scholarly journals Interaction between vitamins C and E affects their tissue concentrations, growth, lipid oxidation, and deficiency symptoms in yellow perch (Perca flavescens)

2003 ◽  
Vol 89 (5) ◽  
pp. 589-596 ◽  
Author(s):  
Kyeong-Jun Lee ◽  
Konrad Dabrowski
Keyword(s):  
Vitamin E ◽  
Vitamin C ◽  
Yellow Perch ◽  
Perca Flavescens ◽  
Thiobarbituric Acid ◽  
Deficient Diet ◽  
Deficiency Symptoms ◽  
Supplemental Vitamin ◽  
Vitamin C Supplementation

We have conducted studies with juvenile yellow perch (Perca flavescens) over a period of 20 weeks to address the question of the interaction between water- and lipid-soluble antioxidant vitamins. Fish (2·25±0·14 g) were divided into twelve groups, and triplicate groups were fed one of four casein-based, semi-purified diets formulated to contain low or high vitamin E levels of either 5 or 160 mg/kg without or with vitamin C supplementation (250 mg/kg). Diets were designated as −C−E, −C+E, +C−E, or +C+E, respectively. The fish fed the +C+E diet showed significantly higher weight gain, feed intake, and feed efficiency than the groups fed vitamin C-deficient diets. Total ascorbate concentrations of liver were significantly higher in fish fed vitamin C-supplemented diets than in fish fed the vitamin C-deficient diet after 16 and 20 weeks. The liver α-tocopherol concentrations were increased by supplemental vitamin C in vitamin E-deficient dietary groups which indicates a sparing or regenerating effect of vitamin C on vitamin E. Fish fed vitamin C-deficient diets (−C−E and −C+E) exhibited severe deficiency symptoms, such as scoliosis, lens cataracts, anorexia, and haemorrhages. The cumulative mortality was significantly higher in the −C−E groups. The thiobarbituric acid-reactive substances value was significantly higher in blood plasma of fish fed a diet unsupplemented with both vitamins. The findings in the present study with yellow perch support the hypothesis that vitamin C regenerates and/or spares vitamin E in vivo.

Transfer of vitamin E to piglet tissue, placenta, colostrum and milk from sows supplemented with vitamin E and vitamin C

2001 ◽  
Vol 2001 ◽  
pp. 166-166 ◽  
Author(s):  
A. Pinelli-Saavedra ◽  
J.R Scaife ◽  
H. Celaya ◽  
M. Birnie
Keyword(s):  
Vitamin E ◽  
Vitamin C ◽  
Consumption Rate ◽  
Dietary Supplementation ◽  
Tocopherol Content ◽  
Feed Consumption ◽  
Supplemental Vitamin ◽  
Vitamin C Supplementation ◽  
Effective Level ◽  
Low Rate

The effective level of dietary supplementation of vitamin E and vitamin C is difficult to define because it depends of several factors such as composition of the diet, feed consumption, rate of growth, animal production and living conditions, stress, crowding and environment. Research has demonstrated that supplemental vitamin E improved litter size, increased sow serum a-tocopherol content and enhanced health status (Mahan, 1994; Wuryastuti et al., 1993). Some reports have suggested that the low plasma and tissue levels of a-tocopherol in new-born pigs, suggests a low rate of vitamin E transfer across the placenta which is not influenced by dietary supplementation of the sow during pregnancy. The aim of this experiment was to determine the effect of vitamin E and vitamin C supplementation of sow diets on transfer of vitamin E to piglet tissues via placenta, colostrum and milk.

scholarly journals Effect of Dietary or Supplemental Vitamin C Intake on Vitamin C Levels in Patients with and without Cardiovascular Disease: A Systematic Review

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2330
Author(s):  
Bianca J. Collins ◽  
Mitali S. Mukherjee ◽  
Michelle D. Miller ◽  
Christopher L. Delaney
Keyword(s):  
Systematic Review ◽  
Cardiovascular Disease ◽  
Vitamin C ◽  
Antioxidant Properties ◽  
Plasma Vitamin ◽  
Healthy Population ◽  
Post Intervention ◽  
Supplemental Vitamin ◽  
Vitamin C Supplementation ◽  
Elderly Cohort

Atherosclerosis is a pro-oxidative and pro-inflammatory disease state, which is the underlying cause of most cardiovascular events, estimated to affect 5.2% of the Australian population. Diet, and specifically vitamin C, through its antioxidant properties can play a role in impeding the development and progression of atherosclerosis. This systematic review conducted comprehensive searches in Medline, Emcare, Scopus, PubMed, and Cochrane using key search terms for vitamin C, plasma vitamin C, supplementation, and cardiovascular disease (CVD). The results demonstrated that vitamin C supplementation resulted in a significant increase in vitamin C levels in populations with or without CVD, except for one study on the CVD population. It was also seen that the healthy population baseline and post-intervention vitamin C levels were high compared to the CVD population. However, further research is indicated for CVD population groups with varying baseline vitamin C levels, such as low baseline vitamin C, within a more representative elderly cohort in order to formulate and update vitamin C repletion guidelines.

Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation

2006 ◽  
Vol 40 (4) ◽  
pp. 689-697 ◽  
Author(s):  
Richard S. Bruno ◽  
Scott W. Leonard ◽  
Jeffery Atkinson ◽  
Thomas J. Montine ◽  
Rajasekhar Ramakrishnan ◽  
...  
Keyword(s):  
Vitamin E ◽  
Vitamin C ◽  
Plasma Vitamin ◽  
Vitamin C Supplementation ◽  
Plasma Vitamin E

scholarly journals Effectiveness of Vitamin C and Vitamin E Antioxidant Combination on Caspase-3 Expression in Wistar White Rat Pulmonum Contusion

2020 ◽  
Vol 3 (1) ◽  
pp. 31-44
Author(s):  
Bermansyah ◽  
Gama Satria ◽  
Ahmad Umar
Keyword(s):  
Cell Death ◽  
Vitamin E ◽  
Vitamin C ◽  
Wistar Rats ◽  
Caspase 3 ◽  
Cell Function ◽  
Pulmonary Contusion ◽  
Tnf Α ◽  
Male Wistar Rats

Introduction.Pulmonary contusions can cause a progressive inflammatory response. Activation of TNF-α cytokines and reactive oxygen species (ROS) can cause pulmonary cell death. Antioxidants can have the potential to neutralize ROS. The purpose of this study is to determine the effectiveness of antioxidant administration in maintaining pulmonary cell function in wistar rats that have been induced to experience pulmonary contusions through caspase-3 levels. Methods.This study was an in vivo experimental study conducted on thirty male wistar rats and divided into five groups (n = 6): control, pulmonary contusion + asthaxanthine 5 mg/kgBW, pulmonary contusion + vitamin C and E 50 mg/kgBW, pulmonary contusion + vitamin C and E 100 mg/kgBW, pulmonary contusion + vitamin C and E 200 mg/kgBW. The value of Caspase-3 is evaluated by the IHC. All data analyzes used SPSS 18. Results. Low doses of antioxidants have the potential to reduce pulmonary cell death in wistar rats induced by pulmonary contusions.Conclussion. Vitamin C and E effective to reduce polmonary cell death in pulmonary contusion.Keywords: antioxidants, vitamin C, vitamin E, pulmonary contusions animal model, apoptosis, caspase-3

scholarly journals EFFECTS OF VITAMIN C SUPPLEMENTATION ON THE CHRONIC PHASE OF CHAGAS DISEASE

2015 ◽  
Vol 57 (3) ◽  
pp. 245-250 ◽  
Author(s):  
Ricardo Guimarães MARIM ◽  
Alex Silva de GUSMÃO ◽  
Roberto Esteves Pires CASTANHO ◽  
Rafael DEMINICE ◽  
Altino Luiz Silva THEREZO ◽  
...  
Keyword(s):  
Vitamin C ◽  
Chagas Disease ◽  
Chronic Phase ◽  
Thiobarbituric Acid ◽  
Dose Equivalent ◽  
Thiobarbituric Acid Reactive Substances ◽  
Vitamin C Supplementation ◽  
Histopathologic Analysis ◽  
Different Doses ◽  
Oxidative Insult

Introduction: In order to examine the effectiveness of vitamin C (ascorbic acid) in combating the oxidative insult caused by Trypanosoma cruzi during the development of the chronic phase of Chagas disease, Swiss mice were infected intraperitoneally with 5.0 × 104 trypomastigotes of T. cruzi QM1strain. Methods: Mice were given supplements of two different doses of vitamin C for 180 days. Levels of lipid oxidation (as indicated by thiobarbituric acid reactive substances-TBARS), total peroxide, vitamin C, and reduced glutathione were measured in the plasma, TBARS, total peroxide and vitamin C were measured in the myocardium and histopathologic analysis was undertaken in heart, colon and skeletal muscle. Results: Animals that received a dose equivalent to 500 mg of vitamin C daily showed increased production of ROS in plasma and myocardium and a greater degree of inflammation and necrosis in skeletal muscles than those that received a lower dose or no vitamin C whatsoever. Conclusion: Although some research has shown the antioxidant effect of vitamin C, the results showed that animals subject to a 500 mg dose of vitamin C showed greater tissue damage in the chronic phase of Chagas disease, probably due to the paradoxical actions of the substance, which in this pathology, will have acted as a pro-oxidant or pro-inflammatory.

Vitamin E Deficiency Fails to Affect Myocardial Performance During In Vivo Ischemia-Reperfusion

2000 ◽  
Vol 70 (6) ◽  
pp. 293-300 ◽  
Author(s):  
Jeff Coombes ◽  
Scott Powers ◽  
Haydar Demirel ◽  
Karyn Hamilton ◽  
James Jessup ◽  
...  
Keyword(s):  
Vitamin E ◽  
Corn Oil ◽  
Ischemia Reperfusion ◽  
Control Diet ◽  
Cardiac Performance ◽  
In Vivo Model ◽  
Vitamin E Deficiency ◽  
Deficient Diet ◽  
Protein Thiols

Vitamin E content, of cardiac tissue, has been proposed to play a major, role in the damage caused by myocardial ischemia-reperfusion (I-R). Previous studies using in vitro models have examined vitamin E deficiency and I-R-induced myocardial damage with equivocal results. The purpose of this study was to use an in vivo model of myocardial I-R to determine the effects of vitamin E deficiency on myocardial I-R-induced damage. Female Sprague-Dawly rats (4-mo old) were assigned to either: 1) control diet (CON), or 2) vitamin E deficient diet (VE-DEF). The CON diet was prepared to meet AIN-93M standards, which contains 75 IU vitamin E/kg diet. The VE-DEF diet was the AIN-93M diet prepared with tocopherol stripped corn oil and no vitamin E. Following a 14-week feeding period, significant differences (p < 0.05) existed in mean myocardial VE levels between groups (mean values ± SEM: CON = 48.2 ± 3.5; VE-DEF = 12.4 ± 1,4 mug VE/g wet weight). Animals from both experimental groups were subjected to an in vivo I-R protocol consisting of 25 minutes of left coronary artery occlusion followed by 10 minutes of reperfusion. No group differences (p > 0.05) existed in cardiac performance (peak arterial pressure or ventricular work) or the incidence of ventricular arrhythmias during the I-R protocol. VE-DEF animals had significantly higher (p < 0.05) levels of myocardial lipid peroxidation and lower (p < 0.05) protein thiols following I-R compared to the CON animals. These data suggest that although vitamin E deficiency increases oxidative damage resulting from myocardial I-R, it does not affect cardiac performance during the insult.

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