scholarly journals Whole-body calorimetry studies in adult men

1984 ◽  
Vol 52 (1) ◽  
pp. 49-64 ◽  
Author(s):  
Helen M. Dallosso ◽  
W. P. T. James

1. Eight young men of normal weight were maintained for 1 week on a weight-maintenance diet followed by a 1-week period of over-feeding with extra fat designed to increase energy intake by 50%. Two 36 h calorimetry sessions with low and high physical activities were included in each feeding period. Faecal and urine collections permitted checks on energy malabsorption and nitrogen excretion.2. Over-feeding led to increases in body-weight, faecal energy and N excretion and in estimated N retention. Faecal energy outputs on the maintenance and over-feeding diets were 5 and 4.4% of the respective gross energy intakes.3. Energy expenditure on fat over-feeding increased by 5.6% on the low-activity regimen and 6.4% on the high-activity regimen. This amounted, in terms of the extra energy intake, to 9 and 11 % on the inactive and active schedules respectively. The increase affected day- and night-time rates of energy expenditure plus the basal metabolic rate. Individuals with a low percentage body fat showed the greatest response to over-feeding.4. Nutrient-balance studies derived from calorimetry suggested that fat over-feeding led to substantial fat deposition with no evidence of sparing of carbohydrate oxidation. The theoretical cost of depositing dietary fat was exceeded, suggesting that regulatory thermogenic mechanisms may have been stimulated to a small extent.

1992 ◽  
Vol 263 (2) ◽  
pp. R250-R257 ◽  
Author(s):  
M. B. Heyman ◽  
V. R. Young ◽  
P. Fuss ◽  
R. Tsay ◽  
L. Joseph ◽  
...  

The mechanisms of energy regulation invoked by moderate dietary restriction were investigated in seven healthy young men of normal body weight leading unrestricted lives. Following a baseline period of weight maintenance, subjects were underfed by 806 +/- 162 (mean +/- SE) kcal/day for 21 days. Changes in total energy expenditure (TEE) and resting energy expenditure (REE) and subsequent voluntary nutrient intakes were measured. The REE, averaged for fasting and fed states, decreased during underfeeding by 100 +/- 29 kcal/day (P less than 0.01). TEE decreased nonsignificantly by 296 +/- 170 kcal/day, equivalent to an average of 37% of the decrease in energy intake. Body energy stores were estimated to decrease by 510 +/- 172 kcal/day (P less than 0.03), thus compensating for 63% of the dietary energy deficit on average. Voluntary energy intake following dietary restriction increased above the initial amount required for body weight maintenance, was proportional to the weight loss during underfeeding (P less than 0.03), and was associated with a rapid regain of weight lost during underfeeding. These results indicate that energy balance is regulated by adaptive variations in both energy intake and energy expenditure in normal-weight young men leading unrestricted lives but do not support the hypothesis that energy-wasting mechanisms contribute substantially to body energy regulation.


2009 ◽  
Vol 69 (1) ◽  
pp. 34-38 ◽  
Author(s):  
C. R. Hankey

Treatments to induce weight loss for the obese patient centre on the achievement of negative energy balance. This objective can theoretically be attained by interventions designed to achieve a reduction in energy intake and/or an increase in energy expenditure. Such ‘lifestyle interventions’ usually comprise one or more of the following strategies: dietary modification; behaviour change; increases in physical activity. These interventions are advocated as first treatment steps in algorithms recommended by current clinical obesity guidelines. Medication and surgical treatments are potentially available to those unable to implement ‘lifestyle interventions’ effectively by achieving losses of between 5 kg and 10 kg. It is accepted that the minimum of 5% weight loss is required to achieve clinically-meaningful benefits. Dietary treatments differ widely. Successful weight loss is most often associated with quantification of energy intake rather than macronutrient composition. Most dietary intervention studies secure a weight loss of between 5 kg and 10 kg after intervention for 6 months, with gradual weight regain at 1 year where weight changes are 3–4 kg below the starting weight. Some dietary interventions when evaluated at 2 and 4 years post intervention report the effects of weight maintenance rather than weight loss. Specific anti-obesity medications are effective adjuncts to weight loss, in most cases doubling the weight loss of those given dietary advice only. Greater physical activity alone increases energy expenditure by insufficient amounts to facilitate clinically-important weight losses, but is useful for weight maintenance. Weight losses of between half and three-quarters of excess body weight are seen at 10 years post intervention with bariatric surgery, making this arguably the most effective weight-loss treatment.


1998 ◽  
Vol 76 (2) ◽  
pp. 237-241 ◽  
Author(s):  
L J Martin ◽  
PJH Jones ◽  
R V Considine ◽  
W Su ◽  
N F Boyd ◽  
...  

To investigate whether circulating leptin levels are associated with energy expenditure in healthy humans, doubly labeled water energy measurements and food intake assessment were carried out in 27 women (mean age, 48.6 years; weight, 61.9 kg; body mass index, 23.2). Energy expenditure was determined over 13 days. Food intake was measured by 7-day food records. Leptin was measured by radioimmunoassay. Leptin level was strongly associated with percentage body fat (r = 0.59; p < 0.001), fat mass (r = 0.60; p < 0.001), and body mass index (r = 0.41; p = 0.03), but no correlation was observed with energy expenditure (r = 0.02; p = 0.93). After controlling for percentage body fat, a positive association of leptin level with energy expenditure of marginal significance (p = 0.06) was observed. There were no significant univariate associations of age, physical activity, lean body mass, height, or dietary variables with leptin level. When controlling for body fat, a significant positive correlation was observed for percent energy from carbohydrate and negative correlations with dietary fat and alcohol intake. These findings confirm previous associations between leptin and body fat content and suggest a relationship between serum leptin and energy expenditure level in healthy humans.Key words: leptin, energy expenditure, body composition, diet.


2021 ◽  
Vol 18 (4) ◽  
pp. 433-439
Author(s):  
David Thivel ◽  
Pauline Genin ◽  
Alicia Fillon ◽  
Marwa Khammassi ◽  
Johanna Roche ◽  
...  

Background: While mental work has been shown to favor overconsumption, the present study compared the effect of a cognitive task alone, followed by acute exercise, or performed on a cycling desk, on short-term food intake and appetite in adults. Methods: A total of 19 normal-weight adults randomly completed: resting session (CON), 30-minute cognitive task (CT), 30-minute cognitive task followed by a 15-minute high-intensity interval exercise bout (CT–EX), and 30-minute cognitive task performed on a cycling desk (CT-CD). Energy expenditure was estimated (heart rate–workload relationship), and energy intake (EI; ad libitum) and appetite (visual analog scales) were assessed. Results: Energy expenditure was higher in CT-EX (P < .001) compared with the other conditions and in CT-CD compared with CON and CT (P < .01). EI was higher in CON (P < .05) and CT-CD compared with CT (P < .01). Relative EI was higher in CON compared with CT (P < .05) and lower in CT-EX compared with CT, CT-CD, and CON (all Ps < .001). Area under the curve desire to eat was higher in CON compared with CT (P < .05) and CT-EX (P < .01). Area under the curve prospective food consumption was higher in CON compared with CT-EX (P < .01). Overall composite appetite score was not different between conditions. Conclusion: While cycling desks are recommended to break up sedentary time, the induced increase in energy expenditure might not be enough to significantly reduce overall short-term relative EI after mental work.


Author(s):  
Rousset S ◽  
◽  
Médard S ◽  
Fleury G ◽  
Fardet A ◽  
...  

The evaluation of food intake based on various assessment methods is critical and underreporting is frequent. The aim of the study was to develop an indirect statistical method of the total energy intake estimation based on gender, weight and the number of portions. Energy intake prediction was developed and evaluated for validity using energy expenditure measurements given by the WellBeNet app. A total of 190 volunteers with various BMIs were recruited and assigned either in the train or the test sample. The mean energy provided by a portion was evaluated by linear regression models from the train sample. The absolute values of the error between the energy intake estimation and the energy expenditure measurement were calculated for each volunteer, by subgroup and for the whole group. The performance of the models was determined using the validation dataset. As the number of portions is the only variable used in the model, the error was 30.7% and 26.5% in the train and test sample. After adding body weight in the model, the error in absolute value decreased to 8.8% and 10.8% for the normal-weight women and men, and 11.7% and 12.8% for the overweight female and male volunteers, respectively. The findings of this study indicate that a statistical approach and knowledge of the usual number of portions and body weight is effective and sufficient to obtain a precise evaluation of energy intake (about 10% of error) after a simple and brief enquiry.


1987 ◽  
Vol 57 (2) ◽  
pp. 201-209 ◽  
Author(s):  
Janna O. De Boer ◽  
Aren J. H. Van Es ◽  
Joop E. Vogt ◽  
Joop M. A. Van Raaij ◽  
Joseph G. A. J. Hautvast

1. Ten female subjects completed two similar experimental procedures (periods 1 and 2) to obtain values of reproducibility of energy intake and 24 h energy expenditure (24hEE) measurements in a whole body indirect calorimeter. The periods consisted of consumption of a provided weight-maintenance diet for 6–8 d, faeces and urine collection during the last 4 d and occupation of the calorimeter during the last 3 d. The daily routine inside the calorimeter simulated a sedentary day in normal life with some physical activity: 8 h sleep, 75 min bicycling and the remaining time spent on sedentary activities. The metabolizable energy (ME) content of the diet (14% energy as protein, 46% energy as carbohydrate, 40% energy as fat) was calculated using food tables. The actual ME intake as well as digestibility and metabolizability of the diet were obtained later by analyses of food, faeces and urine for energy. Three consecutive 24hEE measurements were performed during the stay in the calorimeter in each period. The time interval between the two periods varied from 2 to 24 months. Reproducibility was assessed at group and individual level.2. Mean digestibility and metabolizability of the diet showed no significant difference between periods. The within-subject coefficient of variation of metabolizability between periods was 1.7%.3. Mean 24hEE (MJ) over 3 d did not differ between period 1 (8.78 (SD 0.63)) and period 2 (8.73 (SD 0.66)). The within-subject coefficient of variation in mean 24hEE over three successive days between periods was 3.1% but decreased, after deletion of values for subjects who were less adapted to the calorimeter, to 1.9%.4. The results are discussed with regard to length of trial and the number of subjects required to test a difference in energy metabolism using whole body indirect calorimeters.


2015 ◽  
Vol 13 (3) ◽  
pp. 66-71 ◽  
Author(s):  
Todd Hagobian ◽  
Alyssa D’Amico ◽  
Camille Vranna ◽  
Anna Brannen ◽  
Suzanne Phelan

Background and Purpose: Prenatal changes in energy intake (EI), physical activity (PA), and resting energy expenditure (REE) are important determinants of future health and obesity outcomes. This study examined changes in EI, PA and REE in 16 adult, pregnant women (75% Normal-weight, 15% overweight/obese) early in pregnancy (


1990 ◽  
Vol 258 (2) ◽  
pp. E347-E351 ◽  
Author(s):  
W. G. Abbott ◽  
B. V. Howard ◽  
G. Ruotolo ◽  
E. Ravussin

A high-dietary fat intake may be an important environmental factor leading to obesity in some people. The mechanism could be either a decrease in energy expenditure and/or an increase in caloric intake. To determine the relative importance of these mechanisms we measured 24-h energy expenditure in a whole body calorimeter in 14 nondiabetic subjects and in six subjects with non-insulin-dependent diabetes mellitus, eating isocaloric, weight-maintenance, high-fat, and high-carbohydrate diets. All subjects were Pima Indians. In nondiabetics, the mean total 24-h energy expenditure was similar (2,436 +/- 103 vs. 2,359 +/- 82 kcal/day) on high-fat and high-carbohydrate diets, respectively. The means for sleeping and resting metabolic rates, thermic effect of food, and spontaneous physical activity were unchanged. Similar results were obtained in the diabetic subjects. In summary, using a whole body calorimeter, we found no evidence of a decrease in 24-h energy expenditure on a high-fat diet compared with a high-carbohydrate diet.


1990 ◽  
Vol 259 (4) ◽  
pp. R807-R812 ◽  
Author(s):  
V. S. Quek ◽  
P. Trayhurn

The energetics of pregnancy have been assessed in the golden hamster, using continuous whole body indirect calorimetry to determine energy expenditure throughout gestation. Energy intake was unchanged during pregnancy, either on a daily or cumulative basis. The total energy expenditure per animal was, however, significantly higher (14%) in pregnant hamsters than in virgin control animals. The increase in total expenditure was the result of increases in daily energy expenditure over the last one-third of gestation (mean increase 21%), the period during which the energy costs associated with fetal growth are highest. The respiratory quotient (RQ) of the control hamsters was approximately 0.95, but in the pregnant group there was a progressive reduction over the second half of gestation, and by parturition the RQ had fallen to 0.80. The changes in RQ indicate that there is a switch toward the oxidation of fat, away from the oxidation of carbohydrate, in the later stages of pregnancy. Measurements of body lipid suggest that the fall in RQ in the second half of pregnancy is the result of a net utilization of maternal fat reserves; 42% of maternal body lipid was lost during pregnancy, with most of the loss occurring over the final one-third of gestation. Because energy expenditure is increased (relative to virgin controls) without any change in energy intake, it is evident that the efficiency of energy utilization (energy gain per unit of energy intake) is not increased during pregnancy in the golden hamster.


1998 ◽  
Vol 76 (8) ◽  
pp. 1520-1528 ◽  
Author(s):  
D A Rosen ◽  
D Renouf

This study tested the hypothesis that seasonal variation in resting metabolic rate (RMR) was more closely related to changes in total energy use than to energy intake. It also quantified the extent to which variation in metabolism contributed to changes in total energy expenditure. RMR, gross energy intake, and body mass and composition were measured in six captive Atlantic harbour seals (Phoca vitulina concolor) over 16 months. Gross energy intake during the year (across all seals) averaged 25.4 ± 4.1 MJ/d (mean ± SD). The energy used by the seals Eused a composite measure of energy expenditure from ingested energy and tissue catabolism) averaged 19.2 ± 3.4 MJ/d. RMR averaged 11.2 ± 1.5 MJ/d during the year, while mass-corrected metabolism declined with age. The seals displayed significant changes in both absolute and mass-corrected metabolism during the year. Overall, Eused was a stronger predictor of changes in metabolism than either gross energy intake or body mass. Mass-corrected metabolic rate was more closely related to Eused than was absolute metabolism. Energy changes in metabolism during the year (range = 6.9 ± 1.9 MJ/d) were minor compared with those in Eused (27.8 ± 7.3 MJ/d). These results suggest that seasonal changes in metabolism were a response to, or facilitated by, concurrent changes in Eused but were not the cause of variation in Eused. Rather, variation in both RMR and Eused was the result of changes in other bioenergetic components of the seals' energy budget, such as activity.


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