Structure Activity Evaluation and Computational analysis identifies potent, novel 3-Benzylidene Chroman-4-one analogues with Anti-fungal, Anti-oxidant and Anti-cancer activities.

2021 ◽  
pp. 1-21
Author(s):  
Gaffar S Zaman ◽  
Hossam Kamli ◽  
Suresh Radhakrishnan ◽  
Irfan Ahmad ◽  
Hassan Otifi ◽  
...  
Keyword(s):  
Computational Analysis ◽  
Activity Evaluation ◽  
Structure Activity ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Anti Fungal

A review on phyto-pharmacology of Oxalis corniculata

2021 ◽  
Vol 24 ◽  
Author(s):  
Iqra Sarfraz ◽  
Azhar Rasul ◽  
Ghulam Hussain ◽  
Muhammad Ajmal Shah ◽  
Bushra Nageen ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Current Effort ◽  
Isolation And Characterization ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Anti Fungal ◽  
Warm Temperate

: Oxalis corniculata (Oxalidaceae) is a small decumbent and delicate appearing medicinal herb flourishing in warm temperate and tropical domains such as Pakistan and India. Main bioactive chemical constituents of Oxalis plant include several alkaloids, flavonoids, terpenoids, cardiac glycosides, saponins, phlobatannins along with steroids. Due to its polyphenolic, glycosides and flavonoid profile, it is proved to be protective in numerous ailments and exhibit various biological activities such as anti-fungal, anti-cancer, anti-oxidant, anti-bacterial, anti-diabetic, and cardioprotective. Moreover, bioactive phytochemicals from this plant possess significant wound healing potential. Our current effort intends to emphasize on the immense significance of this plant species, which have not been the subject matter of clinical trials and effective pharmacological studies, even though its favored usage has been stated. This review proposes that Oxalis corniculata possess potential for the cure of various diseases, however, further researches on isolation and characterization of bioactive compounds along with pre-clinical trials are compulsory to figure out its pharmacological applications.

Phytochemical and pharmacological aspects of Nothapodytes nimmoniana. An overview

2013 ◽  
Vol 59 (1) ◽  
pp. 53-66 ◽  
Author(s):  
Nazeerullah Khan ◽  
Ennus Tajuddin Tamboli ◽  
V.K. Sharma ◽  
Sunil Kumar
Keyword(s):  
Wide Spectrum ◽  
Pharmacological Activities ◽  
Nothapodytes Nimmoniana ◽  
Jammu And Kashmir ◽  
Medicinal Uses ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Anti Fungal ◽  
Anti Hiv ◽  
Important Medicinal Plant

Summary Nothapodytes nimmoniana (J. Graham) (Icacinaceae), commonly known as Amruta is found in India particularly in Maharashtra, Goa, Kerala, Assam, Jammu and Kashmir as well as Tamilnadu areas. It is an important medicinal plant, the major source of a potent alkaloid, namely camptothecin, of a wide spectrum of pharmacological activities like anti-cancer, anti-HIV, antimalarial, antibacterial, anti-oxidant, anti-inflammatory, anti-fungal and also applied in the treatment of anaemia. Camptothecin is still not synthesized, therefore, its production entirely depends on natural sources. N. nimmoniana is one such plant which yields contain camptothecin in significantly high amount. The plant is gaining international recognition due to its diversified medicinal uses. It is subjected to excessive harvest. It has been categorized as a vulnerable and endangered plant. The present review encompasses the phytochemical, analytical, pharmacological, biotechnological, and other specific aspects of N. nimmoniana.

scholarly journals An Overview on Medicinal Perspective and Biological Behavior of Benzotriazole; Synthetic Study on Its Multifaceted Biological Activities

2021 ◽  
Vol 8 (5) ◽  
pp. 365-378
Author(s):  
V. S. Anjana ◽  
P. Manoj Kumar
Keyword(s):  
Biological Activities ◽  
Wide Spectrum ◽  
Research Field ◽  
Synthetic Methods ◽  
Biological Behavior ◽  
Sar Studies ◽  
Structure Activity ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Anti Fungal

Benzotriazole (BTA) is a nitrogen containing heterocyclic derivative containing three nitrogen atoms at 1st, 2nd and 3rd positions with chemical formula C6H5N3. Benzotriazole and its derivatives have great significance in medicinal chemistry and these derivatives were used by several chemists for therapeutic conditions because it possessing a wide spectrum of pharmacological activities including anti bacterial, anti fungal, anti viral, anti inflammatory, anti hyperglycemic, anti hypertensive, anti cancer and analgesic activity. In this review, different synthetic methods for the preparation of benzotriazole, importance of benzotriazole derivatives in biomedical research, highlighting its biological behavior, versatile activities and Structure Activity Relationship (SAR) studies are described. This review will help the researchers to understand the structure activity relationships and improvise the concepts in their research field. Keywords: Benzotriazole, Anti microbial, Anthelmintic, Analgesic, Anti mycobacterial, Anti viral, Anti oxidative, Anti tumor, Anti inflammatory, Anti hyperglycemia, Anti fungal, Anticonvulsant activity.

Phytochemical Composition and Pharmacological Effects of Cassia Fistula

2020 ◽  
Vol 4 (1) ◽  
pp. 59-69
Author(s):  
Muhammad Saeed ◽  
Sumra Naseer ◽  
Shabbir Hussain ◽  
Muhammad Iqbal
Keyword(s):  
Skin Diseases ◽  
Sterculic Acid ◽  
Stem Bark ◽  
Pharmacological Effects ◽  
Cassia Fistula ◽  
Phytochemical Composition ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Cardiac Disorders ◽  
Anti Fungal

Cassia fistula is widely utilized in conventional medicines against various diseases. The plant possesses diverse pharmacological characteristics including anti-tussive, hepatoprotective, anti-pyretic, anti-oxidant, anti-inflammatory, anti-cancer, anti-fungal, anti-microbial, anti-itching, anti-ulcer, anti-epileptic, anti-fertility and wound healing characteristics. Its leaves and bark are used to treat skin diseases,while its roots are useful as diuretic and are used to treat tubercular glands, cardiac disorders, and ulcer. Its fruit pulp is used as a mild laxative in numerous stomach problems. Its flowers are used to treat leprosy, abdominal problems and fever and its seeds possess anti-pyretic, cooling and laxativeproperties. The plant isan important source of tannins, glycosides and flavonoides, linoleic, oleic, stearic and carbohydrates. Its leaves contain glycosides, free rhein, sennosides A and B, isofavoneoxalic acidsandoxyanthraquinones derivatives,while the stem bark contains lepeol, hexacosanol, tannins and B-sitosterol. The pulp is composed of carbohydrate, arginine, protein, leucine and flavonid-3-ol-subordinates. Its pods contain astringent matter, fistulic acids, glutten matter and kaempferol,whereas its seeds are rich in malvalic acid, sterculic acid and vernolic oil. Moreover, aurantimide, ceryl alcohol, kaempferol, anthraquinonees, bianthroquonones and glycosides basic oils are present in the flower.

scholarly journals KEGIATAN FARMAKOLOGIS DARI BERBAGAI BAGIAN Carica papaya Linn. EKSTRAK: BUAH, DAUN, BENIH, UAP, KULIT DAN AKAR

2020 ◽  
Vol 2 (3) ◽  
pp. 211-226
Author(s):  
Tita Kosima Hidayati ◽  
Yasmiwar Susilawati ◽  
Ahmad Muhtadi
Keyword(s):  
Carica Papaya ◽  
Stem Bark ◽  
Phytochemical Content ◽  
Tropical Plant ◽  
Anti Cancer ◽  
Phytochemical Compounds ◽  
Anti Oxidant ◽  
Medicinal Properties ◽  
Anti Fungal ◽  
Phytochemical Contents

Carica papaya (Caricaceae) Linn. (CP) is a popular tropical plant which provide a huge benefit. The fruit is either delicious and healthy while other parts have a great potential medicinal properties. CP are classified as plants that have anti-microbial activity, anti oxidant, anti malaria, anti-ulcer, anti-HIV, anti-inflammatory, anti-cancer, anti-hypertension, anti-fertility, anti-fungal and anti diabetic. Pharmacological activity of papaya plants related to the content of phytochemical  compounds of alkaloid, flavonoid , tannin, saponin, enzyme: papain and chymopapain. These phytochemical  content have been found in the young leaf, stem bark, dry seeds. Papaya leaf reveal more pharmacologycal activities because that have wide variety of phytochemical contents. In this review will be studied pharmacologycal activities  of Carica papaya Linn. extract that  obtained from fruit, leaf, seeds, stem bark and root. Besides, their  various phytochemical contents are also described. 

scholarly journals Flavonoids: isolation, characterization, and health benefits

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Abiche Ekalu ◽  
James Dama Habila
Keyword(s):  
Secondary Metabolites ◽  
Health Benefits ◽  
The Body ◽  
Pharmacological Activities ◽  
Potential Health ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Plant Families ◽  
Anti Fungal

Abstract Background The unique and vast pharmacological activities of flavonoids have made them of research interest. This led to the use of various techniques to isolate and characterize them, intending to determine their potential health benefits. Main text The medicinal values of plant-based flavonoids that this literature review tends to summarize the pharmacological activities of these secondary metabolites from 22 selected plant families. The pharmacological shreds of evidence reported in the literature have proven that flavonoids have shown anti-cancer, anti-microbial, anti-oxidant, anti-inflammatory, anti-fungal, anti-ulcer, and anti-edematogenic activities. Out of these, 30% showed to have anti-oxidant activity, key in protecting the body against free radicals. Besides, 18% of the references showed anti-microbial and anti-cancer activities. Further literature reports indicated that flavonoids from these families exhibited anti-inflammatory and anti-edematogenic (9%), anti-viral and anti-ulcer (5%), anti-fungal, anti-nociceptive, and anti-histamine (2%). Conclusion The pharmacological activities of flavonoids from the various sources reviewed in this study show that the secondary metabolites could provide a scaffold for the development of potent anti-cancer drugs in the future.

Role of Rasayan Churna in outbreak of Covid -19 as preventive and curative aspect

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1208-1212
Author(s):  
Amol Madhav Deshpande ◽  
Mayuri Amol Deshpande
Keyword(s):  
Recurrent Infection ◽  
Symptomatic Patient ◽  
H1n1 Influenza ◽  
Drug Of Choice ◽  
Asymptomatic Patients ◽  
Diseased Person ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Immune Booster ◽  
Respiratory Droplets

In last two decade world suffer with three epidemic diseases like SARS-CoV, H1N1 influenza, MERS –CoV and presently the world under a pandemic of Covid-19, out of these SARS-CoV, MERS –CoV and Covid-19 are form the same virus call as corona, which primary present on bats and transferred from animal to human, and then it transfer from human to human mostly by respiratory droplets or in the direct contact with the diseased person, these recurrent infection of corona virus is the burning issue in the word, so to avoid these recurrent infections good habitual behaviour with regular immune booster medicine should be taken which can be used in both normal and symptomatic patient for this Rasayan churna  is the best drug of choice as it is used for  rejuvenation therapy. From literally study from various recourses it is found that Rasayan churna have property anti-depressant, anti-xylotic, Immunomodulatory, Anti-diabetes, anti hypertensive, anti-inflammatory, Anti-toxic effects, Anti-arthritic, Anti-cancer effects, Anti-microbial effect, and Anti-oxidant which can be useful in preventive aspect of Covid -19 in all phase like normal individual, also can be used in asymptomatic patients and symptomatic patients, clinical study can be performed for the same to evaluate the result.

Ferula hermonis: A Review of Current Use and Pharmacological Studies of its Sesquiterpene Ester Ferutinin

2020 ◽  
Vol 21 (5) ◽  
pp. 499-508 ◽  
Author(s):  
Rémi Safi ◽  
Marwan El-Sabban ◽  
Fadia Najjar
Keyword(s):  
Wide Spectrum ◽  
Endemic Plant ◽  
Anti Cancer ◽  
Pharmacological Studies ◽  
Sexual Impotence ◽  
Novel Applications ◽  
Anti Fungal ◽  
Sesquiterpene Ester

Ferula hermonis Boiss, is an endemic plant of Lebanon, locally known as “shilsh Elzallouh”. It has been extensively used in the traditional medicine as an aphrodisiac and for the treatment of sexual impotence. Crude extracts and isolated compounds of ferula hermonis contain phytoestrogenic substances having a wide spectrum of in vitro and in vivo pharmacological properties including anti-osteoporosis, anti-inflammatory, anti-microbial and anti-fungal, anti-cancer and as sexual activity enhancer. The aim of this mini-review is to highlight the traditional and novel applications of this plant’s extracts and its major sesquiterpene ester, ferutinin. The phytochemical constituents and the pharmacological uses of ferula hermonis crude extract and ferutinin specifically will be discussed.

1,4-Dihydropyridine: A Dependable Heterocyclic Ring with the Promising and the Most Anticipable Therapeutic Effects

2019 ◽  
Vol 19 (15) ◽  
pp. 1219-1254 ◽  
Author(s):  
Abhinav Prasoon Mishra ◽  
Ankit Bajpai ◽  
Awani Kumar Rai
Keyword(s):  
Calcium Ion ◽  
Heterocyclic Compounds ◽  
Channel Blocker ◽  
Heterocyclic Ring ◽  
Therapeutic Effects ◽  
Voltage Gated ◽  
Therapeutic Benefits ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Synthetic Medicinal

: Nowadays, heterocyclic compounds act as a scaffold and are the backbone of medicinal chemistry. Among all of the heterocyclic scaffolds, 1,4-Dihydropyridine (1,4-DHP) is one of the most important heterocyclic rings that possess prominent therapeutic effects in a very versatile manner and plays an important role in synthetic, medicinal, and bioorganic chemistry. The main aim of the study is to review and encompass relevant studies related to 1,4-DHP and excellent therapeutic benefits of its derivatives. An extensive review of Pubmed-Medline, Embase and Lancet’s published articles was done to find all relevant studies on the activity of 1,4-DHP and its derivatives. 1,4-DHP is a potent Voltage-Gated Calcium Channel (VGCC) antagonist derivative which acts as an anti-hypertensive, anti- anginal, anti-tumor, anti-inflammatory, anti-tubercular, anti-cancer, anti-hyperplasia, anti-mutagenic, anti-dyslipidemic, and anti-ulcer agent. From the inferences of the study, it can be concluded that the basic nucleus, 1,4-DHP which is a voltage-gated calcium ion channel blocker, acts as a base for its derivatives that possess different important therapeutic effects. There is a need of further research of this basic nucleus as it is a multifunctional moiety, on which addition of different groups can yield a better drug for its other activities such as anti-convulsant, anti-oxidant, anti-mutagenic, and anti-microbial. This review would be significant for further researches in the development of several kinds of drugs by representing successful matrix for the medicinal agents.

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