakarta: Universitas Terbuka. Suryana, D. (2014). Dasar-dasar Pendidikan TK. Jakarta: Universitas Terbuka. Suyadi. (2011). Pegangan Bimbingan Konseling untuk PAUD. Yogyakarta: Diva Press. Tafsir, A. (n.d.). Pendidikan Agama dalam Keluarga. Bandung: PT Remaja Rosdakarya. Yamin, M., & Sanan, J. S. (2010). Panduan Pendidikan Anak Usia Dini (PAUD). Jakarta: Gaung Persada (GP) Press. Yusmawati, & Lubis, J. (2019). The Implementation of Curriculum by Using Motion Pattern. Jurnal Pendidikan Usia Dini. https://doi.org/DOI:https://doi.org/10.21009/10.21009/JPUD.131.14

scholarly journals Attentive and emotional listening to music: The role of positive and negative affect

2021 ◽  
Vol 30 ◽  
Author(s):  
Bernhard Leipold ◽  
Tim Loepthien
Keyword(s):  
Negative Affect ◽  
Emotional Regulation ◽  
Cross Sectional Study ◽  
Dual Function ◽  
Positive And Negative Affect ◽  
Affective States ◽  
Sectional Study ◽  
Dimensional Model ◽  
Cross Sectional

In a cross-sectional study, associations of global affect with two ways of listening to music – attentive-analytical listening (AL) and emotional listening (EL) – were examined. Based on a two-dimensional model of general affect, we focused on the degrees to which AL and EL are differentially correlated with positive and negative affect. In addition to bivariate relationships, the interactions between different states of general affect were tested. In Study 1, a sample of 1,291 individuals responded to questionnaires on listening to music, positive affect (PA), and negative affect (NA). We used the PANAS, which measures PA and NA as high arousal dimensions. AL was positively correlated with PA, EL with NA. Moderation analyses showed stronger associations between PA and AL when NA was low. Study 2 (N = 499 participants) differentiated between three facets of affect and focused, in addition to PA and NA, on the role of relaxation. Similar to the findings of Study 1, AL was correlated with PA, EL with NA and PA. Moderation analyses indicated that the degree to which PA was associated with an individual´s tendency to listen to music attentively depended on their degree of relaxation. In addition, the correlation between PA and EL was stronger for individuals who were more relaxed; for individuals who were less relaxed, the correlation between NA and EL was stronger. In sum, the results demonstrate not only simple bivariate correlations, but also that the expected associations vary, depending on the different affective states. We argue that the results reflect a dual function of listening to music, which includes emotional regulation and information processing.

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